Open Access

Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway

  • Authors:
    • Kuijing Wang
    • Bo Li
    • Yuanyuan Xie
    • Nan Xia
    • Minghui Li
    • Guang Gao
  • View Affiliations

  • Published online on: June 23, 2020     https://doi.org/10.3892/mmr.2020.11266
  • Pages: 2052-2062
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of the present study was to explore the potential molecular signaling pathway mediated by the statin rosuvastatin in cultured human coronary artery endothelial cells (HCAECs) induced by CoCl2. CoCl2 was used to induce the apoptosis of HCAECs. Myocardial infarction rats were established and received statin or PBS treatment. Reverse transcription‑quantitative PCR, western blotting, ELISA, TUNEL assay and immunohistochemistry were used to analyze the role of statin treatment. The results showed that rosuvastatin treatment decreased apoptosis of HCAECs induced by CoCl2 by increasing anti‑apoptosis Bcl‑xl and Bcl‑2 expression, and decreasing pro‑apoptosis Bax, Bad, caspase‑3 and caspase‑9 expression. The myocardial ischemia rat model demonstrated that rosuvastatin treatment decreased the mitochondrial reactive oxygen species, inflammation, mitochondrial damage, lipid catabolism, heart failure and the myocardial infarction areas, but improved the cardiac function indicators, right and left ventricular ejection fraction and increased expression levels of Janus kinase (JAK) and signal transducer and activator of transcription (STAT)3 in myocardial tissue. In conclusion, the results of the current study revealed that the statin rosuvastatin presents cardioprotective effects by activation of the JAK2/STAT3 signaling pathway.
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September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang K, Li B, Xie Y, Xia N, Li M and Gao G: Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Mol Med Rep 22: 2052-2062, 2020
APA
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., & Gao, G. (2020). Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway. Molecular Medicine Reports, 22, 2052-2062. https://doi.org/10.3892/mmr.2020.11266
MLA
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., Gao, G."Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway". Molecular Medicine Reports 22.3 (2020): 2052-2062.
Chicago
Wang, K., Li, B., Xie, Y., Xia, N., Li, M., Gao, G."Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway". Molecular Medicine Reports 22, no. 3 (2020): 2052-2062. https://doi.org/10.3892/mmr.2020.11266