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Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis

  • Authors:
    • Xiaojie Chen
    • Yuanbo Pan
    • Mengxia Yan
    • Guanshui Bao
    • Xuhong Sun
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, P.R. China, Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 859-869
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    Published online on: May 20, 2020
       https://doi.org/10.3892/mmr.2020.11160
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Abstract

Glioblastoma multiforme (GBM) is the most common and malignant brain tumor of the adult central nervous system and is associated with poor prognosis. The present study aimed to identify the hub genes in GBM in order to improve the current understanding of the underlying mechanism of GBM. The RNA‑seq data were downloaded from The Cancer Genome Atlas database. The edgeR package in R software was used to identify differentially expressed genes (DEGs) between two groups: Glioblastoma samples and normal brain samples. Gene Ontology (GO) functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed using Database for Annotation, Visualization and Integrated Discovery software. Additionally, Cytoscape and Search Tool for the Retrieval of Interacting Genes/Proteins tools were used for the protein‑protein interaction network, while the highly connected modules were extracted from this network using the Minimal Common Oncology Data Elements plugin. Next, the prognostic significance of the candidate hub genes was analyzed using UALCAN. In addition, the identified hub genes were verified by reverse transcription‑quantitative (RT‑q) PCR. In total, 1,483 DEGs were identified between GBM and control samples, including 954 upregulated genes and 529 downregulated genes (P<0.01; fold‑change >16) and these genes were involved in different GO terms and signaling pathways. Furthermore, CDK1, BUB1, BUB1B, CENPA and GNG3 were identified as key genes in the GBM samples. The UALCAN tool verified that higher expression level of CENPA was relevant to poorer overall survival rates. In conclusion, CDK1, BUB1, BUB1B, CENPA and GNG3 were found to be potential biomarkers for GBM. Additionally, ‘cell cycle’ and ‘γ‑aminobutyric acid signaling’ pathways may serve a significant role in the pathogenesis of GBM.
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View References

1 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 World Health Organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Kloosterhof NK, de Rooi JJ, Kros M, Eilers PH, Sillevis Smitt PA, van den Bent MJ and French PJ: Molecular subtypes of glioma identified by genome-wide methylation profiling. Gene Chromosomes Cancer. 52:665–674. 2013.

4 

Rao SS, Lannutti JJ, Viapiano MS, Sarkar A and Winter JO: Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells. Tissue Eng Part B Rev. 20:314–327. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Alifieris C and Trafalis DT: Glioblastoma multiforme: Pathogenesis and treatment. Pharmacol Ther. 152:63–82. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Yang B, Ma YB and Chu SH: Silencing SATB1 overcomes temozolomide resistance by downregulating MGMT expression and upregulating SLC22A18 expression in human glioblastoma cells. Cancer Gene Ther. 25:309–316. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Doan NB, Nguyen HS, Al-Gizawiy MM, Mueller WM, Sabbadini RA, Rand SD, Connelly JM, Chitambar CR, Schmainda KM and Mirza SP: Acid ceramidase confers radioresistance to glioblastoma cells. Oncol Rep. 38:1932–1940. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Martinez R, Rohde V and Schackert G: Different molecular patterns in glioblastoma multiforme subtypes upon recurrence. J Neurooncol. 96:321–329. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Witthayanuwat S, Pesee M, Supaadirek C, Supakalin N, Thamronganantasakul K and Krusun S: Survival analysis of glioblastoma multiforme. Asian Pac J Cancer Prev. 19:2613–2617. 2018.PubMed/NCBI

10 

Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, et al: Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): A randomised, open-label, phase 3 trial. Lancet. 393:678–688. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Hashemi M, Hadjighassem M, Zali A and Hashemi J: Tumoricidal effect of human olfactory ensheathing cell mediated suicide gene therapy in human glioblastoma cells. Mol Biol Rep. 45:2263–2273. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Chao CN, Yang YH, Wu MS, Chou MC, Fang CY, Lin MC, Tai CK, Shen CH, Chen PL, Chang D and Wang M: Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector. Sci Rep. 8:22132018. View Article : Google Scholar : PubMed/NCBI

