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Article Open Access

ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling

  • Authors:
    • Xian Zhang
    • Xinying Yang
    • Ming Chen
    • Shaolie Zheng
    • Jinyuan Li
    • Shaoqiang Lin
    • Xiaoyu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, P.R. China, Guangdong Second People's Hospital, Guangzhou, Guangdong 510317, P.R. China, Institute of Clinical Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4499-4506
    |
    Published online on: September 26, 2019
       https://doi.org/10.3892/mmr.2019.10712
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Abstract

The aberrant expression of sialyltransferase has a role in cell differentiation, neoplastic transformation and the progression of various types of cancer. Our previous studies have shown that high expression of β‑galactoside‑α2,3‑sialyltransferase III (ST3Gal3) in the metastatic ovarian cancer cell line HO8910PM attenuated cisplatin‑induced apoptosis. The present study demonstrated that paclitaxel‑induced chemoresistance in ovarian cancer cells upregulated the expression of ST3Gal3 and reduced the activity of caspase‑8/3. The results of the present study revealed that the endogenous levels of ST3Gal3 mRNA and protein were significantly higher in HO8910PM cells compared with SKOV3 cells. A higher expression of ST3Gal3 was correlated with an increased resistance to paclitaxel, while the downregulation of ST3Gal3 resulted in paclitaxel‑induced apoptosis. Paclitaxel upregulated ST3Gal3 expression at the mRNA and protein levels in HO8910PM cells, but not in SKOV3 cells. Silencing of ST3Gal3 by small interfering RNA reversed these effects and increased the protein levels of caspase‑8/3, which may contribute to paclitaxel‑induced apoptosis. The results of the present study suggested that ST3Gal3 was a target for paclitaxel‑­related resistance during ovarian cancer chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Yang X, Chen M, Zheng S, Li J, Lin S and Wang X: ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling. Mol Med Rep 20: 4499-4506, 2019.
APA
Zhang, X., Yang, X., Chen, M., Zheng, S., Li, J., Lin, S., & Wang, X. (2019). ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling. Molecular Medicine Reports, 20, 4499-4506. https://doi.org/10.3892/mmr.2019.10712
MLA
Zhang, X., Yang, X., Chen, M., Zheng, S., Li, J., Lin, S., Wang, X."ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling". Molecular Medicine Reports 20.5 (2019): 4499-4506.
Chicago
Zhang, X., Yang, X., Chen, M., Zheng, S., Li, J., Lin, S., Wang, X."ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling". Molecular Medicine Reports 20, no. 5 (2019): 4499-4506. https://doi.org/10.3892/mmr.2019.10712
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Yang X, Chen M, Zheng S, Li J, Lin S and Wang X: ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling. Mol Med Rep 20: 4499-4506, 2019.
APA
Zhang, X., Yang, X., Chen, M., Zheng, S., Li, J., Lin, S., & Wang, X. (2019). ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling. Molecular Medicine Reports, 20, 4499-4506. https://doi.org/10.3892/mmr.2019.10712
MLA
Zhang, X., Yang, X., Chen, M., Zheng, S., Li, J., Lin, S., Wang, X."ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling". Molecular Medicine Reports 20.5 (2019): 4499-4506.
Chicago
Zhang, X., Yang, X., Chen, M., Zheng, S., Li, J., Lin, S., Wang, X."ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling". Molecular Medicine Reports 20, no. 5 (2019): 4499-4506. https://doi.org/10.3892/mmr.2019.10712
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