Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation

Ono,Hisaya  K.; Yoshimura,Sayuri; Hirose,Shouhei; Narita,Kouji; Tsuboi,Makoto; Asano,Krisana; Nakane,Akio

doi:10.3892/mmr.2018.9364

Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation

Authors:
- Hisaya K. Ono
- Sayuri Yoshimura
- Shouhei Hirose
- Kouji Narita
- Makoto Tsuboi
- Krisana Asano
- Akio Nakane
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Affiliations: Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori 034‑8628, Japan, Tohoku Women's College, Hirosaki, Aomori 036‑8503, Japan, Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Research and Development Department, Ichimaru Pharcos Co., Ltd., Motosu, Gifu 501‑0475, Japan
Published online on: August 8, 2018 https://doi.org/10.3892/mmr.2018.9364
Pages: 4058-4064

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Abstract

Proteoglycan (PG) is a complex glycohydrate, which is widely distributed in the extracellular matrix. It has been reported that daily oral administration of PG (extracted from salmon nasal cartilage) modulates the severity of proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen‑induced arthritis and obesity‑induced inflammation. The present study investigated the effect of salmon nasal cartilage PG on allergic responses using a mouse model of papain‑induced respiratory inflammation. Low titers of immunoglobulin E were identified in the sera of the PG‑administered mice. Oral administration of PG attenuated eosinophil infiltration in the lung. In the acute model of papain‑induced allergic inflammation, PG‑administered mice exhibited low titers of epithelium‑derived and T helper 2‑associated cytokines. The results of the present study demonstrated that salmon cartilage PG has an immunomodulatory effect on intranasally delivered papain. These results suggest a potential role for PG as a prophylactic agent which may attenuate allergic respiratory inflammation.

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