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Article Open Access

Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R

  • Authors:
    • Yuanyuan Cui
    • Yuting Li
    • Jiayi Ning
    • Yajing Mi
    • Xiaolong  Wang
    • Zhongying Qiu
    • Le Li
    • Xingchun Gou
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences and Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China, School of Clinical Medicine, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 957-963
    |
    Published online on: May 18, 2020
       https://doi.org/10.3892/mmr.2020.11157
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Abstract

Mechanical allodynia, which develops in patients of diabetes mellitus as a neuropathic manifestation, remains without an effective treatment. The aim of the present study was to investigate the effects and potential mechanisms underlying resveratrol (RES) in a rat model of streptozocin (STZ)‑induced diabetic mechanical allodynia (DMA). The rat model of DMA was established by the administration of an intraperitoneal injection of STZ. From day 8 post‑STZ injection, rats were administered with an intragastric injection of various doses of RES for 14 consecutive days. The von Frey filaments were applied to detect the paw withdrawal threshold and evaluate the analgesic effects of RES. Based on the dose‑effect curve, the ED50 of RES was calculated. Immunofluorescence staining and western blotting were performed to detect the expression of purinergic receptor P2X3 (P2X3R) in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) following RESED50 treatment. The results indicated that RES significantly alleviated mechanical allodynia in DMA model rats in a dose‑dependent manner. Compared with the control group, the expression of P2X3R in DRG neurons and SDH terminals was markedly decreased following the administration of RESED50 (P<0.05). Collectively, the results indicated that RES displayed a dose‑dependent analgesic effect on DMA model rats. Furthermore, P2X3R expression downregulation in the DRG and SDH may be a mechanism underlying the analgesic effects of RES on DMA‑related behaviors.
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1 

American Diabetes Association, . (2) Classification and diagnosis of diabetes. Diabetes Care. 38 (Suppl):S8–S16. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Guastella V and Mick G: Strategies for the diagnosis and treatment of neuropathic pain secondary to diabetic peripheral sensory polyneuropathy. Diabetes Metab. 35:12–19. 2009.

3 

Rajchgot T, Thomas SC, Wang JC, Ahmadi M, Balood M, Crosson T, Dias JP, Couture R, Claing A and Talbot S: Neurons and Microglia; A sickly-sweet duo in diabetic pain neuropathy. Front Neurosci. 13:252019. View Article : Google Scholar : PubMed/NCBI

4 

Scholz J, Rathmell JP, David WS, Chad DA, Broderick AC, Perros SG, Shin NS, Wells JL, Davis JB, DiMaggio CJ, et al: A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy. Pain. 157:2297–2308. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Dubin AE and Patapoutian A: Nociceptors: The sensors of the pain pathway. J Clin Invest. 120:3760–3772. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Castro OW, Upadhya D, Kodali M and Shetty AK: Resveratrol for easing status epilepticus induced brain injury, inflammation, epileptogenesis, and cognitive and memory dysfunction-are we there yet? Front Neurol. 8:6032017. View Article : Google Scholar : PubMed/NCBI

7 

Daverey A and Agrawal SK: Pre and post treatment with curcumin and resveratrol protects astrocytes after oxidative stress. Brain Res. 1692:45–55. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Lancon A, Frazzi R and Latruffe N: Anti-oxidant, anti-inflammatory and anti-angiogenic properties of resveratrol in ocular diseases. Molecules. 21:3042016. View Article : Google Scholar : PubMed/NCBI

9 

Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C: Resveratrol promotes nerve regeneration via activation of p300 acetyltransferase-mediated VEGF signaling in a rat model of sciatic nerve crush injury. Front Neurosci. 12:3412018. View Article : Google Scholar : PubMed/NCBI

10 

Oda H, Ohta S, Ikeguchi R, Noguchi T, Kaizawa Y, Yurie H, Takeuchi H, Mitsuzawa S and Matsuda S: Pretreatment of nerve grafts with resveratrol improves axonal regeneration following replantation surgery for nerve root avulsion injury in rats. Restor Neurol Neurosci. 36:647–658. 2018.PubMed/NCBI

