Falany CN, Johnson MR, Barnes S and Diasio RB: Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem. 269:19375–19379. 1994.PubMed/NCBI

Lambert IH, Jensen JV and Pedersen PA: mTOR ensures increased release and reduced uptake of the organic osmolyte taurine under hypoosmotic conditions in mouse fibroblasts. Am J Physiol Cell Physiol. 306:C1028–C1040. 2014. View Article : Google Scholar : PubMed/NCBI

Espe M and Holen E: Taurine attenuates apoptosis in primary liver cells isolated from Atlantic salmon (Salmo salar). Br J Nutr. 110:20–28. 2013. View Article : Google Scholar : PubMed/NCBI

Trenkner E: Possible role of glutamate with taurine in neuron-glia interaction during cerebellar development. Prog Clin Biol Res. 351:133–140. 1990.PubMed/NCBI

Schaffer SW, Azuma J and Madura JD: Mechanisms underlying taurine-mediated alterations in membrane function. Amino Acids. 8:231–246. 1995. View Article : Google Scholar : PubMed/NCBI

Tappaz ML: Taurine biosynthetic enzymes and taurine transporter: Molecular identification and regulations. Neurochem Res. 29:83–96. 2004. View Article : Google Scholar : PubMed/NCBI

Stipanuk MH: Role of the liver in regulation of body cysteine and taurine levels: A brief review. Neurochem Res. 29:105–110. 2004. View Article : Google Scholar : PubMed/NCBI

Palkovits M, Elekes I, Láng T and Patthy A: Taurine levels in discrete brain nuclei of rats. J Neurochem. 47:1333–1335. 1986. View Article : Google Scholar : PubMed/NCBI

Stipanuk MH, Londono M, Lee JI, Hu M and Yu AF: Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J Nutr. 132:3369–3378. 2002. View Article : Google Scholar : PubMed/NCBI

Ueki I and Stipanuk MH: 3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways. J Nutr. 139:207–214. 2009. View Article : Google Scholar : PubMed/NCBI

Ueki I and Stipanuk MH: Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland. J Nutr. 137:1887–1894. 2007. View Article : Google Scholar : PubMed/NCBI

Park E, Park SY, Wang C, Xu J, LaFauci G and Schuller-Levis G: Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues. Biochim Biophys Acta. 1574:403–406. 2002. View Article : Google Scholar : PubMed/NCBI

Marcinkiewicz J and Kontny E: Taurine and inflammatory diseases. Amino Acids. 46:7–20. 2014. View Article : Google Scholar : PubMed/NCBI

Jerkins AA and Steele RD: Quantification of cysteine sulfinic acid decarboxylase in male and female rats: Effect of adrenalectomy and methionine. Arch Biochem Biophys. 294:534–538. 1992. View Article : Google Scholar : PubMed/NCBI

Ueki I, Roman HB, Valli A, Fieselmann K, Lam J, Peters R, Hirschberger LL and Stipanuk MH: Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide. Am J Physiol Endocrinol Metab. 301:E668–E684. 2011. View Article : Google Scholar : PubMed/NCBI

Roman HB, Hirschberger LL, Krijt J, Valli A, Kožich V and Stipanuk MH: The cysteine dioxgenase knockout mouse: Altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(−) production and evidence of pancreatic and lung toxicity. Antioxid Redox Signal. 19:1321–1336. 2013. View Article : Google Scholar : PubMed/NCBI

Sturman JA: Taurine in development. J Nutr. 118:1169–1176. 1988. View Article : Google Scholar : PubMed/NCBI

Miyamoto Y, Tiruppathi C, Ganapathy V and Leibach FH: Active transport of taurine in rabbit jejunal brush-border membrane vesicles. Am J Physiol. 257:G65–G72. 1989.PubMed/NCBI

O'Flaherty L, Stapleton PP, Redmond HP and Bouchier-Hayes DJ: Intestinal taurine transport: A review. Eur J Clin Invest. 27:873–880. 1997. View Article : Google Scholar : PubMed/NCBI

Glass EN, Odle J and Baker DH: Urinary taurine excretion as a function of taurine intake in adult cats. J Nutr. 122:1135–1142. 1992. View Article : Google Scholar : PubMed/NCBI

