Open Access

Construction of a transcription factor‑long non‑coding RNA‑microRNA network for the identification of key regulators in lung adenocarcinoma and lung squamous cell carcinoma

  • Authors:
    • Shuai Zhao
    • Hong Chen
    • Beichen Ding
    • Jianing Li
    • Fuzhen Lv
    • Kaiyu Han
    • Dan Zhou
    • Baiquan Yu
    • Yao Yu
    • Wei Zhang
  • View Affiliations

  • Published online on: December 14, 2018     https://doi.org/10.3892/mmr.2018.9769
  • Pages: 1101-1109
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The interactions of microRNAs (miRNAs), transcription factors (TFs) and their common target long non‑coding RNAs (lncRNAs) can lead to the production of TF‑miRNA‑lncRNA (TML) network motifs. These motifs are functional regulators that perform a wide range of biological processes, such as carcinogenesis. However, TML network motifs have not been systematically identified, and their roles in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) are largely unknown. In the present study, a computational integration approach was performed using multiple sources in order to construct a global TML network for LUAD and LUSC. The analysis revealed several dysregulated TML network motifs, which were common between the two lung cancer subtypes or specific to a single cancer subtype. In addition, functional analysis further indicated that the TML network motifs may potentially serve as putative biomarkers in LUAD and LUSC. The associations between drug treatments and dysregulated TML network motifs were also examined. Collectively, the present study elucidated the roles of TML network motifs in LUAD and LUSC, which may be beneficial for understanding the pathogenesis of lung cancer and its potential treatment.
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February-2019
Volume 19 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao S, Chen H, Ding B, Li J, Lv F, Han K, Zhou D, Yu B, Yu Y, Zhang W, Zhang W, et al: Construction of a transcription factor‑long non‑coding RNA‑microRNA network for the identification of key regulators in lung adenocarcinoma and lung squamous cell carcinoma. Mol Med Rep 19: 1101-1109, 2019
APA
Zhao, S., Chen, H., Ding, B., Li, J., Lv, F., Han, K. ... Zhang, W. (2019). Construction of a transcription factor‑long non‑coding RNA‑microRNA network for the identification of key regulators in lung adenocarcinoma and lung squamous cell carcinoma. Molecular Medicine Reports, 19, 1101-1109. https://doi.org/10.3892/mmr.2018.9769
MLA
Zhao, S., Chen, H., Ding, B., Li, J., Lv, F., Han, K., Zhou, D., Yu, B., Yu, Y., Zhang, W."Construction of a transcription factor‑long non‑coding RNA‑microRNA network for the identification of key regulators in lung adenocarcinoma and lung squamous cell carcinoma". Molecular Medicine Reports 19.2 (2019): 1101-1109.
Chicago
Zhao, S., Chen, H., Ding, B., Li, J., Lv, F., Han, K., Zhou, D., Yu, B., Yu, Y., Zhang, W."Construction of a transcription factor‑long non‑coding RNA‑microRNA network for the identification of key regulators in lung adenocarcinoma and lung squamous cell carcinoma". Molecular Medicine Reports 19, no. 2 (2019): 1101-1109. https://doi.org/10.3892/mmr.2018.9769