The role of ethanol in the pathogenesis of non‑bacterial prostatitis

  • Authors:
    • Feng Liu
    • Lintao Liu
    • Zhong Wang
    • Lin Chen
    • Jianjun Yu
    • Xiaolin Xu
  • View Affiliations

  • Published online on: February 27, 2019     https://doi.org/10.3892/mmr.2019.9991
  • Pages: 3848-3854
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chronic prostatitis (CP) is a common disease within the field of urology, and it is difficult to treat. Prostatitis mainly occurs in young men and presents with various clinical symptoms, manifested as urinary frequency, urinary urgency, urinary pain, prolonged urination, dysuria and other urinary abnormalities. There are various forms of the syndrome that can cause discomfort or pain in the perineum, the lower abdomen, the penis, the scrotum and the lumbosacral area. To investigate CP in more detail, animal models are necessary to determine the etiology of prostatitis and develop new, specific drug therapies. In the present study, Sprague Dawley rats that were induced to develop a model of chronic and non‑bacterial prostatitis drank ethanol or water to determine the effects of ethanol on prostatitis. Total antioxidant capacity, the concentration of inflammatory factors, such as tumor necrosis factor‑α and interleukin‑1β, and the expression changes of α1‑adrenoreceptor were measured. The susceptibility of ethanol‑drinking rats to CP was confirmed and some simple mechanism of this susceptibility was investigated to further guide the diagnosis and treatment of patients with prostatitis.
View Figures
View References

Related Articles

Journal Cover

May-2019
Volume 19 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Liu L, Wang Z, Chen L, Yu J and Xu X: The role of ethanol in the pathogenesis of non‑bacterial prostatitis. Mol Med Rep 19: 3848-3854, 2019
APA
Liu, F., Liu, L., Wang, Z., Chen, L., Yu, J., & Xu, X. (2019). The role of ethanol in the pathogenesis of non‑bacterial prostatitis. Molecular Medicine Reports, 19, 3848-3854. https://doi.org/10.3892/mmr.2019.9991
MLA
Liu, F., Liu, L., Wang, Z., Chen, L., Yu, J., Xu, X."The role of ethanol in the pathogenesis of non‑bacterial prostatitis". Molecular Medicine Reports 19.5 (2019): 3848-3854.
Chicago
Liu, F., Liu, L., Wang, Z., Chen, L., Yu, J., Xu, X."The role of ethanol in the pathogenesis of non‑bacterial prostatitis". Molecular Medicine Reports 19, no. 5 (2019): 3848-3854. https://doi.org/10.3892/mmr.2019.9991