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Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing

  • Authors:
    • Ying Li
    • Xiao Lv
    • Xueling Ge
    • Dai Yuan
    • Mei Ding
    • Changqing Zhen
    • Wenbo Zhao
    • Xin Liu
    • Xianghua Wang
    • Hongzhi Xu
    • Ying Li
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Haematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4147-4158
    |
    Published online on: March 22, 2019
       https://doi.org/10.3892/mmr.2019.10081
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Abstract

The aim of the present study was to examine the associations between 112 acute myeloid leukaemia (AML)‑associated genes and the prognosis and clinical features of AML using bioinformatics analysis in 62 patients with AML. A total of 61 gene mutations were identified, and ≥1 mutations were detected in 96.77% of the patients. A total of 11 frequent mutations were identified, including nucleophosmin 1 (NPM1), Fms related tyrosine kinase 3 (FLT3), DNA methyltransferase 3α (DNMT3A) and Notch 2 (NOTCH2), with a mutation rate of ≥10%. The FLT3 mutation was significantly associated with the white blood cell count at the time of diagnosis, and DNMT3A was significantly associated with the French‑American‑British subtype and cytogenetics of patients with AML. The FLT3, NPM1 and DNMT3A mutations were significantly associated with a poor overall survival (OS) in patients with AML. In addition, the co‑mutation of DNMT3A‑CCAAT enhancer binding protein α (CEBPA) was observed to be significantly associated with a poor OS in patients with AML. Furthermore, the functional enrichment analysis revealed that the co‑mutations of FLT3‑NOTCH2, SETBP1‑CREBBP and DNMT3A‑CEBPA were significantly enriched in processes of ‘negative regulation of cell differentiation’ and ‘immune system development’, indicating that these mutations may serve crucial roles in the diagnosis and treatment of AML.
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1 

Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, Bloomfield CD, Estey E, Burnett A, Cornelissen JJ, et al: Acute myeloid leukaemia. Nat Rev Dis Primers. 2:160102016. View Article : Google Scholar : PubMed/NCBI

2 

Pan Y, Liu D, Wei Y, Su D, Lu C, Hu Y and Zhou F: Azelaic acid exerts antileukemic activity in acute myeloid leukemia. Front Pharmacol. 8:3592017. View Article : Google Scholar : PubMed/NCBI

3 

Liang H, Zheng QL, Fang P, Zhang J, Zhang T, Liu W, Guo M, Robinson CL, Chen SB, Chen XP, et al: Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Sci Rep. 7:403612017. View Article : Google Scholar : PubMed/NCBI

4 

Sanders MA and Valk PJ: The evolving molecular genetic landscape in acute myeloid leukaemia. Curr Opin Hematol. 20:79–85. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Kohlmann A, Grossmann V, Nadarajah N and Haferlach T: Next-generation sequencing-feasibility and practicality in haematology. Br J Haematol. 160:736–753. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC and Majeti R: Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci USA. 111:2548–2553. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer AM, Nazir A, Stein EM, Knapp K, Glass J, et al: Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia. Cancer Discov. 7:494–505. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yen K, Travins J, Wang F, David MD, Artin E, Straley K, Padyana A, Gross S, DeLaBarre B, Tobin E, et al: AG-221, a first-in-class therapy targeting acute myeloid leukemia harboring oncogenic IDH2 mutations. Cancer Discov. 7:478–493. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Feng J, Li Y, Jia Y, Fang Q, Gong X, Dong X, Ru K, Li Q, Zhao X, Liu K, et al: Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia. J Hematol Oncol. 10:612017. View Article : Google Scholar : PubMed/NCBI

10 

Feng J, Gong XY, Jia YJ, Liu KQ, Li Y, Dong XB, Fang QY, Ru K, Li QH, Wang HJ, et al: Spectrum of somatic mutations and their prognostic significance in adult patients with B cell acute lymphoblastic leukemia. Zhonghua Xue Ye Xue Za Zhi. 39:98–104. 2018.(In Chinese). PubMed/NCBI

11 

Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A and Bloomfield CD: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood. 114:937–951. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Löffler H: Morphology, immunology, cytochemistry, and cytogenetics and the classification of subtypes in AML. Haematol Blood Transfus. 33:239–242. 1990.PubMed/NCBI

13 

Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM and Sirotkin K: dbSNP: The NCBI database of genetic variation. Nucleic Acids Res. 29:308–311. 2001. View Article : Google Scholar : PubMed/NCBI

14 

1000 Genomes Project Consortium, ; Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT and McVean GA: An integrated map of genetic variation from 1,092 human genomes. Nature. 491:56–65. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Adzhubei I, Jordan DM and Sunyaev SR: Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet Chapter. 7:Unit7.202013.

