Open Access

Mechanisms shaping the role of ERK1/2 in cellular senescence (Review)

  • Authors:
    • Junrong Zou
    • Tingting Lei
    • Pei Guo
    • Jason Yu
    • Qichao Xu
    • Yunfei Luo
    • Rong Ke
    • Deqiang Huang
  • View Affiliations

  • Published online on: November 29, 2018     https://doi.org/10.3892/mmr.2018.9712
  • Pages: 759-770
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell cycle, cell proliferation and cell development. Previous studies demonstrated that ERK1/2 is closely associated with cell aging; however other previous studies suggested that ERK1/2 exerts an opposite effect on aging models and target proteins, even within the same cell model. Recent studies demonstrated that the effect of ERK1/2 on aging is likely associated with its target proteins and regulators, negative feedback loops, phosphorylated ERK1/2 factors and ERK1/2 translocation from the cytoplasm to the nucleus. The present review aims to examine the mechanism of ERK1/2 and discuss its role in cellular outcomes and novel drug development.
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February-2019
Volume 19 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zou J, Lei T, Guo P, Yu J, Xu Q, Luo Y, Ke R and Huang D: Mechanisms shaping the role of ERK1/2 in cellular senescence (Review). Mol Med Rep 19: 759-770, 2019
APA
Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y. ... Huang, D. (2019). Mechanisms shaping the role of ERK1/2 in cellular senescence (Review). Molecular Medicine Reports, 19, 759-770. https://doi.org/10.3892/mmr.2018.9712
MLA
Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y., Ke, R., Huang, D."Mechanisms shaping the role of ERK1/2 in cellular senescence (Review)". Molecular Medicine Reports 19.2 (2019): 759-770.
Chicago
Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y., Ke, R., Huang, D."Mechanisms shaping the role of ERK1/2 in cellular senescence (Review)". Molecular Medicine Reports 19, no. 2 (2019): 759-770. https://doi.org/10.3892/mmr.2018.9712