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Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells

  • Authors:
    • Daofu Shen
    • Yu Wang
    • Hongmei Niu
    • Chunying Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, College of Combine Traditional Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, P.R. China, Life Science Institution, Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China, Department of Clinical Laboratory, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1267-1275
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    Published online on: January 3, 2020
       https://doi.org/10.3892/mmr.2020.10909
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Abstract

Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and the most common cause of mortality in patients with lung cancer. The efficacy of cisplatin‑based chemotherapy in NSCLC is limited by drug resistance, therefore, the development of novel anticancer agents is required to overcome cisplatin resistance. The present study investigated the anticancer activity of gambogenic acid (GNA), derived from gamboge, in the cisplatin‑resistant NSCLC cell line A549/Cis. GNA was revealed to have a potent inhibitory effect on cell growth in A549/Cis cells by blocking the cell cycle and inducing apoptosis. The investigation of the molecular mechanisms identified that GNA arrested the cell cycle at the G1 phase through the downregulation of cyclin Ds, cyclin dependent kinase (CDK)4 and CDK6, and the upregulation of p53 and p21. In addition, GNA induced apoptosis by increasing the activation of caspase 3 and caspase 7, in addition to the cleavage of poly(ADP‑ribose) polymerase. The results of the present study supported the potential application of GNA in cisplatin‑resistant NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Shen D, Wang Y, Niu H and Liu C: Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells. Mol Med Rep 21: 1267-1275, 2020.
APA
Shen, D., Wang, Y., Niu, H., & Liu, C. (2020). Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells. Molecular Medicine Reports, 21, 1267-1275. https://doi.org/10.3892/mmr.2020.10909
MLA
Shen, D., Wang, Y., Niu, H., Liu, C."Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells". Molecular Medicine Reports 21.3 (2020): 1267-1275.
Chicago
Shen, D., Wang, Y., Niu, H., Liu, C."Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells". Molecular Medicine Reports 21, no. 3 (2020): 1267-1275. https://doi.org/10.3892/mmr.2020.10909
Copy and paste a formatted citation
x
Spandidos Publications style
Shen D, Wang Y, Niu H and Liu C: Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells. Mol Med Rep 21: 1267-1275, 2020.
APA
Shen, D., Wang, Y., Niu, H., & Liu, C. (2020). Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells. Molecular Medicine Reports, 21, 1267-1275. https://doi.org/10.3892/mmr.2020.10909
MLA
Shen, D., Wang, Y., Niu, H., Liu, C."Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells". Molecular Medicine Reports 21.3 (2020): 1267-1275.
Chicago
Shen, D., Wang, Y., Niu, H., Liu, C."Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells". Molecular Medicine Reports 21, no. 3 (2020): 1267-1275. https://doi.org/10.3892/mmr.2020.10909
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