Schuller-Levis G and Park E: Is taurine a biomarker. Advances in Clinical Chemistry. 41:Elsevier. 1–21. 2006. View Article : Google Scholar : PubMed/NCBI

Anderson CMH, Howard A, Walters JRF, Ganapathy V and Thwaites DT: Taurine uptake across the human intestinal brush-border membrane is via two transporters: H⁺-coupled PAT1 (SLC36A1) and Na⁺- and Cl⁻-dependent TauT (SLC6A6): intestinal taurine transport via PAT1 (SLC36A1) and TauT (SLC6A6). J Physiol. 587:731–744. 2009. View Article : Google Scholar : PubMed/NCBI

Voss JW, Pedersen SF, Christensen ST and Lambert IH: Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts. Eur J Biochem. 271:4646–4658. 2004. View Article : Google Scholar : PubMed/NCBI

Jensen A, Figueiredo-Larsen M, Holm R, Broberg ML, Brodin B and Nielsen CU: PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. Am J Physiol Endocrinol Metab. 306:E65–E74. 2014. View Article : Google Scholar : PubMed/NCBI

Jong CJ, Ito T, Mozaffari M, Azuma J and Schaffer S: Effect of β-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content. J Biomed Sci. 17 (Suppl 1):S252010. View Article : Google Scholar : PubMed/NCBI

Ubuka T, Okada A and Nakamura H: Production of hypotaurine from L-cysteinesulfinate by rat liver mitochondria. Amino Acids. 35:53–58. 2008. View Article : Google Scholar : PubMed/NCBI

Suzuki T, Suzuki T, Wada T, Saigo K and Watanabe K: Taurine as a constituent of mitochondrial tRNAs: New insights into the functions of taurine and human mitochondrial diseases. EMBO J. 21:6581–6589. 2002. View Article : Google Scholar : PubMed/NCBI

Ögmundsdóttir MH, Heublein S, Kazi S, Reynolds B, Visvalingam SM, Shaw MK and Goberdhan DCI: Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS One. 7:e366162012. View Article : Google Scholar : PubMed/NCBI

Takeuchi K, Toyohara H and Sakaguchi M: A hyperosmotic stress-induced mRNA of carp cell encodes Na⁺- and Cl⁻-dependent high affinity taurine transporter1 the sequence reported in this paper has been deposited in the DDBJ/EMBL/GenBank database with accession no. AB006986.1. Biochim Biophys Acta Biomembr. 1464:219–230. 2000. View Article : Google Scholar

Mollerup J and Lambert IH: Calyculin a modulates the kinetic constants for the Na⁺-coupled taurine transport in Ehrlich ascites tumour cells. Biochim Biophys Acta Biomembr. 1371:335–344. 1998. View Article : Google Scholar

Sakai S, Tosaka T, Tasaka J, Hashiguchi T and Yoshihama I: Taurine uptake by glial cells in the bullfrog sympathetic ganglia. Neurochem Int. 14:193–198. 1989. View Article : Google Scholar : PubMed/NCBI

Han X, Patters AB, Jones DP, Zelikovic I and Chesney RW: The taurine transporter: Mechanisms of regulation. Acta Physiol (Oxf). 187:61–73. 2006. View Article : Google Scholar : PubMed/NCBI

Heller-Stilb B, van Roeyen C, Rascher K, Hartwig HG, Huth A, Seeliger MW, Warskulat U and Häussinger D: Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 16:231–233. 2002. View Article : Google Scholar : PubMed/NCBI

Han X, Patters AB and Chesney RW: Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. J Biol Chem. 277:39266–39273. 2002. View Article : Google Scholar : PubMed/NCBI

Lambert IH: Regulation of the cellular content of the organic osmolyte taurine in mammalian cells. Neurochem Res. 29:27–63. 2004. View Article : Google Scholar : PubMed/NCBI

Miyazaki T and Matsuzaki Y: Taurine and liver diseases: A focus on the heterogeneous protective properties of taurine. Amino Acids. 46:101–110. 2014. View Article : Google Scholar : PubMed/NCBI

