Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2019 Volume 20 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 20 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

  • Authors:
    • Si Lei
    • Yanling She
    • Jie Zeng
    • Rui Chen
    • Shanyao Zhou
    • Huacai Shi
  • View Affiliations / Copyright

    Affiliations: Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, P.R. China, Department of Medical Ultrasonics, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4175-4185
    |
    Published online on: September 10, 2019
       https://doi.org/10.3892/mmr.2019.10661
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Starvation or severe deprivation of nutrients, which is commonly seen in surgical patients, can result in catabolic changes in skeletal muscles, such as muscle atrophy. Therefore, it is important to elucidate the underlying molecular regulatory mechanisms during skeletal muscle atrophy. In the present study, muscular atrophy was induced by starvation and the results demonstrated that myosin heavy chain was decreased, whereas muscle RING finger protein 1 and atrogin‑1 were increased, both in vitro and in vivo. The impact of starvation on the expression patterns of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) was next determined. The expression patterns of miR‑23a, miR‑206 and miR‑27b in the starved mice exhibited similar trends as those in starved C2C12 cells in vitro, whereas the expression patterns of six other miRNAs (miR‑18a, miR‑133a, miR‑133b, miR‑186, miR‑1a and miR‑29b) differed between the in vivo and the in vitro starvation models. The present study indicated that in vitro expression of the selected miRNAs was not completely consistent with that in vivo. By contrast, lncRNAs showed excellent consistency in their expression patterns in both the in vitro and in vivo starvation models; six of the lncRNAs (Atrolnc‑1, long intergenic non‑protein coding RNA of muscle differentiation 1, Myolinc, lncRNA myogenic differentiation 1, Dum and muscle anabolic regulator 1) were significantly elevated in starved tissues and cells, while lnc‑mg was significantly decreased, compared with the control groups. Thus, lncRNAs involved in muscle atrophy have the potential to be developed as diagnostic tools.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wallimann T, Dolder M, Schlattner U, Eder M, Hornemann T, Kraft T and Stolz M: Creatine kinase: An enzyme with a central role in cellular energy metabolism. MAGMA. 6:116–119. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Zhao C, Shang L, Wang W and Jacobs DO: Myocellular creatine and creatine transporter serine phosphorylation after starvation. J Surg Res. 105:10–16. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Sun L, Si M, Liu X, Choi JM, Wang Y, Thomas SS, Peng H and Hu Z: Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease. J Cachexia Sarcopenia Muscle. 9:962–974. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G and Zhang BT: Long noncoding RNA lncMUMA reverses established skeletal muscle atrophy following mechanical unloading. Mol Ther. 26:2669–2680. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Chen R, Jiang T, She Y, Xu J, Li C, Zhou S, Shen H, Shi H and Liu S: Effects of cobalt chloride, a hypoxia-mimetic agent, on autophagy and atrophy in skeletal C2C12 myotubes. Biomed Res Int. 2017:70975802017.PubMed/NCBI

6 

Chen R, She Y, Fu Q, Chen X, Shi H, Lei S, Zhou S, Ou J and Liu Y: Differentially expressed coding and noncoding RNAs in CoCl2-induced cytotoxicity of C2C12 cells. Epigenomics. 11:423–438. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Mak RH, Ikizler AT, Kovesdy CP, Raj DS, Stenvinkel P and Kalantar-Zadeh K: Wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2:9–25. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR and Smith SM: Amino acid supplementation alters bone metabolism during simulated weightlessness. J Appl Physiol (1985). 99:134–140. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Alzghoul Mb, Gerrard D, Watkins BA and Hannon K: Ectopic expression of IGF-I and shh by skeletal muscle inhibits disuse-mediated skeletal muscle atrophy and bone osteopenia in vivo. FASEB J. 18:221–223. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Gregory CM, Vandenborne K, Huang HF, Ottenweller JE and Dudley GA: Effects of testosterone replacement therapy on skeletal muscle after spinal cord injury. Spinal Cord. 41:23–28. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Finkle WD, Greenland S, Ridgeway GK, Adams JL, Frasco MA, Cook MB, Fraumeni JF Jr and Hoover RN: Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men. PLoS One. 9:e858052014. View Article : Google Scholar : PubMed/NCBI

12 

Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, et al: Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 6:66702015. View Article : Google Scholar : PubMed/NCBI

13 

Cid-Díaz T, Santos-Zas I, González-Sánchez J, Gurriarán-Rodríguez U, Mosteiro CS, Casabiell X, García-Caballero T, Mouly V, Pazos Y and Camiña JP: Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in glucocorticoid-induced muscle cell atrophy. J Cachexia Sarcopenia Muscle. 8:974–990. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Miller BF, Baehr LM, Musci RV, Reid JJ, Peelor FF III, Hamilton KL and Bodine SC: Muscle-specific changes in protein synthesis with aging and reloading after disuse atrophy. J Cachexia Sarcopenia Muscle. Jul 16–2019.(Epub ahead of print). doi: 10.1002/jcsm.12470. View Article : Google Scholar : PubMed/NCBI

