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Article Open Access

Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147

  • Authors:
    • Na Guo
    • Rui Miao
    • Xingchun Gao
    • Dong Huang
    • Zhifang Hu
    • Naichun Ji
    • Ying Nan
    • Fengliang Jiang
    • Xingchun Gou
  • View Affiliations / Copyright

    Affiliations: Institute of Basic and Translational Medicine, and Department of Immunology, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China, Department of Neurology, Shaanxi Second Provincial People's Hospital, Xi'an, Shaanxi 710005, P.R. China, Department of Sports, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4335-4343
    |
    Published online on: March 28, 2019
       https://doi.org/10.3892/mmr.2019.10101
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Abstract

Shikonin, a traditional Chinese medicine, has been identified as being capable of inducing apoptosis in various tumors, including glioma, and is thus considered to be a promising therapeutic agent for tumor therapy. However, little is known about the molecular mechanism of shikonin in glioma. The present study investigated the influence of shikonin on the proliferation and apoptosis of glioma cells U251 and U87MG and explored the potential molecular mechanisms. It was identified that shikonin was able to induce apoptosis in human glioma cells in a time‑ and dose‑dependent manner, and a decreased expression level of cluster of differentiation (CD)147 was observed in shikonin‑treated U251 and U87MG cells. Knockdown of CD147 inhibited U251 and U87MG cell growth, whereas CD147 overexpression enhanced cell growth and decreased shikonin‑induced apoptosis. Additionally, an increased expression level of CD147 suppressed the elevated production of reactive oxygen species and mitochondrial membrane potential levels induced by shikonin. The data indicated that shikonin‑induced apoptosis in glioma cells was associated with the downregulation of CD147 and the upregulation of oxidative stress. CD147 may be an optional target of shikonin‑induced cell apoptosis in glioma cells.
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Copy and paste a formatted citation
Spandidos Publications style
Guo N, Miao R, Gao X, Huang D, Hu Z, Ji N, Nan Y, Jiang F and Gou X: Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147. Mol Med Rep 19: 4335-4343, 2019.
APA
Guo, N., Miao, R., Gao, X., Huang, D., Hu, Z., Ji, N. ... Gou, X. (2019). Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147. Molecular Medicine Reports, 19, 4335-4343. https://doi.org/10.3892/mmr.2019.10101
MLA
Guo, N., Miao, R., Gao, X., Huang, D., Hu, Z., Ji, N., Nan, Y., Jiang, F., Gou, X."Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147". Molecular Medicine Reports 19.5 (2019): 4335-4343.
Chicago
Guo, N., Miao, R., Gao, X., Huang, D., Hu, Z., Ji, N., Nan, Y., Jiang, F., Gou, X."Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147". Molecular Medicine Reports 19, no. 5 (2019): 4335-4343. https://doi.org/10.3892/mmr.2019.10101
Copy and paste a formatted citation
x
Spandidos Publications style
Guo N, Miao R, Gao X, Huang D, Hu Z, Ji N, Nan Y, Jiang F and Gou X: Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147. Mol Med Rep 19: 4335-4343, 2019.
APA
Guo, N., Miao, R., Gao, X., Huang, D., Hu, Z., Ji, N. ... Gou, X. (2019). Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147. Molecular Medicine Reports, 19, 4335-4343. https://doi.org/10.3892/mmr.2019.10101
MLA
Guo, N., Miao, R., Gao, X., Huang, D., Hu, Z., Ji, N., Nan, Y., Jiang, F., Gou, X."Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147". Molecular Medicine Reports 19.5 (2019): 4335-4343.
Chicago
Guo, N., Miao, R., Gao, X., Huang, D., Hu, Z., Ji, N., Nan, Y., Jiang, F., Gou, X."Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147". Molecular Medicine Reports 19, no. 5 (2019): 4335-4343. https://doi.org/10.3892/mmr.2019.10101
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