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Article

Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling

  • Authors:
    • Guangwen Wu
    • Jiahui Zhang
    • Wenlie Chen
    • Sainan Chen
    • Yunmei Huang
    • Ruhui Lin
    • Meiya Huang
    • Zuanfang Li
    • Liangpu Zheng
    • Xihai Li
  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, National Laboratory of Traditional Chinese Medicine Pharmacology (Cell Structure and Function), Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China
  • Pages: 1858-1866
    |
    Published online on: December 20, 2018
       https://doi.org/10.3892/mmr.2018.9778
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Abstract

Previous studies have shown that Tougu Xiaotong capsule (TGXTC) has therapeutic effects on knee osteoarthritis (OA) through multiple targets. However, the mechanisms of action underlying its regulation of subchondral bone reconstruction remain unclear. In this study, we investigated the effects of TGXTC on subchondral bone remodeling. Eighteen six-month-old New Zealand white rabbits of average sex were randomly divided into the normal, model and TGXTC groups. The rabbit knee OA model was induced by a modified Hulth's method in the model and TGXTC groups, but not the normal group. Five weeks postoperatively, intragastric administration of TGXTC was performed for four weeks. After drug administration, the medial femoral condyle and tibia were prepared for observation of cartilage histology via optical microscopy and micro-computed tomography, the serum was collected for biochemical parameters assay and the subchondral bone isolated from the lateral femoral condyle was collected for detection of IL-1β and TNF-α mRNA and protein by reverse transcription-quantitative polymerase chain reaction and western blot analysis, respectively. The results showed that treatment with TGXTC significantly mitigated cartilage injury and subchondral bone damage, improved the parameter of subchondral trabecular bone, decreased alkaline phosphatase and tartrate-resistant acid phosphatase activity, and significantly reducing the osteoprotegerin/receptor activator of nuclear factor-κB ligand ratio, reduced the expression of IL-1β and TNF-α mRNA and protein. These results suggest that TGXTC could delay the pathological development of OA by regulating subchondral bone remodeling through regulation of bone formation and bone resorption and its relating inflammatory factors, and this may partly explain its clinical efficacy in the treatment of knee OA.
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View References

1 

Mansell JP, Tarlton JF and Bailey AJ: Biochemical evidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip. Br J Rheumatol. 36:16–19. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Bobinac D, Marinovic M, Bazdulj E, Cvijanovic O, Celic T, Maric I, Spanjol J and Cicvaric T: Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis. Osteoarthritis Cartilage. 21:1724–1730. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Kwan Tat S, Pelletier JP, Lajeunesse D, Fahmi H, Lavigne M and Martel-Pelletier J: The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells. Clin Exp Rheumatol. 26:295–304. 2008.PubMed/NCBI

4 

Tat SK, Pelletier JP, Lajeunesse D, Fahmi H, Duval N and Martel-Pelletier J: Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors. Bone. 43:284–291. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Orth P, Cucchiarini M, Kaul G, Ong MF, Gräber S, Kohn DM and Madry H: Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model. Osteoarthritis Cartilage. 20:1161–1169. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Roman-Blas JA and Herrero-Beaumont G: Targeting subchondral bone in osteoporotic osteoarthritis. Arthritis Res Ther. 16:4942014. View Article : Google Scholar : PubMed/NCBI

7 

Li G, Yin J, Gao J, Cheng TS, Pavlos NJ, Zhang C and Zheng MH: Subchondral bone in osteoarthritis: Insight into risk factors and microstructural changes. Arthritis Res Ther. 15:2232013. View Article : Google Scholar : PubMed/NCBI

8 

Effendy NM, Khamis MF and Shuid AN: The effects of Labisia pumila extracts on bone microarchitecture of ovariectomized-induced osteoporosis rats: A micro-CT analysis. J XRay Sci Technol. 25:101–112. 2017.PubMed/NCBI

9 

Permuy M, Guede D, López-Peña M, Muñoz F, Caeiro JR and González-Cantalapiedra A: Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model. BMC Vet Res. 11:1432015. View Article : Google Scholar : PubMed/NCBI

10 

Mohan G, Perilli E, Kuliwaba JS, Humphries JM, Parkinson IH and Fazzalari NL: Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis. Arthritis Res Ther. 13:R2102011. View Article : Google Scholar : PubMed/NCBI

11 

Bellido M, Lugo L, Roman-Blas JA, Castañeda S, Caeiro JR, Dapia S, Calvo E, Largo R and Herrero-Beaumont G: Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. Arthritis Res Ther. 12:R1522010. View Article : Google Scholar : PubMed/NCBI

