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miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment

  • Authors:
    • Feng Chen
    • Ren‑Jie Wang
    • Guang‑Zong Li
    • Yi Zhang
    • Shuo Yu
    • Ying‑Fu Liu
    • Xiao‑Yi Chen
    • Shi‑Ke Hou
  • View Affiliations / Copyright

    Affiliations: Graduate School, Tianjin Medical University, Tianjin 300070, P.R. China, Department of Neurosurgery, Logistics University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China, Key Laboratory of Disaster and Emergency Rescue Medicine in People's Liberation Army, Logistics University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China , Department of Cell Biology, Logistics University of Chinese People's Armed Police Forces, Tianjin 300309, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5502-5510
    |
    Published online on: October 22, 2018
       https://doi.org/10.3892/mmr.2018.9570
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Abstract

In the present study, the microRNA (miRNA) expression profiles of rats exposed to high altitude hypoxia and normal conditions were obtained from miRNA array analysis. Bioinformatics analyses, including the use of the Gene Oncology and Kyoto Encyclopedia of Genes and Genomes databases, were used to identify the genes and pathways, which were specifically associated with high altitude hypoxic environment‑associated miRNAs. A total of 26 miRNAs were differentially expressed in the two groups, comprising six upregulated and 20 downregulated miRNAs. In the present study, a novel pattern of upregulated miRNAs and their associated pathways were constructed, including proteoglycans in cancer, spliceosome, gluamatergic synapse, glycolysis/gluconeogenesis, Foxo, cGMP‑PKG and p53 signaling pathways, which may provide novel targets for diagnosing and understanding the mechanism of high altitude hypoxia‑induced disease.
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Copy and paste a formatted citation
Spandidos Publications style
Chen F, Wang RJ, Li GZ, Zhang Y, Yu S, Liu YF, Chen XY and Hou SK: miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment. Mol Med Rep 18: 5502-5510, 2018.
APA
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y. ... Hou, S. (2018). miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment. Molecular Medicine Reports, 18, 5502-5510. https://doi.org/10.3892/mmr.2018.9570
MLA
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y., Chen, X., Hou, S."miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment". Molecular Medicine Reports 18.6 (2018): 5502-5510.
Chicago
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y., Chen, X., Hou, S."miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment". Molecular Medicine Reports 18, no. 6 (2018): 5502-5510. https://doi.org/10.3892/mmr.2018.9570
Copy and paste a formatted citation
x
Spandidos Publications style
Chen F, Wang RJ, Li GZ, Zhang Y, Yu S, Liu YF, Chen XY and Hou SK: miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment. Mol Med Rep 18: 5502-5510, 2018.
APA
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y. ... Hou, S. (2018). miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment. Molecular Medicine Reports, 18, 5502-5510. https://doi.org/10.3892/mmr.2018.9570
MLA
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y., Chen, X., Hou, S."miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment". Molecular Medicine Reports 18.6 (2018): 5502-5510.
Chicago
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y., Chen, X., Hou, S."miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment". Molecular Medicine Reports 18, no. 6 (2018): 5502-5510. https://doi.org/10.3892/mmr.2018.9570
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