11 

Xie J, Liu S, Wu B, Li G, Rao S, Zou L, Yi Z, Zhang C, Jia T, Zhao S, et al: The protective effect of resveratrol in the transmission of neuropathic pain mediated by the P2X7 receptor in the dorsal root ganglia. Neurochem Int. 103:24–35. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Zou P, Liu X, Li G and Wang Y: Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1. Mol Med Rep. 17:3212–3217. 2018.PubMed/NCBI

13 

Zhao H, Chen S, Gao K, Zhou Z, Wang C, Shen Z, Guo Y, Li Z, Wan Z, Liu C and Mei X: Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway. Neuroscience. 348:241–251. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Tao L, Ding Q, Gao C and Sun X: Resveratrol attenuates neuropathic pain through balancing pro-inflammatory and anti-inflammatory cytokines release in mice. Int Immunopharmacol. 34:165–172. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Yang YJ, Hu L, Xia YP, Jiang CY, Miao C, Yang CQ, Yuan M and Wang L: Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. J Neuroinflammation. 13:842016. View Article : Google Scholar : PubMed/NCBI

16 

Sharma S, Kulkarni SK and Chopra K: Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Fundam Clin Pharmacol. 21:89–94. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Sharma S, Chopra K and Kulkarni SK: Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: participation of nitric oxide and TNF-alpha. Phytother Res. 21:278–283. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Sharma SS, Kumar A, Arora M and Kaundal RK: Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: Focus on functional, sensorimotor and biochemical changes. Free Radic Res. 43:400–408. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Edwards FA and Gibb AJ: ATP-a fast neurotransmitter. FEBS Lett. 325:86–89. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Bernier LP, Ase AR and Séguéla P: P2X receptor channels in chronic pain pathways. Br J Pharmacol. 175:2219–2230. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Zhang HH, Hu J, Zhou YL, Qin X, Song ZY, Yang PP, Hu S, Jiang X and Xu GY: Promoted interaction of nuclear factor-κB with demethylated purinergic P2X3 receptor gene contributes to neuropathic pain in rats with diabetes. Diabetes. 64:4272–4284. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Guo J, Wang C, Niu X, Zhou F, Li H and Gao W: Effects of resveratrol in the signaling of neuropathic pain involving P2X3 in the dorsal root ganglion of rats. Acta Neurol Belg. Apr 19–2019.(Epub ahead of print). View Article : Google Scholar

23 

Cui YY, Wu HH, Wa L, Shi J and Li YQ: Spatio-temporal expression of P2X3 receptor in rats with diabetic mechanical allodynia. Acta Anatomica Sinica. 45:540–544. 2014.

24 

Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:109–110. 1983. View Article : Google Scholar : PubMed/NCBI

25 

Chaplan SR, Bach FW, Pogrel JW, Chung JM and Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 53:55–63. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Wu HH, Yin JB, Zhang T, Cui YY, Dong YL, Chen GZ and Wang W: Inhibiting spinal neuron-astrocytic activation correlates with synergistic analgesia of dexmedetomidine and ropivacaine. PLoS One. 9:e923742014. View Article : Google Scholar : PubMed/NCBI

27 

Yin JB, Zhou KC, Wu HH, Hu W, Ding T, Zhang T, Wang LY, Kou JP, Kaye AD and Wang W: Analgesic effects of Danggui-Shaoyao-San on various ‘Phenotypes’ of nociception and inflammation in a formalin pain model. Mol Neurobiol. 53:6835–6848. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Tallarida RJ: Drug synergism: Its detection and applications. J Pharmacol Exp Ther. 298:865–872. 2001.PubMed/NCBI

29 

Ke HH, Wu HH, Zhu Q, Zhang Y, Xiao JR, Su XZ, Zheng WJ, Cai YP, Wu XZ, Wang YT and Chen GZ: Neuromuscular effect of dexmedetomidine on sevoflurane: An open-label, dose-escalation clinical trial. Minerva Anestesiol. 83:790–797. 2017.PubMed/NCBI

