Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway

  • Authors:
    • Bing Fei
    • Zhibiao Liu
    • Lisheng Xie
    • Lingyun Lv
    • Wenyan Zhu
    • Jing Liu
    • Yanhong Dai
    • Wandong She
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Department of Otolaryngology‑Head and Neck Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, Jiangsu 210008, P.R. China
  • Pages: 3533-3540
    |
    Published online on: July 30, 2020
       https://doi.org/10.3892/mmr.2020.11390
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cisplatin‑induced cytotoxicity, such as nephrotoxicity, neurotoxicity and ototoxicity, restricts the clinical application of this compound. Panax notoginseng Saponins (PNS) exhibit potent free radical scavenging and antioxidant activity. PNS have been demonstrated to reduce cisplatin‑induced nephrotoxicity and neurotoxicity. The present study investigated the ability of PNS to protect the auditory HEI‑OC1 cell line against ototoxicity induced by cisplatin. PNS induced activation of the AKT/nuclear factor erythroid 2‑related factor 2 (Nrf2) signaling pathway. Following pretreatment with PNS, HEI‑OC1 cells were treated with cisplatin and cultured for 24 h. The viability of HEI‑OC1 cells was examined using a Cell Counting Kit‑8 assay. Double staining analysis was used to measure cell apoptosis. The ability of PNS to reduce reactive oxygen species (ROS) levels was assessed by flow cytometry. The levels of phosphorylated (p)‑AKT, heme oxygenase 1 (HO‑1), NAD(P)H quinone dehydrogenase 1 (NQO1), glutamate‑cysteine ligase catalytic (GCLC) and Nrf2 were measured by western blotting. HEI‑OC1 cells that were pretreated with PNS exhibited significantly increased cell viability compared with that noted in cells treated only with cisplatin. In addition, PNS suppressed the induction of apoptosis and ROS production following cisplatin treatment. The upregulation of NQO1, HO‑1 and GCLC expression in PNS‑pretreated cells was associated with p‑AKT levels and the activation of Nrf2. These findings suggested that PNS protected auditory cells against ototoxicity induced by cisplatin by activating AKT/Nrf2 signaling. PNS may serve as a potential candidate in regulating cisplatin‑induced cytotoxicity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Kelland L: The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer. 7:3533–584. 2007. View Article : Google Scholar

2 

Chovanec M, Abu Zaid M, Hanna N, El-Kouri N, Einhorn LH and Albany C: Long-term toxicity of cisplatin in germ-cell tumor survivors. Ann Oncol. 28:2670–2679. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Rybak LP, Mukherjea D, Jajoo S and Ramkumar V: Cisplatin ototoxicity and protection: Clinical and experimental studies. Tohoku J Exp Med. 219:177–186. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Sheth S, Mukherjea D, Rybak LP and Ramkumar V: Mechanisms of cisplatin-induced ototoxicity and otoprotection. Front Cell Neurosci. 11:3382017. View Article : Google Scholar : PubMed/NCBI

5 

Kursunluoglu G, Taskiran D and Kayali HA: The investigation of the antitumor agent toxicity and capsaicin effect on the electron transport chain enzymes, catalase activities and lipid peroxidation levels in lung, heart and brain tissues of rats. Molecules. 23:32672018. View Article : Google Scholar

6 

Breglio AM, Rusheen AE, Shide ED, Fernandez KA, Spielbauer KK, McLachlin MM, Hall MD, Amable L and Cunningham LL: Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun. 8:16542017. View Article : Google Scholar : PubMed/NCBI

7 

Moroso MJ and Blair RL: A review of cis-platinum ototoxicity. J Otolaryngol. 12:365–379. 1983.PubMed/NCBI

8 

Sakamoto M, Kaga K and Kamio T: Extended high-frequency ototoxicity induced by the first administration of cisplatin. Otolaryngol Head Neck Surg. 122:828–833. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Waissbluth S and Daniel SJ: Cisplatin-induced ototoxicity: Transporters playing a role in cisplatin toxicity. Hear Res. 299:37–45. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Ravi R, Somani SM and Rybak LP: Mechanism of cisplatin ototoxicity: Antioxidant system. Pharmacol Toxicol. 76:386–394. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Rybak LP, Ravi R and Somani SM: Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: Antioxidant system. Fundam Appl Toxicol. 26:293–300. 1995. View Article : Google Scholar : PubMed/NCBI

12 

So H, Kim H, Kim Y, Kim E, Pae HO, Chung HT, Kim HJ, Kwon KB, Lee KM, Lee HY, et al: Evidence that cisplatin-induced auditory damage is attenuated by downregulation of pro-inflammatory cytokines via Nrf2/HO-1. J Assoc Res Otolaryngol. 9:290–306. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Vomund S, Schäfer A, Parnham MJ, Brüne B and Knethen A: Nrf2, the master regulator of anti-oxidative responses. Int J Mol Sci. 18:27722017. View Article : Google Scholar

