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Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway

  • Authors:
    • Zheng Wang
    • Hesheng Luo
    • Hong Xia
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3791-3799
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    Published online on: August 3, 2018
       https://doi.org/10.3892/mmr.2018.9352
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Abstract

Ethanol‑induced diseases of the gastric mucosa are the most common and refractory diseases of gastrointestinal system in clinic, and are mediated by oxidative stress and apoptosis pathways. Theaflavins (TFs) are considered to be antioxidants. The present study aimed to determine the molecular mechanism underlying the ability of TFs to attenuate ethanol‑induced oxidative stress and apoptosis in GES‑1 gastric mucosa epithelial cells. A Cell Counting Kit‑8 (CCK‑8) assay was performed to investigate the cell viability of GES‑1 cells following administration of ethanol (0.5 mol/l) and subsequent treatment with TFs (20, 40 and 80 µg/ml) for specific time intervals. A carboxyfluorescein diacetate succinimidyl ester assay was used to measure proliferation and further investigate the results of the CCK‑8 assay. Flow cytometry was performed to measure reactive oxygen species (ROS) levels and the apoptosis rates of GES‑1 cells. Furthermore, levels of oxidative stress‑associated factors, including malondialdehyde, superoxide dismutase and glutathione, were investigated using commercial kits. Reverse transcription‑quantitative polymerase chain reaction and western blot assays were performed to determine the expression levels of apoptosis‑associated factors, as well as the phosphorylation levels of extracellular signal‑regulated kinase (ERK), c‑Jun N‑terminal kinase (JNK) and p38 kinase (p38). The results of the present study demonstrated that treatment with ethanol inhibited GES‑1 cell proliferation, and enhanced ROS levels and apoptosis rates, potentially via downregulation of B‑cell lymphoma‑2 (Bcl‑2) expression and upregulation of Bcl‑2‑associated X and caspase‑3 expression levels, as well as enhancing the phosphorylation levels of ERK, JNK and p38. However, treatment with TFs was revealed to attenuate the effects of ethanol administration on GES‑1 cells in a dose‑dependent manner. In conclusion, TFs may attenuate ethanol‑induced oxidative stress and apoptosis in gastric mucosa epithelial cells via downregulation of various mitogen‑activated protein kinase pathways.
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1 

Boutemine IM, Amri M, Amir ZC, Fitting C, Mecherara-Idjeri S, Layaida K, Sennoun N, Berkane S, Cavaillon JM and Touil-Boukoffa C: Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. Fatty oil against ethanol-induced gastric ulcers in rats. J Ethnopharmacol. 224:273–282. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Chi YC, Lee SL, Lee YP, Lai CL and Yin SJ: Modeling of human hepatic and gastrointestinal ethanol metabolism with kinetic mechanism-based full rate equations of the component alcohol dehydrogenase isozymes and allozymes. Chem Res Toxicol. 31:556–569. 2018. View Article : Google Scholar : PubMed/NCBI

3 

de Araujo ERD, Guerra GCB, Araujo DFS, de Araujo AA, Fernandes JM, de Araujo Junior RF, da Silva VC, de Carvalho TG, Ferreira LS and Zucolotto SM: Gastroprotective and antioxidant activity of kalanchoe brasiliensis and kalanchoe pinnata leaf juices against indomethacin and ethanol-induced gastric lesions in rats. Int J Mol Sci. 19(pii): E12652018. View Article : Google Scholar : PubMed/NCBI

4 

Yang J, Zhou W, Gu Y, Dai J, Li X, Tai P, Li Y, Ma X and Zhang Y: Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats. Biomed Rep. 8:335–342. 2018.PubMed/NCBI

5 

Chen H, Liao H, Liu Y, Zheng Y, Wu X and Su Z, Zhang X, Lai Z, Lai X, Lin ZX and Su Z: Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats. Fitoterapia. 100:110–117. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Gong J, Zhang Z, Zhang X, Chen F, Tan Y, Li H, Jiang J and Zhang J: Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats. Pharm Biol. 56:294–301. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Moris D, Spartalis M, Tzatzaki E, Spartalis E, Karachaliou GS, Triantafyllis AS, Karaolanis GI, Tsilimigras DI and Theocharis S: The role of reactive oxygen species in myocardial redox signaling and regulation. Ann Transl Med. 5:3242017. View Article : Google Scholar : PubMed/NCBI

