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Article

Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis

  • Authors:
    • Yajun Chen
    • Fanghua Qiu
    • Lichan Huang
    • Weiping Liu
    • Liqin Li
    • Canhua Ji
    • Xianqi Zeng
    • Lingli Qiao
    • Mengqin Liu
    • Xiaoqian Gong
  • View Affiliations / Copyright

    Affiliations: Medical Genetic Center, Maternal and Child Health Hospital of Shaoguan, Shaoguan, Guangdong 512026, P.R. China, Department of Infection Control, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510130, P.R. China, Department of Breast Surgery, Maternal and Child Health Hospital of Shaoguan, Shaoguan, Guangdong 512026, P.R. China, Department of Gynecology, Maternal and Child Health Hospital of Shaoguan, Shaoguan, Guangdong 512026, P.R. China
  • Pages: 1296-1303
    |
    Published online on: December 18, 2019
       https://doi.org/10.3892/mmr.2019.10895
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Abstract

Long non‑coding RNAs (lncRNAs) are important mediators of the initiation and progression of tumors, including breast cancer (BC). The exact role of long intergenic non‑coding RNA 00312 (LINC00312) in BC and its mechanism of action have not been reported to date. In the present study, LINC00312 was found to be downregulated in human BC tissues and cell lines by RT‑qPCR. The findings of a functional study indicated that overexpression of LINC00312 suppressed the proliferation, colony forming ability, migration and invasiveness of BC cell lines. Mechanistically, LINC00312 was found to induce suppression of cell migration and invasion by directly binding to miR‑9. Overexpression of LINC00312 increased the expression of cadherin 1 (CDH1), a direct target of miR‑9, and decreased the expression of vimentin (VIM), a major cytoskeletal component of mesenchymal cells as determined by western blot analysis. miR‑9 partly abrogated the upregulation of CDH1 and downregulation of VIM induced by LINC00312. Taken together, the results of the present study indicate a role for the LINC00312/miR‑9/CDH1 axis in the progression of BC, and suggest a novel lncRNA‑based diagnostic biomarker or therapeutic target for BC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Cardoso F, Spence D, Mertz S, Corneliussen-James D, Sabelko K, Gralow J, Cardoso MJ, Peccatori F, Paonessa D, Benares A, et al: Global analysis of advanced/metastatic breast cancer: Decade report (2005–2015). Breast. 39:131–138. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Nagini S: Breast cancer: Current molecular therapeutic targets and new players. Anticancer Agents Med Chem. 17:152–163. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Daskalakis NP, Provost AC, Hunter RG and Guffanti G: Noncoding RNAs: Stress, glucocorticoids, and posttraumatic stress disorder. Biol Psychiatry. 83:849–865. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Alvarez-Dominguez JR and Lodish HF: Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis. Blood. 130:1965–1975. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Wang YY, Wu ZY, Wang GC, Liu K, Niu XB, Gu S and Meng JS: LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p. Tumour Biol. 37:14553–14563. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Chen Y, Pan Y, Ji Y, Sheng L and Du X: Network analysis of differentially expressed smoking-associated mRNAs, lncRNAs and miRNAs reveals key regulators in smoking-associated lung cancer. Exp Ther Med. 16:4991–5002. 2018.PubMed/NCBI

9 

Zhu Q, Lv T, Wu Y, Shi X, Liu H and Song Y: Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer. J Cell Mol Med. 21:2184–2198. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Peng Z, Wang J, Shan B, Li B, Peng W, Dong Y, Shi W, Zhao W, He D, Duan M, et al: The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1. Mol Cancer. 17:1672018. View Article : Google Scholar : PubMed/NCBI

