Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012

  • Authors:
    • Joana Marinho‑Dias
    • João Lobo
    • Rui Henrique
    • Inês Baldaque
    • Carlos Pinho‑Vaz
    • Luísa Regadas
    • Rosa Branca
    • Fernando Campilho
    • António Campos Jr
    • Rui Medeiros
    • Hugo Sousa
  • View Affiliations

  • Published online on: September 3, 2018     https://doi.org/10.3892/mmr.2018.9433
  • Pages: 4650-4656
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Abstract

Post‑transplant lymphoproliferative disorder (PTLD), despite its rarity, is an important mortality/morbidity event in transplant patients. The purpose of the present study was to retrospectively examine the clinical and pathologic characteristics, and outcomes of PTLD at the Portuguese Oncology Institute of Porto. A retrospective review of patient information was performed for patients that developed PTLD following allogeneic hematopoietic stem cell transplant (aHSCT) and were diagnosed between 2005 and 2012. The present study included a total of 15 patients, 8 females (53.3%) and 7 males (46.7%), with different clinicopathological characteristics. The most frequent clinical condition inducing aHSCT was acute lymphocytic leukemia (40.0%). Conditioning regimens consisted primarily in busulfan and cyclophosphamide, with anti‑thymocyte globulin, and myeloablation was the preferential treatment. Epstein‑Barr virus (EBV) was present in all patients with a median time of diagnosis following transplant of 75 days (range, 25‑485 days) and a median viral load of 4.75 log10 copies/ml (range, 3.30‑6.26 log10 copies/ml). PTLD diagnosis was mainly assessed by clinical findings, and histological confirmation was available for 5 patients: 3 monomorphic, 1 polymorphic and 1 with early lesions of PTLD. To the best of our knowledge, this is the first study to describe PTLD cases in HSCT patients in Portugal. The data reinforces the importance of performing EBV monitoring in high‑risk patients, particularly those receiving a transplant from mismatch/unrelated donors, and those with myeloablative conditioning regimen including antithymocyte globulin. The results also suggested that EBV viral load may be significant for the prediction of PTLD development.
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November-2018
Volume 18 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Marinho‑Dias J, Lobo J, Henrique R, Baldaque I, Pinho‑Vaz C, Regadas L, Branca R, Campilho F, Jr AC, Medeiros R, Medeiros R, et al: Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012. Mol Med Rep 18: 4650-4656, 2018
APA
Marinho‑Dias, J., Lobo, J., Henrique, R., Baldaque, I., Pinho‑Vaz, C., Regadas, L. ... Sousa, H. (2018). Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012. Molecular Medicine Reports, 18, 4650-4656. https://doi.org/10.3892/mmr.2018.9433
MLA
Marinho‑Dias, J., Lobo, J., Henrique, R., Baldaque, I., Pinho‑Vaz, C., Regadas, L., Branca, R., Campilho, F., Jr, A. C., Medeiros, R., Sousa, H."Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012". Molecular Medicine Reports 18.5 (2018): 4650-4656.
Chicago
Marinho‑Dias, J., Lobo, J., Henrique, R., Baldaque, I., Pinho‑Vaz, C., Regadas, L., Branca, R., Campilho, F., Jr, A. C., Medeiros, R., Sousa, H."Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012". Molecular Medicine Reports 18, no. 5 (2018): 4650-4656. https://doi.org/10.3892/mmr.2018.9433