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Article Open Access

TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats

Corrigendum in: /10.3892/mmr.2021.12144
  • Authors:
    • Zhi‑Peng Lin
    • Hui‑Li Lin
    • Xue‑Ping Yu
    • Yi‑Juan Zheng
    • Si‑Yu Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The First Quanzhou Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 651-660
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    Published online on: May 7, 2020
       https://doi.org/10.3892/mmr.2020.11134
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Abstract

Obstructive sleep apnea syndrome (OSAS) is a common and complex disorder that is associated with liver injury. Moreover, previous studies have revealed that chronic intermittent hypoxia (CIH) is associated with the development of non‑alcoholic fatty liver disease and hepatic fibrosis. However, the underlying molecular mechanisms remain largely unknown. The present study aimed to investigate whether chronic intermittent hypoxia induced hepatic fibrosis, in addition to determining its underlying mechanisms, in CIH model rats using immunohistochemistry, western blotting and reverse transcription‑quantitative PCR. The present results suggested that CIH caused hepatic fibrosis and increased the expression levels of interleukin (IL)‑1β, IL‑8, monocyte chemotactic‑1, tumor necrosis factor‑α, intercellular adhesion molecule‑1 and vascular cell adhesion molecule‑1 in the liver; these conditions could be reversed by Toll‑like receptor 4 (TLR4) short hairpin RNA lentivirus treatment. Moreover, immunohistochemistry and western blotting results indicated that TLR4 and NF‑κB expression levels were significantly increased in the CIH and CIH‑TLR4 empty vector lentivirus group. However, protein expression levels of TLR4, NF‑κB, inhibitor of NF‑κB and phosphorylated‑mitogen‑activated protein kinase (MAPK)‑1 in the hypoxia/reoxygenation group were significantly higher compared with the control group (P<0.05), and these results were reversed by the MAPK inhibitor U0126 in vitro. Collectively, the present preliminary results suggested that inflammation and the TLR4/NF‑κB/MAPK signaling pathway may be involved in CIH‑induced liver fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Lin ZP, Lin HL, Yu XP, Zheng YJ and Cheng SY: TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144. Mol Med Rep 22: 651-660, 2020.
APA
Lin, Z., Lin, H., Yu, X., Zheng, Y., & Cheng, S. (2020). TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144. Molecular Medicine Reports, 22, 651-660. https://doi.org/10.3892/mmr.2020.11134
MLA
Lin, Z., Lin, H., Yu, X., Zheng, Y., Cheng, S."TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144". Molecular Medicine Reports 22.2 (2020): 651-660.
Chicago
Lin, Z., Lin, H., Yu, X., Zheng, Y., Cheng, S."TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144". Molecular Medicine Reports 22, no. 2 (2020): 651-660. https://doi.org/10.3892/mmr.2020.11134
Copy and paste a formatted citation
x
Spandidos Publications style
Lin ZP, Lin HL, Yu XP, Zheng YJ and Cheng SY: TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144. Mol Med Rep 22: 651-660, 2020.
APA
Lin, Z., Lin, H., Yu, X., Zheng, Y., & Cheng, S. (2020). TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144. Molecular Medicine Reports, 22, 651-660. https://doi.org/10.3892/mmr.2020.11134
MLA
Lin, Z., Lin, H., Yu, X., Zheng, Y., Cheng, S."TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144". Molecular Medicine Reports 22.2 (2020): 651-660.
Chicago
Lin, Z., Lin, H., Yu, X., Zheng, Y., Cheng, S."TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats Corrigendum in /10.3892/mmr.2021.12144". Molecular Medicine Reports 22, no. 2 (2020): 651-660. https://doi.org/10.3892/mmr.2020.11134
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