Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer

  • Authors:
    • Qiuxia Xiong
    • Songqing Fan
    • Lincan Duan
    • Baiyang Liu
    • Xiulin Jiang
    • Xiaobo Chen
    • Chunyan Xiong
    • Qingyuan Tao
    • Juan Wang
    • Hui Zhang
    • Chuanjiang Chen
    • Yong Duan
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410000, P.R. China, Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, P.R. China, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, P.R. China , Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Zhaotong, Zhaotong, Yunnan 657000, P.R. China, Department of Nuclear Medicine, The Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650021, P.R. China
    Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2916-2924
    |
    Published online on: July 28, 2020
       https://doi.org/10.3892/mmr.2020.11359
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lung cancer has a high mortality rate worldwide. Non‑SMC condensin I complex subunit H (NCAPH) has been identified to be one of the regulatory subunits of the condensin I complex, which is essential for the correct packaging and segregation of chromosomes in eukaryotes. NCAPH is abnormally overexpressed in various types of cancer. A pro‑survival member of the Bcl‑2 family, myeloid cell leukemia sequence 1 (Mcl‑1) is also frequently overexpressed in multiple cancers and is associated with poorer clinical outcomes for patients. The association of NCAPH and Mcl‑1 proteins with the clinical and pathological features of non‑small cell lung cancer (NSCLC) remains to be elucidated. In the current study, the positive percentage of NCAPH in the non‑cancerous lung tissues was revealed to be higher compared with that in NSCLC. However, the positive percentage of Mcl‑1 in the non‑cancerous lung tissues was lower compared with NSCLC. In addition, NCAPH high‑expression patients had a higher overall survival rate compared with patients exhibiting low expression, whereas the Mcl‑1 high‑expression group had a lower survival rate. Pairwise association in 260 cases of NSCLC revealed that overexpression of the NCAPH protein was negatively associated with Mcl‑1 expression and vice versa. The results of multivariate Cox proportional hazard regression analysis also indicated that NCAPH and Mcl‑1 demonstrated potential as distinct prognostic factors that may be used in NSCLC. The expression of NCAPH and Mcl‑1 may be associated with, and act as distinct molecular marks for the prediction of a poor prognosis in patients with NSCLC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Torre LA, Siegel RL, Ward EM and Jemal A: Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25:2916–27. 2016. View Article : Google Scholar

2 

Chen M, Liu X, Du J, Wang XJ and Xia L: Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers. Oncotarget. 8:133–144. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Yoshioka H, Shimokawa M, Seto T, Morita S, Yatabe Y, Okamoto I, Tsurutani J, Satouchi M, Hirashima T, Atagi S, et al: Final overall survival results of WJTOG3405, a randomized phase III trial comparing gefitinib versus cisplatin with docetaxel as the first-line treatment for patients with stage IIIB/IV or postoperative recurrent EGFR mutation-positive non-small-cell lung cancer. Ann Oncol. 30:1978–1984. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Bobbili P, Ryan K, Duh MS, Dua A, Fernandes AW, Pavilack M and Gomez JE: Treatment patterns and overall survival among patients with unresectable, stage III non-small-cell lung cancer. Future Oncol. 15:3381–3393. 2019. View Article : Google Scholar : PubMed/NCBI

5 

León-Atance P, Moreno-Mata N, González-Aragoneses F, Cañizares-Carretero MA, García-Jiménez MD, Genovés-Crespo M, Honguero-Martínez AF, Rombolá CA, Simón-Adiego CM and Peñalver-Pascual R: Multicenter analysis of survival and prognostic factors in pathologic stage I non-small-cell lung cancer according to the new 2009 TNM Classification. Arch Bronconeumol. 47:441–446. 2011.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

6 

Criss SD, Mooradian MJ, Watson TR, Gainor JF, Reynolds KL and Kong CY: Cost-effectiveness of atezolizumab combination therapy for first-line treatment of metastatic nonsquamous non-small cell lung cancer in the United States. JAMA Netw Open. 2:e19119522019. View Article : Google Scholar : PubMed/NCBI

7 

Rosser CJ and Goodison S: CD24, a promising biomarker in NSCLC. Biomark Med. 4:4952010. View Article : Google Scholar

8 

Zhan SJ, Liu B and Linghu H: Identifying genes as potential prognostic indicators in patients with serous ovarian cancer resistant to carboplatin using integrated bioinformatics analysis. Oncol Rep. 39:2653–2663. 2018.PubMed/NCBI