13 

Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, et al: Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 343:72–76. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zhou K, Yao H, Zhang X, Liu J, Qi Z, Xie X, Xu X, Zhou Y, Yu Z, Wang Z, et al: Next generation sequencing and molecular imaging identify EGFR mutation and amplification in a glioblastoma multiforme patient treated with an EGFR inhibitor: A case report. Oncotarget. 8:50305–50313. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Hatanpaa KJ, Burma S, Zhao D and Habib AA: Epidermal growth factor receptor in glioma: Signal transduction, neuropathology, imaging, and radioresistance. Neoplasia. 12:675–684. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Ji C, Guo H, Zhang P, Kuang W, Fan Y and Wu L: AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway. J Neurooncol. 138:469–478. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Siebzehnrubl FA, Silver DJ, Tugertimur B, Deleyrolle LP, Siebzehnrubl D, Sarkisian MR, Devers KG, Yachnis AT, Kupper MD, Neal D, et al: The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med. 5:1196–1212. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Liu J, Liu D and Yang Z and Yang Z: High LAMC1 expression in glioma is associated with poor prognosis. OncoTargets Ther. 12:4253–4260. 2019. View Article : Google Scholar

19 

Yates AD, Achuthan P, Akanni W, Allen J, Allen J, Alvarez-Jarreta J, Amode MR, Armean IM, Azov AG, Bennett R, et al: Ensembl 2020. Nucleic Acids Res. 48:D682–D688. 2020.PubMed/NCBI

20 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Anders S, McCarthy DJ, Chen Y, Okoniewski M, Smyth GK, Huber W and Robinson MD: Count-based differential expression analysis of RNA sequencing data using R and Bioconductor. Nat Protoc. 8:1765–1786. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Warnes GR, Bolker B, Bonebakker L, Gentleman R, Huber W, Liaw A, Lumley T, Maechler M, Magnusson A, Moeller S, et al: gplots: Various R programming tools for plotting data. R Package Version 2.4. 2009.

23 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

24 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Diaz-Montana JJ, Gomez-Vela F and Diaz-Diaz N: GNC-app: A new Cytoscape app to rate gene networks biological coherence using gene-gene indirect relationships. Biosystems. 166:61–65. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112018. View Article : Google Scholar

28 

Bandettini WP, Kellman P, Mancini C, Booker OJ, Vasu S, Leung SW, Wilson JR, Shanbhag SM, Chen MY and Arai AE: MultiContrast delayed enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: A clinical validation study. J Cardiovasc Magn Reson. 14:832012. View Article : Google Scholar : PubMed/NCBI

29 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Li L, Chen X and Chen Z: Identification of key candidate genes in dairy cow in response to escherichia coli mastitis by bioinformatical analysis. Front Genet. 10:12512019. View Article : Google Scholar : PubMed/NCBI

32 

Watkins S and Sontheimer H: Unique biology of gliomas: Challenges and opportunities. Trends Neurosci. 35:546–556. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Teng J, da Hora CC, Kantar RS, Nakano I, Wakimoto H, Batchelor TT, Chiocca EA, Badr CE and Tannous BA: Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 19:820–832. 2017.PubMed/NCBI

34 

Bonavia R, Inda MM, Cavenee WK and Furnari FB: Heterogeneity maintenance in glioblastoma: A social network. Cancer Res. 71:4055–4060. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Xiao S, Yang Z, Lv R, Zhao J, Wu M, Liao Y and Liu Q: miR-135b contributes to the radioresistance by targeting GSK3β in human glioblastoma multiforme cells. PLoS One. 9:e1088102014. View Article : Google Scholar : PubMed/NCBI

36 

Zhu J, Ye J, Zhang L, Xia L, Hu H, Jiang H, Wan Z, Sheng F, Ma Y, Li W, et al: Differential expression of circular RNAs in glioblastoma multiforme and its correlation with prognosis. Transl Oncol. 10:271–279. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Song YC, Lu GX, Zhang HW, Zhong XM, Cong XL, Xue SB, Kong R, Li D, Chang ZY, Wang XF, et al: Proteogenomic characterization and integrative analysis of glioblastoma multiforme. Oncotarget. 8:97304–97312. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Fourest-Lieuvin A, Peris L, Gache V, Garcia-Saez I, Juillan-Binard C, Lantez V and Job D: Microtubule regulation in mitosis: Tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol Biol Cell. 17:1041–1050. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Malumbres M and Barbacid M: Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer. 9:153–166. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Malumbres M and Barbacid M: Mammalian cyclin-dependent kinases. Trends Biochem Sci. 30:630–641. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Nigg EA: Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol. 2:21–32. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T and Du G: 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. J Exp Clin Cancer Res. 37:1322018. View Article : Google Scholar : PubMed/NCBI

43 

Song Z, Pan Y, Ling G, Wang S, Huang M, Jiang X and Ke Y: Escape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signaling. Am J Transl Res. 9:2163–2180. 2017.PubMed/NCBI

44 

Chen H, Huang Q, Dong J, Zhai DZ, Wang AD and Lan Q: Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. BMC Cancer. 8:292008. View Article : Google Scholar : PubMed/NCBI