11 

Tan Q, Yu Y, Li N, Jing W, Zhou H, Qiu S, Liang C, Yu M and Tu J: Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues. Mol Med Rep. 16:4721–4729. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Tian Z, Wen S, Zhang Y, Shi X, Zhu Y, Xu Y, Lv H and Wang G: Identification of dysregulated long non-coding RNAs/microRNAs/mRNAs in TNM I stage lung adenocarcinoma. Oncotarget. 8:51703–51718. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Li G, Wang C, Wang Y, Xu B and Zhang W: LINC00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR-21. J Cell Mol Med. 22:5565–5572. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Wu J, Zhou X, Fan Y, Cheng X, Lu B and Chen Z: Long non-coding RNA 00312 downregulates cyclin B1 and inhibits hepatocellular carcinoma cell proliferation in vitro and in vivo. Biochem Biophys Res Commun. 497:173–180. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, Fan S, Shi L, Li X, Zhang P, et al: Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol. 44:545–554. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 12:247–256. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Pombo A: Cellular genomics: Which genes are transcribed, when and where? Trends Biochem Sci. 28:6–9. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Forterre P: Genomics and early cellular evolution. The origin of the DNA world. C R Acad Sci III. 324:1067–1076. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Kopp F and Mendell JT: Functional classification and experimental dissection of long noncoding RNAs. Cell. 172:393–407. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Evans JR, Feng FY and Chinnaiyan AM: The bright side of dark matter: lncRNAs in cancer. J Clin Invest. 126:2775–2782. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Lin C and Yang L: Long noncoding RNA in cancer: Wiring signaling circuitry. Trends Cell Biol. 28:287–301. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Sullenger BA and Nair S: From the RNA world to the clinic. Science. 352:1417–1420. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Yu H, Xu Q, Liu F, Ye X, Wang J and Meng X: Identification and validation of long noncoding RNA biomarkers in human non-small-cell lung carcinomas. J Thorac Oncol. 10:645–654. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Zhang XM, Wang XY, Sheng SR, Wang JR and Li J: Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. World J Gastroenterol. 9:1729–1733. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Liu K, Huang W, Yan DQ, Luo Q and Min X: Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p. Biosci Rep. 37(pii): BSR201701092017. View Article : Google Scholar : PubMed/NCBI

28 

Min X, Liu K, Zhu H and Zhang J: Long noncoding RNA LINC003121 inhibits proliferation and invasion of thyroid cancer cells by suppression of the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway. Med Sci Monit. 24:4592–4601. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Huang C, Wu M, Tang Y, Li X, Ouyang J, Xiao L, Li D and Li G: NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. J Cell Physiol. 221:394–401. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Saliminejad K, Khorram Khorshid HR, Soleymani Fard S and Ghaffari SH: An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol. 234:5451–5465. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A and Bozzoni I: A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 147:358–369. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Zhu M, Wang X, Gu Y, Wang F, Li L and Qiu X: MEG3 overexpression inhibits the tumorigenesis of breast cancer by downregulating miR-21 through the PI3K/Akt pathway. Arch Biochem Biophys. 661:22–30. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Dai X, Fang M, Li S, Yan Y, Zhong Y and Du B: miR-21 is involved in transforming growth factor β1-induced chemoresistance and invasion by targeting PTEN in breast cancer. Oncol Lett. 14:6929–6936. 2017.PubMed/NCBI

34 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Qiu F, Huang L, Liu W, Li L, Ji C, Zeng X, Qiao L, Liu M, Gong X, Gong X, et al: Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis. Mol Med Rep 21: 1296-1303, 2020.
APA
Chen, Y., Qiu, F., Huang, L., Liu, W., Li, L., Ji, C. ... Gong, X. (2020). Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis. Molecular Medicine Reports, 21, 1296-1303. https://doi.org/10.3892/mmr.2019.10895
MLA
Chen, Y., Qiu, F., Huang, L., Liu, W., Li, L., Ji, C., Zeng, X., Qiao, L., Liu, M., Gong, X."Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis". Molecular Medicine Reports 21.3 (2020): 1296-1303.
Chicago
Chen, Y., Qiu, F., Huang, L., Liu, W., Li, L., Ji, C., Zeng, X., Qiao, L., Liu, M., Gong, X."Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis". Molecular Medicine Reports 21, no. 3 (2020): 1296-1303. https://doi.org/10.3892/mmr.2019.10895
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Qiu F, Huang L, Liu W, Li L, Ji C, Zeng X, Qiao L, Liu M, Gong X, Gong X, et al: Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis. Mol Med Rep 21: 1296-1303, 2020.
APA
Chen, Y., Qiu, F., Huang, L., Liu, W., Li, L., Ji, C. ... Gong, X. (2020). Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis. Molecular Medicine Reports, 21, 1296-1303. https://doi.org/10.3892/mmr.2019.10895
MLA
Chen, Y., Qiu, F., Huang, L., Liu, W., Li, L., Ji, C., Zeng, X., Qiao, L., Liu, M., Gong, X."Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis". Molecular Medicine Reports 21.3 (2020): 1296-1303.
Chicago
Chen, Y., Qiu, F., Huang, L., Liu, W., Li, L., Ji, C., Zeng, X., Qiao, L., Liu, M., Gong, X."Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis". Molecular Medicine Reports 21, no. 3 (2020): 1296-1303. https://doi.org/10.3892/mmr.2019.10895
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