30 

Bai L, Wang W, Dong YL, Wang W, Huang J, Wang XY, Wang LY, Li YQ and Wu SX: Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation. Pain Physician. 15:311–326. 2012.PubMed/NCBI

31 

Cui YY, Xu H, Wu HH, Qi J, Shi J and Li YQ: Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats. PLoS One. 9:e1020522014. View Article : Google Scholar : PubMed/NCBI

32 

Baur JA and Sinclair DA: Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov. 5:493–506. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Shimazu Y, Shibuya E, Takehana S, Sekiguchi K, Oshima K, Kamata H, Karibe H and Takeda M: Local administration of resveratrol inhibits excitability of nociceptive wide-dynamic range neurons in rat trigeminal spinal nucleus caudalis. Brain Res Bull. 124:262–268. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Takehana S, Sekiguchi K, Inoue M, Kubota Y, Ito Y, Yui K, Shimazu Y and Takeda M: Systemic administration of resveratrol suppress the nociceptive neuronal activity of spinal trigeminal nucleus caudalis in rats. Brain Res Bull. 120:117–122. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Xu M, Cheng Z, Ding Z, Wang Y, Guo Q and Huang C: Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury. Mol Pain. 14:17448069187675492018. View Article : Google Scholar : PubMed/NCBI

36 

Zou L, Gong Y, Liu S and Liang S: Natural compounds acting at P2 receptors alleviate peripheral neuropathy. Brain Res Bull. 151:125–131. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Schreiber AK, Nones CF, Reis RC, Chichorro JG and Cunha JM: Diabetic neuropathic pain: Physiopathology and treatment. World J Diabetes. 6:432–444. 2015. View Article : Google Scholar : PubMed/NCBI

38 

McDonnell A, Collins S, Ali Z, Iavarone L, Surujbally R, Kirby S and Butt RP: Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy. Pain. 159:1465–1476. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Schiavuzzo JG, Teixeira JM, Melo B, da Silva dos Santos DF, Jorge CO, Oliveira-Fusaro MC and Parada CA: Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators. Neuroscience. 285:24–33. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Han Y, Jiang C, Tang J, Wang C, Wu P, Zhang G, Liu W, Jamangulova N, Wu X and Song X: Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain. 18:1458–1470. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cui Y, Li Y, Ning J, Mi Y, Wang X, Qiu Z, Li L and Gou X: Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R . Mol Med Rep 22: 957-963, 2020.
APA
Cui, Y., Li, Y., Ning, J., Mi, Y., Wang, X., Qiu, Z. ... Gou, X. (2020). Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R . Molecular Medicine Reports, 22, 957-963. https://doi.org/10.3892/mmr.2020.11157
MLA
Cui, Y., Li, Y., Ning, J., Mi, Y., Wang, X., Qiu, Z., Li, L., Gou, X."Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R ". Molecular Medicine Reports 22.2 (2020): 957-963.
Chicago
Cui, Y., Li, Y., Ning, J., Mi, Y., Wang, X., Qiu, Z., Li, L., Gou, X."Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R ". Molecular Medicine Reports 22, no. 2 (2020): 957-963. https://doi.org/10.3892/mmr.2020.11157
Copy and paste a formatted citation
x
Spandidos Publications style
Cui Y, Li Y, Ning J, Mi Y, Wang X, Qiu Z, Li L and Gou X: Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R . Mol Med Rep 22: 957-963, 2020.
APA
Cui, Y., Li, Y., Ning, J., Mi, Y., Wang, X., Qiu, Z. ... Gou, X. (2020). Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R . Molecular Medicine Reports, 22, 957-963. https://doi.org/10.3892/mmr.2020.11157
MLA
Cui, Y., Li, Y., Ning, J., Mi, Y., Wang, X., Qiu, Z., Li, L., Gou, X."Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R ". Molecular Medicine Reports 22.2 (2020): 957-963.
Chicago
Cui, Y., Li, Y., Ning, J., Mi, Y., Wang, X., Qiu, Z., Li, L., Gou, X."Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R ". Molecular Medicine Reports 22, no. 2 (2020): 957-963. https://doi.org/10.3892/mmr.2020.11157
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