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Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes

  • Authors:
    • Hangyu Tian
    • Dan Yu
    • Yan Hu
    • Pan Zhang
    • Yang Yang
    • Qiang Hu
    • Ming Li
  • View Affiliations / Copyright

    Affiliations: Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China, Department of Emergency Medicine, The Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan 650101, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4349-4355
    |
    Published online on: September 4, 2018
       https://doi.org/10.3892/mmr.2018.9448
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Abstract

Angiotensin II (Ang II) is a principal molecule of the renin‑angiotensin system, which promotes hypertrophy and fibrosis. It has been demonstrated that Ang II upregulates the expression of cyclophilin A (CypA), which is a potential myocardial hypertrophy factor. However, the mechanisms by which Ang II induces the expression of CypA in cardiomyocytes remain unclear. In the present study, reactive oxygen species (ROS) were detected by fluorescence microscopy, and western blot analysis and ELISA were used to measure CypA expression. It was identified that Ang II enhanced the production of ROS in rat cardiomyocytes. ROS, in turn, promoted CypA expression and secretion. Notably, the action of Ang II was primarily dependent on the angiotensin type 2 receptor (AT2R), not the type 1 receptor. These results provided an insight into the role of the AT2R signaling pathway in Ang II‑induced myocardial hypertrophy.
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1 

Satoh K, Shimokawa H and Berk BC: Cyclophilin A-promising new target in cardiovascular therapy. Circ J. 74:2249–2256. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Bernardo BC, Weeks KL, Pretorius L and McMullen JR: Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies. Pharmacol Ther. 128:191–227. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Diwan A and Dorn GW II: Decompensation of cardiac hypertrophy: Cellular mechanisms and novel therapeutic targets. Physiology (Bethesda). 22:56–64. 2007.PubMed/NCBI

4 

Olson ER, Shamhart PE, Naugle JE and Meszaros JG: Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts. Hypertension. 51:704–711. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Rosenkranz S: TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 63:423–432. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K and Itoh N: Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. Genes Cells. 18:544–553. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Handschumacher R, Harding M, Rice J, Drugge R and Speicher D: Cyclophilin: A specific cytosolic binding protein for cyclosporin a. Science. 226:544–547. 1984. View Article : Google Scholar : PubMed/NCBI

8 

Göthel S and Marahiel M: Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol Life Sci. 55:423–436. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Ivery MT: Immunophilins: Switched on protein binding domains? Med Res Rev. 20:452–484. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Liu L, Li C, Cai C, Xiang J and Cao Z: Cyclophilin a (CypA) is associated with the inflammatory infiltration and alveolar bone destruction in an experimental periodontitis. Biochem Biophys Res Commun. 391:1000–1006. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Seizer P, Geisler T, Bigalke B, Schneider M, Klingel K, Kandolf R, Stellos K, Schreieck J, Gawaz M and May AE: EMMPRIN and its ligand cyclophilin a as novel diagnostic markers in inflammatory cardiomyopathy. Int J Cardiol. 163:299–304. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Seizer P, Klingel K, Sauter M, Westermann D, Ochmann C, Schönberger T, Schleicher R, Stellos K, Schmidt EM, Borst O, et al: Cyclophilin a affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. J Mol Cell Cardiol. 53:6–14. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Takapoo M, Chamseddine AH, Bhalla RC and Miller FJ Jr: Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin a. Vascul Pharmacol. 55:143–148. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Jabri B and Barreiro LB: Don't move: LRRK2 arrests NFAT in the cytoplasm. Nat Immunol. 12:1029–1030. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Li H, Pink MD, Murphy JG, Stein A, Dell'Acqua ML and Hogan PG: Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat Struct Mol Biol. 19:337–345. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Candé C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, Luban J, Kroemer RT, Giordanetto F, Garrido C, et al: AIF and cyclophilin a cooperate in apoptosis-associated chromatinolysis. Oncogene. 23:1514–1521. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Tanaka H, Shimazaki H, Kimura M, Izuta H, Tsuruma K, Shimazawa M and Hara H: Apoptosis-inducing factor and cyclophilin a cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice. CNS Neurosci Ther. 17:294–304. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N, Neagu MR, Nilsson M, Eriksson PS, Hagberg H, et al: Cyclophilin a participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med. 204:1741–1748. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Piao CS, Loane DJ, Stoica BA, Li S, Hanscom M, Cabatbat R, Blomgren K and Faden AI: Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis. 46:745–758. 2012. View Article : Google Scholar : PubMed/NCBI

20 

He H, Zhou D, Fan W, Fu X, Zhang J, Shen Z, Li J, Li J and Wu Y: Cyclophilin a inhibits rotavirus replication by facilitating host IFN-I production. Biochem Biophys Res Commun. 422:664–669. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Zhou D, Mei Q, Li J and He H: Cyclophilin a and viral infections. Biochem Biophys Res Commun. 424:647–650. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P and Chandrasekar B: EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling. J Mol Cell Cardiol. 49:655–663. 2010. View Article : Google Scholar : PubMed/NCBI

