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Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study

  • Authors:
    • Rulin Zhao
    • Conghua Song
    • Li Liu
    • Qiong Liu
    • Nanjin Zhou
    • Xiaojiang Zhou
    • Yong Xie
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Jiangxi Institute of Medical Sciences, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2851-2859
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    Published online on: July 28, 2020
       https://doi.org/10.3892/mmr.2020.11379
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Abstract

Single immunoglobulin and Toll‑interleukin‑1 receptor domain‑containing molecule (SIGIRR) is a specific inhibitor of IL‑1R and Toll‑like receptor (TLR) signaling and considered a potential target for the treatment of inflammatory diseases. Pathogenic mechanisms associated with the TLR4 signaling pathway have a critical role in the development of severe acute pancreatitis (SAP). The aim of the present study was to determine the role of SIGIRR in the regulation of TLR4 signaling during the progression of SAP. Pancreatitis‑associated ascitic fluid (PAAF) was collected from patients with SAP. Murine RAW264.7 macrophages were transfected with a SIGIRR overexpression plasmid and co‑cultured with the PAAF from the donors in order to evaluate the effect of SIGIRR in vitro. The mRNA expression of TLR4, SIGIRR and other key downstream signaling molecules was quantified using semi‑quantitative PCR with agarose gel electrophoresis. Furthermore, the levels of pro‑inflammatory cytokines in the culture supernatant were detected using ELISA. In contrast to SIGIRR, the mRNA expression levels of TLR4, myeloid differentiation factor 88 (MyD88), IL‑1R‑associated kinase‑1 (IRAK‑1) and TNF receptor‑associated factor‑6 (TRAF‑6) were significantly increased in RAW264.7 cells following treatment with PAAF. Furthermore, TLR4, MyD88, IRAK‑1 and TRAF‑6 mRNA levels were significantly downregulated following SIGIRR overexpression and PAAF treatment in RAW264.7 cells. The levels of IL‑2, IL‑12, IL‑17 and IFN‑γ in the culture supernatant were also significantly decreased, while IL‑10 levels were increased. Overall, SIGIRR negatively regulated the TLR4 signaling pathway to protect against the development of SAP in an in vitro model. Therefore, SIGIRR may represent a promising therapeutic target for SAP.
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View References

1 

Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG and Vege SS; Acute Pancreatitis Classification Working Group, : Classification of acute pancreatitis-2012: Revision of the Atlanta classification and definitions by international consensus. Gut. 62:2851–111. 2013. View Article : Google Scholar

2 

Roberts SE, Akbari A, Thorne K, Atkinson M and Evans PA: The incidence of acute pancreatitis: Impact of social deprivation, alcohol consumption, seasonal and demographic factors. Aliment Pharmacol Ther. 38:539–548. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Gou S, Yang C, Yin T, Liu T, Wu H, Xiong J, Yang Z and Wang C: Percutaneous catheter drainage of pancreatitis-associated ascitic fluid in early-stage severe acute pancreatitis. Pancreas. 44:1161–1162. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Li Z, Xia C, Zhang L, Zhang Y, Liu Z and Qiu F: Peritoneal lavage for severe acute pancreatitis: A meta-analysis and systematic review. Pancreas. 45:806–813. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Huang Z, Yu SH, Liang HY, Zhou J, Yan HT, Chen T, Cheng L, Ning L, Wang T, Luo ZL, et al: Outcome benefit of abdominal paracentesis drainage for severe acute pancreatitis patients with serum triglyceride elevation by decreasing serum lipid metabolites. Lipids Health Dis. 15:1102016. View Article : Google Scholar : PubMed/NCBI

6 

De Nardo D: Toll-like receptors: Activation, signalling and transcriptional modulation. Cytokine. 74:181–189. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Molteni M, Gemma S and Rossetti C: The role of toll-like receptor 4 in infectious and noninfectious inflammation. Mediators Inflamm. 2016:69789362016. View Article : Google Scholar : PubMed/NCBI

