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Disorders of sex development: Genetic characterization of a patient cohort

  • Authors:
    • Mary García-Acero
    • Olga Moreno-Niño
    • Fernando Suárez-Obando
    • Mónica Molina
    • María Carolina Manotas
    • Juan Carlos Prieto
    • Catalina Forero
    • Camila Céspedes
    • Jaime Pérez
    • Nicolas Fernandez
    • Adriana Rojas
  • View Affiliations / Copyright

    Affiliations: Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá 110231, Colombia, Pediatric Endocrinology, Hospital Universitario San Ignacio, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá 110231, Colombia, Division of Urology, Hospital Universitario San Ignacio, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá 110231, Colombia
    Copyright: © García-Acero et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 97-106
    |
    Published online on: November 12, 2019
       https://doi.org/10.3892/mmr.2019.10819
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Abstract

Disorders of sex development (DSDs) are congenital conditions in which the external appearance of the individual does not coincide with the chromosomal constitution or the gonadal sex. In other words, there is an ambiguous or intermediate condition between the male and female phenotypes of the anatomical sex. These atypical conditions are manifested in several ways, ranging from genital ambiguity to phenotypes that are so attenuated that they can go unnoticed or appear normal. Currently, there is a lack of understanding of the factors responsible for these outcomes; however, they are likely to be conditioned by genetic, hormonal and environmental factors during prenatal and postnatal development. The present study determined the genetic etiology of DSDs in Colombian patients by conventional cytogenetic analysis, FISH and MLPA (for SF1, DAX1, SOX9, SRY and WNT4). A cohort of 43 patients with clinical phenotypes of sex development disorder was used in the present study. Using this multistep experimental approach, a diagnostic percentage of 25.58% was obtained: 17 patients (39.53%) were classified as having gonadal development disorders, the majority of which were ovotesticular disorders with numerical and/or structural alterations of the sex chromosomes, 9 patients (20.93%) were classified as having testicular DSD with a 46,XY karyotype, and 3 patients (6.98%) as having ovarian DSD with a 46,XX karyotype. The remaining 14 patients (32.56%) were classified as ‘other’ since they could not be grouped into a specific class of gonadal development, corresponding to hypospadias and multiple congenital anomalies. These findings highlight the importance of histological and cytogenetic studies in a gonadal biopsy. In 11/43 cases, the multistep experimental protocol presented in the present study yielded etiological or histological findings that could be used to define the medical management of patients with DSDs. In conclusion, for the etiological diagnosis of DSDs, a broad‑spectrum approach that includes endocrinological tests, conventional karyotyping, molecular karyotyping by FISH and, molecular tests is required, in addition to gonadal tissue analyses, to identify genetic alterations.
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1 

Woodward MN and Patwardhan N: Disorders of sex development. Surg. 28:396–401. 2010.

2 

Dreger AD, Chase C, Sousa A, Gruppuso PA and Frader J: Changing the nomenclature/taxonomy for intersex: A scientific and clinical rationale. J Pediatr Endocrinol Metab. 18:729–33. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Hughes IA: Disorders of Sexual Differentiation. Horm Res Paediatr. 67:91–95. 2007. View Article : Google Scholar

4 

Lee PA, Nordenström A, Houk CP, Ahmed SF, Auchus R, Baratz A, Baratz Dalke K, Liao LM, Lin-Su K, Looijenga LH III, et al: Global disorders of sex development update since 2006: Perceptions, approach and care. Horm Res Paediatr. 85:158–180. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hughes IA, Houk CP, Ahmed SF and Lee PA; LWPES Consensus Group; ESPE Consensus Group, : Consensus statement on management of intersex disorders. Arch Dis Child. 91:554–563. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Sax L: How common is lntersex? A response to Anne Fausto-Sterling. J Sex Res. 39:174–178. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Nordenvall AS, Frisén L, Nordenström A, Lichtenstein P and Nordenskjöld A: Population based nationwide study of hypospadias in sweden, 1973 to 2009: Incidence and risk factors. J Urol. 191:783–789. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zarante I, Franco L, López C and Fernández N: Frecuencia de malformaciones congénitas: Evaluación y pronóstico de 52.744 nacimientos en tres ciudades colombianas. Biomédica. 30:65–71. 2010. View Article : Google Scholar

9 

Biason-Lauber A: Control of sex development. Best Pract Res Clin Endocrinol Metab. 24:163–186. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Houmard B, Small C, Yang L, Naluai-Cecchini T, Cheng E, Hassold T and Griswold M: Global gene expression in the human fetal testis and Ovary1. Biol Reprod. 81:438–443. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Eggers S, Sadedin S, van den Bergen JA, Robevska G, Ohnesorg T, Hewitt J, Lambeth L, Bouty A, Knarston IM, Tan TY, et al: Disorders of sex development: Insights from targeted gene sequencing of a large international patient cohort. Genome Biol. 17:2432016. View Article : Google Scholar : PubMed/NCBI

