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Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury

  • Authors:
    • Xiaoli Niu
    • Simin Zheng
    • Hongtao Liu
    • Siyuan Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4516-4522
    |
    Published online on: September 6, 2018
       https://doi.org/10.3892/mmr.2018.9465
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Abstract

The protective effect of taurine against inflammation, apoptosis and oxidative stress in traumatic brain injury was investigated in the present study. Taurine is a non‑proteogenic and essential amino acid in animals. It plays a critical nutritional role in brain cell growth, differentiation, and development. Taurine is involved in regeneration and neuroprotection in the injured nervous system, and is an effective antioxidant against lead‑, cadmium‑, and exercise‑induced oxidative stress. Astrocytes and neuron cells were co‑cultured and cells were treated with different concentrations of taurine (100, 200 and 300 mg/l) for 72 h, and the levels of reactive oxygen species, malondialdehyde, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase, acetylcholinesterase, tumor necrosis factor‑α, interleukin‑6, caspase‑3, p53, B‑cell lymphoma 2 and Bcl‑2‑associated X protein were determined. These inflammatory, apoptotic, and oxidative stress markers were substantially increased in injured cells, and returned to normal levels following taurine supplementation. Thus, taurine supplementation may be effective against oxidative stress, apoptosis, and inflammation in injured brain cells.
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Copy and paste a formatted citation
Spandidos Publications style
Niu X, Zheng S, Liu H and Li S: Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Mol Med Rep 18: 4516-4522, 2018.
APA
Niu, X., Zheng, S., Liu, H., & Li, S. (2018). Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Molecular Medicine Reports, 18, 4516-4522. https://doi.org/10.3892/mmr.2018.9465
MLA
Niu, X., Zheng, S., Liu, H., Li, S."Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury". Molecular Medicine Reports 18.5 (2018): 4516-4522.
Chicago
Niu, X., Zheng, S., Liu, H., Li, S."Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury". Molecular Medicine Reports 18, no. 5 (2018): 4516-4522. https://doi.org/10.3892/mmr.2018.9465
Copy and paste a formatted citation
x
Spandidos Publications style
Niu X, Zheng S, Liu H and Li S: Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Mol Med Rep 18: 4516-4522, 2018.
APA
Niu, X., Zheng, S., Liu, H., & Li, S. (2018). Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Molecular Medicine Reports, 18, 4516-4522. https://doi.org/10.3892/mmr.2018.9465
MLA
Niu, X., Zheng, S., Liu, H., Li, S."Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury". Molecular Medicine Reports 18.5 (2018): 4516-4522.
Chicago
Niu, X., Zheng, S., Liu, H., Li, S."Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury". Molecular Medicine Reports 18, no. 5 (2018): 4516-4522. https://doi.org/10.3892/mmr.2018.9465
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