12 

Zhou J, Ma XN, Gao YH, Yan JL, Shi WG, Xian CJ and Chen KM: Sinusoidal electromagnetic fields promote bone formation and inhibit bone resorption in rat femoral tissues in vitro. Electromagn Biol Med. 35:75–83. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Huang LQ, He HC, He CQ, Chen J and Yang L: Clinical update of pulsed electromagnetic fields on osteoporosis. Chin Med J (Engl). 121:2095–2099. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Janckila AJ and Yam LT: Biology and clinical significance of tartrate-resistant acid phosphatases: New perspectives on an old enzyme. Calcif Tissue Int. 85:465–483. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Suchecki D and Tufik S: Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat. Physiol Behav. 68:309–316. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Bolon B, Grisanti M, Villasenor K, Morony S, Feige U and Simonet WS: Generalized Degenerative Joint Disease in Osteoprotegerin (Opg) Null Mutant Mice. Vet Pathol. 52:873–882. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Shen Y, Jiang T, Wang R, He S, Guo M, Zuo J and He D: (5R)-5-Hydroxytriptolide (LLDT-8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway. BMC Complement Altern Med. 15:772015. View Article : Google Scholar : PubMed/NCBI

18 

Trouvin AP and Goëb V: Receptor activator of nuclear factor-κB ligand and osteoprotegerin: Maintaining the balance to prevent bone loss. Clin Interv Aging. 5:345–354. 2010.PubMed/NCBI

19 

Lange U, Dischereit G, Tarner I, Frommer K, Neumann E, Müller-Ladner U and Kürten B: The impact of serial radon and hyperthermia exposure in a therapeutic adit on pivotal cytokines of bone metabolism in rheumatoid arthritis and osteoarthritis. Clin Rheumatol. 35:2783–2788. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Aida Y, Maeno M, Suzuki N, Shiratsuchi H, Motohashi M and Matsumura H: The effect of IL-1beta on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human chondrocytes. Life Sci. 77:3210–3221. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Teitelbaum SL: Bone resorption by osteoclasts. Science. 289:1504–1508. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Liao N, Huang Y, Ye J, Chen W, Li ZF, Lin R, Li X, Zheng L and Liu X: Protective effects of Tougu Xiaotong capsule on tumor necrosis factor-α-injured UMR-106 cells. Exp Ther Med. 10:1908–1914. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Chen S, Huang Y, Chen W, Wu G, Liao N, Li X, Huang M, Lin R, Yu C, Li X, et al: Protective effects of the Tougu Xiaotong capsule on morphology and osteoprotegerin/nuclear factor-κB ligand expression in rabbits with knee osteoarthritis. Mol Med Rep. 13:419–425. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Zheng CS, Ye HZ, Xu XJ and Liu XX: Computational pharmacology study of tougu xiaotong granule in preventing and treating knee osteoarthritis. Chin J Integr Med. 15:371–376. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Lin MN and Liu XX: Observation of Tougu Xiaotong Recipe for the treatment of 30 patients with knee osteoarthritis. Fujian J Tradit Chin Med Chin. 36:15–16. 2005.(In Chinese).

26 

Li XH, Wu MX, Ye HZ, Chen WL, Lin JM, Zheng LP and Liu XX: Experimental study on the suppression of sodium nitroprussiate-induced chondrocyte apoptosis by Tougu Xiaotong Capsule -containing serum. Chin J Integr Med. 17:436–443. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Li X, Lang W, Ye H, Yu F, Li H, Chen J, Cai L, Chen W, Lin R, Huang Y, et al: Tougu Xiaotong capsule inhibits the tidemark replication and cartilage degradation of papain-induced osteoarthritis by the regulation of chondrocyte autophagy. Int J Mol Med. 31:1349–1356. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Liu XX, Li XH and Zhou JT: [Experimental study on replicating knee osteoarthritis by modified Hulth's modeling method]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 25:1104–1108. 2005.(In Chinese). PubMed/NCBI

29 

Mankin HJ, Dorfman H, Lippiello L and Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 53:523–537. 1971. View Article : Google Scholar : PubMed/NCBI