8 

Skjesol A, Yurchenko M, Bösl K, Gravastrand C, Nilsen KE, Grøvdal LM, Agliano F, Patane F, Lentini G, Kim H, et al: The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 15:e10076842019. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, Cui Y, Cao F, Qin Y, Li W and Zhang J: Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-κB signaling pathways through TLR4. Int Immunopharmacol. 28:136–145. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Minkov GA, Halacheva KS, Yovtchev YP and Gulubova MV: Pathophysiological mechanisms of acute pancreatitis define inflammatory markers of clinical prognosis. Pancreas. 44:713–717. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Li G, Wu X, Yang L, He Y, Liu Y, Jin X and Yuan H: TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis. Int J Mol Med. 37:99–107. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Zhong K: Curcumin mediates a protective effect via TLR-4/NF-κB signaling pathway in rat model of severe acute pancreatitis. Cell Biochem Biophys. 73:175–180. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Drexler SK, Kong P, Inglis J, Williams RO, Garlanda C, Mantovani A, Yazdi AS, Brennan F, Feldmann M and Foxwell BM: SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis. Arthritis Rheum. 62:2249–2261. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Fawley J, Cuna A, Menden HL, McElroy S, Umar S, Welak SR, Gourlay DM, Li X and Sampath V: Single-immunoglobulin interleukin-1-related receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. Pediatr Res. 83:164–174. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR and Li X: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4:920–927. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Molgora M, Supino D, Mantovani A and Garlanda C: Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8. Immunol Rev. 281:233–247. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Landahl P, Ansari D and Andersson R: Severe acute pancreatitis: Gut barrier failure, systemic inflammatory response, acute lung injury, and the role of the mesenteric lymph. Surg Infect (Larchmt). 16:651–656. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zhou J, Huang Z, Lin N, Liu W, Yang G, Wu D, Xiao H, Sun H and Tang L: Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal XDH/XOD. Free Radic Biol Med. 99:374–384. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Satoh A, Shimosegawa T, Masamune A, Fujita M, Koizumi M and Toyota T: Ascitic fluid of experimental severe acute pancreatitis modulates the function of peritoneal macrophages. Pancreas. 19:268–275. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Ramudo L, Manso MA and De Dios I: Biliary pancreatitis-associated ascitic fluid activates the production of tumor necrosis factor-alpha in acinar cells. Crit Care Med. 33:143–148. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Gutierrez PT, Folch-Puy E, Bulbena O and Closa D: Oxidised lipids present in ascitic fluid interfere with the regulation of the macrophages during acute pancreatitis, promoting an exacerbation of the inflammatory response. Gut. 57:642–648. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Pérez S, Finamor I, Martí-Andrés P, Pereda J, Campos A, Domingues R, Haj F, Sabater L, de-Madaria E and Sastre J: Role of obesity in the release of extracellular nucleosomes in acute pancreatitis: A clinical and experimental study. Int J Obes (Lond). 43:158–168. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Hietaranta A, Mustonen H, Puolakkainen P, Haapiainen R and Kemppainen E: Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB. Biochem Biophys Res Commun. 323:192–196. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Xue J and Habtezion A: Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition. J Clin Invest. 124:437–447. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Pan LF, Yu L, Wang LM, He JT, Sun JL, Wang XB, Wang H, Bai ZH, Feng H and Pei HH: Augmenter of liver regeneration (ALR) regulates acute pancreatitis via inhibiting HMGB1/TLR4/NF-κB signaling pathway. Am J Transl Res. 10:402–410. 2018.PubMed/NCBI

26 

Xiao H, Yin W, Khan MA, Gulen MF, Zhou H, Sham HP, Jacobson K, Vallance BA and Li X: Loss of single immunoglobulin interleukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice. Gastroenterology. 139:574–585. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Zhao J, Zepp J, Bulek K and Li X: SIGIRR, a negative regulator of colon tumorigenesis. Drug Discov Today Dis Mech. 8:e63–e69. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Anders HJ: Pseudoviral immunity-a novel concept for lupus. Trends Mol Med. 15:553–561. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Xu P, Hou YQ, Xu K, Li QH and Huang L: Pancreatitis-associated ascitic fluid induces proinflammatory cytokine expression in THP-1 cells by inhibiting anti-inflammatory signaling. Pancreas. 42:855–860. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Hongliang T, Rong Z, Xiaojing W, Rao S, Lun L, Jinhui T, Nong C and Kehu Y: The effects of continuous blood purification for SIRS/MODS patients: A systematic review and meta-analysis of randomized controlled trials. ISRN Hematol. 2012:9867952012. View Article : Google Scholar : PubMed/NCBI