8 

Slomiany A, Piotrowski E, Piotrowski J and Slomiany BL: Impact of ethanol on innate protection of gastric mucosal epithelial surfaces and the risk of injury. J Physiol Pharmacol. 51:433–447. 2000.PubMed/NCBI

9 

Shindo Y, Konagaya M, Harasawa S, Miwa T and Osamura Y: The role of histamine in ethanol-induced gastric mucosal injury in the rat. Tokai J Exp Clin Med. 22:59–64. 1997.PubMed/NCBI

10 

Liu J, Wang J, Shi Y, Su W, Chen J, Zhang Z, Wang G and Wang F: Short chain fatty acid acetate protects against ethanol-induced acute gastric mucosal lesion in mice. Biol Pharm Bull. 40:1439–1446. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Yang HJ, Kim MJ, Kwon DY, Kang ES, Kang S and Park S: Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis. J Ethnopharmacol. 208:84–93. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Liu W, Shang P, Liu T, Xu H, Ren D, Zhou W, Wen A and Ding Y: Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats. Chem Biol Interact. 278:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Yang Y, Yin B, Lv L, Wang Z, He J, Chen Z, Wen X, Zhang Y, Sun W, Li Y and Zhao Y: Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice. Life Sci. 189:44–51. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Ilacqua AN, Shettler JA, Wernke KM, Skalla JK and McQuade KJ: Theaflavins from black tea affect growth, development, and motility in Dictyostelium discoideum. Biochem Biophys Res Commun. 491:449–454. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Pereira-Caro G, Moreno-Rojas JM, Brindani N, Del Rio D, Lean MEJ, Hara Y and Crozier A: Bioavailability of black tea theaflavins: Absorption, metabolism, and colonic catabolism. J Agric Food Chem. 65:5365–5374. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Thakur VS, Gupta K and Gupta S: The chemopreventive and chemotherapeutic potentials of tea polyphenols. Curr Pharm Biotechnol. 13:191–199. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Zaveri NT: Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications. Life Sci. 78:2073–2080. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Gao Y, Rankin GO, Tu Y and Chen YC: Theaflavin-3,3′-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways. Int J Oncol. 48:281–292. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Pan H, Wang F, Rankin GO, Rojanasakul Y, Tu Y and Chen YC: Inhibitory effect of black tea pigments, theaflavin3/3′-gallate against cisplatin-resistant ovarian cancer cells by inducing apoptosis and G1 cell cycle arrest. Int J Oncol. 51:1508–1520. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Sur S and Panda CK: Molecular aspects of cancer chemopreventive and therapeutic efficacies of tea and tea polyphenols. Nutrition 43–44. 1–15. 2017.

21 

Yang CS, Wang X, Lu G and Picinich SC: Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance. Nat Rev Cancer. 9:429–439. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Kong L, Qi X, Huang S, Chen S, Wu Y and Zhao L: Theaflavins inhibit pathogenic properties of P. Gingivalis and MMPs production in P. Gingivalis-stimulated human gingival fibroblasts. Arch Oral Biol. 60:12–22. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Lombardo Bedran TB, Morin MP, Palomari Spolidorio D and Grenier D: Black tea extract and its theaflavin derivatives inhibit the growth of periodontopathogens and modulate interleukin-8 and beta-defensin secretion in oral epithelial cells. PLoS One. 10:e01431582015. View Article : Google Scholar : PubMed/NCBI

24 

Frei B and Higdon JV: Antioxidant activity of tea polyphenols in vivo: Evidence from animal studies. J Nutrition. 133:3275s–3284s. 2003. View Article : Google Scholar

25 

Han X, Zhang J, Xue X, Zhao Y, Lu L, Cui M, Miao W and Fan S: Theaflavin ameliorates ionizing radiation-induced hematopoietic injury via the NRF2 pathway. Free Radic Biol Med. 113:59–70. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Chang H, Wang Y, Yin X, Liu X and Xuan H: Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. BMC Complement Altern Med. 17:4712017. View Article : Google Scholar : PubMed/NCBI