Hammarqvist F, Angsten G, Meurling S, Andersson K and Wernerman J: Age-related changes of muscle and plasma amino acids in healthy children. Amino Acids. 39:359–366. 2010. View Article : Google Scholar : PubMed/NCBI

Li Y, Hu Z, Chen B, Bu Q, Lu W, Deng Y, Zhu R, Shao X, Hou J, Zhao J, et al: Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway. Toxicol Lett. 215:1–7. 2012. View Article : Google Scholar : PubMed/NCBI

Holecek M and Sispera L: Effects of arginine supplementation on amino acid profiles in blood and tissues in fed and overnight-fasted rats. Nutrients. 8:2062016. View Article : Google Scholar : PubMed/NCBI

Li Y, Li F, Wu L, Wei H, Liu Y, Li T, Tan B, Kong X, Yao K, Chen S, et al: Effects of dietary protein restriction on muscle fiber characteristics and mTORC1 pathway in the skeletal muscle of growing-finishing pigs. J Anim Sci Biotechnol. 7:472016. View Article : Google Scholar : PubMed/NCBI

Holecek M and Kovarik M: Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - effect of starvation. Food Chem Toxicol. 49:3336–3342. 2011. View Article : Google Scholar : PubMed/NCBI

Chen X, Sebastian BM, Tang H, McMullen MM, Axhemi A, Jacobsen DW and Nagy LE: Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats. Hepatology. 49:1554–1562. 2009. View Article : Google Scholar : PubMed/NCBI

Mochizuki T, Satsu H, Nakano T and Shimizu M: Regulation of the human taurine transporter by TNF-α and an anti-inflammatory function of taurine in human intestinal Caco-2 cells. Biofactors. 21:141–144. 2004. View Article : Google Scholar : PubMed/NCBI

Ishizuka K, Miyamoto Y, Satsu H, Sato R and Shimizu M: Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells. Biosci Biotechnol Biochem. 66:730–736. 2002. View Article : Google Scholar : PubMed/NCBI

Mochizuki T, Satsu H and Shimizu M: Signaling pathways involved in tumor necrosis factor α-induced upregulation of the taurine transporter in Caco-2 cells. FEBS Lett. 579:3069–3074. 2005. View Article : Google Scholar : PubMed/NCBI

Merheb M, Daher RT, Nasrallah M, Sabra R, Ziyadeh FN and Barada K: Taurine intestinal absorption and renal excretion test in diabetic patients: A pilot study. Diabetes Care. 30:2652–2654. 2007. View Article : Google Scholar : PubMed/NCBI

Han X, Budreau AM and Chesney RW: The taurine transporter gene and its role in renal development. Amino Acids. 19:499–507. 2000. View Article : Google Scholar : PubMed/NCBI

Chesney RW, Scriver CR and Mohyuddin F: Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. J Clin Invest. 57:183–193. 1976. View Article : Google Scholar : PubMed/NCBI

Satsu H, Miyamoto Y and Shimizu M: Hypertonicity stimulates taurine uptake and transporter gene expression in Caco-2 cells. Biochim Biophys Acta. 1419:89–96. 1999. View Article : Google Scholar : PubMed/NCBI

Uchida S, Kwon HM, Yamauchi A, Preston AS, Marumo F and Handler JS: Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci USA. 89:8230–8234. 1992. View Article : Google Scholar : PubMed/NCBI

Pramod AB, Foster J, Carvelli L and Henry LK: SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 34:197–219. 2013. View Article : Google Scholar : PubMed/NCBI

Kubo Y, Akanuma SI and Hosoya KI: Impact of SLC6A transporters in physiological taurine transport at the blood-retinal barrier and in the liver. Biol Pharm Bull. 39:1903–1911. 2016. View Article : Google Scholar : PubMed/NCBI

Zelikovic I and Chesney RW: Sodium-coupled amino acid transport in renal tubule. Kidney Int. 36:351–359. 1989. View Article : Google Scholar : PubMed/NCBI

Silbernagl S: The renal handling of amino acids and oligopeptides. Physiol Rev. 68:911–1007. 1988. View Article : Google Scholar : PubMed/NCBI

Zelikovic I and Chesney RW: Ionic requirements for amino acid transport. Am J Kidney Dis. 14:313–316. 1989. View Article : Google Scholar : PubMed/NCBI

