Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells

  • Authors:
    • Gang Liu
    • Kanglei Zhang
    • Wenxuan Dong
    • Yun Tan
    • Mengfei Long
    • Hui Zou
    • Zongping Liu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China
  • Pages: 2551-2563
    |
    Published online on: July 6, 2020
       https://doi.org/10.3892/mmr.2020.11301
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cadmium (Cd) is a heavy metal that can accumulate and cause damage to a variety of tissues and organs. The kidney is the primary target organ for Cd accumulation and toxic damage. Autophagy, which is a critical intracellular process, serves an important role in maintaining the homeostasis of the intracellular environment. Endoplasmic reticulum stress (ERS) is another key process that functions to promote cell survival or results in cell injury and death. Both autophagy and ERS are associated with oxidative stress; however, the mechanism by which ERS is regulated by autophagy in Cd‑induced nephrotoxicity remains unclear. The present study employed a rat NRK‑52E cell model, where alterations in cell morphology, density and viability, the accumulation of reactive oxygen species, an increase in malondialdehyde generation and a decrease in antioxidant enzyme activity and apoptosis were induced by Cd treatment. Cd induced the activation of nuclear factor erythroid 2‑related factor 2 (NRF2), an obstruction of autophagic flux and ERS, which were attenuated by puerarin administration. Furthermore, puerarin failed to alleviate ERS following knockdown of autophagy‑related protein 7 in NRK‑52E cells. Overexpression of Ras‑related protein Rab‑7, which promotes the fusion of autophagosomes and lysosomes, efficiently reduced ERS. Taken together, these results indicate that puerarin administration restored the autophagic flux to alleviate ERS, via blocking the activation of NRF2.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Jarup L, Rogenfelt A, Elinder CG, Nogawa K and Kjellstrom T: Biological half-time of cadmium in the blood of workers after cessation of exposure. Scand J Work Environ Health. 9:327–331. 1983. View Article : Google Scholar : PubMed/NCBI

2 

Tchounwou PB, Yedjou CG, Patlolla AK and Sutton DJ: Heavy metal toxicity and the environment. Exp Suppl. 101:133–164. 2012.PubMed/NCBI

3 

Programme UNE and World Health Organization: Cadmium: Environmental aspects. Environmental Health Criteria. 1992.

4 

Lind Y, Engman J, Jorhem L and Glynn AW: Cadmium accumulation in liver and kidney of mice exposed to the same weekly cadmium dose continuously or once a week. Food Chem Toxicol. 35:891–895. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Bernard A: Renal dysfunction induced by cadmium: Biomarkers of critical effects. Biometals. 17:519–523. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Prozialeck WC, Wellington DR, Mosher TL, Lamar PC and Laddaga RA: The cadmium-induced disruption of tight junctions in LLC-PK1 cells does not result from apoptosis. Life Sci. 57:199–204. 1995. View Article : Google Scholar

7 

Dong Z, Wang L, Xu J, Li Y, Zhang Y, Zhang S and Miao J: Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells. Toxicol In Vitro. 23:105–110. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Wang L, Cao J, Chen D, Liu X, Lu H and Liu Z: Role of oxidative stress, apoptosis, and intracellular homeostasis in primary cultures of rat proximal tubular cells exposed to cadmium. Biol Trace Elem Res. 127:53–68. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Shen R, Liu D, Hou C, Liu D, Zhao L, Cheng J, Wang D and Bai D: Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo. Food Funct. 8:3636–3646. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wang L, Wang H, Li J, Chen D and Liu Z: Simultaneous effects of lead and cadmium on primary cultures of rat proximal tubular cells: Interaction of apoptosis and oxidative stress. Arch Environ Contam Toxicol. 61:500–511. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Mizushima N: Autophagy: Process and function. Genes Dev. 21:2861–2873. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Mizushima N, Yoshimori T and Levine B: Methods in mammalian autophagy research. Cell. 140:313–326. 2010. View Article : Google Scholar : PubMed/NCBI

