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Article Open Access

Screening and identification of key biomarkers in prostate cancer using bioinformatics

  • Authors:
    • Song Li
    • Junqing Hou
    • Weibo Xu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 311-319
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    Published online on: November 6, 2019
       https://doi.org/10.3892/mmr.2019.10799
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Abstract

Prostate cancer (PCa) is the second most common cancer amongst males worldwide. In the current study, microarray datasets GSE3325 and GSE6919 from the Gene Expression Omnibus database were screened to identify candidate genes that are associated with the progression of PCa. A total of 273 differentially expressed genes (DEGs) were identified, which included 173 downregulated genes and 100 upregulated genes, and a protein‑protein interaction network was constructed using Search Tool for the Retired of Interacting Genes. The enriched functions and pathways of the identified DEGs included cell adhesion, the negative regulation of cell proliferation, protein binding and focal adhesion. A total of 8 hub genes were identified, of which PDZ binding kinase, Krüppel‑like factor 4, collagen type XII α‑1 chain, RAP1A and RAP39B were indicated to be associated with the progression and recurrence of PCa. In conclusion, the DEGs and hub genes identified in the present study may aid in determining the molecular mechanisms associated with PCa carcinogenesis and progression.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:359–386. 2015. View Article : Google Scholar

2 

Roobol MJ, Steyerberg EW, Kranse R, Wolters T, van den Bergh RC, Bangma CH and Schröder FH: A risk-based strategy improves prostatespecific antigen-driven detection of prostate cancer. Eur Urol. 57:79–85. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Bussemakers MJ, van Bokhoven A, Verhaegh GW, Smit FP, Karthaus HF, Schalken JA, Debruyne FM, Ru N and Isaacs WB: DD3: A new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res. 59:5975–5979. 1999.PubMed/NCBI

4 

Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, et al: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 310:644–648. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Harden SV, Sanderson H, Goodman SN, Partin AA, Walsh PC, Epstein JI and Sidransky D: Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies. J Natl Cancer Inst. 95:1634–1637. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Ilic D, Neuberger MM, Djulbegovic M and Dahm P: Screening for prostate cancer. Cochrane Database Syst Rev. CD0047202013.PubMed/NCBI

7 

Wang Y, Wu N, Pang B, Tong D, Sun D, Sun H, Zhang C, Sun W, Meng X, Bai J, et al: TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways. Oncotarget. 8:47931–47942. 2017.PubMed/NCBI

8 

Yoshida A, Kato JY, Nakamae I and Yoneda-Kato N: COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1. Blood. 122:1750–1760. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ye Y, Wang G, Wang G, Zhuang J, He S, Song Y, Ni J, Xia W and Wang J: The oncogenic role of tribbles 1 in hepatocellular carcinoma is mediated by a feedback loop involving microRNA-23a and p53. Front Physiol. 8:7892017. View Article : Google Scholar : PubMed/NCBI

10 

García-Perdomo HA, Chaves MJ, Osorio JC and Sanchez A: Association between TMPRSS2:ERG fusion gene and the prostate cancer: Systematic review and meta-analysis. Cent European J Urol. 71:410–419. 2018.PubMed/NCBI

11 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, Shah RB, Chandran U, Monzon FA, Becich MJ, et al: Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell. 8:393–406. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, McDonald C, Thomas R, Dhir R, Finkelstein S, et al: Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol. 22:2790–2799. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID gene functional classification tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8:R1832007. View Article : Google Scholar : PubMed/NCBI

16 

Kanehisa M: The KEGG database. Novartis Found Symp. 247:91-103, 119–128, 244–252. 2002.

17 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Bandettini WP, Kellman P, Mancini C, Booker OJ, Vasu S, Leung SW, Wilson JR, Shanbhag SM, Chen MY and Arai AE: MultiContrast delayed enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: A clinical validation study. J Cardiovasc Magn Reson. 14:832012. View Article : Google Scholar : PubMed/NCBI

20 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

21 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM and Haussler D: The human genome browser at UCSC. Genome Res. 12:996–1006. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, et al: Gene expression patterns in human liver cancers. Mol Biol Cell. 13:1929–1939. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX and Wang XW: A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res. 70:10202–10212. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Wurmbach E, Chen YB, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, et al: Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology. 45:938–947. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Zhao H, Li J, Li X, Han C, Zhang Y, Zheng L and Guo M: Silencing GPX3 expression promotes tumor metastasis in human thyroid cancer. Curr Protein Pept Sci. 16:316–321. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Cao S, Yan B, Lu Y, Zhang G, Li J, Zhai W, Guo W and Zhang S: Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue. Clin Res Hepatol Gastroenterol. 39:198–204. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Yu YP, Yu G, Tseng G, Cieply K, Nelson J, Defrances M, Zarnegar R, Michalopoulos G and Luo JH: Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res. 67:8043–8050. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Edelman GM and Crossin KL: Cell adhesion molecules: Implications for a molecular histology. Annu Rev Biochem. 60:155–190. 1991. View Article : Google Scholar : PubMed/NCBI