Hoffmann EK and Lambert IH: Amino acid transport and cell volume regulation in Ehrlich ascites tumour cells. J Physiol. 338:613–625. 1983. View Article : Google Scholar : PubMed/NCBI

Han X, Budreau AM and Chesney RW: Identification of promoter elements involved in adaptive regulation of the taurine transporter gene: Role of cytosolic Ca²⁺ signaling. Adv Exp Med Biol. 483:535–544. 2000. View Article : Google Scholar : PubMed/NCBI

Wójcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M and Chen Y: The potential protective effects of taurine on coronary heart disease. Atherosclerosis. 208:19–25. 2010. View Article : Google Scholar : PubMed/NCBI

Jones DP, Miller LA and Chesney RW: Polarity of taurine transport in cultured renal epithelial cell lines: LLC-PK1 and MDCK. Am J Physiol. 265:F137–F145. 1993.PubMed/NCBI

Jones DP, Miller LA, Dowling C and Chesney RW: Regulation of taurine transporter activity in LLC-PK1 cells: Role of protein synthesis and protein kinase C activation. J Am Soc Nephrol. 2:1021–1029. 1991.PubMed/NCBI

Jones DP, Miller LA and Chesney RW: Adaptive regulation of taurine transport in two continuous renal epithelial cell lines. Kidney Int. 38:219–226. 1990. View Article : Google Scholar : PubMed/NCBI

Jones DP, Miller LA, Budreau A and Chesney RW: Characteristics of taurine transport in cultured renal epithelial cell lines: asymmetric polarity of proximal and distal cell lines. Adv Exp Med Biol. 315:405–411. 1992. View Article : Google Scholar : PubMed/NCBI

Handler JS and Kwon HM: Transcriptional regulation by changes in tonicity. Kidney Int. 60:408–411. 2001. View Article : Google Scholar : PubMed/NCBI

Ito T, Fujio Y, Schaffer SW and Azuma J: Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte. Adv Exp Med Biol. 643:523–532. 2009. View Article : Google Scholar : PubMed/NCBI

Ito T, Fujio Y, Hirata M, Takatani T, Matsuda T, Muraoka S, Takahashi K and Azuma J: Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells. Biochem J. 382:177–182. 2004. View Article : Google Scholar : PubMed/NCBI

Ortells MC, Morancho B, Drews-Elger K, Viollet B, Laderoute KR, López-Rodríguez C and Aramburu J: Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin. Nucleic Acids Res. 40:4368–4384. 2012. View Article : Google Scholar : PubMed/NCBI

Roos S, Kanai Y, Prasad PD, Powell TL and Jansson T: Regulation of placental amino acid transporter activity by mammalian target of rapamycin. Am J Physiol Cell Physiol. 296:C142–C150. 2009. View Article : Google Scholar : PubMed/NCBI

Han X and Chesney RW: The role of taurine in renal disorders. Amino Acids. 43:2249–2263. 2012. View Article : Google Scholar : PubMed/NCBI

Han X, Yue J and Chesney RW: Functional TauT protects against acute kidney injury. J Am Soc Nephrol. 20:1323–1332. 2009. View Article : Google Scholar : PubMed/NCBI

Matsell DG, Bennett T, Han X, Budreau AM and Chesney RW: Regulation of the taurine transporter gene in the S3 segment of the proximal tubule. Kidney Int. 52:748–754. 1997. View Article : Google Scholar : PubMed/NCBI

Shalby AB, Assaf N and Ahmed HH: Possible mechanisms for N-acetyl cysteine and taurine in ameliorating acute renal failure induced by cisplatin in rats. Toxicol Mech Methods. 21:538–546. 2011. View Article : Google Scholar : PubMed/NCBI

Han X: Targeting taurine transporter (TauT) for cancer immunotherapy of p53 mutation mediated cancers - molecular basis and preclinical implication. Adv Exp Med Biol. 1155:543–553. 2019. View Article : Google Scholar : PubMed/NCBI

Hansen DB, Friis MB, Hoffmann EK and Lambert IH: Downregulation of the taurine transporter TauT during hypo-osmotic stress in NIH3T3 mouse fibroblasts. J Membr Biol. 245:77–87. 2012. View Article : Google Scholar : PubMed/NCBI