45 

de Voer RM, Geurts van Kessel A, Weren RD, Ligtenberg MJ, Smeets D, Fu L, Vreede L, Kamping EJ, Verwiel ET, Hahn MM, et al: Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are risk factors for colorectal cancer. Gastroenterology. 145:544–547. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Bie L, Zhao G, Cheng P, Rondeau G, Porwollik S, Ju Y, Xia XQ and McClelland M: The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression. PLoS One. 6:e256312011. View Article : Google Scholar : PubMed/NCBI

47 

Ma Q, Liu Y, Shang L, Yu J and Qu Q: The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma. Oncol Rep. 38:3367–3375. 2017.PubMed/NCBI

48 

Lee E, Pain M, Wang H, Herman JA, Toledo CM, DeLuca JG, Yong RL, Paddison P and Zhu J: Sensitivity to BUB1B inhibition defines an alternative classification of glioblastoma. Cancer Res. 77:5518–5529. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Tannous BA, Kerami M, Van der Stoop PM, Kwiatkowski N, Wang J, Zhou W, Kessler AF, Lewandrowski G, Hiddingh L, Sol N, et al: Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 105:1322–1331. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Kessler AF, Frombling GE, Gross F, Hahn M, Dzokou W, Ernestus RI, Löhr M and Hagemann C: Effects of tumor treating fields (TTFields) on glioblastoma cells are augmented by mitotic checkpoint inhibition. Cell Death Discov. 4:122018. View Article : Google Scholar : PubMed/NCBI

51 

De Rop V, Padeganeh A and Maddox PS: CENP-A: The key player behind centromere identity, propagation, and kinetochore assembly. Chromosoma. 121:527–538. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Tomonaga T, Matsushita K, Yamaguchi S, Oohashi T, Shimada H, Ochiai T, Yoda K and Nomura F: Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. Cancer Res. 63:3511–3516. 2003.PubMed/NCBI

53 

Rajput AB, Hu N, Varma S, Chen CH, Ding K, Park PC, Chapman JA, Sengupta SK, Madarnas Y, Elliott BE and Feilotter HE: Immunohistochemical assessment of expression of centromere protein-A (CENPA) in Human invasive breast cancer. Cancers. 3:4212–4227. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Li YM, Liu XH, Cao XZ, Wang L and Zhu MH: Expression of centromere protein A in hepatocellular carcinoma. Zhonghua Bing Li Xue Za Zhi. 36:175–178. 2007.(In Chinese). PubMed/NCBI

55 

Downes GB, Copeland NG, Jenkins NA and Gautam N: Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lg. Genomics. 53:220–230. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Schwindinger WF, Giger KE, Betz KS, Stauffer AM, Sunderlin EM, Sim-Selley LJ, Selley DE, Bronson SK and Robishaw JD: Mice with deficiency of G protein gamma3 are lean and have seizures. Mol Cell Biol. 24:7758–7768. 2004. View Article : Google Scholar : PubMed/NCBI

57 

El-Habr EA, Dubois LG, Burel-Vandenbos F, Bogeas A, Lipecka J, Turchi L, Lejeune FX, Coehlo PL, Yamaki T, Wittmann BM, et al: A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. Acta Neuropathol. 133:645–660. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Pan Y, Yan M, Bao G and Sun X: Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis. Mol Med Rep 22: 859-869, 2020.
APA
Chen, X., Pan, Y., Yan, M., Bao, G., & Sun, X. (2020). Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis. Molecular Medicine Reports, 22, 859-869. https://doi.org/10.3892/mmr.2020.11160
MLA
Chen, X., Pan, Y., Yan, M., Bao, G., Sun, X."Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis". Molecular Medicine Reports 22.2 (2020): 859-869.
Chicago
Chen, X., Pan, Y., Yan, M., Bao, G., Sun, X."Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis". Molecular Medicine Reports 22, no. 2 (2020): 859-869. https://doi.org/10.3892/mmr.2020.11160
Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Pan Y, Yan M, Bao G and Sun X: Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis. Mol Med Rep 22: 859-869, 2020.
APA
Chen, X., Pan, Y., Yan, M., Bao, G., & Sun, X. (2020). Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis. Molecular Medicine Reports, 22, 859-869. https://doi.org/10.3892/mmr.2020.11160
MLA
Chen, X., Pan, Y., Yan, M., Bao, G., Sun, X."Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis". Molecular Medicine Reports 22.2 (2020): 859-869.
Chicago
Chen, X., Pan, Y., Yan, M., Bao, G., Sun, X."Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis". Molecular Medicine Reports 22, no. 2 (2020): 859-869. https://doi.org/10.3892/mmr.2020.11160
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