12 

McClelland K, Bowles J and Koopman P: Male sex determination: Insights into molecular mechanisms. Asian J Androl. 14:164–171. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Arboleda VA, Sandberg DE and Vilain E: DSDs: Genetics, underlying pathologies and psychosexual differentiation. Nat Rev Endocrinol. 10:603–615. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Baxter RM and Vilain E: Translational genetics for diagnosis of human disorders of sex development. Annu Rev Genomics Hum Genet. 14:371–392. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Rajfer J and Walsh PC: The incidence of intersexuality in patients with hypospadias and cryptorchidism. J Urol. 116:769–770. 1976. View Article : Google Scholar : PubMed/NCBI

16 

van der Zwan YG, Biermann K, Wolffenbuttel KP, Cools M and Looijenga LH: Gonadal maldevelopment as risk factor for germ cell cancer: Towards a clinical decision model. Eur Urol. 67:692–701. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Moorhead PS, Nowell PC, Mellman WJ, Battips DM and Hungerford DA: Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res. 20:613–616. 1960. View Article : Google Scholar : PubMed/NCBI

18 

Laino L, Majore S, Preziosi N, Grammatico B, De Bernardo C, Scommegna S, Rapone AM, Marrocco G, Bottillo I and Grammatico P: Disorders of sex development: A genetic study of patients in a multidisciplinary clinic. Endocr Connect. 3:180–192. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Arboleda VA, Lee H, Sánchez FJ, Délot EC, Sandberg DE, Grody WW, Nelson SF and Vilain E: Targeted massively parallel sequencing provides comprehensive genetic diagnosis for patients with disorders of sex development. Clin Genet. 83:35–43. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Dong Y, Yi Y, Yao H, Hu H, Liu J, Gao C, Zhang M, Zhou L, Asan, Yi X and Liang Z: Targeted next-generation sequencing identification of mutations in patients with disorders of sex development. BMC Med Genet. 17:232016. View Article : Google Scholar : PubMed/NCBI

21 

Marrocco G, Grammatico P, Vallasciani S, Gulia C, Zangari A, Marrocco F, Bateni ZH, Porrello A and Piergentili R: Environmental, parental and gestational factors that influence the occurrence of hypospadias in male patients. J Pediatr Urol. 11:12–19. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Audí L and Fernández-Cancio MF: Etiopatogenia del hipospadias. Rev Esp Endocrinol Pediatr. 5 (Suppl):S72014.

23 

Si YM, Dong Y, Wang W, Qi KY and Wang X: Hypospadias in a male infant with an unusual mosaic 45,X/46,X,psu idic(Y)(p11.32)/46,XY and haploinsufficiency of SHOX: A case report. Mol Med Rep. 16:201–207. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Köhler B, Schumacher V, L'Allemand D, Royer-Pokora B and Grüters A: Germline Wilms tumor suppressor gene (WT1) mutation leading to isolated genital malformation without Wilms tumor or nephropathy. J Pediatr. 138:421–424. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Wang Y, Li Q, Xu J, Liu Q, Wang W, Lin Y, Ma F, Chen T, Li S and Shen Y: Mutation analysis of five candidate genes in Chinese patients with hypospadias. Eur J Hum Genet. 12:706–712. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Beaulieu Bergeron M, Brochu P, Lemyre E and Lemieux N: Correlation of intercentromeric distance, mosaicism, and sexual phenotype: Molecular localization of breakpoints in isodicentric Y chromosomes. Am J Med Genet A 155A. 2705–2712. 2011. View Article : Google Scholar

27 

Haines B, Hughes J, Corbett M, Shaw M, Innes J, Patel L, Gecz J, Clayton-Smith J and Thomas P: Interchromosomal insertional translocation at Xq26.3 Alters SOX3 expression in an individual with XX male sex reversal. J Clin Endocrinol Metab. 100:E815–E820. 2015. View Article : Google Scholar : PubMed/NCBI

28 

García-Acero M, Molina M, Moreno O, Ramirez A, Forero C, Céspedes C, Prieto JC, Pérez J, Suárez-Obando F and Rojas A: Gene dosage of DAX-1, determining in sexual differentiation: Duplication of DAX-1 in two sisters with gonadal dysgenesis. Mol Biol Rep. 46:2971–2978. 2019. View Article : Google Scholar : PubMed/NCBI

29 

McElreavy K, Vilain E, Abbas N, Costa JM, Souleyreau N, Kucheria K, Boucekkine C, Thibaud E, Brauner R, Flamant F, et al: XY sex reversal associated with a deletion 5′ to the SRY ‘HMG box’ in the testis-determining region. Proc Natl Acad Sci USA. 89:11016–11020. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Sarkar A and Hochedlinger K: The Sox family of transcription factors: Versatile regulators of stem and progenitor cell fate. Cell Stem Cell. 12:15–30. 2013. View Article : Google Scholar : PubMed/NCBI

