Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2019 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes

  • Authors:
    • Jung Hwan Oh
    • Fatih Karadeniz
    • Jung Im Lee
    • Youngwan Seo
    • Chang‑Suk Kong
  • View Affiliations / Copyright

    Affiliations: Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan 46958, Republic of Korea, Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University, Busan 46958, Republic of Korea, Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Republic of Korea
  • Pages: 763-770
    |
    Published online on: May 21, 2019
       https://doi.org/10.3892/mmr.2019.10258
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Derivatives of caffeoylquinic acid (CQA) have been studied and reported as potent bioactive molecules possessing various health benefits including antioxidant and anti‑inflammatory activities. In the present study, the protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid (DCEQA) isolated from Atriplex gmelinii on UVB‑induced damages was investigated in human HaCaT keratinocytes. The effect of DCEQA against UVB‑induced oxidative stress‑mediated damages was determined measuring its ability to alleviate UVB‑induced elevation of oxidative stress, proinflammatory response and antioxidant enzyme suppression through nuclear factor‑like 2 (Nrf2). Treatment with DCEQA hindered the generation of intracellular reactive oxygen species. Increased levels of proinflammatory cytokines TNF‑α, COX‑2, IL‑6 and IL‑1β following UVB exposure were suppressed by the introduction of DCEQA. Additionally, DCEQA upregulated the mRNA and protein expression of antioxidant enzymes superoxide dismutase‑1 and heme oxygenase‑1 which were inhibited under UVB irradiation. Antioxidant enzyme regulation transcription factor Nrf2 was also upregulated in the presence of DCEQA. These results suggest that DCEQA prevents photoaging via protection of keratinocytes from UVB irradiation by ameliorating the oxidative stress and pro‑inflammatory response.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S and Voorhees JJ: Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 138:1462–1470. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Rittié L and Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res Rev. 1:705–720. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Fisher GJ: The pathophysiology of photoaging of the skin. Cutis 75 (2 Suppl). S5–S9. 2005.

4 

Ichihashi M, Ueda M, Budiyanto A, Bito T, Oka M, Fukunaga M, Tsuru K and Horikawa T: UV-induced skin damage. Toxicology. 189:21–39. 2003. View Article : Google Scholar : PubMed/NCBI

5 

de Gruijl FR: Photocarcinogenesis: UVA vs. UVB radiation. Skin Pharmacol Appl Skin Physiol. 15:316–320. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Simon MM, Aragane Y, Schwarz A, Luger TA and Schwarz T: UVB light induces nuclear factor kappa B (NF kappa B) activity independently from chromosomal DNA damage in cell-free cytosolic extracts. J Invest Dermatol. 102:422–427. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Pillai S, Oresajo C and Hayward J: Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation-a review. Int J Cosmet Sci. 27:17–34. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Herrling T, Jung K and Fuchs J: Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin. Spectrochim Acta A Mol Biomol Spectrosc. 63:840–845. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Yoshizumi M, Nakamura T, Kato M, Ishioka T, Kozawa K, Wakamatsu K and Kimura H: Release of cytokines/chemokines and cell death in UVB-irradiated human keratinocytes, HaCaT. Cell Biol Int. 32:1405–1411. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Yang WS and Stockwell BR: Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26:165–176. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Briganti S and Picardo M: Antioxidant activity, lipid peroxidation and skin diseases. What's new. J Eur Acad Dermatol Venereol. 17:663–669. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Buckman SY, Gresham A, Hale P, Hruza G, Anast J, Masferrer J and Pentland AP: COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer. Carcinogenesis. 19:723–729. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Kim AL, Labasi JM, Zhu Y, Tang X, McClure K, Gabel CA, Athar M and Bickers DR: Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol. 124:1318–1325. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Suschek CV, Mahotka C, Schnorr O and Kolb-Bachofen V: UVB radiation-mediated expression of inducible nitric oxide synthase activity and the augmenting role of co-induced TNF-alpha in human skin endothelial cells. J Invest Dermatol. 123:950–957. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Bashir MM, Sharma MR and Werth VP: UVB and proinflammatory cytokines synergistically activate TNF-alpha production in keratinocytes through enhanced gene transcription. J Invest Dermatol. 129:994–1001. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Bosch R, Philips N, Suárez-Pérez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J and González S: Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals. Antioxidants (Basel). 4:248–268. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Lin TK, Zhong L and Santiago JL: Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci. 19(pii): E702017. View Article : Google Scholar : PubMed/NCBI

