Open Access

Molecular basis of degenerative spinal disorders from a proteomic perspective (Review)

  • Authors:
    • Chang Liu
    • Minghui Yang
    • Libangxi Liu
    • Yang Zhang
    • Qi Zhu
    • Cong Huang
    • Hongwei Wang
    • Yaqing Zhang
    • Haiyin Li
    • Changqing Li
    • Bo Huang
    • Chencheng Feng
    • Yue Zhou
  • View Affiliations

  • Published online on: November 12, 2019     https://doi.org/10.3892/mmr.2019.10812
  • Pages: 9-19
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intervertebral disc degeneration (IDD) and ligamentum flavum hypertrophy (LFH) are major causes of degenerative spinal disorders. Comparative and proteomic analysis was used to identify differentially expressed proteins (DEPs) in IDD and LFH discs compared with normal discs. Subsequent gene ontology term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of the DEPs in human IDD discs or LFH samples were performed to identify the biological processes and signaling pathways involved in IDD and LFH. The PI3K‑AKT signaling pathway, advanced glycation endproducts‑receptor for advanced glycation endproducts signaling pathway, p53 signaling pathway, and transforming growth factor‑b signaling pathway were activated in disc degeneration. This review summarizes the recently identified DEPs, including prolargin, fibronectin 1, cartilage intermediate layer protein, cartilage oligomeric matrix protein, and collagen types I, II and IV, and their pathophysiological roles in degenerative spinal disorders, and may provide a deeper understanding of the pathological processes of human generative spinal disorders. The present review aimed to summarize significantly changed proteins in degenerative spinal disorders and provide a deeper understanding to prevent these diseases.
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January-2020
Volume 21 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Liu C, Yang M, Liu L, Zhang Y, Zhu Q, Huang C, Wang H, Zhang Y, Li H, Li C, Li C, et al: Molecular basis of degenerative spinal disorders from a proteomic perspective (Review). Mol Med Rep 21: 9-19, 2020
APA
Liu, C., Yang, M., Liu, L., Zhang, Y., Zhu, Q., Huang, C. ... Zhou, Y. (2020). Molecular basis of degenerative spinal disorders from a proteomic perspective (Review). Molecular Medicine Reports, 21, 9-19. https://doi.org/10.3892/mmr.2019.10812
MLA
Liu, C., Yang, M., Liu, L., Zhang, Y., Zhu, Q., Huang, C., Wang, H., Zhang, Y., Li, H., Li, C., Huang, B., Feng, C., Zhou, Y."Molecular basis of degenerative spinal disorders from a proteomic perspective (Review)". Molecular Medicine Reports 21.1 (2020): 9-19.
Chicago
Liu, C., Yang, M., Liu, L., Zhang, Y., Zhu, Q., Huang, C., Wang, H., Zhang, Y., Li, H., Li, C., Huang, B., Feng, C., Zhou, Y."Molecular basis of degenerative spinal disorders from a proteomic perspective (Review)". Molecular Medicine Reports 21, no. 1 (2020): 9-19. https://doi.org/10.3892/mmr.2019.10812