Open Access

Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)

  • Authors:
    • Alexandra Trivli
    • Maria I. Zervou
    • George N. Goulielmos
    • Demetrios A. Spandidos
    • Efstathios T. Detorakis
  • View Affiliations

  • Published online on: June 9, 2020     https://doi.org/10.3892/mmr.2020.11215
  • Pages: 1103-1110
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Abstract

Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environmental and genetic factors contributing to its pathogenesis. Approximately 5% of POAG is currently attributed to single‑gene or Mendelian forms of glaucoma. Genetic linkage analysis and genome‑wide association studies have identified various genomic loci, paving the path to understanding the pathogenesis of this enigmatic, blinding disease. In this review we summarize the most common variants reported thus far and their possible clinical correlations.

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August-2020
Volume 22 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Trivli, A., Zervou, M.I., Goulielmos, G.N., Spandidos, D.A., & Detorakis, E.T. (2020). Primary open angle glaucoma genetics: The common variants and their clinical associations (Review). Molecular Medicine Reports, 22, 1103-1110. https://doi.org/10.3892/mmr.2020.11215
MLA
Trivli, A., Zervou, M. I., Goulielmos, G. N., Spandidos, D. A., Detorakis, E. T."Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)". Molecular Medicine Reports 22.2 (2020): 1103-1110.
Chicago
Trivli, A., Zervou, M. I., Goulielmos, G. N., Spandidos, D. A., Detorakis, E. T."Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)". Molecular Medicine Reports 22, no. 2 (2020): 1103-1110. https://doi.org/10.3892/mmr.2020.11215