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Article

A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients

  • Authors:
    • Le Lu
    • Yufan Wu
    • Min Feng
    • Xiaofeng Xue
    • Yuan Fan
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China , Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China, Department of Oral Medicine, The Stomatological Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, P.R. China
  • Pages: 4340-4348
    |
    Published online on: September 10, 2019
       https://doi.org/10.3892/mmr.2019.10665
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is highly prevalent worldwide, and the outcome of HNSCC is still difficult to predict due to the lack of appropriate prognostic markers. In the present study, a prognostic model based on a miRNA panel was established to better predict the survival of HNSCC patients. miRNA expression data and clinical information regarding HNSCC patients were acquired from The Cancer Genome Atlas (TCGA) database. Accompanying clinical data was obtained from the University of California, Santa Cruz (UCSC) Xena browser. Using this data, 140 differentially expressed miRNAs (DEMs) were identified between HNSCC tissue samples (n=525) and adjacent normal tissue samples (n=44). The present prognostic model included seven miRNAs (i.e. hsa‑miR‑499a, hsa‑miR‑548k, hsa‑miR‑3619, hsa‑miR‑99a, hsa‑miR‑137, hsa‑miR‑3170, and hsa‑miR‑654), which were identified using least absolute shrinkage and selection operator (LASSO) and Cox regression analyses. The independence of the predictive power of this model was validated by further analyses using clinical information. The outstanding performance of the seven‑miRNA prognostic model was confirmed by time‑dependent receiver operating characteristic curve (ROC) analysis. These results indicated that combining the miRNA panel with pathological characteristics may provide a more accurate prognosis for HNSCC. Functional identification of the target genes of the focal miRNAs using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were also performed. The present study demonstrated that the novel miRNA panel reported here may be useful in making different prognoses and may improve the clinical management of patients with HNSCC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Petti S, Masood M and Scully C: The magnitude of tobacco smoking-betel quid chewing-alcohol drinking interaction effect on oral cancer in South-East Asia. A meta-analysis of observational studies. PLoS One. 8:e789992013. View Article : Google Scholar : PubMed/NCBI

3 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Tomczak K, Czerwinska P and Wiznerowicz M: The cancer genome atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

6 

Long J, Zhang L, Wan X, Lin J, Bai Y, Xu W, Xiong J and Zhao H: A four-gene-based prognostic model predicts overall survival in patients with hepatocellular carcinoma. J Cell Mol Med. 22:5928–5938. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Cancer Genome Atlas Research Network, ; Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C and Stuart JM: The cancer genome atlas pan-cancer analysis project. Nat Genet. 45:1113–1120. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Tibshirani R: The lasso method for variable selection in the Cox model. Stat Med. 16:385–395. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Li Z, Yamada S, Wu Y, Wang KY, Liu YP, Uramoto H, Kohno K and Sasaguri Y: Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection. Oncotarget. 7:54463–54473. 2016.PubMed/NCBI

11 

Simon RM, Subramanian J, Li MC and Menezes S: Using cross-validation to evaluate predictive accuracy of survival risk classifiers based on high-dimensional data. Brief Bioinform. 12:203–214. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Xu JH, Chang WH, Fu HW, Shu WQ, Yuan T and Chen P: Upregulated long non-coding RNA LOC90784 promotes cell proliferation and invasion and is associated with poor clinical features in HCC. Biochem Biophys Res Commun. 490:920–926. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Dai M, Chen S, Wei X, Zhu X, Lan F, Dai S and Qin X: Diagnosis, prognosis and bioinformatics analysis of lncRNAs in hepatocellular carcinoma. Oncotarget. 8:95799–95809. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Niu ZS, Niu XJ and Wang WH: Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications. World J Gastroenterol. 23:5860–5874. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Ma Y, Luo T, Dong D, Wu X and Wang Y: Characterization of long non-coding RNAs to reveal potential prognostic biomarkers in hepatocellular carcinoma. Gene. 663:148–156. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Cui H, Zhang Y, Zhang Q, Chen W, Zhao H and Liang J: A comprehensive genome-wide analysis of long noncoding RNA expression profile in hepatocellular carcinoma. Cancer Med. 6:2932–2941. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wang Z, Wu Q, Feng S, Zhao Y and Tao C: Identification of four prognostic LncRNAs for survival prediction of patients with hepatocellular carcinoma. PeerJ. 5:e35752017. View Article : Google Scholar : PubMed/NCBI

