Open Access

Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)

  • Authors:
    • Martha Cristina Diaz‑Franco
    • Raul Franco‑Diaz de Leon
    • Jose Rafael Villafan‑Bernal
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  • Published online on: November 5, 2018     https://doi.org/10.3892/mmr.2018.9627
  • Pages: 15-22
  • Copyright: © Diaz‑Franco et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteocalcin is no longer regarded as a molecule exclusive to bone remodeling and osteogenesis, but as a hormone with manifold functions. The discovery of the interaction of osteocalcin with the G protein‑coupled receptor family C group 6‑member A (GPRC6A) receptor has accompanied the characterization of several roles that this peptide serves in body regulation and homeostasis. These roles include the modulation of memory in the brain, fertility in the testis, fat accumulation in the liver, incretins release in the intestine and adaptation to exercise in muscle, in addition to the well‑known effects on β‑cell proliferation, insulin release and adiponectin secretion. The aim of the present review was to provide a practical update of the multi‑organ effects that osteocalcin exerts through its interaction with GPRC6A and the clinical implications of this.
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January-2019
Volume 19 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Diaz‑Franco MC, Franco‑Diaz de Leon R and Villafan‑Bernal JR: Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review). Mol Med Rep 19: 15-22, 2019
APA
Diaz‑Franco, M.C., Franco‑Diaz de Leon, R., & Villafan‑Bernal, J.R. (2019). Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review). Molecular Medicine Reports, 19, 15-22. https://doi.org/10.3892/mmr.2018.9627
MLA
Diaz‑Franco, M. C., Franco‑Diaz de Leon, R., Villafan‑Bernal, J. R."Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)". Molecular Medicine Reports 19.1 (2019): 15-22.
Chicago
Diaz‑Franco, M. C., Franco‑Diaz de Leon, R., Villafan‑Bernal, J. R."Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)". Molecular Medicine Reports 19, no. 1 (2019): 15-22. https://doi.org/10.3892/mmr.2018.9627