Mollerup J and Lambert IH: Phosphorylation is involved in the regulation of the taurine influx via the β-system in Ehrlich ascites tumor cells. J Membr Biol. 150:73–82. 1996. View Article : Google Scholar : PubMed/NCBI

Qian X, Vinnakota S, Edwards C and Sarkar HK: Molecular characterization of taurine transport in bovine aortic endothelial cells. Biochim Biophys Acta. 1509:324–334. 2000. View Article : Google Scholar : PubMed/NCBI

Jacobsen JH, Clement CA, Friis MB and Lambert IH: Casein kinase 2 regulates the active uptake of the organic osmolyte taurine in NIH3T3 mouse fibroblasts. Pflugers Arch. 457:327–337. 2008. View Article : Google Scholar : PubMed/NCBI

Smith KE, Borden LA, Wang CH, Hartig PR, Branchek TA and Weinshank RL: Cloning and expression of a high affinity taurine transporter from rat brain. Mol Pharmacol. 42:563–569. 1992.PubMed/NCBI

Kang YS, Ohtsuki S, Takanaga H, Tomi M, Hosoya K and Terasaki T: Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-α, taurine and hypertonicity. J Neurochem. 83:1188–1195. 2002. View Article : Google Scholar : PubMed/NCBI

Frank RN: Diabetic retinopathy. N Engl J Med. 350:48–58. 2004. View Article : Google Scholar : PubMed/NCBI

Lorenzi M, Healy DP, Hawkins R, Printz JM and Printz MP: Studies on the permeability of the blood-brain barrier in experimental diabetes. Diabetologia. 29:58–62. 1986. View Article : Google Scholar : PubMed/NCBI

Schoch HJ, Fischer S and Marti HH: Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain. 125:2549–2557. 2002. View Article : Google Scholar : PubMed/NCBI

Yeh WL, Lu DY, Lin CJ, Liou HC and Fu WM: Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1α accumulation and VEGF expression. Mol Pharmacol. 72:440–449. 2007. View Article : Google Scholar : PubMed/NCBI

Nicholson BP and Schachat AP: A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 248:915–930. 2010. View Article : Google Scholar : PubMed/NCBI

Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J, Yancopoulos GD and Adamis AP: Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF. J Clin Invest. 109:805–815. 2002. View Article : Google Scholar : PubMed/NCBI

Napoli Z, Seghieri G, Bianchi L, Anichini R, De Bellis A, Campesi I, Carru C, Occhioni S, Zinellu A and Franconi F: Taurine transporter gene expression in mononuclear blood cells of type 1 diabetes patients. J Diabetes Res. 2016:73131622016. View Article : Google Scholar : PubMed/NCBI

Bianchi L, Lari R, Anichini R, De Bellis A, Berti A, Napoli Z, Seghieri G and Franconi F: Taurine transporter gene expression in peripheral mononuclear blood cells of type 2 diabetic patients. Amino Acids. 42:2267–2274. 2012. View Article : Google Scholar : PubMed/NCBI

Han X and Chesney RW: Knockdown of TauT expression impairs human embryonic kidney 293 cell development. Adv Exp Med Biol. 776:307–320. 2013. View Article : Google Scholar : PubMed/NCBI

Son HY, Kim H and Kwon YH: Taurine prevents oxidative damage of high glucose-induced cataractogenesis in isolated rat lenses. J Nutr Sci Vitaminol (Tokyo). 53:324–330. 2007. View Article : Google Scholar : PubMed/NCBI

Hou X, Wang Z, Ding F, He Y, Wang P, Liu X, Xu F, Wang J and Yang Y: Taurine transporter regulates adipogenic differentiation of human adipose-derived stem cells through affecting Wnt/β-catenin signaling pathway. Int J Biol Sci. 15:1104–1112. 2019. View Article : Google Scholar : PubMed/NCBI

Tervaert TWC, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, et al Renal Pathology Society, : Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 21:556–563. 2010. View Article : Google Scholar : PubMed/NCBI

Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang F, Häussinger D, Vallon V, et al: Blunted apoptosis of erythrocytes from taurine transporter deficient mice. Cell Physiol Biochem. 13:337–346. 2003. View Article : Google Scholar : PubMed/NCBI