27 

Sims EK, Lakhter AJ, Anderson-Baucum E, Kono T, Tong X and Evans-Molina C: MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. Diabetologia. 60:1057–1065. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Zhang J, Cai S, Li J, Xiong L, Tian L, Liu J, Huang J and Liu Z: Neuroprotective effects of theaflavins against oxidative stress-induced apoptosis in PC12 cells. Neurochem Res. 41:3364–3372. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Anandhan A, Essa MM and Manivasagam T: Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease. Neurotox Res. 23:166–173. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Dong Z, Ma W, Huang C and Yang CS: Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (−)-epigallocatechin gallate, and theaflavins. Cancer Res. 57:4414–4419. 1997.PubMed/NCBI

31 

Lu G, Liao J, Yang G, Reuhl KR, Hao X and Yang CS: Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. Cancer Res. 66:11494–11501. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Shao J, Meng Q and Li Y: Theaflavins suppress tumor growth and metastasis via the blockage of the STAT3 pathway in hepatocellular carcinoma. Onco Targets Ther. 9:4265–4275. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Ganguly S, G TK, Mantha S and Panda K: Simultaneous determination of black tea-derived catechins and theaflavins in tissues of tea consuming animals using ultra-performance liquid-chromatography tandem mass spectrometry. PLoS One. 11:e01634982016. View Article : Google Scholar : PubMed/NCBI

34 

Jiang M, Gao PF, Li HQ, Tian PY and Fan XM: Ghrelin inhibition of ethanol-induced gastric epithelial cell apoptosis is mediated by miR-21. Int J Clin Exp Pathol. 8:4662–4672. 2015.PubMed/NCBI

35 

Chang W, Bai J, Tian S, Ma M, Li W, Yin Y, Deng R, Cui J, Li J, Wang G, et al: Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway. Exp Biol Med (Maywood). 242:1025–1033. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Olguin-Martinez M, Hernandez-Espinosa DR and Hernandez-Munoz R: High alpha-Tocopherol dosing increases lipid metabolism by changing redox state in damaged rat gastric mucosa and liver after ethanol treatment. Clin Sci (Lond). 132:1257–1272. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Isbil-Buyukcoskun N, Cam B, Suyen GG and Ozluk K: Effects of intracerebroventricularly injected glucagon-like peptide-2 on ethanol-induced gastric mucosal damage in rats. Endocr Res. Apr 9–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

39 

Sahin HH, Cumbul A, Uslu U, Yilmaz Z, Ercan F and Alican I: The effect of 1,25 dihydroxyvitamin D3 on HCl/Ethanol-induced gastric injury in rats. Tissue Cell. 51:68–76. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Guo L, Guo J, Liu H, Zhang J, Chen X, Qiu Y and Fu S: Tea polyphenols suppress growth and virulence-related factors of Haemophilus parasuis. J Vet Med Sci. 80:1047–1053. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Sun L, Gidley MJ and Warren FJ: Tea polyphenols enhance binding of porcine pancreatic alpha-amylase with starch granules but reduce catalytic activity. Food Chem. 258:164–173. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Arent SM, Senso M, Golem DL and McKeever KH: The effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: A randomized, double-blind, crossover study. J Int Soc Sports Nutr. 7:112010. View Article : Google Scholar : PubMed/NCBI

43 

Fatima M, Kesharwani RK, Misra K and Rizvi SI: Protective effect of theaflavin on erythrocytes subjected to in vitro oxidative stress. Biochem Res Int. 2013:6497592013. View Article : Google Scholar : PubMed/NCBI

44 

Wu YY, Li W, Xu Y, Jin EH and Tu YY: Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses. J Zhejiang Univ Sci B. 12:744–751. 2011. View Article : Google Scholar : PubMed/NCBI

45 

do Carmo TLL, Azevedo VC, de Siqueira PR, Galvao TD, Dos Santos FA, Dos Reis Martinez CB, Appoloni CR and Fernandes MN: Reactive oxygen species and other biochemical and morphological biomarkers in the gills and kidneys of the Neotropical freshwater fish, Prochilodus lineatus, exposed to titanium dioxide (TiO2) nanoparticles. Environ Sci Pollut Res Int. Jun 1–2018.(Epub ahead of print). View Article : Google Scholar

