Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2020 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling

  • Authors:
    • Zengfa Huang
    • Hui Wei
    • Xiang Wang
    • Jianwei Xiao
    • Zuoqin Li
    • Yuanliang Xie
    • Yun Hu
    • Xiang Li
    • Zheng Wang
    • Shutong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China, Department of Orthopedics, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1590-1596
    |
    Published online on: January 20, 2020
       https://doi.org/10.3892/mmr.2020.10954
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Increasing research has demonstrated that expression of brain and muscle ARNT‑like 1 (BMAL1) and other circadian clock genes can be regulated by drugs and toxicants. We previously demonstrated that icariin, extracted from Herba Epimedii, sromotes osteogenic differentiation. However, the mechanism underlying the association between icariin and BMAL1 in osteogenic differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs) remains unclear. The present study was designed with an aim to clarify the association between icariin and BMAL1 in osteogenic differentiation of BMSCs. The Cell Counting Kit‑8 assay was used to evaluate cell proliferation. The expression of bone morphogenetic protein 2 (BMP2), RUNX family transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteocalcin (OC) and BMAL1 in BMSCs was evaluated by reverse transcription‑quantitative PCR and western blotting. ALP and Alizarin red S (ARS) staining were also performed. Icariin promoted BMSC proliferation, and upregulated expression of osteogenic genes and BMAL1. In addition, expression of the osteogenic genes BMP2, RUNX2, ALP and OC were upregulated by BMAL1 overexpression. Furthermore, we confirmed that BMAL1 deficiency suppressed osteogenic differentiation in BMSCs. Finally, ARS staining of BMAL1‑/‑ BMSCs revealed that BMAL1 was an essential intermediary in matrix mineralization during osteogenic differentiation. In conclusion, these results demonstrated that icariin promoted osteogenic differentiation through BMAL1‑BMP2 signaling in BMSCs. The present study thus described a novel target of icariin that has potential applications in the treatment of osteogenic disorders.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Mankin HJ: Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med. 326:1473–1479. 1992. View Article : Google Scholar : PubMed/NCBI

2 

Yu Y, Zhang Y, Wu J, Sun Y, Xiong Z, Niu F, Lei L, Du S, Chen P and Yang Z: Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han population. Osteoporos Int. 30:871–877. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Mont MA, Cherian JJ, Sierra RJ, Jones LC and Lieberman JR: Nontraumatic osteonecrosis of the femoral head: Where do we stand today? A ten-year update. J Bone Joint Surg Am. 97:1604–1627. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Shui C, Spelsberg TC, Riggs BL and Khosla S: Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res. 18:213–221. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Samsa WE, Vasanji A, Midura RJ and Kondratov RV: Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype. Bone. 84:194–203. 2016. View Article : Google Scholar : PubMed/NCBI

6 

He Y, Chen Y, Zhao Q and Tan Z: Roles of brain and muscle ARNT-like 1 and Wnt antagonist Dkk1 during osteogenesis of bone marrow stromal cells. Cell Prolif. 46:644–653. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Mohawk JA, Green CB and Takahashi JS: Central and peripheral circadian clocks in mammals. Annu Rev Neurosci. 35:445–462. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Richards J and Gumz ML: Mechanism of the circadian clock in physiology. Am J Physiol Regul Integr Comp Physiol. 304:R1053–R1064. 2013. View Article : Google Scholar : PubMed/NCBI

9 

DeBruyne JP, Weaver DR and Dallmann R: The hepatic circadian clock modulates xenobiotic metabolism in mice. J Biol Rhythms. 29:277–287. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zmrzljak UP and Rozman D: Circadian regulation of the hepatic endobiotic and xenobitoic detoxification pathways: The time matters. Chem Res Toxicol. 25:811–824. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Bailey SM, Udoh US and Young ME: Circadian regulation of metabolism. J Endocrinol. 222:R75–R96. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Miranda J, Portillo MP, Madrid JA, Arias N, Macarulla MT and Garaulet M: Effects of resveratrol on changes induced by high-fat feeding on clock genes in rats. Br J Nutr. 110:1421–1428. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Chen P, Kakan X and Zhang J: Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride. FEBS Lett. 584:1597–1601. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Gabás-Rivera C, Martínez-Beamonte R, Ríos JL, Navarro MA, Surra JC, Arnal C, Rodríguez-Yoldi MJ and Osada J: Dietary oleanolic acid mediates circadian clock gene expression in liver independently of diet and animal model but requires apolipoprotein A1. J Nutr Biochem. 24:2100–2109. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Huang Z, Cheng C, Wang J, Liu X, Wei H, Han Y, Yang S and Wang X: Icariin regulates the osteoblast differentiation and cell proliferation of MC3T3-E1 cells through microRNA-153 by targeting Runt-related transcription factor 2. Exp Ther Med. 15:5159–5166. 2018.PubMed/NCBI