Villumsen KR, Duelund L and Lambert IH: Acute cholesterol depletion leads to net loss of the organic osmolyte taurine in Ehrlich Lettré tumor cells. Amino Acids. 39:1521–1536. 2010. View Article : Google Scholar : PubMed/NCBI

Lambert IH, Nielsen JH, Andersen HJ and Ørtenblad N: Cellular model for induction of drip loss in meat. J Agric Food Chem. 49:4876–4883. 2001. View Article : Google Scholar : PubMed/NCBI

Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH and Hoffmann EK: Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: Role of chloride channels. Am J Physiol Cell Physiol. 298:C14–C25. 2010. View Article : Google Scholar : PubMed/NCBI

Lambert IH: Effect of arachidonic acid on conductive Na, K and anion transport in Ehlrich ascites tumor cells under isotonic and hypotonic conditions. Cell Physiol Biochem. 1:177–194. 1991. View Article : Google Scholar

Lambert IH: Effect of arachidonic acid, fatty acids, prostaglandins, and leukotrienes on volume regulation in Ehrlich ascites tumor cells. J Membr Biol. 98:207–221. 1987. View Article : Google Scholar : PubMed/NCBI

Lambert IH: Reactive oxygen species regulate swelling-induced taurine efflux in NIH3T3 mouse fibroblasts. J Membr Biol. 192:19–32. 2003. View Article : Google Scholar : PubMed/NCBI

Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, et al: Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol. 44:927–937. 2008. View Article : Google Scholar : PubMed/NCBI

Izumi K, Kishita C, Nakagawa K, Huxtable RJ, Shimizu T, Koja T and Fukuda T: Modification of the antiepileptic actions of phenobarbital and phenytoin by the taurine transport inhibitor, guanidinoethane sulfonate. Eur J Pharmacol. 110:219–224. 1985. View Article : Google Scholar : PubMed/NCBI

Schaffer SW, Shimada-Takaura K, Jong CJ, Ito T and Takahashi K: Impaired energy metabolism of the taurine deficient heart. Amino Acids. 48:549–558. 2016. View Article : Google Scholar : PubMed/NCBI

Choi D, Kim SJ, Kwon DY, Lee SY and Kim YC: Taurine depletion by beta-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. Adv Exp Med Biol. 643:305–311. 2009. View Article : Google Scholar : PubMed/NCBI

Warskulat U, Flögel U, Jacoby C, Hartwig HG, Thewissen M, Merx MW, Molojavyi A, Heller-Stilb B, Schrader J and Häussinger D: Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J. 18:577–579. 2004. View Article : Google Scholar : PubMed/NCBI

Lötsch J, Hummel T, Warskulat U, Coste O, Häussinger D, Geisslinger G and Tegeder I: Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation. Neuroscience. 259:63–70. 2014. View Article : Google Scholar : PubMed/NCBI

Ito T, Oishi S, Takai M, Kimura Y, Uozumi Y, Fujio Y, Schaffer SW and Azuma J: Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice. J Biomed Sci. 17 (Suppl 1):S202010. View Article : Google Scholar : PubMed/NCBI

Kaesler S, Sobiesiak M, Kneilling M, Volz T, Kempf WE, Lang PA, Lang KS, Wieder T, Heller-Stilb B, Warskulat U, et al: Effective T-cell recall responses require the taurine transporter Taut. Eur J Immunol. 42:831–841. 2012. View Article : Google Scholar : PubMed/NCBI

Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Mönnighoff I, Buchczyk D, Donner M, Flögel U, Kappert G, Soboll S, et al: Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J. 20:574–576. 2006. View Article : Google Scholar : PubMed/NCBI

Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Roth C, Witt M and Häussinger D: Taurine deficiency and apoptosis: Findings from the taurine transporter knockout mouse. Arch Biochem Biophys. 462:202–209. 2007. View Article : Google Scholar : PubMed/NCBI

Qvartskhava N, Jin CJ, Buschmann T, Albrecht U, Bode JG, Monhasery N, Oenarto J, Bidmon HJ, Görg B and Häussinger D: Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver. Proc Natl Acad Sci USA. 116:6313–6318. 2019. View Article : Google Scholar : PubMed/NCBI