23 

de Gasparo M and Siragy HM: The AT2 receptor: Fact, fancy and fantasy. Regul Pept. 81:11–24. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Ma Y, Kong L, Qi S and Wang D: Atorvastatin blocks increased l-type Ca2+current and cell injury elicited by angiotensin II via inhibiting oxide stress. Acta Biochim Biophys Sin (Shanghai). 48:378–384. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Martens GA, Cai Y, Hinke S, Stangé G, Van de Casteele M and Pipeleers D: Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem. 280:20389–20396. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Perrotta I and Aquila S: The role of oxidative stress and autophagy in atherosclerosis. Oxid Med Cell Longev. 2015:1303152015. View Article : Google Scholar : PubMed/NCBI

27 

Mehta PK and Griendling KK: Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 292:C82–C97. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, Mohan A, Yan C, Abe J, Illig KA and Berk BC: Cyclophilin a enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 15:649–656. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Maeda H, Yamamoto K, Kohno I, Hafsi L, Itoh N, Nakagawa S, Kanagawa N, Suzuki K and Uno T: Design of a practical fluorescent probe for superoxide based on protection-deprotection chemistry of fluoresceins with benzenesulfonyl protecting groups. Chemistry. 13:1946–1954. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Maeda H, Yamamoto K, Nomura Y, Kohno I, Hafsi L, Ueda N, Yoshida S, Fukuda M, Fukuyasu Y, Yamauchi Y and Itoh N: A design of fluorescent probes for superoxide based on a nonredox mechanism. J Am Chem Soc. 127:68–69. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Chang MC, Tsai YL, Chen YW, Chan CP, Huang CF, Lan WC, Lin CC, Lan WH and Jeng JH: Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts. J Periodontal Res. 48:66–73. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Liu Q, Shimoyama T, Suzuki K, Umeda T, Nakaji S and Sugawara K: Effect of sodium butyrate on reactive oxygen species generation by human neutrophils. Scand J Gastroenterol. 36:744–750. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Wang LP, Wang Y, Zhao LM, Li GR and Deng XL: Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. Biochem Pharmacol. 85:1486–1494. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Seko Y, Fujimura T, Taka H, Mineki R, Murayama K and Nagai R: Hypoxia followed by reoxygenation induces secretion of cyclophilin a from cultured rat cardiac myocytes. Biochem Biophys Res Commun. 317:162–168. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Savoia C, Burger D, Nishigaki N, Montezano A and Touyz RM: Angiotensin II and the vascular phenotype in hypertension. Expert Rev Mol Med. 13:e112011. View Article : Google Scholar : PubMed/NCBI

36 

Mercure C, Yogi A, Callera GE, Aranha AB, Bader M, Ferreira AJ, Santos RA, Walther T, Touyz RM and Reudelhuber TL: Angiotensin(1–7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circ Res. 103:1319–1326. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Vinturache AE and Smith FG: Angiotensin type 1 and type 2 receptors during ontogeny: Cardiovascular and renal effects. Vascul Pharmacol. 63:145–154. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Lopez JJ, Lorell BH, Ingelfinger JR, Weinberg EO, Schunkert H, Diamant D and Tang SS: Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol. 267:H844–H852. 1994.PubMed/NCBI

39 

Ohkubo N, Matsubara H, Nozawa Y, Mori Y, Murasawa S, Kijima K, Maruyama K, Masaki H, Tsutumi Y, Shibazaki Y, et al: Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation. 96:3954–3962. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Thakur S, Du J, Hourani S, Ledent C and Li JM: Inactivation of adenosine A2A receptor attenuates basal and angiotensin II-induced ROS production by Nox2 in endothelial cells. J Biol Chem. 285:40104–40113. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Perrucci GL, Straino S, Corlianò M, Scopece A, Napolitano M, Berk BC, Lombardi F, Pompilio G, Capogrossi MC and Nigro P: Cyclophilin a modulates bone marrow-derived CD117(+) cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis. Int J Cardiol. 212:324–335. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Nagai T, Anzai T, Kaneko H, Mano Y, Anzai A, Maekawa Y, Takahashi T, Meguro T, Yoshikawa T and Fukuda K: C-reactive protein overexpression exacerbates pressure overload-induced cardiac remodeling through enhanced inflammatory response. Hypertension. 57:208–215. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tian H, Yu D, Hu Y, Zhang P, Yang Y, Hu Q and Li M: Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes. Mol Med Rep 18: 4349-4355, 2018.
APA
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., & Li, M. (2018). Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes. Molecular Medicine Reports, 18, 4349-4355. https://doi.org/10.3892/mmr.2018.9448
MLA
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., Li, M."Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes". Molecular Medicine Reports 18.5 (2018): 4349-4355.
Chicago
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., Li, M."Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes". Molecular Medicine Reports 18, no. 5 (2018): 4349-4355. https://doi.org/10.3892/mmr.2018.9448
Copy and paste a formatted citation
x
Spandidos Publications style
Tian H, Yu D, Hu Y, Zhang P, Yang Y, Hu Q and Li M: Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes. Mol Med Rep 18: 4349-4355, 2018.
APA
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., & Li, M. (2018). Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes. Molecular Medicine Reports, 18, 4349-4355. https://doi.org/10.3892/mmr.2018.9448
MLA
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., Li, M."Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes". Molecular Medicine Reports 18.5 (2018): 4349-4355.
Chicago
Tian, H., Yu, D., Hu, Y., Zhang, P., Yang, Y., Hu, Q., Li, M."Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes". Molecular Medicine Reports 18, no. 5 (2018): 4349-4355. https://doi.org/10.3892/mmr.2018.9448
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