Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway

  • Authors:
    • Kuijing Wang
    • Bo Li
    • Yuanyuan Xie
    • Nan Xia
    • Minghui Li
    • Guang Gao
  • View Affiliations / Copyright

    Affiliations: Cadre Ward (Geriatric), The First Hospital of Harbin in Heilongjiang, Harbin, Heilongjiang 150000, P.R. China, Department of Cardiology, The First Hospital of Harbin in Heilongjiang, Harbin, Heilongjiang 150000, P.R. China, Department of Clinical Laboratory, The First Hospital of Harbin in Heilongjiang, Harbin, Heilongjiang 150000, P.R. China, Department of General Surgery, AnZhen Hospital of Beijing, Beijing 100029, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2052-2062
    |
    Published online on: June 23, 2020
       https://doi.org/10.3892/mmr.2020.11266
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present study was to explore the potential molecular signaling pathway mediated by the statin rosuvastatin in cultured human coronary artery endothelial cells (HCAECs) induced by CoCl2. CoCl2 was used to induce the apoptosis of HCAECs. Myocardial infarction rats were established and received statin or PBS treatment. Reverse transcription‑quantitative PCR, western blotting, ELISA, TUNEL assay and immunohistochemistry were used to analyze the role of statin treatment. The results showed that rosuvastatin treatment decreased apoptosis of HCAECs induced by CoCl2 by increasing anti‑apoptosis Bcl‑xl and Bcl‑2 expression, and decreasing pro‑apoptosis Bax, Bad, caspase‑3 and caspase‑9 expression. The myocardial ischemia rat model demonstrated that rosuvastatin treatment decreased the mitochondrial reactive oxygen species, inflammation, mitochondrial damage, lipid catabolism, heart failure and the myocardial infarction areas, but improved the cardiac function indicators, right and left ventricular ejection fraction and increased expression levels of Janus kinase (JAK) and signal transducer and activator of transcription (STAT)3 in myocardial tissue. In conclusion, the results of the current study revealed that the statin rosuvastatin presents cardioprotective effects by activation of the JAK2/STAT3 signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Fan FF, Xu Q, Sun Q, Zhao SJ, Wang P and Guo XR: Assessment of the reporting quality of randomized controlled trials on treatment of coronary heart disease with traditional Chinese medicine from the Chinese journal of integrated traditional and Western medicine: A systematic review. PLoS One. 9:e863602014. View Article : Google Scholar : PubMed/NCBI

2 

Doyle F, Rohde D, Rutkowska A, Morgan K, Cousins G and McGee H: Systematic review and meta-analysis of the impact of depression on subsequent smoking cessation in patients with coronary heart disease: 1990 to 2013. Psychosom Med. 76:44–57. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tully PJ and Baumeister H: Collaborative care for the treatment of comorbid depression and coronary heart disease: A systematic review and meta-analysis protocol. Syst Rev. 3:1272014. View Article : Google Scholar : PubMed/NCBI

4 

Schwingshackl L and Hoffmann G: Dietary fatty acids in the secondary prevention of coronary heart disease: A systematic review, meta-analysis and meta-regression. BMJ Open. 4:e0044872014. View Article : Google Scholar : PubMed/NCBI

5 

Tully PJ, Cosh SM and Baumeister H: The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease. J Psychosom Res. 77:439–448. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Li SM, Xu H and Chen KJ: Integrative medicine on coronary heart disease: Annual academic review 2013. Zhongguo Zhong Xi Yi Jie He Za Zhi. 34:1029–1034. 2014.(In Chinese). PubMed/NCBI

7 

Ray IB, Menezes AR, Malur P, Hiltbold AE, Reilly JP and Lavie CJ: Meditation and coronary heart disease: A review of the current clinical evidence. Ochsner J. 14:696–703. 2014.PubMed/NCBI

8 

Niermann C, Gorressen S, Klier M, Gowert NS, Billuart P, Kelm M, Merx MW and Elvers M: Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis. Cell Signal. 28:967–978. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Guo CX, Jiang X, Zeng XJ, Wang HX, Li HH, Du FH and Chen BX: Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system. Free Radic Biol Med. 94:17–26. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Shi ZY, Liu Y, Dong L, Zhang B, Zhao M, Liu WX, Zhang X and Yin XH: Cortistatin improves cardiac function after acute myocardial infarction in rats by suppressing myocardial apoptosis and endoplasmic reticulum stress. J Cardiovasc Pharmacol Ther. 22:83–93. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Nishikido T, Oyama J, Shiraki A, Komoda H and Node K: Deletion of Apoptosis Inhibitor of Macrophage (AIM)/CD5L attenuates the inflammatory response and infarct size in acute myocardial infarction. J Am Heart Assoc. 5:e0028632016. View Article : Google Scholar : PubMed/NCBI