13 

De Duve C: The lysosome. Sci Am. 208:64–72. 1963. View Article : Google Scholar : PubMed/NCBI

14 

Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Terman A and Brunk UT: Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res. 68:355–365. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Yang LY, Wu KH, Chiu WT, Wang SH and Shih CM: The cadmium-induced death of mesangial cells results in nephrotoxicity. Autophagy. 5:571–572. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Jin Y, Tanaka A, Choi AM and Ryter SW: Autophagic proteins: New facets of the oxygen paradox. Autophagy. 8:426–428. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, Zhang G, Chen Y, Feng D, Hu J and Zhang H: The vici syndrome protein EPG5 Is a Rab7 effector that determines the fusion specificity of autophagosomes with late Endosomes/Lysosomes. Mol Cell. 63:781–795. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Chen M, Li X, Fan R, Yang J, Jin X, Hamid S and Xu S: Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. Chemosphere. 194:396–402. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Fujishiro H, Liu Y, Ahmadi B and Templeton DM: Protective effect of cadmium-induced autophagy in rat renal mesangial cells. Arch Toxicol. 92:619–631. 2018. View Article : Google Scholar : PubMed/NCBI

21 

So KY, Lee BH and Oh SH: The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes. Toxicology. 393:15–25. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Thevenod F and Lee WK: Cadmium and cellular signaling cascades: Interactions between cell death and survival pathways. Arch Toxicol. 87:1743–1786. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Lee AS: The glucose-regulated proteins: Stress induction and clinical applications. Trends Biochem Sci. 26:504–510. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Kaufman RJ: Orchestrating the unfolded protein response in health and disease. J Clin Invest. 110:1389–1398. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Luo B, Lin Y, Jiang S, Huang L, Yao H, Zhuang Q, Zhao R, Liu H, He C and Lin Z: Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death Dis. 7:e22512016. View Article : Google Scholar : PubMed/NCBI

26 

Qi Z and Chen L: Endoplasmic reticulum stress and autophagy. Adv Exp Med Biol. 1206:167–177. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Kang SW and Hegde RS: Lighting up the stressed ER. Cell. 135:787–789. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Oslowski CM and Urano F: Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol. 490:71–92. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Rivas A, Vidal RL and Hetz C: Targeting the unfolded protein response for disease intervention. Expert Opin Ther Targets. 19:1203–1218. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Cai Y, Arikkath J, Yang L, Guo ML, Periyasamy P and Buch S: Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy. 12:225–244. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, et al: Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 522:354–358. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Zhang L, Xia Q, Zhou Y and Li J: Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. Toxicol Lett. 311:105–113. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Hernandez-Gea V, Hilscher M, Rozenfeld R, Lim MP, Nieto N, Werner S, Devi LA and Friedman SL: Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J Hepatol. 59:98–104. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Digaleh H, Kiaei M and Khodagholi F: Nrf2 and Nrf1 signaling and ER stress crosstalk: Implication for proteasomal degradation and autophagy. Cell Mol Life Sci. 70:4681–4694. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Bellezza I, Giambanco I, Minelli A and Donato R: Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 1865:721–733. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Tang Z, Hu B, Zang F, Wang J, Zhang X and Chen H: Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration. Cell Death Dis. 10:5102019. View Article : Google Scholar : PubMed/NCBI

37 

Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V and Zhang J: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem J. 469:347–355. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, et al: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell. 51:618–631. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Li W, Yang Q and Mao Z: Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions. Autophagy. 14:1094–1096. 2018.PubMed/NCBI

40 

Ryabaya O, Prokofieva A, Khochenkov D, Abramov I, Zasedatelev A and Stepanova E: Inhibition of endoplasmic reticulum stress-induced autophagy sensitizes melanoma cells to temozolomide treatment. Oncol Rep. 40:385–394. 2018.PubMed/NCBI