15 

Tanaka M, Sugimoto K, Fujimoto T, Xie K, Takahashi T, Akasaka H, Kurinami H, Yasunobe Y, Matsumoto T, Fujino H and Rakugi H: Preventive effects of low-intensity exercise on cancer cachexia-induced muscle atrophy. FASEB J. 33:7852–7862. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Boltaña S, Valenzuela-Miranda D, Aguilar A, Mackenzie S and Gallardo-Escárate C: Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV–Infected Atlantic salmon (Salmo salar). Sci Rep. 6:226982016. View Article : Google Scholar : PubMed/NCBI

17 

Chen R, Jiang T, She Y, Xie S, Zhou S, Li C, Ou J and Liu Y: Comprehensive analysis of lncRNAs and mRNAs with associated co-expression and ceRNA networks in C2C12 myoblasts and myotubes. Gene. 647:164–173. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A and Bozzoni I: A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 147:358–369. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Gong C, Li Z, Ramanujan K, Clay I, Zhang Y, Lemire-Brachat S and Glass DJ: A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation. Dev Cell. 34:181–191. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Legnini I, Morlando M, Mangiavacchi A, Fatica A and Bozzoni I: A feedforward regulatory loop between HuR and the long noncoding RNA linc-MD1 controls early phases of myogenesis. Mol Cell. 6:506–514. 2014. View Article : Google Scholar

21 

Militello G, Hosen MR, Ponomareva Y, Gellert P, Weirick T, John D, Hindi SM, Mamchaoui K, Mouly V, Döring C, et al: A novel long non-coding RNA myolinc regulates myogenesis through TDP-43 and Filip1. J Mol Cell Biol. 10:102–117. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Wang L, Zhao Y, Bao X, Zhu X, Kwok YK, Sun K, Chen X, Huang Y, Jauch R and Esteban MA: LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. Cell Res. 25:335–350. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G and Zhang BT: A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. J Cachexia Sarcopenia Muscle. 9:613–626. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Zhu M, Liu J, Xiao J, Yang L, Cai M, Shen H, Chen X, Ma Y, Hu S, Wang Z, et al: Lnc-mg is a long non-coding RNA that promotes myogenesis. Nat Commun. 8:147182017. View Article : Google Scholar : PubMed/NCBI

25 

Xiong W, Jiang Y, Ai Y, Liu S, Wu XR, Cui JG, Qin JY, Liu Y, Xia YX and Ju YH: Microarray analysis of long non-coding RNA expression profile associated with 5-fluorouracil-based chemoradiation resistance in colorectal cancer cells. Asian Pac J Cancer Prev. 16:3395–3402. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Du J, Zhang P, Zhao X, He J, Xu Y, Zou Q, Luo J, Shen L, Gu H, Tang Q, et al: MicroRNA-351-5p mediates skeletal myogenesis by directly targeting lactamase-β and is regulated by lnc-mg. FASEB J. 33:1911–1926. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Neguembor MV, Jothi M and Gabellini D: Long noncoding RNAs, emerging players in muscle differentiation and disease. Skelet Muscle. 4:82014. View Article : Google Scholar : PubMed/NCBI

28 

Simionescu-Bankston A and Kumar A: Noncoding RNAs in the regulation of skeletal muscle biology in health and disease. J Mol Med (Berl). 94:853–866. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Ivey KN and Srivastava D: MicroRNAs as developmental regulators. Cold Spring Harb Perspect biol. 7:a0081442015. View Article : Google Scholar : PubMed/NCBI

31 

Lei Z, Sluijter JP and van Mil A: MicroRNA therapeutics for cardiac regeneration. Mini Rev Med Chem. 15:441–451. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Li J, Chan MC, Yu Y, Bei Y, Chen P, Zhou Q, Cheng L, Chen L, Ziegler O, Rowe GC, et al: miR-29b contributes to multiple types of muscle atrophy. Nat Commun. 8:152012017. View Article : Google Scholar : PubMed/NCBI

33 

Horak M, Novak J and Bienertova-Vasku J: Muscle-specific microRNAs in skeletal muscle development. Dev Biol. 410:1–13. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W and Tuschl T: Identification of tissue-specific microRNAs from mouse. Curr Biol. 12:735–739. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Walden TB, Timmons JA, Keller P, Nedergaard J and Cannon B: Distinct expression of muscle-specific MicroRNAs (myomirs) in brown adipocytes. J Cell Physiol. 218:444–449. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Chen J, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL and Wang DZ: The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet. 38:228–233. 2006. View Article : Google Scholar : PubMed/NCBI