Ito T, Okazaki K, Nakajima D, Shibata D, Murakami S and Schaffer S: Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart. Amino Acids. 50:117–124. 2018. View Article : Google Scholar : PubMed/NCBI

Franchi-Gazzola R, Gaccioli F, Bevilacqua E, Visigalli R, Dall'Asta V, Sala R, Varoqui H, Erickson JD, Gazzola GC and Bussolati O: The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system a transport activity. Biochim Biophys Acta Biomembr. 1667:157–166. 2004. View Article : Google Scholar

Trama J, Go WY and Ho SN: The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol. 169:5477–5488. 2002. View Article : Google Scholar : PubMed/NCBI

Burg MB and Ferraris JD: Intracellular organic osmolytes: Function and regulation. J Biol Chem. 283:7309–7313. 2008. View Article : Google Scholar : PubMed/NCBI

Schaffer SW, Jong CJ, Ito T and Azuma J: Role of taurine in the pathologies of MELAS and MERRF. Amino Acids. 46:47–56. 2014. View Article : Google Scholar : PubMed/NCBI

Board PG, Moore KA and Smith JE: Purification and properties of γ-glutamylcyclotransferase from human erythrocytes. Biochem J. 173:427–431. 1978. View Article : Google Scholar : PubMed/NCBI

Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L and Sharpless NE: Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 114:1299–1307. 2004. View Article : Google Scholar : PubMed/NCBI

Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer SW and Azuma J: Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PLoS One. 9:e1074092014. View Article : Google Scholar : PubMed/NCBI

Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S and Kaufman RJ: Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in β cells. Cell Metab. 10:13–26. 2009. View Article : Google Scholar : PubMed/NCBI

Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M and Ron D: Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 6:1099–1108. 2000. View Article : Google Scholar : PubMed/NCBI

Araki K and Nagata K: Protein folding and quality control in the ER. Cold Spring Harb Perspect Biol. 4:a015438. 2012. View Article : Google Scholar : PubMed/NCBI

Salminen A and Kaarniranta K: ER stress and hormetic regulation of the aging process. Ageing Res Rev. 9:211–217. 2010. View Article : Google Scholar : PubMed/NCBI

Jong CJ, Ito T, Azuma J and Schaffer S: Taurine depletion decreases GRP78 expression and downregulates Perk-dependent activation of the unfolded protein response. Adv Exp Med Biol. 803:571–579. 2015. View Article : Google Scholar : PubMed/NCBI

Ito T, Yamamoto N, Nakajima S and Schaffer SW: Beta-catenin and SMAD3 are associated with skeletal muscle aging in the taurine transporter knockout mouse. Adv Exp Med Biol 975 (Pt 1). 497–502. 2017. View Article : Google Scholar

Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K and Suzuki T: Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci USA. 101:15070–15075. 2004. View Article : Google Scholar : PubMed/NCBI

Yasukawa T, Suzuki T, Ueda T, Ohta S and Watanabe K: Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. J Biol Chem. 275:4251–4257. 2000. View Article : Google Scholar : PubMed/NCBI

Mozaffari MS, Tan BH, Lucia MA and Schaffer SW: Effect of drug-induced taurine depletion on cardiac contractility and metabolism. Biochem Pharmacol. 35:985–989. 1986. View Article : Google Scholar : PubMed/NCBI

Jong CJ, Azuma J and Schaffer S: Mechanism underlying the antioxidant activity of taurine: Prevention of mitochondrial oxidant production. Amino Acids. 42:2223–2232. 2012. View Article : Google Scholar : PubMed/NCBI

Vionnet N, Passa P and Froguel P: Prevalence of mitochondrial gene mutations in families with diabetes mellitus. Lancet. 342:1429–1430. 1993. View Article : Google Scholar : PubMed/NCBI

Maassen JA, 'T Hart LM, Van Essen E, Heine RJ, Nijpels G, Jahangir Tafrechi RSJ, Raap AK, Janssen GMC and Lemkes HHPJ: Mitochondrial diabetes: Molecular mechanisms and clinical presentation. Diabetes. 53 (Suppl 1):S103–S109. 2004. View Article : Google Scholar : PubMed/NCBI