Open Access

NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer

  • Authors:
    • Qiuxia Xiong
    • Songqing Fan
    • Lincan Duan
    • Baiyang Liu
    • Xiulin Jiang
    • Xiaobo Chen
    • Chunyan Xiong
    • Qingyuan Tao
    • Juan Wang
    • Hui Zhang
    • Chuanjiang Chen
    • Yong Duan
  • View Affiliations

  • Published online on: July 28, 2020     https://doi.org/10.3892/mmr.2020.11359
  • Pages: 2916-2924
  • Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer has a high mortality rate worldwide. Non‑SMC condensin I complex subunit H (NCAPH) has been identified to be one of the regulatory subunits of the condensin I complex, which is essential for the correct packaging and segregation of chromosomes in eukaryotes. NCAPH is abnormally overexpressed in various types of cancer. A pro‑survival member of the Bcl‑2 family, myeloid cell leukemia sequence 1 (Mcl‑1) is also frequently overexpressed in multiple cancers and is associated with poorer clinical outcomes for patients. The association of NCAPH and Mcl‑1 proteins with the clinical and pathological features of non‑small cell lung cancer (NSCLC) remains to be elucidated. In the current study, the positive percentage of NCAPH in the non‑cancerous lung tissues was revealed to be higher compared with that in NSCLC. However, the positive percentage of Mcl‑1 in the non‑cancerous lung tissues was lower compared with NSCLC. In addition, NCAPH high‑expression patients had a higher overall survival rate compared with patients exhibiting low expression, whereas the Mcl‑1 high‑expression group had a lower survival rate. Pairwise association in 260 cases of NSCLC revealed that overexpression of the NCAPH protein was negatively associated with Mcl‑1 expression and vice versa. The results of multivariate Cox proportional hazard regression analysis also indicated that NCAPH and Mcl‑1 demonstrated potential as distinct prognostic factors that may be used in NSCLC. The expression of NCAPH and Mcl‑1 may be associated with, and act as distinct molecular marks for the prediction of a poor prognosis in patients with NSCLC.
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October-2020
Volume 22 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Xiong Q, Fan S, Duan L, Liu B, Jiang X, Chen X, Xiong C, Tao Q, Wang J, Zhang H, Zhang H, et al: NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer . Mol Med Rep 22: 2916-2924, 2020
APA
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X. ... Duan, Y. (2020). NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer . Molecular Medicine Reports, 22, 2916-2924. https://doi.org/10.3892/mmr.2020.11359
MLA
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X., Xiong, C., Tao, Q., Wang, J., Zhang, H., Chen, C., Duan, Y."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer ". Molecular Medicine Reports 22.4 (2020): 2916-2924.
Chicago
Xiong, Q., Fan, S., Duan, L., Liu, B., Jiang, X., Chen, X., Xiong, C., Tao, Q., Wang, J., Zhang, H., Chen, C., Duan, Y."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer ". Molecular Medicine Reports 22, no. 4 (2020): 2916-2924. https://doi.org/10.3892/mmr.2020.11359