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MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer

  • Authors:
    • Ling Li
    • Dongqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xintai People's Hospital, Xintai, Shandong 271200, P.R. China, Department of Radiation Oncology, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4803-4810
    |
    Published online on: October 8, 2019
       https://doi.org/10.3892/mmr.2019.10731
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Abstract

The expression of epidermal growth factor receptor (EGFR) is regulated by microRNA (miRNA)‑128‑b in non‑small cell lung cancer (NSCLC); however, the association between miRNA‑128‑b expression and EGFR expression has not been determined in vivo. The expression of miRNA‑128‑b was detected by reverse transcription (RT)‑quantitative polymerase chain reaction (PCR); semi‑quantitative RT‑PCR was used to detect EGFR mRNA expression; immunostaining was used to detect EGFR protein expression. The results revealed that expression of miR28b in cancer tissues was decreased compared with normal tissues, and the expression of EGFR mRNA in cancer tissues was increased compared with normal tissues. Immunohistochemistry analysis revealed that the normal tissues did not express EGFR protein, and the positive expression rate of EGFR in cancer tissues was 60%. Furthermore, the relative expression levels of miRNA‑128‑b were demonstrated to be correlated with EGFR mRNA and protein expression levels. In addition, the results revealed that miRNA‑128‑b regulated EGFR expression in NSCLC cells. In conclusion, the results of the present study suggested that miRNA‑128‑b may regulate the expression of EGFR in NSCLC cells, and that optimizing targeted therapy is conducive to the development of novel therapeutic strategies for the treatment of patients with lung cancer.
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1 

Kligerman S and White C: Epidemiology of lung cancer in women: Risk factors, survival, and screening. AJR Am J Roentgenol. 196:287–295. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Yang JC, Kang JH, Mok T, Ahn MJ, Srimuninnimit V, Lin CC, Kim DW, Tsai CM, Barraclough H, Altug S, et al: First-line pemetrexed plus cisplatin followed by gefitinib maintenance therapy versus gefitinib monotherapy in East Asian patients with locally advanced or metastatic non-squamous non-small cell lung cancer: A randomised, phase 3 trial. Eur J Cancer. 50:2219–2230. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Brown T, Boland A, Bagust A, Oyee J, Hockenhull J, Dundar Y, Dickson R, Ramani VS and Proudlove C: Gefitinib for the first-line treatment of locally advanced or metastatic non-small cell lung cancer. Health Technol Assess. 14 (Suppl):71–99. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Mendoza L: Targeted therapies in the treatment of advanced non-small-cell lung cancer: Update. Klin Onkol. 22:131–138. 2009.PubMed/NCBI

5 

Avery EJ, Kessinger A and Ganti AK: Therapeutic options for elderly patients with advanced non-small cell lung cancer. Cancer Treat Rev. 35:340–344. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Ahn HK, Choi YL, Han JH, Ahn YC, Kim K, Kim J, Shim YM, Um SW, Kim H, Kwon OJ, et al: Epidermal growth factor receptor mutation and treatment outcome of mediastinoscopic N2 positive non-small cell lung cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery. Lung Cancer. 79:300–306. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Tanaka K, Hida T, Oya Y, Oguri T, Yoshida T, Shimizu J, Horio Y, Hata A, Kaji R, Fujita S, et al: EGFR mutation impact on definitive concurrent chemoradiation therapy for inoperable stage III adenocarcinoma. J Thorac Oncol. 10:1720–1725. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Dahabreh IJ, Linardou H, Kosmidis P, Bafaloukos D and Murray S: EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: A systematic review and meta-analysis in non-small-cell lung cancer. Ann Oncol. 22:545–552. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Fukuoka M, Wu YL, Thongprasert S, Sunpaweravong P, Leong SS, Sriuranpong V, Chao TY, Nakagawa K, Chu DT, Saijo N, et al: Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol. 29:2866–2874. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Murphy M and Stordal B: Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review. Drug Resist Updat. 14:177–190. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Pirker R: What is the best strategy for targeting EGF receptors in non-small-cell lung cancer. Future Oncol. 11:153–167. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Cheng Q, Yi B, Wang A and Jiang X: Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis. Oncol Targets Ther. 6:1675–1684. 2013.