41 

Liu CM, Ma JQ, Liu SS, Feng ZJ and Wang AM: Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. Chem Biol Interact. 243:29–34. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Wang N, Zhang Y, Wu L, Wang Y, Cao Y, He L, Li X and Zhao J: Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. Neuropharmacology. 79:282–289. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Wang B, Chen S, Yan X, Li M, Li D, Lv P and Ti G: The therapeutic effect and possible harm of puerarin for treatment of stage III diabetic nephropathy: A meta-analysis. Altern Ther Health Med. 21:36–44. 2015.PubMed/NCBI

44 

Shapiro DL: Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP. Nature. 241:203–204. 1973. View Article : Google Scholar : PubMed/NCBI

45 

Lin YN, Jiang M, Chen WJ, Zhao TJ and Wei YF: Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response. Biomed Pharmacother. 118:1092492019. View Article : Google Scholar : PubMed/NCBI

46 

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12:1–222. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Zhou XL, Wan XM, Fu XX and Xie CG: Puerarin prevents cadmium-induced hepatic cell damage by suppressing apoptosis and restoring autophagic flux. Biomed Pharmacother. 115:1089292019. View Article : Google Scholar : PubMed/NCBI

48 

Cybulsky AV: Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Nat Rev Nephrol. 13:681–696. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Yu SN, Kim SH, Kim KY, Ji JH, Seo YK, Yu HS and Ahn SC: Salinomycin induces endoplasmic reticulum stressmediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells. Oncol Rep. 37:3321–3328. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Duann P, Lianos EA, Ma J and Lin PH: Autophagy, innate immunity and tissue repair in acute kidney injury. Int J Mol Sci. 17:6622016. View Article : Google Scholar

51 

Coker-Gurkan A, Ayhan-Sahin B, Keceloglu G, Obakan-Yerlikaya P, Arisan ED and Palavan-Unsal N: Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways. J Cell Biochem. 120:19749–19763. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Chou X, Ding F, Zhang XY, Ding XQ, Gao H and Wu Q: Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells. Arch Toxicol. 93:965–986. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Wang JC, Zhu HL, Zhang C, Wang HW and Yang ZJ: Baicalein ameliorates cadmium-induced hepatic and renal oxidative damage in rats. Indian J Anim Res. 53:523–527. 2019.

54 

Nair AR, Lee WK, Smeets K, Swennen Q, Sanchez A, Thévenod F and Cuypers A: Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney. Arch Toxicol. 89:2273–2289. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Pathak N and Khandelwal S: Role of oxidative stress and apoptosis in cadmium induced thymic atrophy and splenomegaly in mice. Toxicol Lett. 169:95–108. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Chen J and Shaikh ZA: Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells. Toxicol Appl Pharmacol. 241:81–89. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A and Groneberg DA: The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol. 1:222006. View Article : Google Scholar : PubMed/NCBI

58 

Alli LA: Blood level of cadmium and lead in occupationally exposed persons in Gwagwalada, Abuja, Nigeria. Interdiscip Toxicol. 8:146–150. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Goyal T, Mitra P, Singh P, Sharma S and Sharma P: Assessement of blood lead and cadmium levels in occupationally exposed workers of Jodhpur, Rajasthan. Ind J Clin Biochem. 2020. View Article : Google Scholar

60 

Gu J, Dai SY, Liu YM, Liu H, Zhang Y, Ji X, Yu F, Zhou Y, Chen L, Tse WKF, et al: Activation of Ca(2+)-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells. Sci Rep. 8:10922018. View Article : Google Scholar : PubMed/NCBI

61 

Tu W, Wang H, Li S, Liu Q and Sha H: The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging Dis. 10:637–651. 2019. View Article : Google Scholar : PubMed/NCBI

62 

Chen DL, Tavana O, Chu B, Erber L, Chen Y, Baer R and Gu W: NRF2 is a major target of ARF in p53-independent tumor suppression. Mol Cell. 68:224–232.e4. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Towers CG, Fitzwalter BE, Regan D, Goodspeed A, Morgan MJ, Liu CW, Gustafson DL and Thorburn A: Cancer cells upregulate NRF2 signaling to adapt to autophagy inhibition. Dev Cell. 50:690–703.e6. 2019. View Article : Google Scholar : PubMed/NCBI