18 

Wu PY, Huang CC, Chu Y, Huang YH, Lin P, Liu YH, Wen KC, Lin CY, Hsu MC and Chiang HM: Alleviation of ultraviolet B-induced photodamage by coffea arabica extract in human skin fibroblasts and hairless mouse skin. Int J Mol Sci. 18(pii): E7822017. View Article : Google Scholar : PubMed/NCBI

19 

De Luca C, Mikhal'chik EV, Suprun MV, Papacharalambous M, Truhanov AI and Korkina LG: Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: A single-blind case-control clinical study. Oxid Med Cell Longev. 2016:43894102016. View Article : Google Scholar : PubMed/NCBI

20 

Działo M, Mierziak J, Korzun U, Preisner M, Szopa J and Kulma A: The potential of plant phenolics in prevention and therapy of skin disorders. Int J Mol Sci. 17:1602016. View Article : Google Scholar : PubMed/NCBI

21 

Katiyar SK: Dietary proanthocyanidins inhibit UV radiation-induced skin tumor development through functional activation of the immune system. Mol Nutr Food Res. 60:1374–1382. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Jiang XW, Bai JP, Zhang Q, Hu XL, Tian X, Zhu J, Liu J, Meng WH and Zhao QC: Caffeoylquinic acid derivatives protect SH-SY5Y neuroblastoma cells from hydrogen peroxide-induced injury through modulating oxidative status. Cell Mol Neurobiol. 37:499–509. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Tian Y, Puganen A, Alakomi HL, Uusitupa A, Saarela M and Yang B: Antioxidative and antibacterial activities of aqueous ethanol extracts of berries, leaves, and branches of berry plants. Food Res Int. 106:291–303. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Roleira FM, Tavares-da-Silva EJ, Varela CL, Costa SC, Silva T, Garrido J and Borges F: Plant derived and dietary phenolic antioxidants: Anticancer properties. Food Chem. 183:235–258. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Liang N and Kitts DD: Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions. Nutrients. 8(pii): E162015. View Article : Google Scholar : PubMed/NCBI

26 

Kwak CS, Yang J, Shin CY and Chung JH: Topical or oral treatment of peach flower extract attenuates UV-induced epidermal thickening, matrix metalloproteinase-13 expression and pro-inflammatory cytokine production in hairless mice skin. Nutr Res Pract. 12:29–40. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Choi HS, Park ED, Park Y and Suh HJ: Spent coffee ground extract suppresses ultraviolet B-induced photoaging in hairless mice. J Photochem Photobiol B. 153:164–172. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Kim HJ and Lee YS: Identification of new dicaffeoylquinic acids from Chrysanthemum morifolium and their antioxidant activities. Planta Med. 71:871–876. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Miller SA, Coelho SG, Miller SW, Yamaguchi Y, Hearing VJ and Beer JZ: Evidence for a new paradigm for ultraviolet exposure: A universal schedule that is skin phototype independent. Photodermatol Photoimmunol Photomed. 28:187–195. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Oh JH, Seo Y and Kong CS: Anti-photoaging effects of solvent-partitioned fractions from Portulaca oleracea L. on UVB-stressed human keratinocytes. J Food Biochem. 43:25–Feb;2019.doi.org/10.1111/jfbc.12814. View Article : Google Scholar