12 

Kvan E, Pettersen KI, Landmark K and Reikvam A: Treatment with statins after acute myocardial infarction in patients >or=80 years: Underuse despite general acceptance of drug therapy for secondary prevention. Pharmacoepidemiol Drug Saf. 15:261–267. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Zhou Z, Rahme E, Abrahamowicz M, Tu JV, Eisenberg MJ, Humphries K, Austin PC and Pilote L: Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: An evaluation of class effect. CMAJ. 172:1187–1194. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Iwakura K, Ito H, Kawano S, Okamura A, Kurotobi T, Date M, Inoue K and Fujii K: Chronic pre-treatment of statins is associated with the reduction of the no-reflow phenomenon in the patients with reperfused acute myocardial infarction. Eur Heart J. 27:534–539. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Matetzky S, Fefer P, Shenkman B, Shechter M, Novikov I, Savion N, Varon D and Hod H: Statins have an early antiplatelet effect in patients with acute myocardial infarction. Platelets. 22:103–110. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Lewinter C, Bland JM, Crouch S, Cleland JG, Doherty P, LeWinter MM, Køber L, Hall AS and Gale CP: Impact of aspirin and statins on long-term survival in patients hospitalized with acute myocardial infarction complicated by heart failure: An analysis of 1706 patients. Eur J Heart Fail. 16:95–102. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Verrier RL: Statins protect against arrhythmogenic calcium alternans in the post-myocardial infarction diabetic heart: Pleiotropy on steroids. Heart Rhythm. 14:1417–1418. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Yamac AH and Kilic U: Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction. Turk Kardiyol Dern Ars. 46:205–215. 2018.PubMed/NCBI

19 

Xu H, Yang YJ, Qian HY, Tang YD, Wang H and Zhang Q: Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts. Circ J. 75:1476–1485. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Rajtik T, Carnicka S, Szobi A, Mesárošová L, Máťuš M, Švec P, Ravingerová T and Adameová A: Pleiotropic effects of simvastatin are associated with mitigation of apoptotic component of cell death upon lethal myocardial reperfusion-induced injury. Physiol Res. 61 (Suppl 2):S33–S41. 2012.PubMed/NCBI

21 

Qiu R, Cai A, Dong Y, Zhou Y, Yu D, Huang Y, Zheng D, Rao S, Feng Y and Mai W: SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects. J Biomed Sci. 19:992012. View Article : Google Scholar : PubMed/NCBI

22 

Han L, Zhang X and Qian Y: Propofol protects human cardiac AC16 cells from CoCl2-induced hypoxic injury. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 44:307–314. 2019.(In Chinese). PubMed/NCBI

23 

Radecke CE, Warrick AE, Singh GD, Rogers JH, Simon SI and Armstrong EJ: Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction. Thromb Haemost. 113:605–616. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Xiao S, Wang J and Xiao N: MicroRNAs as noninvasive biomarkers in bladder cancer detection: A diagnostic meta-analysis based on qRT-PCR data. Int J Biol Markers. 31:e276–e285. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Naganuma Y, Ichii O, Otsuka S, Hashimoto Y and Kon Y: Analysis of TdT-mediated dUTP nick end labeling (TUNEL)-positive cells associated with cardiac myogenesis in mouse embryo. J Vet Med Sci. 75:283–290. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang R, Kang X, Wang Y, Wang F, Yu P, Shen J and Fu L: Effects of carvedilol on ventricular remodeling and the expression of β3-adrenergic receptor in a diabetic rat model subjected myocardial infarction. Int J Cardiol. 222:178–184. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Bagno LL, Carvalho D, Mesquita F, Louzada RA, Andrade B, Kasai-Brunswick TH, Lago VM, Suhet G, Cipitelli D, Werneck-de-Castro JP and Campos-de-Carvalho AC: Sustained IGF-1 secretion by adipose-derived stem cells improves infarcted heart function. Cell Transplant. 25:1609–1622. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Paradiso A, Caretto S, Leone A, Bove A, Nisi R and De Gara L: ROS production and scavenging under anoxia and re-oxygenation in arabidopsis cells: A balance between redox signaling and impairment. Front Plant Sci. 7:18032016. View Article : Google Scholar : PubMed/NCBI