31 

XIA XY, ZHANG C, LI TF, Wu QY, Li N, Li WW, Cui YX, Li XJ and Shi YC: A duplication upstream of SOX9 was not positively correlated with the SRY-negative 46,XX testicular disorder of sex development: A case report and literature review. Mol Med Rep. 12:5659–5664. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Hashimoto K, Horibe YU, Ezaki J, Kanno T, Takahashi N, Akizawa Y, Matsui H, Yamamoto T and Shibata N: Laparoscopically removed streak gonad revealed gonadoblastoma in frasier syndrome. Anticancer Res. 37:3975–3979. 2017.PubMed/NCBI

33 

Mandelberger A, Mathews S, Andikyan V and Chuang L: Laparoscopic removal of streak gonads in turner syndrome. J Minim Invasive Gynecol. 23:10252016. View Article : Google Scholar : PubMed/NCBI

34 

Lepais L, Morel Y, Mouriquand P, Gorduza D, Plotton I, Collardeau-Frachon S and Dijoud F: A novel morphological approach to gonads in disorders of sex development. Mod Pathol. 29:1399–1414. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Achermann JC, Domenice S, Bachega TA, Nishi MY and Mendonca BB: Disorders of sex development: Effect of molecular diagnostics. Nat Rev Endocrinol. 11:478–488. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Délot EC, Papp JC, Délot EC; DSD-TRN Genetics Workgroup, ; Sandberg DE and Vilain E: Genetics of Disorders of Sex Development: The DSD-TRN experience. Endocrinol Metab Clin North Am. 46:519–537. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Anthony E, Baratz AB, Boney C, et al: Clinical Guidelines for the Management of Disorders of Sex Development in Childhood. 1st. Intersex Society of North America; Rohnert Park, CA: 2006

38 

Gomez-Lobo V: Multidisciplinary care for individuals with disorders of sex development. Curr Opin Obstet Gynecol. 26:366–371. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
García-Acero M, Moreno-Niño O , Suárez-Obando F, Molina M, Manotas MC, Prieto JC, Forero C, Céspedes C, Pérez J, Fernandez N, Fernandez N, et al: Disorders of sex development: Genetic characterization of a patient cohort. Mol Med Rep 21: 97-106, 2020.
APA
García-Acero, M., Moreno-Niño, O. ., Suárez-Obando, F., Molina, M., Manotas, M.C., Prieto, J.C. ... Rojas, A. (2020). Disorders of sex development: Genetic characterization of a patient cohort. Molecular Medicine Reports, 21, 97-106. https://doi.org/10.3892/mmr.2019.10819
MLA
García-Acero, M., Moreno-Niño, O. ., Suárez-Obando, F., Molina, M., Manotas, M. C., Prieto, J. C., Forero, C., Céspedes, C., Pérez, J., Fernandez, N., Rojas, A."Disorders of sex development: Genetic characterization of a patient cohort". Molecular Medicine Reports 21.1 (2020): 97-106.
Chicago
García-Acero, M., Moreno-Niño, O. ., Suárez-Obando, F., Molina, M., Manotas, M. C., Prieto, J. C., Forero, C., Céspedes, C., Pérez, J., Fernandez, N., Rojas, A."Disorders of sex development: Genetic characterization of a patient cohort". Molecular Medicine Reports 21, no. 1 (2020): 97-106. https://doi.org/10.3892/mmr.2019.10819
Copy and paste a formatted citation
x
Spandidos Publications style
García-Acero M, Moreno-Niño O , Suárez-Obando F, Molina M, Manotas MC, Prieto JC, Forero C, Céspedes C, Pérez J, Fernandez N, Fernandez N, et al: Disorders of sex development: Genetic characterization of a patient cohort. Mol Med Rep 21: 97-106, 2020.
APA
García-Acero, M., Moreno-Niño, O. ., Suárez-Obando, F., Molina, M., Manotas, M.C., Prieto, J.C. ... Rojas, A. (2020). Disorders of sex development: Genetic characterization of a patient cohort. Molecular Medicine Reports, 21, 97-106. https://doi.org/10.3892/mmr.2019.10819
MLA
García-Acero, M., Moreno-Niño, O. ., Suárez-Obando, F., Molina, M., Manotas, M. C., Prieto, J. C., Forero, C., Céspedes, C., Pérez, J., Fernandez, N., Rojas, A."Disorders of sex development: Genetic characterization of a patient cohort". Molecular Medicine Reports 21.1 (2020): 97-106.
Chicago
García-Acero, M., Moreno-Niño, O. ., Suárez-Obando, F., Molina, M., Manotas, M. C., Prieto, J. C., Forero, C., Céspedes, C., Pérez, J., Fernandez, N., Rojas, A."Disorders of sex development: Genetic characterization of a patient cohort". Molecular Medicine Reports 21, no. 1 (2020): 97-106. https://doi.org/10.3892/mmr.2019.10819
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