31 

Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, Ma W, Kuhr L, Schneider L and Scharffetter-Kochanek K: UV-induced oxidative stress and photoaging. In: Oxidants and antioxidants in cutaneous biology. Curr Probl Dermatol. 29:83–94. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Saewan N and Jimtaisong A: Natural products as photoprotection. J Cosmet Dermatol. 14:47–63. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Pallela R, Na-Young Y and Kim SK: Anti-photoaging and photoprotective compounds derived from marine organisms. Mar Drugs. 8:1189–1202. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Mukherjee PK, Maity N, Nema NK and Sarkar BK: Bioactive compounds from natural resources against skin aging. Phytomedicine. 19:64–73. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Rabe JH, Mamelak AJ, McElgunn PJ, Morison WL and Sauder DN: Photoaging: Mechanisms and repair. J Am Acad Dermatol. 55:1–19. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Schmidt HH, Stocker R, Vollbracht C, Paulsen G, Riley D, Daiber A and Cuadrado A: Antioxidants in translational medicine. Antioxid Redox Signal. 23:1130–1143. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Rojo de la Vega M, Krajisnik A, Zhang DD and Wondrak GT: Targeting NRF2 for improved skin barrier function and photoprotection: Focus on the achiote-derived apocarotenoid bixin. Nutrients. 9(pii): E13712017. View Article : Google Scholar : PubMed/NCBI

38 

Saito Y, Tsuruma K, Ichihara K, Shimazawa M and Hara H: Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation. BMC Complement Altern Med. 15:4212015. View Article : Google Scholar : PubMed/NCBI

39 

Oh JH, Lee JI, Karadeniz F, Seo Y and Kong CS: 3,5-dicaffeoyl-epi-quinic acid isolated from edible halophyte Atriplex gmelinii inhibits adipogenesis via AMPK/MAPK pathway in 3T3-L1 adipocytes. Evid Based Complement Alternat Med. 2018:85725712018. View Article : Google Scholar : PubMed/NCBI

40 

Ryu KJ, Yoou MS, Seo Y, Yoon KW, Kim HM and Jeong HJ: Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis. Clin Exp Dermatol. 43:798–805. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Lee JY, Song DG, Lee EH, Jung SH, Nho CW, Cha KH and Pan CH: Inhibitory effects of 3,5-O-dicaffeoyl-epi-quinic acid from Gymnaster koraiensis on AKR1B10. J Korean Soc Appl Biol Chem. 52:731–734. 2009. View Article : Google Scholar

42 

Miyamae Y, Kurisu M, Han J, Isoda H and Shigemori H: Structure-activity relationship of caffeoylquinic acids on the accelerating activity on ATP production. Chem Pharm Bull (Tokyo). 59:502–507. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Oh JH, Karadeniz F, Lee JI, Seo Y and Kong CS: Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes. Mol Med Rep 20: 763-770, 2019.
APA
Oh, J.H., Karadeniz, F., Lee, J.I., Seo, Y., & Kong, C. (2019). Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes. Molecular Medicine Reports, 20, 763-770. https://doi.org/10.3892/mmr.2019.10258
MLA
Oh, J. H., Karadeniz, F., Lee, J. I., Seo, Y., Kong, C."Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes". Molecular Medicine Reports 20.1 (2019): 763-770.
Chicago
Oh, J. H., Karadeniz, F., Lee, J. I., Seo, Y., Kong, C."Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes". Molecular Medicine Reports 20, no. 1 (2019): 763-770. https://doi.org/10.3892/mmr.2019.10258
Copy and paste a formatted citation
x
Spandidos Publications style
Oh JH, Karadeniz F, Lee JI, Seo Y and Kong CS: Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes. Mol Med Rep 20: 763-770, 2019.
APA
Oh, J.H., Karadeniz, F., Lee, J.I., Seo, Y., & Kong, C. (2019). Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes. Molecular Medicine Reports, 20, 763-770. https://doi.org/10.3892/mmr.2019.10258
MLA
Oh, J. H., Karadeniz, F., Lee, J. I., Seo, Y., Kong, C."Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes". Molecular Medicine Reports 20.1 (2019): 763-770.
Chicago
Oh, J. H., Karadeniz, F., Lee, J. I., Seo, Y., Kong, C."Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes". Molecular Medicine Reports 20, no. 1 (2019): 763-770. https://doi.org/10.3892/mmr.2019.10258
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team