37 

McCarthy JJ and Esser KA: MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. J Appl Physiol (1985). 102:306–313. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Boutz PL, Chawla G, Stoilov P and Black DL: MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Gene Dev. 21:71–84. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Anderson C, Catoe H and Werner R: MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res. 34:5863–5871. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Kim HK, Lee YS, Sivaprasad U, Malhotra A and Dutta A: Muscle-specific microRNA miR-206 promotes muscle differentiation. J Cell Biol. 174:677–687. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Antoniou A, Mastroyiannopoulos NP, Uney JB and Phylactou LA: MiR-186 inhibits muscle cell differentiation through myogenin regulation. J Biol Chem. 289:3923–3935. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Guan L, Hu X, Liu L, Xing Y, Zhou Z, Liang X, Yang Q, Jin S, Bao J, Gao H, et al: bta-miR-23a involves in adipogenesis of progenitor cells derived from fetal bovine skeletal muscle. Sci Rep. 7:437162017. View Article : Google Scholar : PubMed/NCBI

43 

Mercatelli N, Fittipaldi S, De Paola E, Dimauro I, Paronetto MP, Jackson MJ and Caporossi D: MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation. Sci Rep. 7:72192017. View Article : Google Scholar : PubMed/NCBI

44 

Hou L, Xu J, Jiao Y, Li H, Pan Z, Duan J, Gu T, Hu C and Wang C: MiR-27b promotes muscle development by inhibiting MDFI expression. Cell Physiol Biochem. 46:2271–2283. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Liu C, Wang M, Chen M, Zhang K, Gu L, Li Q, Yu Z, Li N and Meng Q: MiR-18a induces myotubes atrophy by down-regulating IgfI. Int J Biochem Cell Biol. 90:145–154. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Liu C, Chen M, Wang M, Pi W, Li N and Meng Q: MiR-18a regulates myoblasts proliferation by targeting Fgf1. PLoS One. 13:e2015512018.

47 

Chen J, Tao Y, Li J, Deng Z, Yan Z, Xiao X and Wang DZ: MicroRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 190:867–879. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS and Zhang H: The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 52:101–112. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Wang G, Wang Y, Xiong Y, Chen XC, Ma ML, Cai R, Gao Y, Sun YM, Yang GS and Pang WJ: Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a. Sci Rep. 6:218652016. View Article : Google Scholar : PubMed/NCBI

50 

Chen R, Jiang T, Lei S, She Y, Shi H, Zhou S, Ou J and Liu Y: Expression of circular RNAs during C2C12 myoblast differentiation and prediction of coding potential based on the number of open reading frames and N6-methyladenosine motifs. Cell Cycle. 17:1832–1845. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Li F, Li X, Peng X, Sun L, Jia S, Wang P, Ma S, Zha H, Yu Q and Huo H: Ginsenoside Rg1 prevents starvation-induced muscle protein degradation via regulation of AKT/mTOR/FoxO signaling in C2C12 myotubes. Exp Ther Med. 14:1241–1247. 2017. View Article : Google Scholar : PubMed/NCBI

52 

The Ministry of Science and Technology of the People's Republic of China, . Guidance suggestions for the care and use of laboratory animals. Sep 30–2006.

53 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Kim W, Kim J, Park H and Jeon J: Development of microfluidic stretch system for studying recovery of damaged skeletal muscle cells. Micromachines (Basel). 9:E6712018. View Article : Google Scholar : PubMed/NCBI

55 

von Roretz C, Beauchamp P, Di Marco S and Gallouzi I: HuR and myogenesis: Being in the right place at the right time. Biochim Biophys Acta. 1813:1663–1667. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Chen CM, Kraut N, Groudine M and Weintraub H: I-mf, a novel myogenic repressor, interacts with members of the MyoD family. Cell. 86:731–741. 1996. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lei S, She Y, Zeng J, Chen R, Zhou S and Shi H: Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo. Mol Med Rep 20: 4175-4185, 2019.
APA
Lei, S., She, Y., Zeng, J., Chen, R., Zhou, S., & Shi, H. (2019). Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo. Molecular Medicine Reports, 20, 4175-4185. https://doi.org/10.3892/mmr.2019.10661
MLA
Lei, S., She, Y., Zeng, J., Chen, R., Zhou, S., Shi, H."Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo". Molecular Medicine Reports 20.5 (2019): 4175-4185.
Chicago
Lei, S., She, Y., Zeng, J., Chen, R., Zhou, S., Shi, H."Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo". Molecular Medicine Reports 20, no. 5 (2019): 4175-4185. https://doi.org/10.3892/mmr.2019.10661
Copy and paste a formatted citation
x
Spandidos Publications style
Lei S, She Y, Zeng J, Chen R, Zhou S and Shi H: Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo. Mol Med Rep 20: 4175-4185, 2019.
APA
Lei, S., She, Y., Zeng, J., Chen, R., Zhou, S., & Shi, H. (2019). Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo. Molecular Medicine Reports, 20, 4175-4185. https://doi.org/10.3892/mmr.2019.10661
MLA
Lei, S., She, Y., Zeng, J., Chen, R., Zhou, S., Shi, H."Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo". Molecular Medicine Reports 20.5 (2019): 4175-4185.
Chicago
Lei, S., She, Y., Zeng, J., Chen, R., Zhou, S., Shi, H."Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo". Molecular Medicine Reports 20, no. 5 (2019): 4175-4185. https://doi.org/10.3892/mmr.2019.10661
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team