64 

Guerrero-Hue M, Farre-Alins V, Palomino-Antolin A, Parada E, Rubio-Navarro A, Egido J, Egea J and Moreno JA: Targeting Nrf2 in protection against renal disease. Curr Med Chem. 24:3583–3605. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Ma JQ, Ding J, Xiao ZH and Liu CM: Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. Food Chem Toxicol. 71:264–271. 2014. View Article : Google Scholar : PubMed/NCBI

66 

Ullah MZ, Khan AU, Afridi R, Rasheed H, Khalid S, Naveed M, Ali H, Kim YS and Khan S: Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators. Int Immunopharmacol. 61:306–316. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Chen ZJ, Chen JX, Wu LK, Li BY, Tian YF, Xian M, Huang ZP and Yu RA: Induction of endoplasmic reticulum stress by cadmium and its regulation on Nrf2 signaling pathway in kidneys of rats. Biomed Environ Sci. 32:1–10. 2019.PubMed/NCBI

68 

Liao W, Wang Z, Fu Z, Ma H, Jiang M, Xu A and Zhang W: p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway. Free Radic Res. 53:800–814. 2019. View Article : Google Scholar : PubMed/NCBI

69 

Manley S, Ni HM, Kong B, Apte U, Guo G and Ding WX: Suppression of autophagic flux by bile acids in hepatocytes. Toxicol Sci. 137:478–490. 2014. View Article : Google Scholar : PubMed/NCBI

70 

Khambu B, Huda N, Chen X, Antoine DJ, Li Y, Dai G, Köhler UA, Zong WX, Waguri S, Werner S, et al: HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest. 129:21632019. View Article : Google Scholar

71 

Nakka VP, Prakash-Babu P and Vemuganti R: Crosstalk between endoplasmic reticulum stress, oxidative stress, and autophagy: Potential therapeutic targets for acute CNS injuries. Mol Neurobiol. 53:532–544. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu G, Zhang K, Dong W, Tan Y, Long M, Zou H and Liu Z: Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells. Mol Med Rep 22: 2551-2563, 2020.
APA
Liu, G., Zhang, K., Dong, W., Tan, Y., Long, M., Zou, H., & Liu, Z. (2020). Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells. Molecular Medicine Reports, 22, 2551-2563. https://doi.org/10.3892/mmr.2020.11301
MLA
Liu, G., Zhang, K., Dong, W., Tan, Y., Long, M., Zou, H., Liu, Z."Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells". Molecular Medicine Reports 22.3 (2020): 2551-2563.
Chicago
Liu, G., Zhang, K., Dong, W., Tan, Y., Long, M., Zou, H., Liu, Z."Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells". Molecular Medicine Reports 22, no. 3 (2020): 2551-2563. https://doi.org/10.3892/mmr.2020.11301
Copy and paste a formatted citation
x
Spandidos Publications style
Liu G, Zhang K, Dong W, Tan Y, Long M, Zou H and Liu Z: Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells. Mol Med Rep 22: 2551-2563, 2020.
APA
Liu, G., Zhang, K., Dong, W., Tan, Y., Long, M., Zou, H., & Liu, Z. (2020). Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells. Molecular Medicine Reports, 22, 2551-2563. https://doi.org/10.3892/mmr.2020.11301
MLA
Liu, G., Zhang, K., Dong, W., Tan, Y., Long, M., Zou, H., Liu, Z."Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells". Molecular Medicine Reports 22.3 (2020): 2551-2563.
Chicago
Liu, G., Zhang, K., Dong, W., Tan, Y., Long, M., Zou, H., Liu, Z."Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells". Molecular Medicine Reports 22, no. 3 (2020): 2551-2563. https://doi.org/10.3892/mmr.2020.11301
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team