9 

Sun C, Huang S, Wang H, Xie R, Zhang L, Zhou Q, He X and Ju W: Non-SMC condensin I complex subunit H enhances proliferation, migration, and invasion of hepatocellular carcinoma. Mol Carcinog. 58:2266–2275. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Hirano T: Condensins: Universal organizers of chromosomes with diverse functions. Genes Dev. 26:1659–1678. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Wood AJ, Severson AF and Meyer BJ: Condensin and cohesin complexity: The expanding repertoire of functions. Nat Rev Genet. 11:391–404. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kimura K, Cuvier O and Hirano T: Chromosome condensation by a human condensin complex in xenopus egg extracts. J Biol Chem. 276:5417–5420. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Martin CA, Murray JE, Carroll P, Leitch A, Mackenzie KJ, Halachev M, Fetit AE, Keith C, Bicknell LS, Fluteau A, et al: Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Genes Dev. 30:2158–2172. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Yin L, Jiang LP, Shen QS, Xiong QX, Zhuo X, Zhang LL, Yu HJ, Guo X, Luo Y, Dong J, et al: NCAPH plays important roles in human colon cancer. Cell Death Dis. 8:e26802017. View Article : Google Scholar : PubMed/NCBI

15 

Ryu B, Kim DS, Deluca AM and Alani RM: Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One. 2:e5942007. View Article : Google Scholar : PubMed/NCBI

16 

Xu L, Jiang Y, Zheng J, Xie G, Li J, Shi L and Fan S: Aberrant expression of β-catenin and e-cadherin is correlated with poor prognosis of nasopharyngeal cancer. Hum Pathol. 44:1357–1364. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Granville CA and Dennis PA: An overview of lung cancer genomics and proteomics. Am J Respir Cell Mol Biol. 32:169–176. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Kozopas KM, Yang T, Buchan HL, Zhou P and Craig RW: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci USA. 90:3516–3520. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Han Y, Wu N, Jiang M, Chu Y, Wang Z, Liu H, Cao J, Liu H, Xu B and Xie X: Long non-coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-29c-3p in gastric cancer. Cell Prolif. 52:e126782019. View Article : Google Scholar : PubMed/NCBI

20 

Kour S, Rana S, Contreras JI, King HM, Robb CM, Sonawane YA, Bendjennat M, Crawford AJ, Barger CJ, Kizhake S, et al: CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax. Mol Pharmacol. 96:419–429. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Meister MT, Boedicker C, Linder B, Kogel D, Klingebiel T and Fulda S: Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Cancer Lett. 465:1–11. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Akgul C: Mcl-1 is a potential therapeutic target in multiple types of cancer. Cell Mol Life Sci. 66:1326–1336. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Zhang H, Guttikonda S, Roberts L, Uziel T, Semizarov D, Elmore SW, Leverson JD and Lam LT: Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines. Oncogene. 30:1963–1968. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Whitsett TG, Mathews IT, Cardone MH, Lena RJ, Pierceall WE, Bittner M, Sima C, LoBello J, Weiss GJ and Tran NL: Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response. Mol Cancer Res. 12:550–559. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Yang S, Kim CY, Hwang S, Kim E, Kim H, Shim H and Lee I: COEXPEDIA: Exploring biomedical hypotheses via co-expressions associated with medical subject headings (MeSH). Nucleic Acids Res. 45(D1):D389–D396. 2017. View Article : Google Scholar

26 

Travis WD, Brambilla E, Burke AP, Marx A and Nicholson AG: WHO Classification of tumours of the lung, pleura, thymus and heart. WHO Classification of Tumours. 7. 4th. IARC; Lyon: 2015

27 

Boffa DJ and Greene FL: Reacting to changes in staging designations in the 7th edition of the AJCC staging manual. Ann Surg Oncol. 18:1–3. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Wen Q, Wang W, Luo J, Chu S, Chen L, Xu L, Zang H, Alnemah MM, Ma J and Fan S: CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway. Oncotarget. 7:27787–27801. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Wen Q, Wang W, Chu S, Luo J, Chen L, Xie G, Xu L, Li M and Fan S: Flot-2 expression correlates with EGFR levels and poor prognosis in surgically resected non-small cell lung cancer. PLoS One. 10:e01321902015. View Article : Google Scholar : PubMed/NCBI