31 

Sharif R, Dawra R, Wasiluk K, Phillips P, Dudeja V, Kurt-Jones E, Finberg R and Saluja A: Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Gut. 58:813–819. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Sawa H, Ueda T, Takeyama Y, Yasuda T, Shinzeki M, Nakajima T and Kuroda Y: Role of toll-like receptor 4 in the pathophysiology of severe acute pancreatitis in mice. Surg Today. 37:867–873. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Awla D, Abdulla A, Regnér S and Thorlacius H: TLR4 but not TLR2 regulates inflammation and tissue damage in acute pancreatitis induced by retrograde infusion of taurocholate. Inflamm Res. 60:1093–1098. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Riva F, Bonavita E, Barbati E, Muzio M, Mantovani A and Garlanda C: TIR8/SIGIRR is an interleukin-1 receptor/Toll like receptor family member with regulatory functions in inflammation and immunity. Front Immunol. 3:3222012. View Article : Google Scholar : PubMed/NCBI

35 

Huang X, Hazlett LD, Du W and Barrett RP: SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. J Immunol. 177:548–556. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Stahl M, Ries J, Vermeulen J, Yang H, Sham HP, Crowley SM, Badayeva Y, Turvey SE, Gaynor EC, Li X and Vallance BA: A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection. PLoS Pathog. 10:e10042642014. View Article : Google Scholar : PubMed/NCBI

37 

Gong D, Zhang P, Ji D, Chen Z, Li W, Li J, Li L and Liu Z: Improvement of immune dysfunction in patients with severe acute pancreatitis by high-volume hemofiltration: A preliminary report. Int J Artif Organs. 33:22–29. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Dai SR, Li Z and Zhang JB: Serum interleukin 17 as an early prognostic biomarker of severe acute pancreatitis receiving continuous blood purification. Int J Artif Organs. 38:192–198. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Keceli M, Kucuk C, Sozuer E, Kerek M, Ince O and Arar M: The effect of interleukin-10 on acute pancreatitis induced by cerulein in a rat experimental model. J Invest Surg. 18:7–12. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Liu J, Chen Y, Liu D, Liu W, Hu S, Zhou N and Xie Y: Ectopic expression of SIGIRR in the colon ameliorates colitis in mice by downregulating TLR4/NF-κB overactivation. Immunol Lett. 183:52–61. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao R, Song C, Liu L, Liu Q, Zhou N, Zhou X and Xie Y: Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study. Mol Med Rep 22: 2851-2859, 2020.
APA
Zhao, R., Song, C., Liu, L., Liu, Q., Zhou, N., Zhou, X., & Xie, Y. (2020). Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study. Molecular Medicine Reports, 22, 2851-2859. https://doi.org/10.3892/mmr.2020.11379
MLA
Zhao, R., Song, C., Liu, L., Liu, Q., Zhou, N., Zhou, X., Xie, Y."Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study". Molecular Medicine Reports 22.4 (2020): 2851-2859.
Chicago
Zhao, R., Song, C., Liu, L., Liu, Q., Zhou, N., Zhou, X., Xie, Y."Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study". Molecular Medicine Reports 22, no. 4 (2020): 2851-2859. https://doi.org/10.3892/mmr.2020.11379
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao R, Song C, Liu L, Liu Q, Zhou N, Zhou X and Xie Y: Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study. Mol Med Rep 22: 2851-2859, 2020.
APA
Zhao, R., Song, C., Liu, L., Liu, Q., Zhou, N., Zhou, X., & Xie, Y. (2020). Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study. Molecular Medicine Reports, 22, 2851-2859. https://doi.org/10.3892/mmr.2020.11379
MLA
Zhao, R., Song, C., Liu, L., Liu, Q., Zhou, N., Zhou, X., Xie, Y."Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study". Molecular Medicine Reports 22.4 (2020): 2851-2859.
Chicago
Zhao, R., Song, C., Liu, L., Liu, Q., Zhou, N., Zhou, X., Xie, Y."Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study". Molecular Medicine Reports 22, no. 4 (2020): 2851-2859. https://doi.org/10.3892/mmr.2020.11379
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