30 

Fang E, Zhang X, Wang Q and Wang D: Identification of prostate cancer hub genes and therapeutic agents using bioinformatics approach. Cancer Biomark. 20:553–561. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Yang Y, Zhang X, Song D and Wei J: Piwil2 modulates the invasion and metastasis of prostate cancer by regulating the expression of matrix meta lloproteinase-9 and epithelial-mesenchymal transitions. Oncol Lett. 10:1735–1740. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Gaudet S, Branton D and Lue RA: Characterization of PDZ binding kinase, a mitotic kinase. Proc Natl Acad Sci USA. 97:5167–5172. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Abe Y, Matsumoto S, Kito K and Ueda N: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. J Biol Chem. 275:21525–21531. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Zhang C, Habets G and Bollag G: Interrogating the kinome. Nat Biotechnol. 29:981–983. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Lu Y, Muller M, Smith D, Dutta B, Komurov K, Iadevaia S, Ruths D, Tseng JT, Yu S, Yu Q, et al: Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling. Oncogene. 30:4567–4577. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Matsumoto S, Abe Y, Fujibuchi T, Takeuchi T, Kito K, Ueda N, Shigemoto K and Gyo K: Characterization of a MAPKK-like protein kinase TOPK. Biochem Biophys Res Commun. 325:997–1004. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Park JH, Nishidate T, Nakamura Y and Katagiri T: Critical roles of T-LAK cell-originated protein kinase in cytokinesis. Cancer Sci. 101:403–411. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Fujibuchi T, Abe Y, Takeuchi T, Ueda N, Shigemoto K, Yamamoto H and Kito K: Expression and phosphorylation of TOPK during spermatogenesis. Dev Growth Differ. 47:637–644. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Park JH, Lin ML, Nishidate T, Nakamura Y and Katagiri T: PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer. Cancer Res. 66:9186–9195. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Singh PK, Srivastava AK, Dalela D, Rath SK, Goel MM and Bhatt ML: Expression of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) in human urinary bladder transitional cell carcinoma. Immunobiology. 219:469–474. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Kim DJ, Li Y, Reddy K, Lee MH, Kim MO, Cho YY, Lee SY, Kim JE, Bode AM and Dong Z: Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 72:3060–3068. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Sun H, Zhang L, Shi C, Hu P, Yan W, Wang Z, Duan Q, Lu F, Qin L, Lu T, et al: TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer. Oncotarget. 6:12392–12404. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Chen JH, Fang SM and Liang YK: Expression and clinical significance of PBK in prostate cancer tissues. Guangzhou Pharm. 48:1000–8535. 2017.

44 

Simons-Evelyn M, Bailey-Dell K, Toretsky JA, Ross DD, Fenton R, Kalvakolanu D and Rapoport AP: PBK/TOPK is a novel mitotic kinase which isupregulated in burkitt's lymphoma and other highly proliferative malignant cells. Blood Cells Mol Dis. 27:825–829. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Simons-Evelyn M, Bailey-Dell K, Toretsky JA, Ross DD, Fenton R, Kalvakolanu D and Rapoport AP: PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells. Blood Cells Mol Dis. 27:825–829. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S and Xie K: Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res. 65:2746–2754. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F and Yoshida T: Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem Biophys Res Commun. 308:251–256. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Wei D, Kanai M, Jia Z, Le X and Xie K: Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res. 68:4631–4639. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Katz JP, Perreault N, Goldstein BG, Lee CS, Labosky PA, Yang VW and Kaestner KH: The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 129:2619–2628. 2002.PubMed/NCBI

50 

Ghaleb AM, McConnell BB, Nandan MO, Katz JP, Kaestner KH and Yang VW: Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 67:7147–7154. 2007. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Li S, Hou J and Xu W: Screening and identification of key biomarkers in prostate cancer using bioinformatics. Mol Med Rep 21: 311-319, 2020.
APA
Li, S., Hou, J., & Xu, W. (2020). Screening and identification of key biomarkers in prostate cancer using bioinformatics. Molecular Medicine Reports, 21, 311-319. https://doi.org/10.3892/mmr.2019.10799
MLA
Li, S., Hou, J., Xu, W."Screening and identification of key biomarkers in prostate cancer using bioinformatics". Molecular Medicine Reports 21.1 (2020): 311-319.
Chicago
Li, S., Hou, J., Xu, W."Screening and identification of key biomarkers in prostate cancer using bioinformatics". Molecular Medicine Reports 21, no. 1 (2020): 311-319. https://doi.org/10.3892/mmr.2019.10799
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Hou J and Xu W: Screening and identification of key biomarkers in prostate cancer using bioinformatics. Mol Med Rep 21: 311-319, 2020.
APA
Li, S., Hou, J., & Xu, W. (2020). Screening and identification of key biomarkers in prostate cancer using bioinformatics. Molecular Medicine Reports, 21, 311-319. https://doi.org/10.3892/mmr.2019.10799
MLA
Li, S., Hou, J., Xu, W."Screening and identification of key biomarkers in prostate cancer using bioinformatics". Molecular Medicine Reports 21.1 (2020): 311-319.
Chicago
Li, S., Hou, J., Xu, W."Screening and identification of key biomarkers in prostate cancer using bioinformatics". Molecular Medicine Reports 21, no. 1 (2020): 311-319. https://doi.org/10.3892/mmr.2019.10799
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