30 

Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J, et al: Genomic and functional approaches to understanding cancer aneuploidy. Cancer Cell. 33:676–689.e673. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, et al: Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies. Cancer Discov. 7:596–609. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Janjigian YY, Sanchez-Vega F, Jonsson P, Chatila WK, Hechtman JF, Ku GY, Riches JC, Tuvy Y, Kundra R, Bouvier N, et al: Genetic predictors of response to systemic therapy in esophagogastric cancer. Cancer Discov. 8:49–58. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Soumerai TE, Donoghue MTA, Bandlamudi C, Srinivasan P, Chang MT, Zamarin D, Cadoo KA, Grisham RN, O'Cearbhaill RE, Tew WP, et al: Clinical utility of prospective molecular characterization in advanced endometrial cancer. Clin Cancer Res. 24:5939–5947. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Witkiewicz AK, McMillan EA, Balaji U, Baek G, Lin WC, Mansour J, Mollaee M, Wagner KU, Koduru P, Yopp A, et al: Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat Commun. 6:67442015. View Article : Google Scholar : PubMed/NCBI

35 

Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER III, Barretina J, Gelfand ET, Bielski CM, Li H, et al: Next-generation characterization of the cancer cell line encyclopedia. Nature. 569:503–508. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Yaeger R, Chatila WK, Lipsyc MD, Hechtman JF, Cercek A, Sanchez-Vega F, Jayakumaran G, Middha S, Zehir A, Donoghue MTA, et al: Clinical sequencing defines the genomic landscape of metastatic colorectal cancer. Cancer Cell. 33:125–136.e3. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Pereira B, Chin SF, Rueda OM, Vollan HK, Provenzano E, Bardwell HA, Pugh M, Jones L, Russell R, Sammut SJ, et al: The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. Nat Commun. 7:114792016. View Article : Google Scholar : PubMed/NCBI

38 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: StarBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42((Database Issue)): D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Neuwald AF and Hirano T: HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions. Genome Res. 10:1445–1452. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Lawrimore J and Bloom K: The regulation of chromosome segregation via centromere loops. Crit Rev Biochem Mol Biol. 54:352–370. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Senichkin VV, Streletskaia AY, Zhivotovsky B and Kopeina GS: Molecular comprehension of Mcl-1: From gene structure to cancer therapy. Trends Cell Biol. 29:549–562. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Song L, Coppola D, Livingston S, Cress D and Haura EB: Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther. 4:267–276. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Huang H, Shah K, Bradbury NA, Li C and White C: Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation. Cell Death Dis. 5:e14822014. View Article : Google Scholar : PubMed/NCBI

44 

Mojsa B, Lassot I and Desagher S: Mcl-1 ubiquitination: Unique regulation of an essential survival protein. Cells. 3:418–437. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Young AI, Timpson P, Gallego-Ortega D, Ormandy CJ and Oakes SR: Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion. Cell Adh Migr. 12:513–523. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Fujise K, Zhang D, Liu J and Yeh ET: Regulation of apoptosis and cell cycle progression by MCL1: Differential role of proliferating cell nuclear antigen. J Biol Chem. 275:39458–39465. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Jamil S, Mojtabavi S, Hojabrpour P, Cheah S and Duronio V: An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation. Mol Biol Cell. 19:3212–3220. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiong Q, Fan S, Duan L, Liu B, Jiang X, Chen X, Xiong C, Tao Q, Wang J, Zhang H, Zhang H, et al: NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer . Mol Med Rep 22: 2916-2924, 2020.
APA
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X. ... Duan, Y. (2020). NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer . Molecular Medicine Reports, 22, 2916-2924. https://doi.org/10.3892/mmr.2020.11359
MLA
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X., Xiong, C., Tao, Q., Wang, J., Zhang, H., Chen, C., Duan, Y."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer ". Molecular Medicine Reports 22.4 (2020): 2916-2924.
Chicago
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X., Xiong, C., Tao, Q., Wang, J., Zhang, H., Chen, C., Duan, Y."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer ". Molecular Medicine Reports 22, no. 4 (2020): 2916-2924. https://doi.org/10.3892/mmr.2020.11359
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong Q, Fan S, Duan L, Liu B, Jiang X, Chen X, Xiong C, Tao Q, Wang J, Zhang H, Zhang H, et al: NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer . Mol Med Rep 22: 2916-2924, 2020.
APA
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X. ... Duan, Y. (2020). NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer . Molecular Medicine Reports, 22, 2916-2924. https://doi.org/10.3892/mmr.2020.11359
MLA
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X., Xiong, C., Tao, Q., Wang, J., Zhang, H., Chen, C., Duan, Y."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer ". Molecular Medicine Reports 22.4 (2020): 2916-2924.
Chicago
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X., Xiong, C., Tao, Q., Wang, J., Zhang, H., Chen, C., Duan, Y."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer ". Molecular Medicine Reports 22, no. 4 (2020): 2916-2924. https://doi.org/10.3892/mmr.2020.11359
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team