Open Access

Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis

  • Authors:
    • Yang Hu
    • Man Wang
    • Yunzheng Pan
    • Qingju Li
    • Li Xu
  • View Affiliations

  • Published online on: June 15, 2020     https://doi.org/10.3892/mmr.2020.11229
  • Pages: 1325-1334
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Salvianolic acid B (Sal B) is one of the main water‑soluble components of Salvia miltiorrhiza Bge. Numerous reports have demonstrated that it could exert significant renal‑protective effects, but the underlying mechanism remains unclear. The present study demonstrated that Sal B could alleviate renal injury by regulating the heparanase/syndecan‑1 (HPSE/SDC1) axis. In vivo, the serum creatinine, blood urea nitrogen, transforming growth factor‑β1 (TGF‑β1) and fibroblast growth factor‑2 (FGF‑2) levels, and the histopathological changes of mice kidneys were examined. Sal B could notably reduce the renal injury caused by left ureteral ligation. In vitro, Sal B downregulated the expression levels of HPSE/FGF‑2/TGF‑β1/α‑smooth muscle actin and upregulated the expression levels of SDC1/E‑cadherin in angiotensin II‑stimulated HK‑2 cells in a dose‑dependent manner. In summary, to the best of the authors' knowledge, the present study provided evidence for the first time that Sal B could exert renal‑protective effects via the inhibition of the HPSE/SDC1 axis, and these results suggest that the administration of Sal B may be a novel therapeutic strategy in treating renal interstitial fibrosis.

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August-2020
Volume 22 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Hu, Y., Wang, M., Pan, Y., Li, Q., & Xu, L. (2020). Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis. Molecular Medicine Reports, 22, 1325-1334. https://doi.org/10.3892/mmr.2020.11229
MLA
Hu, Y., Wang, M., Pan, Y., Li, Q., Xu, L."Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis". Molecular Medicine Reports 22.2 (2020): 1325-1334.
Chicago
Hu, Y., Wang, M., Pan, Y., Li, Q., Xu, L."Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis". Molecular Medicine Reports 22, no. 2 (2020): 1325-1334. https://doi.org/10.3892/mmr.2020.11229