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Article

Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro

  • Authors:
    • Hui Wang
    • Yanjun Jia
    • Jiamou Li
    • Qingsong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology Head and Neck Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing 101199, P.R. China, Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China, Department of Orthopedics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China
  • Pages: 1640-1646
    |
    Published online on: January 24, 2020
       https://doi.org/10.3892/mmr.2020.10960
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Abstract

Following peripheral nerve injury, factors in the local microenvironment can induce the differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs) into Schwann cells; however, the specific factors that participate in this process remain unclear. The present study aimed to investigate the role of Schwann cell‑derived exosomes in the differentiation of BMSCs into Schwann cells. Exosomes were extracted from Schwann cells or fibroblasts and co‑cultured with BMSCs. The morphology, as well as gene and protein expressions of the BMSCs were measured to determine the effect of exosomes on cell differentiation. The levels of Schwann cell‑specific markers in BMSCs were significantly increased by Schwann cell‑derived exosomes compared with untreated BMSCs; however, fibroblast‑derived exosomes did not demonstrate the same effects. In conclusion, Schwann cell‑derived exosomes may be involved in the differentiation of BMSCs into Schwann cells, which may provide a novel target for promoting nerve regeneration following injury.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Jia Y, Li J and Liu Q: Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro. Mol Med Rep 21: 1640-1646, 2020.
APA
Wang, H., Jia, Y., Li, J., & Liu, Q. (2020). Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro. Molecular Medicine Reports, 21, 1640-1646. https://doi.org/10.3892/mmr.2020.10960
MLA
Wang, H., Jia, Y., Li, J., Liu, Q."Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro". Molecular Medicine Reports 21.3 (2020): 1640-1646.
Chicago
Wang, H., Jia, Y., Li, J., Liu, Q."Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro". Molecular Medicine Reports 21, no. 3 (2020): 1640-1646. https://doi.org/10.3892/mmr.2020.10960
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Jia Y, Li J and Liu Q: Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro. Mol Med Rep 21: 1640-1646, 2020.
APA
Wang, H., Jia, Y., Li, J., & Liu, Q. (2020). Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro. Molecular Medicine Reports, 21, 1640-1646. https://doi.org/10.3892/mmr.2020.10960
MLA
Wang, H., Jia, Y., Li, J., Liu, Q."Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro". Molecular Medicine Reports 21.3 (2020): 1640-1646.
Chicago
Wang, H., Jia, Y., Li, J., Liu, Q."Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro". Molecular Medicine Reports 21, no. 3 (2020): 1640-1646. https://doi.org/10.3892/mmr.2020.10960
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