14 

Kopke RD, Liu W, Gabaizadeh R, Jacono A, Feghali J, Spray D, Garcia P, Steinman H, Malgrange B, Ruben RJ, et al: Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol. 18:559–571. 1997.PubMed/NCBI

15 

Kim SJ, Park C, Han AL, Youn MJ, Lee JH, Kim Y, Kim ES, Kim HJ, Kim JK, Lee HK, et al: Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells. Hear Res. 251:70–82. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Na HK and Surh YJ: Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1. Free Radic Biol Med. 67:353–365. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Vriend J and Reiter RJ: The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome. Mol Cell Endocrinol. 401:213–220. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Li C, Xu T, Zhou P, Zhang J, Guan G, Zhang H, Ling X, Li W, Meng F, Liu G, et al: Post-marketing safety surveillance and re-evaluation of Xueshuantong injection. BMC Complement Altern Med. 18:2772018. View Article : Google Scholar : PubMed/NCBI

19 

Huang Y, Guo B, Shi B, Gao Q and Zhou Q: Chinese herbal medicine xueshuantong enhances cerebral blood flow and improves neural functions in Alzheimer's disease mice. J Alzheimers Dis. 63:1089–1107. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Liang X, Yang Y, Huang Z, Zhou J, Li Y and Zhong X: Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α. Oncotarget. 8:102989–103003. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Liu X, Huang Z, Zou X, Yang Y, Qiu Y and Wen Y: Panax notoginseng saponins attenuates cisplatin-induced nephrotoxicity via inhibiting the mitochondrial pathway of apoptosis. Int J Clin Exp Pathol. 7:8391–8400. 2014.PubMed/NCBI

22 

Liu X, Huang Z, Zou X, Yang Y, Qiu Y and Wen Y: Possible mechanism of PNS protection against cisplatin-induced nephrotoxicity in rat models. Toxicol Mech Methods. 25:347–354. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Liu SJ and Zhou SW: Panax notoginseng saponins attenuated cisplatin-induced nephrotoxicity. Acta Pharmacol Sin. 21:257–260. 2000.PubMed/NCBI

24 

Hu S, Wu Y, Zhao B, Hu H, Zhu B, Sun Z, Li P and Du S: Panax notoginseng saponins protect cerebral microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/Akt/Nrf2 antioxidant signaling pathway. Molecules. 23:27812018. View Article : Google Scholar

25 

Kalinec G, Thein P, Park C and Kainec F: HEI-OC1 cells as a model for investigating drug cytotoxicity. Hear Res. 335:105–117. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Kalinec GM, Webster P, Lim DJ and Kalinec F: A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol. 8:177–189. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Unoki T, Akiyama M, Kumagai Y, Gonçalves FM, Farina M, da Rocha JBT and Aschner M: Molecular pathways associated with methylmercury-induced Nrf2 modulation. Front Genet. 9:3732018. View Article : Google Scholar : PubMed/NCBI

28 

Hill JM, Loeb E, MacLellan A, Hill NO, Khan A and King JJ: Clinical studies of platinum coordination compounds in the treatment of various malignant diseases. Cancer Chemother Rep. 59:647–659. 1975.PubMed/NCBI

29 

Hill JM and Speer RJ: Organo-platinum complexes as antitumor agents (review). Anticancer Res. 2:173–186. 1982.PubMed/NCBI

30 

Sun CY, Zhang QY, Zheng GJ and Feng B: Phytochemicals: Current strategy to sensitize cancer cells to cisplatin. Biomed Pharmacother. 110:518–527. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Cepeda V, Fuertes MA, Castilla J, Alonso C, Quevedo C and Pérez JM: Biochemical mechanisms of cisplatin cytotoxicity. Anticancer Agents Med Chem. 7:3–18. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Trendowski MR, El Charif O, Dinh PC Jr, Travis LB and Dolan ME: Genetic and modifiable risk factors contributing to cisplatin-induced toxicities. Clin Cancer Res. 25:1147–1155. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Travis LB, Fossa SD, Sesso HD, Frisina RD, Herrmann DN, Beard CJ, Feldman DR, Pagliaro LC, Miller RC, Vaughn DJ, et al: Chemotherapy-induced peripheral neurotoxicity and ototoxicity: New paradigms for translational genomics. J Natl Cancer Inst. 106:dju0442014. View Article : Google Scholar : PubMed/NCBI