18 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. ELife. 4:e050052015. View Article : Google Scholar :

19 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. Omics. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Friedman J, Hastie T and Tibshirani R: Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 33:1–22. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Shi H, Yang X, Zhen Y, Huo S, Xiao R and Xu Z: MicroRNA499 rs3746444 A/G polymorphism functions as a biomarker to predict recurrence following endoscopic submucosal dissection in primary early gastric cancer. Mol Med Rep. 15:3245–3251. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Zhang W, Hong R, Li L, Wang Y, Du P, Ou Y, Zhao Z, Liu X, Xiao W, Dong D, et al: The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment. Mol Cancer. 17:1252018. View Article : Google Scholar : PubMed/NCBI

23 

Yu SL, Chen HY, Chang GC, Chen CY, Chen HW, Singh S, Cheng CL, Yu CJ, Lee YC, Chen HS, et al: MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell. 13:48–57. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Lu M, Wang C, Chen W, Mao C and Wang J: miR-654-5p targets GRAP to promote proliferation, metastasis, and chemoresistance of oral squamous cell carcinoma through ras/MAPK signaling. DNA Cell Boil. 37:381–388. 2018. View Article : Google Scholar

25 

Wang Y, Xu M and Yang Q: A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. Curr Probl Cancer. 43:167–176. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Chen YT, Yao JN, Qin YT, Hu K, Wu F and Fang YY: Biological role and clinical value of miR-99a-5p in head and neck squamous cell carcinoma (HNSCC): A bioinformatics-based study. FEBS Open Bio. 8:1280–1298. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Niu X, Liu S, Jia L and Chen J: Role of miR-3619-5p in β-catenin-mediated non-small cell lung cancer growth and invasion. Cell Physiol Biochem. 37:1527–1536. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu L, Wu Y, Feng M, Xue X and Fan Y: A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients. Mol Med Rep 20: 4340-4348, 2019.
APA
Lu, L., Wu, Y., Feng, M., Xue, X., & Fan, Y. (2019). A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients. Molecular Medicine Reports, 20, 4340-4348. https://doi.org/10.3892/mmr.2019.10665
MLA
Lu, L., Wu, Y., Feng, M., Xue, X., Fan, Y."A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients". Molecular Medicine Reports 20.5 (2019): 4340-4348.
Chicago
Lu, L., Wu, Y., Feng, M., Xue, X., Fan, Y."A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients". Molecular Medicine Reports 20, no. 5 (2019): 4340-4348. https://doi.org/10.3892/mmr.2019.10665
Copy and paste a formatted citation
x
Spandidos Publications style
Lu L, Wu Y, Feng M, Xue X and Fan Y: A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients. Mol Med Rep 20: 4340-4348, 2019.
APA
Lu, L., Wu, Y., Feng, M., Xue, X., & Fan, Y. (2019). A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients. Molecular Medicine Reports, 20, 4340-4348. https://doi.org/10.3892/mmr.2019.10665
MLA
Lu, L., Wu, Y., Feng, M., Xue, X., Fan, Y."A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients". Molecular Medicine Reports 20.5 (2019): 4340-4348.
Chicago
Lu, L., Wu, Y., Feng, M., Xue, X., Fan, Y."A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients". Molecular Medicine Reports 20, no. 5 (2019): 4340-4348. https://doi.org/10.3892/mmr.2019.10665
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