16 

Huang Z, Cheng C, Cao B, Wang J, Wei H, Liu X, Han Y, Yang S and Wang X: Icariin protects against glucocorticoid-induced osteonecrosis of the femoral head in rats. Cell Physiol Biochem. 47:694–706. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Gong H, Wang X, Wang L, Liu Y, Wang QL, Pang H, Zhang Q and Wang Z: Inhibition of IGF-1 receptor kinase blocks the differentiation into cardiomyocyte-like cells of BMSCs induced by IGF-1. Molecular medicine reports. 16:787–793. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Dierickx P, Van Laake LW and Geijsen N: Circadian clocks: From stem cells to tissue homeostasis and regeneration. EMBO Rep. 19:18–28. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Murray IR, West CC, Hardy WR, James AW, Park TS, Nguyen A, Tawonsawatruk T, Lazzari L, Soo C and Péault B: Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci. 71:1353–1374. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Weger M, Diotel N, Dorsemans AC, Dickmeis T and Weger BD: Stem cells and the circadian clock. Dev Biol. 431:111–123. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Fu L, Patel MS, Bradley A, Wagner EF and Karsenty G: The molecular clock mediates leptin-regulated bone formation. Cell. 122:803–815. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Gosselet FP, Magnaldo T, Culerrier RM, Sarasin A and Ehrhart JC: BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes. Cell Signal. 19:731–739. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Rogers MB, Shah TA and Shaikh NN: Turning bone morphogenetic protein 2 (BMP2) on and off in mesenchymal cells. J Cell Biochem. 116:2127–2138. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, et al: BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 124:3428–3440. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Hirai T, Tanaka K and Togari A: α1-adrenergic receptor signaling in osteoblasts regulates clock genes and bone morphogenetic protein 4 expression through up-regulation of the transcriptional factor nuclear factor IL-3 (Nfil3)/E4 promoter-binding protein 4 (E4BP4). J Biol Chem. 289:17174–17183. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Nam D, Guo B, Chatterjee S, Chen MH, Nelson D, Yechoor VK and Ma K: The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways. J Cell Sci. 128:1835–1847. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Tasaki H, Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S and Hattori MA: Inhibitory role of REV-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells. Am J Physiol Cell Physiol. 308:C528–C538. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Gloston GF, Yoo SH and Chen ZJ: Clock-enhancing small molecules and potential applications in chronic diseases and aging. Front Neurol. 8:1002017. View Article : Google Scholar : PubMed/NCBI

30 

Sun L, Wang Y, Song Y, Cheng XR, Xia S, Rahman MR, Shi Y and Le G: Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice. Biochem Biophys Res Commun. 458:86–91. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Tsuchiya S, Sugiyama K and Van Gelder RN: Adrenal and glucocorticoid effects on the circadian rhythm of murine intraocular pressure. Invest Ophthalmol Vis Sci. 59:5641–5647. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Yang P, Guan YQ, Li YL, Zhang L, Zhang L and Li L: Icariin promotes cell proliferation and regulates gene expression in human neural stem cells in vitro. Mol Med Rep. 14:1316–1322. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Mok SK, Chen WF, Lai WP, Leung PC, Wang XL, Yao XS and Wong MS: Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. Br J Pharmacol. 159:939–949. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Chen SR, Xu XZ, Wang YH, Chen JW, Xu SW, Gu LQ and Liu PQ: Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways. Biol Pharm Bull. 33:1307–1313. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX and Dong JC: Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-kappaB signaling pathway. Eur J Pharmacol. 642:146–153. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Zhou J, Wu J, Chen X, Fortenbery N, Eksioglu E, Kodumudi KN, Pk EB, Dong J, Djeu JY and Wei S: Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions. Int Immunopharmacol. 11:890–898. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Wei H, Wang X, Xiao J, Li Z, Xie Y, Hu Y, Li X, Wang Z, Zhang S, Zhang S, et al: Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling. Mol Med Rep 21: 1590-1596, 2020.
APA
Huang, Z., Wei, H., Wang, X., Xiao, J., Li, Z., Xie, Y. ... Zhang, S. (2020). Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling. Molecular Medicine Reports, 21, 1590-1596. https://doi.org/10.3892/mmr.2020.10954
MLA
Huang, Z., Wei, H., Wang, X., Xiao, J., Li, Z., Xie, Y., Hu, Y., Li, X., Wang, Z., Zhang, S."Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling". Molecular Medicine Reports 21.3 (2020): 1590-1596.
Chicago
Huang, Z., Wei, H., Wang, X., Xiao, J., Li, Z., Xie, Y., Hu, Y., Li, X., Wang, Z., Zhang, S."Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling". Molecular Medicine Reports 21, no. 3 (2020): 1590-1596. https://doi.org/10.3892/mmr.2020.10954
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Wei H, Wang X, Xiao J, Li Z, Xie Y, Hu Y, Li X, Wang Z, Zhang S, Zhang S, et al: Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling. Mol Med Rep 21: 1590-1596, 2020.
APA
Huang, Z., Wei, H., Wang, X., Xiao, J., Li, Z., Xie, Y. ... Zhang, S. (2020). Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling. Molecular Medicine Reports, 21, 1590-1596. https://doi.org/10.3892/mmr.2020.10954
MLA
Huang, Z., Wei, H., Wang, X., Xiao, J., Li, Z., Xie, Y., Hu, Y., Li, X., Wang, Z., Zhang, S."Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling". Molecular Medicine Reports 21.3 (2020): 1590-1596.
Chicago
Huang, Z., Wei, H., Wang, X., Xiao, J., Li, Z., Xie, Y., Hu, Y., Li, X., Wang, Z., Zhang, S."Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling". Molecular Medicine Reports 21, no. 3 (2020): 1590-1596. https://doi.org/10.3892/mmr.2020.10954
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team