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Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma

  • Authors:
    • Jie Wei
    • Zhijie Xu
    • Xi Chen
    • Xiang Wang
    • Shuangshuang Zeng
    • Long Qian
    • Xue Yang
    • Chunlin Ou
    • Wei Lin
    • Zhicheng Gong
    • Yuanliang Yan
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 360-370
    |
    Published online on: November 20, 2019
       https://doi.org/10.3892/mmr.2019.10837
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Abstract

The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles of the GSDM superfamily on the occurrence and prognosis of lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses and in vitro methods. Here, data from several bioinformatic platforms revealed that GSDMC is significantly upregulated in LUAD tissues and cell lines. Real‑time fluorescence quantitative PCR (qPCR) demonstrated that GSDMC was obviously upregulated in radio‑resistant LUAD cells, compared with their parental cells. Moreover, upregulated GSDMC expression was confirmed to be an independent indicator of poor first progression (FP) and overall survival (OS) in LUAD patients. DNA methylation analysis showed an evidently negative correlation between GSDMC expression and methylation status of one CpG site (cg05316065) in its DNA sequence. Patients with high methylation values had significantly higher Karnofsky performance scores (KPSs) and prolonged OS rates. Together, we confirmed that overexpression of GSDMC acts as a promising predictive factor for the poor prognosis of LUAD patients.
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1 

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Yan Y, Su W, Zeng S, Qian L, Chen X, Wei J, Chen N, Gong Z and Xu Z: Effect and mechanism of tanshinone I on the radiosensitivity of lung cancer cells. Mol Pharm. 15:4843–4853. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, et al: Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies. Cancer Discov. 7:596–609. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Kovacs SB and Miao EA: Gasdermins: Effectors of pyroptosis. Trends Cell Biol. 27:673–684. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Shi J, Gao W and Shao F: Pyroptosis: Gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 42:245–254. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Yuan YY, Xie KX, Wang SL and Yuan LW: Inflammatory caspase-related pyroptosis: Mechanism, regulation and therapeutic potential for inflammatory bowel disease. Gastroenterol Rep (Oxf). 6:167–176. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Lutkowska A, Roszak A, Lianeri M, Sowinska A, Sotiri E and Jagodzinski PP: Analysis of rs8067378 polymorphism in the risk of uterine cervical cancer from a polish population and its impact on gasdermin B expression. Mol Diagn Ther. 21:199–207. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, et al: Gasdermin C is upregulated by inactivation of transforming growth factor β receptor type II in the presence of mutated apc, promoting colorectal cancer proliferation. PloS One. 11:e01664222016. View Article : Google Scholar : PubMed/NCBI

9 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al: The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483:603–607. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, et al: A pathology atlas of the human cancer transcriptome. Science. 357:eaan25072017. View Article : Google Scholar : PubMed/NCBI

14 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

15 

Gyorffy B, Surowiak P, Budczies J and Lanczky A: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PloS One. 8:e822412013. View Article : Google Scholar : PubMed/NCBI

16 

Huang WY, Hsu SD, Huang HY, Sun YM, Chou CH, Weng SL and Huang HD: MethHC: A database of DNA methylation and gene expression in human cancer. Nucleic Acids Res. 43:D856–D861. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Koch A, De Meyer T, Jeschke J and Van Criekinge W: MEXPRESS: Visualizing expression, DNA methylation and clinical TCGA data. BMC Genomics. 16:6362015. View Article : Google Scholar : PubMed/NCBI

18 

Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID Bioinformatics Resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35:W169–W175. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Duncan D, Shi Z and Zhang B: WEB-based GEne SeT analysis toolkit (WebGestalt): Update 2013. Nucleic Acids Res. 41:W77–W83. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Xu Z, Yan Y, Xiao L, Dai S, Zeng S, Qian L, Wang L, Yang X, Xiao Y and Gong Z: Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway. PloS One. 12:e01759772017. View Article : Google Scholar : PubMed/NCBI

