Open Access

Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes

  • Authors:
    • Hangyu Tian
    • Dan Yu
    • Yan Hu
    • Pan Zhang
    • Yang Yang
    • Qiang Hu
    • Ming Li
  • View Affiliations

  • Published online on: September 4, 2018     https://doi.org/10.3892/mmr.2018.9448
  • Pages: 4349-4355
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiotensin II (Ang II) is a principal molecule of the renin‑angiotensin system, which promotes hypertrophy and fibrosis. It has been demonstrated that Ang II upregulates the expression of cyclophilin A (CypA), which is a potential myocardial hypertrophy factor. However, the mechanisms by which Ang II induces the expression of CypA in cardiomyocytes remain unclear. In the present study, reactive oxygen species (ROS) were detected by fluorescence microscopy, and western blot analysis and ELISA were used to measure CypA expression. It was identified that Ang II enhanced the production of ROS in rat cardiomyocytes. ROS, in turn, promoted CypA expression and secretion. Notably, the action of Ang II was primarily dependent on the angiotensin type 2 receptor (AT2R), not the type 1 receptor. These results provided an insight into the role of the AT2R signaling pathway in Ang II‑induced myocardial hypertrophy.
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November-2018
Volume 18 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Tian H, Yu D, Hu Y, Zhang P, Yang Y, Hu Q and Li M: Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes. Mol Med Rep 18: 4349-4355, 2018
APA
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., & Li, M. (2018). Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes. Molecular Medicine Reports, 18, 4349-4355. https://doi.org/10.3892/mmr.2018.9448
MLA
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., Li, M."Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes". Molecular Medicine Reports 18.5 (2018): 4349-4355.
Chicago
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., Li, M."Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes". Molecular Medicine Reports 18, no. 5 (2018): 4349-4355. https://doi.org/10.3892/mmr.2018.9448