Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy

  • Authors:
    • Yuanyuan Wu
    • Wei Li
    • Yifan Hu
    • Yun Liu
    • Xiuzhen Sun
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2219-2226
    |
    Published online on: July 13, 2020
       https://doi.org/10.3892/mmr.2020.11338
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sirtuin 1 (SIRT1) is involved in the pathogenesis of allergic asthma. This study aimed to investigate whether EX‑527, a specific SIRT1 inhibitor, exerted suppressive effects on allergic airway inflammation in mice submitted to ovalbumin (OVA) inhalation. In addition, this study assessed whether such a protective role was mediated by autophagy suppression though mammalian target of rapamycin (mTOR) activation. Female C57BL/6 mice were sensitized to OVA and EX‑527 (10 mg/kg) was administered prior to OVA challenge. The study found that EX‑527 reversed OVA‑induced airway inflammation, and reduced OVA‑induced increases in inflammatory cytokine expression, and total cell and eosinophil counts in bronchoalveolar lavage fluid. In addition, EX‑527 enhanced mTOR activation, thereby suppressing autophagy in allergic mice. To assess whether EX‑527 inhibited airway inflammation in asthma through the mTOR‑mediated autophagy pathway, rapamycin was administered to mice treated with EX‑527 after OVA sensitization. All effects induced by EX‑527, including increased phosphorylated‑mTOR and decreased autophagy, were abrogated by rapamycin treatment. Taken together, the present findings indicated that EX‑527 may inhibit allergic airway inflammation by suppressing autophagy, an effect mediated by mTOR activation in allergic mice.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Tang L, Chen Q, Meng Z, Sun L, Zhu L, Liu J, Hu J, Ni Z and Wang X: suppression of sirtuin-1 increases IL-6 expression by activation of the Akt pathway during allergic asthma. Cell Physiol Biochem. 43:1950–1960. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Ding F, Fu Z and Liu B: Lipopolysaccharide exposure alleviates asthma in mice by regulating Th1/Th2 and Treg/Th17 balance. Med Sci Monit. 24:3220–3229. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Islam S, Abiko Y, Uehara O and Chiba I: Sirtuin 1 and oral cancer. Oncol Lett. 17:729–738. 2019.PubMed/NCBI

4 

Kida Y and Goligorsky MS: Sirtuins, cell senescence, and vascular aging. Can J Cardiol. 32:634–641. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Lin Z and Fang D: The roles of SIRT1 in cancer. Genes Cancer. 4:97–104. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Rahman S and Islam R: Mammalian Sirt1: Insights on its biological functions. Cell Commun Signal. 9:112011. View Article : Google Scholar : PubMed/NCBI

7 

Potteti HR, Rajasekaran S, Rajamohan SB, Tamatam CR, Reddy NM and Reddy SP: Sirtuin 1 promotes hyperoxia-induced lung epithelial cell death independent of NF-E2-related factor 2 activation. Am J Respir Cell Mol Biol. 54:697–706. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kim SR, Lee KS, Park SJ, Min KH, Choe YH, Moon H, Yoo WH, Chae HJ, Han MK and Lee YC: Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease. J Allergy Clin Immunol. 125:449–460.e4. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, Li D, Ma G, Li W, Wu J, Lai T, Huang D, Zhao X, Lv Q, Chen M and Wu B: Increases in peripheral SIRT1: A new biological characteristic of asthma. Respirology. 20:1066–1072. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Liu Y, Yang F, Zou S and Qu L: Rapamycin: A bacteria-derived immunosuppressant that has anti-atherosclerotic effects and its clinical application. Front Pharmacol. 9:15202019. View Article : Google Scholar : PubMed/NCBI

11 

Saxton RA and Sabatini DM: mTOR signaling in growth, metabolism, and disease. Cell. 168:960–976. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Lin J, Huo X and Liu X: ‘mTOR signaling pathway’: A potential target of curcumin in the treatment of spinal cord injury. Biomed Res Int. 2017:16348012017. View Article : Google Scholar : PubMed/NCBI

13 

Salido-Vallejo R, Garnacho-Saucedo G and Vélez A: Elucidation of the mTOR pathway and therapeutic applications in dermatology. Actas Dermosifiliogr. 107:379–390. 2016.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

14 

Perl A: Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases. Nat Rev Rheumatol. 12:169–182. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y, Liu J, Zhou JS, Huang HQ, Li ZY, Xu XC, Lai TW, Hu Y, Zhou HB, Chen HP, et al: MTOR suppresses cigarette smoke-induced epithelial cell death and airway inflammation in chronic obstructive pulmonary disease. J Immunol. 200:2571–2580. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Zou H, Wang LX, Wang M, Cheng C, Li S, Shen Q, Fang L and Liu R: MTOR-mediated autophagy is involved in the protective effect of ketamine on allergic airway inflammation. J Immunol Res. 2019:58797142019. View Article : Google Scholar : PubMed/NCBI