30 

Cox LG, van Donkelaar CC, van Rietbergen B, Emans PJ and Ito K: Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis. Bone. 50:1152–1161. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Zhu S, Chen K, Lan Y, Zhang N, Jiang R and Hu J: Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone. 53:340–349. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Geusens PP and van den Bergh JP: Osteoporosis and osteoarthritis: Shared mechanisms and epidemiology. Curr Opin Rheumatol. 28:97–103. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Matsuo K and Irie N: Osteoclast-osteoblast communication. Arch Biochem Biophys. 473:201–209. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Havill LM, Hale LG, Newman DE, Witte SM and Mahaney MC: Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age. J Med Primatol. 35:97–105. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Ni J, Yuan XM, Yao Q and Peng LB: OSM is overexpressed in knee osteoarthritis and Notch signaling is involved in the effects of OSM on MC3T3-E1 cell proliferation and differentiation. Int J Mol Med. 35:1755–1760. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Bellido M, Lugo L, Roman-Blas JA, Castañeda S, Calvo E, Largo R and Herrero-Beaumont G: Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis. Osteoarthritis Cartilage. 19:1228–1236. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Ross PD, Kress BC, Parson RE, Wasnich RD, Armour KA and Mizrahi IA: Serum bone alkaline phosphatase and calcaneus bone density predict fractures: A prospective study. Osteoporos Int. 11:76–82. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, et al: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397:315–323. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Hofbauer LC and Schoppet M: Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA. 292:490–495. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Whyte MP, Obrecht SE, Finnegan PM, Jones JL, Podgornik MN, McAlister WH and Mumm S: Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med. 347:175–184. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Brzóska MM and Rogalska J: Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats. Toxicol Appl Pharmacol. 272:208–220. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Gurban CV and Mederle O: The OPG/RANKL system and zinc ions are promoters of bone remodeling by osteoblast proliferation in postmenopausal osteoporosis. Rom J Morphol Embryol. 52:1113–1119. 2011.PubMed/NCBI

43 

Fujii T, Kitaura H, Kimura K, Hakami ZW and Takano-Yamamoto T: IL-4 inhibits TNF-α-mediated osteoclast formation by inhibition of RANKL expression in TNF-α-activated stromal cells and direct inhibition of TNF-α-activated osteoclast precursors via a T-cell-independent mechanism in vivo. Bone. 51:771–780. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC and O'Brien CA: Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 287:29851–29860. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Riegel A, Maurer T, Prior B, Stegmaier S, Heppert V, Wagner C and Hänsch GM: Human polymorphonuclear neutrophils express RANK and are activated by its ligand, RANKL. Eur J Immunol. 42:975–981. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Kim KW, Kim HR, Park JY, Park JS, Oh HJ, Woo YJ, Park MK, Cho ML and Lee SH: Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts. Arthritis Rheum. 64:1015–1023. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP and Teitelbaum SL: TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 106:1481–1488. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC and O'Brien CA: The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 26:341–348. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Zeng JZ, Ma LF, Meng H, Yu HM, Zhang YK and Guo A: (5R)-5-hydroxytriptolide (LLDT-8) prevents collagen-induced arthritis through OPG/RANK/RANKL signaling in a rat model of rheumatoid arthritis. Exp Ther Med. 12:3101–3106. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu G, Zhang J, Chen W, Chen S, Huang Y, Lin R, Huang M, Li Z, Zheng L, Li X, Li X, et al: Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling. Mol Med Rep 19: 1858-1866, 2019.
APA
Wu, G., Zhang, J., Chen, W., Chen, S., Huang, Y., Lin, R. ... Li, X. (2019). Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling. Molecular Medicine Reports, 19, 1858-1866. https://doi.org/10.3892/mmr.2018.9778
MLA
Wu, G., Zhang, J., Chen, W., Chen, S., Huang, Y., Lin, R., Huang, M., Li, Z., Zheng, L., Li, X."Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling". Molecular Medicine Reports 19.3 (2019): 1858-1866.
Chicago
Wu, G., Zhang, J., Chen, W., Chen, S., Huang, Y., Lin, R., Huang, M., Li, Z., Zheng, L., Li, X."Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling". Molecular Medicine Reports 19, no. 3 (2019): 1858-1866. https://doi.org/10.3892/mmr.2018.9778
Copy and paste a formatted citation
x
Spandidos Publications style
Wu G, Zhang J, Chen W, Chen S, Huang Y, Lin R, Huang M, Li Z, Zheng L, Li X, Li X, et al: Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling. Mol Med Rep 19: 1858-1866, 2019.
APA
Wu, G., Zhang, J., Chen, W., Chen, S., Huang, Y., Lin, R. ... Li, X. (2019). Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling. Molecular Medicine Reports, 19, 1858-1866. https://doi.org/10.3892/mmr.2018.9778
MLA
Wu, G., Zhang, J., Chen, W., Chen, S., Huang, Y., Lin, R., Huang, M., Li, Z., Zheng, L., Li, X."Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling". Molecular Medicine Reports 19.3 (2019): 1858-1866.
Chicago
Wu, G., Zhang, J., Chen, W., Chen, S., Huang, Y., Lin, R., Huang, M., Li, Z., Zheng, L., Li, X."Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling". Molecular Medicine Reports 19, no. 3 (2019): 1858-1866. https://doi.org/10.3892/mmr.2018.9778
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