21 

You S, Li R, Park D, Xie M, Sica GL, Cao Y, Xiao ZQ and Deng X: Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Mol Cancer Ther. 13:606–616. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Dai S, Yan Y, Xu Z, Zeng S, Qian L, Huo L, Li X, Sun L and Gong Z: SCD1 confers temozolomide resistance to human glioma cells via the Akt/GSK3β/β-catenin signaling axis. Front Pharmacol. 8:9602017. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Ouyang Z, Peng D and Dhakal DP: Risk factors for hematological toxicity of chemotherapy for bone and soft tissue sarcoma. Oncol Lett. 5:1736–1740. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Tandon P, Reddy KR, O'Leary JG, Garcia-Tsao G, Abraldes JG, Wong F, Biggins SW, Maliakkal B, Fallon MB, Subramanian RM, et al: A Karnofsky performance status-based score predicts death after hospital discharge in patients with cirrhosis. Hepatology. 65:217–224. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Watabe K, Ito A, Asada H, Endo Y, Kobayashi T, Nakamoto K, Itami S, Takao S, Shinomura Y, Aikou T, et al: Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. Jap J Cancer Res. 92:140–151. 2001. View Article : Google Scholar

27 

Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T and Sasaki H: Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer. 48:261–271. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Borczuk AC: Prognostic considerations of the new world health organization classification of lung adenocarcinoma. Eur Respir Rev. 25:364–371. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Wang X, Xu Z, Ren X, Chen X, Wei J, Lin W, Li Z, Ou C, Gong Z and Yan Y: Function of low ADARB1 expression in lung adenocarcinoma. PLoS One. 14:e02222982019. View Article : Google Scholar : PubMed/NCBI

30 

Wang X, Xu Z, Chen X, Ren X, Wei J, Zhou S, Yang X, Zeng S, Qian L, Wu G, et al: A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma. PeerJ. 7:e71252019. View Article : Google Scholar : PubMed/NCBI

31 

Yang X, Xu ZJ, Chen X, Zeng SS, Qian L, Wei J, Peng M, Wang X, Liu WL, Ma HY, et al: Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients. World J Gastroenterol. 25:2099–2109. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Chen X, Xu Z, Zeng S, Wang X, Liu W, Qian L, Wei J, Yang X, Shen Q, Gong Z and Yan Y: SIRT5 downregulation is associated with poor prognosis in glioblastoma. Cancer Biomark. 24:449–459. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Zhou S, Yan Y, Chen X, Wang X, Zeng S, Qian L, Wei J, Yang X, Zhou Y, Gong Z and Xu Z: Roles of highly expressed PAICS in lung adenocarcinoma. Gene. 692:1–8. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Upchurch GM, Haney SL and Opavsky R: Aberrant promoter hypomethylation in CLL: Does it matter for disease development? Front Oncol. 6:1822016. View Article : Google Scholar : PubMed/NCBI

35 

Zhang W, Barger CJ, Link PA, Mhawech-Fauceglia P, Miller A, Akers SN, Odunsi K and Karpf AR: DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer. Epigenetics. 10:736–748. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Milanovic M, Yu Y and Schmitt CA: The senescence-stemness alliance-a cancer-hijacked regeneration principle. Trends Cell Biol. 28:1049–1061. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Vymětalová L and Kryštof V: Potential clinical uses of CDK inhibitors: Lessons from synthetic lethality screens. Med Res Rev. 35:1156–1174. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Wu M, Wang Y, Yang D, Gong Y, Rao F, Liu R, Danna Y, Li J, Fan J, Chen J, et al: A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma. EBioMedicine. 41:244–255. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei J, Xu Z, Chen X, Wang X, Zeng S, Qian L, Yang X, Ou C, Lin W, Gong Z, Gong Z, et al: Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Mol Med Rep 21: 360-370, 2020.
APA
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L. ... Yan, Y. (2020). Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Molecular Medicine Reports, 21, 360-370. https://doi.org/10.3892/mmr.2019.10837
MLA
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Yan, Y."Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma". Molecular Medicine Reports 21.1 (2020): 360-370.
Chicago
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Yan, Y."Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma". Molecular Medicine Reports 21, no. 1 (2020): 360-370. https://doi.org/10.3892/mmr.2019.10837
Copy and paste a formatted citation
x
Spandidos Publications style
Wei J, Xu Z, Chen X, Wang X, Zeng S, Qian L, Yang X, Ou C, Lin W, Gong Z, Gong Z, et al: Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Mol Med Rep 21: 360-370, 2020.
APA
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L. ... Yan, Y. (2020). Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. Molecular Medicine Reports, 21, 360-370. https://doi.org/10.3892/mmr.2019.10837
MLA
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Yan, Y."Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma". Molecular Medicine Reports 21.1 (2020): 360-370.
Chicago
Wei, J., Xu, Z., Chen, X., Wang, X., Zeng, S., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Yan, Y."Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma". Molecular Medicine Reports 21, no. 1 (2020): 360-370. https://doi.org/10.3892/mmr.2019.10837
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