Open Access

Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma

  • Authors:
    • Jie Wei
    • Zhijie Xu
    • Xi Chen
    • Xiang Wang
    • Shuangshuang Zeng
    • Long Qian
    • Xue Yang
    • Chunlin Ou
    • Wei Lin
    • Zhicheng Gong
    • Yuanliang Yan
  • View Affiliations

  • Published online on: November 20, 2019     https://doi.org/10.3892/mmr.2019.10837
  • Pages: 360-370
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles of the GSDM superfamily on the occurrence and prognosis of lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses and in vitro methods. Here, data from several bioinformatic platforms revealed that GSDMC is significantly upregulated in LUAD tissues and cell lines. Real‑time fluorescence quantitative PCR (qPCR) demonstrated that GSDMC was obviously upregulated in radio‑resistant LUAD cells, compared with their parental cells. Moreover, upregulated GSDMC expression was confirmed to be an independent indicator of poor first progression (FP) and overall survival (OS) in LUAD patients. DNA methylation analysis showed an evidently negative correlation between GSDMC expression and methylation status of one CpG site (cg05316065) in its DNA sequence. Patients with high methylation values had significantly higher Karnofsky performance scores (KPSs) and prolonged OS rates. Together, we confirmed that overexpression of GSDMC acts as a promising predictive factor for the poor prognosis of LUAD patients.
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January-2020
Volume 21 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wei J, Xu Z, Chen X, Wang X, Zeng S, Qian L, Yang X, Ou C, Lin W, Gong Z, Gong Z, et al: Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Mol Med Rep 21: 360-370, 2020
APA
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L. ... Yan, Y. (2020). Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Molecular Medicine Reports, 21, 360-370. https://doi.org/10.3892/mmr.2019.10837
MLA
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Yan, Y."Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma". Molecular Medicine Reports 21.1 (2020): 360-370.
Chicago
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Yan, Y."Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma". Molecular Medicine Reports 21, no. 1 (2020): 360-370. https://doi.org/10.3892/mmr.2019.10837