13 

Xia H and Hui KM: MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics. Cancer Gene Ther. 19:723–730. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Weiss GJ, Bemis LT, Nakajima E, Sugita M, Birks DK, Robinson WA, Varella-Garcia M, Bunn PA Jr, Haney J, Helfrich BA, et al: EGFR regulation by microRNA in lung cancer: Correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Ann Oncol. 19:1053–1059. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Chheang S and Brown K: Lung cancer staging: Clinical and radiologic perspectives. 30:99–113. 2013.PubMed/NCBI

16 

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Wang W, Wen Q, Xu L, Xie G, Li J, Luo J, Chu S, Shi L, Huang D, Li J and Fan S: Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma. PLoS One. 9:e1060982014. View Article : Google Scholar : PubMed/NCBI

18 

Ling LI and Song LH: The role of MicroRNA in lung cancer. J Clin Oncol. 36:1377–1380. 2009.(In Chinese).

19 

Zhao N, Zhang XC, Yan HH, Yang JJ and Wu YL: Efficacy of epidermal growth factor receptor inhibitors versus chemotherapy as second-line treatment in advanced non-small-cell lung cancer with wild-type EGFR: A meta-analysis of randomized controlled clinical trials. Lung Cancer. 85:66–73. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Wang S, Su X, Bai H, Zhao J, Duan J, An T, Zhuo M, Wang Z, Wu M, Li Z, et al: Identification of plasma microRNA profiles for primary resistance to EGFR-TKIs in advanced non-small cell lung cancer (NSCLC) patients with EGFR activating mutation. J Hematol Oncol. 8:1272015. View Article : Google Scholar : PubMed/NCBI

21 

Duan X and Shi J: Advance in microRNAs and EGFR-TKIs secondary resistance research in non-small cell lung cancer. Zhongguo Fei Ai Za Zhi. 17:860–864. 2014.(In Chinese). PubMed/NCBI

22 

Aichler M, Motschmann M, Jütting U, Luber B, Becker K, Ott K, Lordick F, Langer R, Feith M, Siewert JR and Walch A: Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy. Oncotarget. 5:6620–6632. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Ludovini V, Bellezza G, Pistola L, Bianconi F, Di Carlo L, Sidoni A, Semeraro A, Del Sordo R, Tofanetti FR, Mameli MG, et al: High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients. Ann Oncol. 20:842–849. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L, Wistuba II, Ji L, Roth JA, Minna JD and Pertsemlidis A: miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. Mol Cancer Res. 7:1234–1243. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L and Wang D: MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer. Mol Med Rep 20: 4803-4810, 2019.
APA
Li, L., & Wang, D. (2019). MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer. Molecular Medicine Reports, 20, 4803-4810. https://doi.org/10.3892/mmr.2019.10731
MLA
Li, L., Wang, D."MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer". Molecular Medicine Reports 20.6 (2019): 4803-4810.
Chicago
Li, L., Wang, D."MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer". Molecular Medicine Reports 20, no. 6 (2019): 4803-4810. https://doi.org/10.3892/mmr.2019.10731
Copy and paste a formatted citation
x
Spandidos Publications style
Li L and Wang D: MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer. Mol Med Rep 20: 4803-4810, 2019.
APA
Li, L., & Wang, D. (2019). MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer. Molecular Medicine Reports, 20, 4803-4810. https://doi.org/10.3892/mmr.2019.10731
MLA
Li, L., Wang, D."MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer". Molecular Medicine Reports 20.6 (2019): 4803-4810.
Chicago
Li, L., Wang, D."MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer". Molecular Medicine Reports 20, no. 6 (2019): 4803-4810. https://doi.org/10.3892/mmr.2019.10731
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