16 

Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A, et al: COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res. 39:D945–D950. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Ito K and Murphy D: Application of ggplot2 to pharmacometric graphics. CPT Pharmacometrics Syst Pharmacol. 2:e792013. View Article : Google Scholar : PubMed/NCBI

18 

Plackett RL: Karl pearson and the Chi-squared test. Int Stat Rev. 51:59–72. 1983. View Article : Google Scholar

19 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

20 

Goel MK, Khanna P and Kishore J: Understanding survival analysis: Kaplan-Meier estimate. Int J Ayurveda Res. 1:274–278. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhang YY, Zhou XB, Wang QZ and Zhu XY: Quality of reporting of multivariable logistic regression models in Chinese clinical medical journals. Medicine (Baltimore). 96:e69722017. View Article : Google Scholar : PubMed/NCBI

22 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

23 

The Gene Ontology Consortium: The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Kanehisa M, Sato Y, Furumichi M, Morishima K and Tanabe M: New approach for understanding genome variations in KEGG. Nucleic Acids Res. 47:D590–D595. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Huang Da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia: A report of the French-American-British Cooperative Group. Ann Intern Med. 103:620–625. 1985. View Article : Google Scholar : PubMed/NCBI

28 

Mukherjee A, Nan X, Ensor J, Randhawa JK, Pingali SRK, Zieske AW, Olsen RJ, Chung B and Iyer SP: An integer weighted genomic mutation score (GMS) using next generation sequencing is predictive of prognosis in intermediate risk AML patients. Blood. 130:39402017.

29 

Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, et al: Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia. JAMA. 314:811–822. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Wander SA, Levis MJ and Fathi AT: The evolving role of FLT3 inhibitors in acute myeloid leukemia: Quizartinib and beyond. Ther Adv Hematol. 5:65–77. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Pasquet M, Bellanné-Chantelot C, Tavitian S, Prade N, Beaupain B, Larochelle O, Petit A, Rohrlich P, Ferrand C, Van Den Neste E, et al: High frequency of GATA2 mutations in patients with mild chronic neutropenia evolving to MonoMac syndrome, myelodysplasia, and acute myeloid leukemia. Blood. 121:822–829. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Im AP, Sehgal AR, Carroll MP, Smith BD, Tefferi A, Johnson DE and Boyiadzis M: DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: Associations with prognosis and potential treatment strategies. Leukemia. 28:1774–1783. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, et al: KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 161:117–127. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Höckendorf U, Yabal M and Jost PJ: RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs. Oncotarget. 7:57483–57484. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Kurtz SE, Wilmot B, McWeeney S, Vellanki A, Local A, Benbatoul K, Folger P, Sheng S, Zhang H, Howell SB, et al: CG'806, a first-in-class FLT3/BTK inhibitor, exhibits potent activity against AML patient samples with mutant or wild type FLT3, as well as other hematologic malignancy subtypes. Clin Cancer Res. 23:442017.

36 

Nishida A, Yuasa M, Kageyama K, Ishiwata K, Takagi S, Yamamoto H, Asano-Mori Y, Yamamoto G, Uchida N, Izutsu K, et al: High disease-free and overall survival rate following allogeneic hematopoietic stem cell transplantation for FLT3-mutated acute myeloid leukemia even in non-remission status. Blood. 128:22832016.PubMed/NCBI

37 

Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, et al: Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity. 35:780–791. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Varnum-Finney B, Halasz LM, Sun M, Gridley T, Radtke F and Bernstein ID: Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest. 121:1207–1216. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Fernandez-Mercado M, Pellagatti A, Di Genua C, Larrayoz MJ, Winkelmann N, Aranaz P, Burns A, Schuh A, Calasanz MJ, Cross NC and Boultwood J: Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression. Br J Haematol. 163:235–239. 2013.PubMed/NCBI

