Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)
- Martha Cristina Diaz‑Franco
- Raul Franco‑Diaz de Leon
- Jose Rafael Villafan‑Bernal
Affiliations: Health Science Center, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico
- Published online on: November 5, 2018 https://doi.org/10.3892/mmr.2018.9627
Copyright: © Diaz‑Franco
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Osteocalcin is no longer regarded as a molecule exclusive to bone remodeling and osteogenesis, but as a hormone with manifold functions. The discovery of the interaction of osteocalcin with the G protein‑coupled receptor family C group 6‑member A (GPRC6A) receptor has accompanied the characterization of several roles that this peptide serves in body regulation and homeostasis. These roles include the modulation of memory in the brain, fertility in the testis, fat accumulation in the liver, incretins release in the intestine and adaptation to exercise in muscle, in addition to the well‑known effects on β‑cell proliferation, insulin release and adiponectin secretion. The aim of the present review was to provide a practical update of the multi‑organ effects that osteocalcin exerts through its interaction with GPRC6A and the clinical implications of this.