30 

Dirani M, Nasreddine W, Abdulla F and Beydoun A: Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel. Epilepsy Behav Case Rep. 2:164–166. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hashemian M, Poustchi H, Mohammadi-Nasrabadi F and Hekmatdoost A: Systematic review of zinc biochemical indicators and risk of coronary heart disease. ARYA Atheroscler. 11:357–365. 2015.PubMed/NCBI

32 

Liu LL, Lin LR, Lu CX, Fu JG, Chao PL, Jin HW, Zhang ZY and Yang TC: Expression of inflammatory and apoptosis factors following coronary stent implantation in coronary heart disease patients. Int Immunopharmacol. 11:1850–1854. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Chopra V, Wesorick DH, Sussman JB, Greene T, Rogers M, Froehlich JB, Eagle KA and Saint S: Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: A systematic review and meta-analysis. Arch Surg. 147:181–189. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Gultekin N, Bulut G, Kucukates E, Yildiz A, Kocas C and Bulut L: Apoptosis kinetics at reperfusion period in patients with acute ST-Segment Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention and treated with thrombolytic therapy. J Pak Med Assoc. 66:808–814. 2016.PubMed/NCBI

35 

Pourafkari L, Visnjevac O, Ghaffari S and Nader ND: Statin drugs mitigate cellular inflammatory response after ST elevation myocardial infarction, but do not affect in-hospital mortality. J Cardiovasc Thorac Res. 8:34–39. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Hochhauser E, Cheporko Y, Yasovich N, Pinchas L, Offen D, Barhum Y, Pannet H, Tobar A, Vidne BA and Birk E: Bax deficiency reduces infarct size and improves long-term function after myocardial infarction. Cell Biochem Biophys. 47:11–20. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Li T, Kilic A, Wei X, Wu C, Schwartzbauer G, Yankey GK, DeFilippi C, Bond M, Wu ZJ and Griffith BP: Regional imbalanced activation of the calcineurin/BAD apoptotic pathway and the PI3K/Akt survival pathway after myocardial infarction. Int J Cardiol. 166:158–165. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Lv FH, Yin HL, He YQ, Wu HM, Kong J, Chai XY and Zhang SR: Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury. Exp Ther Med. 12:3877–3884. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Mercier E, Cochery-Nouvellon E, Lavigne G, Bertinchant JP and Gris JC: In support of the revised World Health Organization diagnostic criteria for essential thrombocythemia: JAK2 V617F and premature myocardial infarction. J Thromb Haemost. 6:206–207. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Enomoto D, Obana M, Miyawaki A, Maeda M, Nakayama H and Fujio Y: Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling. Am J Physiol Heart Circ Physiol. 309:H471–H480. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Wu J, Yu J, Xie P, Maimaitili Y, Wang J, Yang L, Ma H, Zhang X, Yang Y and Zheng H: Sevoflurane postconditioning protects the myocardium against ischemia/reperfusion injury via activation of the JAK2-STAT3 pathway. PeerJ. 5:e31962017. View Article : Google Scholar : PubMed/NCBI

42 

Luo R, Chen X, Ma H, Yao C, Liu M, Tao J and Li X: Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of Akt/eNOS/NO pathway. Life Sci. 222:195–202. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Zhao Q, Cui Z, Zheng Y, Li Q, Xu C, Sheng X, Tao M and Xu H: Fenofibrate protects against acute myocardial I/R injury in rat by suppressing mitochondrial apoptosis as decreasing cleaved caspase-9 activation. Cancer Biomark. 19:455–463. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang K, Li B, Xie Y, Xia N, Li M and Gao G: Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Mol Med Rep 22: 2052-2062, 2020.
APA
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., & Gao, G. (2020). Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Molecular Medicine Reports, 22, 2052-2062. https://doi.org/10.3892/mmr.2020.11266
MLA
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., Gao, G."Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway". Molecular Medicine Reports 22.3 (2020): 2052-2062.
Chicago
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., Gao, G."Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway". Molecular Medicine Reports 22, no. 3 (2020): 2052-2062. https://doi.org/10.3892/mmr.2020.11266
Copy and paste a formatted citation
x
Spandidos Publications style
Wang K, Li B, Xie Y, Xia N, Li M and Gao G: Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Mol Med Rep 22: 2052-2062, 2020.
APA
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., & Gao, G. (2020). Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Molecular Medicine Reports, 22, 2052-2062. https://doi.org/10.3892/mmr.2020.11266
MLA
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., Gao, G."Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway". Molecular Medicine Reports 22.3 (2020): 2052-2062.
Chicago
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., Gao, G."Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway". Molecular Medicine Reports 22, no. 3 (2020): 2052-2062. https://doi.org/10.3892/mmr.2020.11266
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team