Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice

  • Authors:
    • Lei Zhu
    • Xiuwei Hao
    • Xiaole Wu
    • Boxiang Qi
    • Ting Yue
    • Haijun Wang
  • View Affiliations

  • Published online on: June 23, 2020     https://doi.org/10.3892/mmr.2020.11265
  • Pages: 2101-2106
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Abstract

Aquaporin-4 (AQP4) is a major water channel of the central nervous system. The present study was designed to determine whether AQP4 deletion could ameliorate enterovirus (EV) 71 infection‑induced hand, foot and mouth disease (HFMD) by inhibiting inflammation and apoptosis in mice. EV 71 strains were injected into neonatal BALB/c mice to induce HFMD. Western blotting and ELISA were used to measure the protein expression and cytokine levels. The levels of AQP4 mRNA and protein in the brain were increased in EV 71‑infected mice, while the survival rate and health score were improved in AQP4‑knockout (KO) mice with EV 71 infection. The EV 71 infection‑induced increases of tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, monocyte chemotactic protein‑1, interferon (IFN)‑α and IFN‑γ in plasma and brain were inhibited in AQP4‑KO mice. AQP4 deletion reversed the decreased levels of Bcl2 and Bcl2/Bax, and the increased levels of Bax induced by EV 71 infection in the brain. These results demonstrated that AQP4 deletion ameliorated EV 71 induced‑HFMD via inhibiting inflammation and apoptosis in mice.
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September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu L, Hao X, Wu X, Qi B, Yue T and Wang H: Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice. Mol Med Rep 22: 2101-2106, 2020
APA
Zhu, L., Hao, X., Wu, X., Qi, B., Yue, T., & Wang, H. (2020). Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice. Molecular Medicine Reports, 22, 2101-2106. https://doi.org/10.3892/mmr.2020.11265
MLA
Zhu, L., Hao, X., Wu, X., Qi, B., Yue, T., Wang, H."Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice". Molecular Medicine Reports 22.3 (2020): 2101-2106.
Chicago
Zhu, L., Hao, X., Wu, X., Qi, B., Yue, T., Wang, H."Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice". Molecular Medicine Reports 22, no. 3 (2020): 2101-2106. https://doi.org/10.3892/mmr.2020.11265