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Article Open Access

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways

  • Authors:
    • Yongyang Tian
    • Hong Yin
    • Xi Deng
    • Beichuan Tang
    • Xianjun Ren
    • Tao Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Third Military Medical University (Army Medical University), Chongqing 400037, P.R. China, Department of Ultrasound, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 4374-4380
    |
    Published online on: September 3, 2018
       https://doi.org/10.3892/mmr.2018.9444
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Abstract

Demyelination is a nervous system disease in which the myelin sheaths of neurons are damaged due to inflammatory reactions, inherited abnormalities or trauma. This damage impairs the conduction of signals in the affected nerves, which in turn causes deficiencies in sensation, movement and cognition. Oligodendrocyte precursor cells (OPCs) are able to induce remyelination. However, the remyelination is suboptimal due to the limited migration of OPCs. In the present study, neonatal OPCs were isolated from rats for the investigation of the role of C‑X‑C motif chemokine ligand 12 (CXCL12), an important chemokine, in mediating the migration ability of OPCs. The present results demonstrated that CXCL12 stimulation markedly promoted the migration of OPCs and activated the dual specificity mitogen‑activated protein kinase kinase 1 (MEK)/extracellular signal‑regulated kinase (ERK) and phosphoinositide 3‑kinase (PI3K)/RAC‑α serine/threonine‑protein kinase (AKT) pathways. Knockdown of C‑X‑C motif chemokine receptor 4 (CXCR4; a receptor of CXCL12) reversed the CXCL12‑induced migration of OPCs and blocked the MEK/ERK and PI3K/AKT pathways. In addition, specific inhibitors of the MEK/ERK and PI3K/AKT pathways significantly reduced the migration of OPCs. Based on these findings, it was concluded that CXCL12 may induce the migration of OPCs through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways. The results of the present study support the manipulation of CXCL12‑mediated OPC migration to improve remyelination.
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Copy and paste a formatted citation
Spandidos Publications style
Tian Y, Yin H, Deng X, Tang B, Ren X and Jiang T: CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways. Mol Med Rep 18: 4374-4380, 2018.
APA
Tian, Y., Yin, H., Deng, X., Tang, B., Ren, X., & Jiang, T. (2018). CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways. Molecular Medicine Reports, 18, 4374-4380. https://doi.org/10.3892/mmr.2018.9444
MLA
Tian, Y., Yin, H., Deng, X., Tang, B., Ren, X., Jiang, T."CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways". Molecular Medicine Reports 18.5 (2018): 4374-4380.
Chicago
Tian, Y., Yin, H., Deng, X., Tang, B., Ren, X., Jiang, T."CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways". Molecular Medicine Reports 18, no. 5 (2018): 4374-4380. https://doi.org/10.3892/mmr.2018.9444
Copy and paste a formatted citation
x
Spandidos Publications style
Tian Y, Yin H, Deng X, Tang B, Ren X and Jiang T: CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways. Mol Med Rep 18: 4374-4380, 2018.
APA
Tian, Y., Yin, H., Deng, X., Tang, B., Ren, X., & Jiang, T. (2018). CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways. Molecular Medicine Reports, 18, 4374-4380. https://doi.org/10.3892/mmr.2018.9444
MLA
Tian, Y., Yin, H., Deng, X., Tang, B., Ren, X., Jiang, T."CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways". Molecular Medicine Reports 18.5 (2018): 4374-4380.
Chicago
Tian, Y., Yin, H., Deng, X., Tang, B., Ren, X., Jiang, T."CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways". Molecular Medicine Reports 18, no. 5 (2018): 4374-4380. https://doi.org/10.3892/mmr.2018.9444
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