40 

Makishima H, Yoshida K, Nguyen N, Przychodzen B, Sanada M, Okuno Y, Ng KP, Gudmundsson KO, Vishwakarma BA, Jerez A, et al: Somatic SETBP1 mutations in myeloid malignancies. Nat Genet. 45:942–946. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Cristóbal I, Blanco FJ, Garcia-Orti L, Marcotegui N, Vicente C, Rifon J, Novo FJ, Bandres E, Calasanz MJ, Bernabeu C and Odero MD: SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia. Blood. 115:615–625. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, et al: SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. Leukemia. 29:847–857. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, et al: DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 363:2424–2433. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Abdel-Wahab O, Pardanani A, Rampal R, Lasho TL, Levine RL and Tefferi A: DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia. 25:1219–1220. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Kao HW, Liang DC, Kuo MC, Wu JH, Dunn P, Wang PN, Lin TL, Shih YS, Liang ST, Lin TH, et al: High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis. Oncotarget. 6:33217–33225. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Quintás-Cardama A, Hu C, Qutub A, Qiu YH, Zhang X, Post SM, Zhang N, Coombes K and Kornblau SM: p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status. Leukemia. 31:1296–1305. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Ufkin ML, Peterson S, Yang X, Driscoll H, Duarte C and Sathyanarayana P: miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia. Leuk Res. 38:402–410. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Curran E, Corrales L and Kline J: Targeting the innate immune system as immunotherapy for acute myeloid leukemia. Front Oncol. 5:832015. View Article : Google Scholar : PubMed/NCBI

49 

Takam Kamga P, Bassi G, Cassaro A, Midolo M, Di Trapani M, Gatti A, Carusone R, Resci F, Perbellini O, Gottardi M, et al: Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia. Oncotarget. 7:21713–21727. 2016.PubMed/NCBI

50 

Witkowski MT, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie MD, Best SA, Tuohey L, Willson TA, Nutt SL, et al: Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia. Leukemia. 29:1301–1311. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Lv X, Ge X, Yuan D, Ding M, Zhen C, Zhao W, Liu X, Wang X, Xu H, Xu H, et al: Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing. Mol Med Rep 19: 4147-4158, 2019.
APA
Li, Y., Lv, X., Ge, X., Yuan, D., Ding, M., Zhen, C. ... Wang, X. (2019). Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing. Molecular Medicine Reports, 19, 4147-4158. https://doi.org/10.3892/mmr.2019.10081
MLA
Li, Y., Lv, X., Ge, X., Yuan, D., Ding, M., Zhen, C., Zhao, W., Liu, X., Wang, X., Xu, H., Li, Y., Wang, X."Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing". Molecular Medicine Reports 19.5 (2019): 4147-4158.
Chicago
Li, Y., Lv, X., Ge, X., Yuan, D., Ding, M., Zhen, C., Zhao, W., Liu, X., Wang, X., Xu, H., Li, Y., Wang, X."Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing". Molecular Medicine Reports 19, no. 5 (2019): 4147-4158. https://doi.org/10.3892/mmr.2019.10081
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Lv X, Ge X, Yuan D, Ding M, Zhen C, Zhao W, Liu X, Wang X, Xu H, Xu H, et al: Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing. Mol Med Rep 19: 4147-4158, 2019.
APA
Li, Y., Lv, X., Ge, X., Yuan, D., Ding, M., Zhen, C. ... Wang, X. (2019). Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing. Molecular Medicine Reports, 19, 4147-4158. https://doi.org/10.3892/mmr.2019.10081
MLA
Li, Y., Lv, X., Ge, X., Yuan, D., Ding, M., Zhen, C., Zhao, W., Liu, X., Wang, X., Xu, H., Li, Y., Wang, X."Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing". Molecular Medicine Reports 19.5 (2019): 4147-4158.
Chicago
Li, Y., Lv, X., Ge, X., Yuan, D., Ding, M., Zhen, C., Zhao, W., Liu, X., Wang, X., Xu, H., Li, Y., Wang, X."Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing". Molecular Medicine Reports 19, no. 5 (2019): 4147-4158. https://doi.org/10.3892/mmr.2019.10081
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