46 

Li H, Cao F, Zhao F, Yang Y, Teng M, Wang C and Qiu L: Developmental toxicity, oxidative stress and immunotoxicity induced by three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) in zebrafish embryos. Chemosphere. 207:781–790. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Sun Y, Liu J, Ye G, Gan F, Hamid M, Liao S and Huang K: Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells. Cell Stress Chaperones. Jun 2–2018.(Epub ahead of print). View Article : Google Scholar

48 

Meng LQ, Wang Y, Luo YH, Piao XJ, Liu C, Wang Y, Zhang Y, Wang JR, Wang H, Xu WT, et al: Quinalizarin induces apoptosis through reactive oxygen Species (ROS)-Mediated mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription 3 (STAT3) signaling pathways in colorectal cancer cells. Med Sci Monit. 24:3710–3719. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Liu X, Kim CN, Yang J, Jemmerson R and Wang X: Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochromec. Cell. 86:147–157. 1996. View Article : Google Scholar : PubMed/NCBI

50 

Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM and Hood L: MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proc Natl Acad Sci USA. 94:pp. 11333–11338. 1997; View Article : Google Scholar : PubMed/NCBI

51 

Scatena R, Bottoni P, Botta G, Martorana GE and Giardina B: The role of mitochondria in pharmacotoxicology: A reevaluation of an old, newly emerging topic. Am J Physiol Cell Physiol. 293:C12–C21. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Becatti M, Barygina V, Mannucci A, Emmi G, Prisco D, Lotti T, Fiorillo C and Taddei N: Sirt1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients: A new insight into the pathogenetic mechanisms of psoriasis. Int J Mol Sci. 19(pii): E15722018. View Article : Google Scholar : PubMed/NCBI

53 

Zhang Y, Miao LS, Cai YM, He JX, Zhang ZN, Wu G and Zheng J: TXNIP knockdown alleviates hepatocyte ischemia reperfusion injury through preventing p38/JNK pathway activation. Biochem Biophys Res Commun. 502:409–414. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Jan S, Gygi SP and Puigserver P: Inhibition of the ER stress IRE1alpha inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. Cell Death Dis. 9:6582018. View Article : Google Scholar : PubMed/NCBI

55 

Junttila MR, Li SP and Westermarck J: Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22:954–965. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Feng W, Li J, Liao S, Ma S, Li F, Zhong C, Li G, Wei Y, Huang H, Wei Q, et al: Go6983 attenuates titanium particle-induced osteolysis and RANKL mediated osteoclastogenesis through the suppression of NFkappaB/JNK/p38 pathways. Biochem Biophys Res Commun. Jun 5–2018.(Epub ahead of print). View Article : Google Scholar

57 

Paudel P, Jung HA and Choi JS: Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation. Arch Pharm Res. 41:677–689. 2018. View Article : Google Scholar : PubMed/NCBI

58 

You MM, Chen YF, Pan YM, Liu YC, Tu J, Wang K and Hu FL: Royal Jelly attenuates LPS-induced inflammation in BV-2 microglial cells through modulating NF-kappaB and p38/JNK signaling pathways. Mediators Inflamm. 2018:78343812018. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Wang Z, Luo H and Xia H: Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway. Mol Med Rep 18: 3791-3799, 2018.
APA
Wang, Z., Luo, H., & Xia, H. (2018). Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway. Molecular Medicine Reports, 18, 3791-3799. https://doi.org/10.3892/mmr.2018.9352
MLA
Wang, Z., Luo, H., Xia, H."Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 18.4 (2018): 3791-3799.
Chicago
Wang, Z., Luo, H., Xia, H."Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 18, no. 4 (2018): 3791-3799. https://doi.org/10.3892/mmr.2018.9352
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Spandidos Publications style
Wang Z, Luo H and Xia H: Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway. Mol Med Rep 18: 3791-3799, 2018.
APA
Wang, Z., Luo, H., & Xia, H. (2018). Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway. Molecular Medicine Reports, 18, 3791-3799. https://doi.org/10.3892/mmr.2018.9352
MLA
Wang, Z., Luo, H., Xia, H."Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 18.4 (2018): 3791-3799.
Chicago
Wang, Z., Luo, H., Xia, H."Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 18, no. 4 (2018): 3791-3799. https://doi.org/10.3892/mmr.2018.9352
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