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Review Open Access

Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)

  • Authors:
    • Alexandra Trivli
    • Maria I. Zervou
    • George N. Goulielmos
    • Demetrios A. Spandidos
    • Efstathios T. Detorakis
  • View Affiliations / Copyright

    Affiliations: Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, 71003 Heraklion, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Ophthalmology, University Hospital of Heraklion, 71110 Heraklion, Greece
  • Pages: 1103-1110
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    Published online on: June 9, 2020
       https://doi.org/10.3892/mmr.2020.11215
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Abstract

Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environmental and genetic factors contributing to its pathogenesis. Approximately 5% of POAG is currently attributed to single‑gene or Mendelian forms of glaucoma. Genetic linkage analysis and genome‑wide association studies have identified various genomic loci, paving the path to understanding the pathogenesis of this enigmatic, blinding disease. In this review we summarize the most common variants reported thus far and their possible clinical correlations.
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Copy and paste a formatted citation
Spandidos Publications style
Trivli A, Zervou MI, Goulielmos GN, Spandidos DA and Detorakis ET: Primary open angle glaucoma genetics: The common variants and their clinical associations (Review). Mol Med Rep 22: 1103-1110, 2020.
APA
Trivli, A., Zervou, M.I., Goulielmos, G.N., Spandidos, D.A., & Detorakis, E.T. (2020). Primary open angle glaucoma genetics: The common variants and their clinical associations (Review). Molecular Medicine Reports, 22, 1103-1110. https://doi.org/10.3892/mmr.2020.11215
MLA
Trivli, A., Zervou, M. I., Goulielmos, G. N., Spandidos, D. A., Detorakis, E. T."Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)". Molecular Medicine Reports 22.2 (2020): 1103-1110.
Chicago
Trivli, A., Zervou, M. I., Goulielmos, G. N., Spandidos, D. A., Detorakis, E. T."Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)". Molecular Medicine Reports 22, no. 2 (2020): 1103-1110. https://doi.org/10.3892/mmr.2020.11215
Copy and paste a formatted citation
x
Spandidos Publications style
Trivli A, Zervou MI, Goulielmos GN, Spandidos DA and Detorakis ET: Primary open angle glaucoma genetics: The common variants and their clinical associations (Review). Mol Med Rep 22: 1103-1110, 2020.
APA
Trivli, A., Zervou, M.I., Goulielmos, G.N., Spandidos, D.A., & Detorakis, E.T. (2020). Primary open angle glaucoma genetics: The common variants and their clinical associations (Review). Molecular Medicine Reports, 22, 1103-1110. https://doi.org/10.3892/mmr.2020.11215
MLA
Trivli, A., Zervou, M. I., Goulielmos, G. N., Spandidos, D. A., Detorakis, E. T."Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)". Molecular Medicine Reports 22.2 (2020): 1103-1110.
Chicago
Trivli, A., Zervou, M. I., Goulielmos, G. N., Spandidos, D. A., Detorakis, E. T."Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)". Molecular Medicine Reports 22, no. 2 (2020): 1103-1110. https://doi.org/10.3892/mmr.2020.11215
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