17 

Cheng Z, Wang X, Dai L, Jia L, Jing X, Liu Y, Wang H, Li P, An L and Liu M: Suppression of microRNA-384 enhances autophagy of airway smooth muscle cells in asthmatic mouse. Oncotarget. 8:67933–67941. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Farooq MB and Walsh GM: Autophagy and asthma. Clin Exp Allergy. 46:7–9. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Urbanska M, Gozdz A, Swiech LJ and Jaworski J: Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons. J Biol Chem. 287:30240–30256. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Ma L, Dong W, Wang R, Li Y, Xu B, Zhang J, Zhao Z and Wang Y: Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice. Brain Res Bull. 116:67–72. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Guo W, Qian L, Zhang J, Zhang W, Morrison A, Hayes P, Wilson S, Chen T and Zhao J: Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. J Neurosci Res. 89:1723–1736. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Huang J, Tian R, Yang Y, Jiang R, Dai J, Tang L and Zhang L: The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia. Innate Immun. 23:678–686. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED and Li X: Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 123:3084–3098. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Kang R, Tang D, Lotze MT and Zeh Iii HJ: Autophagy is required for IL-2-mediated fibroblast growth. Exp Cell Res. 319:556–565. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Mushaben EM, Kramer EL, Brandt EB, Khurana Hershey GK and Le Cras TD: Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma. J Immunol. 187:5756–5763. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Shao YY, Zhou YM, Hu M, Li JZ, Chen CJ, Wang YJ, Shi XY, Wang WJ and Zhang TT: The anti-allergic rhinitis effect of traditional Chinese medicine of shenqi by regulating mast cell degranulation and Th1/Th2 cytokine balance. Molecules. 22:E5042017. View Article : Google Scholar : PubMed/NCBI

27 

Lee M, Kim S, Kwon OK, Oh SR, Lee HK and Ahn K: Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma. Int Immunopharmacol. 9:418–424. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Wang WR, Li TT, Jing T, Li YX, Yang XF, He YH, Zhang W, Lin R and Zhang JY: SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway. Cell Physiol Biochem. 41:569–582. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Luo G, Jian Z, Zhu Y, Zhu Y, Chen B, Ma R, Tang F and Xiao Y: Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int J Mol Med. 43:2033–2043. 2019.PubMed/NCBI

30 

Tan FH, Bai Y, Saintigny P and Darido C: mTOR signalling in head and neck cancer: Heads up. Cells. 8:E3332019. View Article : Google Scholar : PubMed/NCBI

31 

Rabanal-Ruiz Y, Otten EG and Korolchuk VI: mTORC1 as the main gateway to autophagy. Essays Biochem. 61:565–584. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Zhu X, Chu H, Jiang S, Liu Q, Liu L, Xue Y, Zheng S, Wan W, Qiu J, Wang J and Zou H: Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway. J Dermatol Sci. 87:149–158. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Li W, Hu Y, Liu Y and Sun X: Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy. Mol Med Rep 22: 2219-2226, 2020.
APA
Wu, Y., Li, W., Hu, Y., Liu, Y., & Sun, X. (2020). Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy. Molecular Medicine Reports, 22, 2219-2226. https://doi.org/10.3892/mmr.2020.11338
MLA
Wu, Y., Li, W., Hu, Y., Liu, Y., Sun, X."Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy". Molecular Medicine Reports 22.3 (2020): 2219-2226.
Chicago
Wu, Y., Li, W., Hu, Y., Liu, Y., Sun, X."Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy". Molecular Medicine Reports 22, no. 3 (2020): 2219-2226. https://doi.org/10.3892/mmr.2020.11338
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Li W, Hu Y, Liu Y and Sun X: Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy. Mol Med Rep 22: 2219-2226, 2020.
APA
Wu, Y., Li, W., Hu, Y., Liu, Y., & Sun, X. (2020). Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy. Molecular Medicine Reports, 22, 2219-2226. https://doi.org/10.3892/mmr.2020.11338
MLA
Wu, Y., Li, W., Hu, Y., Liu, Y., Sun, X."Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy". Molecular Medicine Reports 22.3 (2020): 2219-2226.
Chicago
Wu, Y., Li, W., Hu, Y., Liu, Y., Sun, X."Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy". Molecular Medicine Reports 22, no. 3 (2020): 2219-2226. https://doi.org/10.3892/mmr.2020.11338
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team