34 

Im GJ, Chang J, Lee S, Choi J, Jung HH, Lee HM, Ryu SH, Park SK, Kim JH and Kim HJ: Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line. Hear Res. 330:113–118. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Kim SJ, Park C, Lee JN, Lim H, Hong GY, Moon SK, Lim DJ, Choe SK and Park R: Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins. Toxicol Appl Pharmacol. 288:192–202. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wang T, Guo R, Zhou G, Zhou X, Kou Z, Sui F, Li C, Tang L and Wang Z: Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review. J Ethnopharmacol. 188:234–258. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Zhao H, Han Z, Li G, Zhang S and Luo Y: Therapeutic potential and cellular mechanisms of Panax notoginseng on prevention of aging and cell senescence-associated diseases. Aging Dis. 8:721–739. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Rybak LP, Mukherjea D and Ramkumar V: Mechanisms of cisplatin-induced ototoxicity and prevention. Semin Hear. 40:197–204. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Callejo A, Sedó-Cabezón L, Juan ID and Llorens J: Cisplatin-induced ototoxicity: Effects, mechanisms and protection strategies. Toxics. 3:268–293. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Op de Beeck K, Schacht J and Van Camp G: Apoptosis in acquired and genetic hearing impairment: The programmed death of the hair cell. Hear Res. 281:18–27. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Yang PF, Song XY and Chen NH: Advances in pharmacological studies of Panax notoginseng saponins on brain ischemia-reperfusion injury. Yao Xue Xue Bao. 51:1039–1046. 2016.(In Chinese).

42 

Su P, Wang L, Du SJ, Xin WF and Zhang WS: Advance in studies of Panax notoginseng saponins on pharmacological mechanism of nervous system disease. Zhongguo Zhong Yao Za Zhi. 39:4516–4521. 2014.(In Chinese). PubMed/NCBI

43 

Ooi BK, Goh BH and Yap WH: Oxidative stress in cardiovascular diseases: Involvement of Nrf2 antioxidant redox signaling in macrophage foam cells formation. Int J Mol Sci. 18:23362017. View Article : Google Scholar

44 

Lourenço Dos Santos S, Petropoulos I and Friguet B: The oxidized protein repair enzymes methionine sulfoxide reductases and their roles in protecting against oxidative stress, in ageing and in regulating protein function. Antioxidants (Basel). 7:1912018. View Article : Google Scholar

45 

Machado-Silva A, Cerqueira PG, Grazielle-Silva V, Gadelha FR, Peloso Ede F, Teixeira SM and Machado CR: How trypanosoma cruzi deals with oxidative stress: Antioxidant defence and DNA repair pathways. Mutat Res Rev Mutat Res. 767:8–22. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fei B, Liu Z, Xie L, Lv L, Zhu W, Liu J, Dai Y and She W: Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway. Mol Med Rep 22: 3533-3540, 2020.
APA
Fei, B., Liu, Z., Xie, L., Lv, L., Zhu, W., Liu, J. ... She, W. (2020). Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway. Molecular Medicine Reports, 22, 3533-3540. https://doi.org/10.3892/mmr.2020.11390
MLA
Fei, B., Liu, Z., Xie, L., Lv, L., Zhu, W., Liu, J., Dai, Y., She, W."Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway". Molecular Medicine Reports 22.4 (2020): 3533-3540.
Chicago
Fei, B., Liu, Z., Xie, L., Lv, L., Zhu, W., Liu, J., Dai, Y., She, W."Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway". Molecular Medicine Reports 22, no. 4 (2020): 3533-3540. https://doi.org/10.3892/mmr.2020.11390
Copy and paste a formatted citation
x
Spandidos Publications style
Fei B, Liu Z, Xie L, Lv L, Zhu W, Liu J, Dai Y and She W: Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway. Mol Med Rep 22: 3533-3540, 2020.
APA
Fei, B., Liu, Z., Xie, L., Lv, L., Zhu, W., Liu, J. ... She, W. (2020). Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway. Molecular Medicine Reports, 22, 3533-3540. https://doi.org/10.3892/mmr.2020.11390
MLA
Fei, B., Liu, Z., Xie, L., Lv, L., Zhu, W., Liu, J., Dai, Y., She, W."Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway". Molecular Medicine Reports 22.4 (2020): 3533-3540.
Chicago
Fei, B., Liu, Z., Xie, L., Lv, L., Zhu, W., Liu, J., Dai, Y., She, W."Panax notoginseng Saponins protect auditory cells against cisplatin‑induced ototoxicity by inducing the AKT/Nrf2 signaling‑mediated redox pathway". Molecular Medicine Reports 22, no. 4 (2020): 3533-3540. https://doi.org/10.3892/mmr.2020.11390
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team