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PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18

  • Authors:
    • Jie Tang
    • Qinge Meng
    • Ruirui Shi
    • Youqi Xu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210017, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3161-3172
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    Published online on: August 3, 2020
       https://doi.org/10.3892/mmr.2020.11402
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Abstract

Lung adenocarcinoma (LUAD), a major subtype of lung cancer, is the leading cause of cancer‑related mortality worldwide. Previous studies have determined the role of the protein arginine methyltransferases (PRMTs) in the physiology and pathology of LUAD. However, to the best of our knowledge, no empirical studies have been performed determining the association between protein arginine methyltransferase 6 (PRMT6) and LUAD. The present study aimed to determine the expression levels of PRMT6 in LUAD and its association with the clinicopathological characteristics. The effect of PRMT6 knockdown on cell growth was analyzed and chromatin immunoprecipitation (ChIP) assay was used to investigate the regulatory mechanisms of PRMT6 on downstream gene expression. In addition, a xenograft model was used to determine whether the PRMT6‑regulated expression levels of p18 in vitro could be validated in vivo. PRMT6 overexpression in LUAD is associated with high clinical stage, lymph node metastasis and poor clinical outcomes. Furthermore, the silencing of PRMT6 significantly reduced the enrichment of Histone H3 asymmetric demethylation at arginine 2 in the promoter region of the p18 gene, thereby activating the expression of the gene. This, in turn, induced G1/S phase cell cycle arrest, resulting in the inhibition of cell proliferation. The xenograft model also suggested that PRMT6 suppressed LUAD development by activating p18 expression in vivo. In conclusion, the findings of the present study suggested that PRMT6 may serve as an oncogene in the progression of LUAD through epigenetically suppressing p18 expression. Thus, PRMT6 may represent a novel potential therapeutic target for LUAD.
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View References

1 

Molina JR, Yang P, Cassivi SD, Schild SE and Adjei AA: Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 83:3161–594. 2008. View Article : Google Scholar

2 

Chen Z, Fillmore CM, Hammerman PS, Kim CF and Wong KK: Non-small-cell lung cancers: A heterogeneous set of diseases. Nat Rev Cancer. 14:535–546. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Wood SL, Pernemalm M, Crosbie PA and Whetton AD: The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev. 40:558–566. 2014. View Article : Google Scholar : PubMed/NCBI

4 

de Perrot M, Fadel E, Mussot S, de Palma A, Chapelier A and Dartevelle P: Resection of locally advanced (T4) non-small cell lung cancer with cardiopulmonary bypass. Ann Thorac Surg. 79:1691–1697. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Wu H, Zhou J, Mei S, Wu D, Mu Z, Chen B, Xie Y, Ye Y and Liu J: Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7. J Cell Mol Med. 21:1228–1236. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Joshi P, Jeon YJ, Laganà A, Middleton J, Secchiero P, Garofalo M and Croce CM: MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC. Proc Natl Acad Sci USA. 112:8650–8655. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, et al: Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss. Cancer Cell. 36:100–114.e25. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Bedford MT and Clarke SG: Protein arginine methylation in mammals: Who, what, and why. Mol Cell. 33:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Pahlich S, Zakaryan RP and Gehring H: Protein arginine methylation: Cellular functions and methods of analysis. Biochim Biophys Acta. 1764:1890–1903. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Blanc RS and Richard S: Arginine methylation: The coming of age. Mol Cell. 65:8–24. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Bowitch A, Michaels KL, Yu MC and Ferkey DM: The protein arginine methyltransferase PRMT-5 regulates SER-2 tyramine receptor-mediated behaviors in caenorhabditis elegans. G3 (Bethesda). 8:2389–2398. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, et al: Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients. Gastric Cancer. 19:789–797. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, et al: Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer. 128:562–573. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Almeida-Rios D, Graça I, Vieira FQ, Ramalho-Carvalho J, Pereira-Silva E, Martins AT, Oliveira J, Gonçalves CS, Costa BM, Henrique R and Jerónimo C: Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer. Oncotarget. 7:53018–53028. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, et al: CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis. Cancer Cell. 35:1562019. View Article : Google Scholar : PubMed/NCBI

16 

Cheung N, Chan LC, Thompson A, Cleary ML and So CW: Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol. 9:1208–1215. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Elakoum R, Gauchotte G, Oussalah A, Wissler MP, Clément-Duchêne C, Vignaud JM, Guéant JL and Namour F: CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features. Biochimie. 97:210–218. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Li M, An W, Xu L, Lin Y, Su L and Liu X: The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 38:642019. View Article : Google Scholar : PubMed/NCBI

19 

Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT and Wygrecka M: Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta Mol Basis Dis. 1864:1816–1827. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S and Bedford MT: The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem. 277:3537–3543. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Limm K, Ott C, Wallner S, Mueller DW, Oefner P, Hellerbrand C and Bosserhoff AK: Deregulation of protein methylation in melanoma. Eur J Cancer. 49:1305–1313. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, et al: PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation. Cell Rep. 25:690–701 e698. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT and Chen T: The arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in cancer. Cell Rep. 21:3390–3397. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Sellers AH: The clinical classification of malignant tumours: The TNM system. Can Med Assoc J. 105:836passim. 1971.PubMed/NCBI

25 

Wohlschläger J, Wittekind C and Theegarten D: New TNM classification of malignant lung tumours. Pathologe. 31:355–360. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

26 

Feldman AT and Wolfe D: Tissue processing and hematoxylin and eosin staining. Methods Mol Biol. 1180:31–43. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Shechter D, Dormann HL, Allis CD and Hake SB: Extraction, purification and analysis of histones. Nat Protoc. 2:1445–1457. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Zhao Q, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, et al: PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 16:304–311. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Clark JD, Gebhart GF, Gonder JC, Keeling ME and Kohn DF: Special report: The 1996 Guide for the Care and Use of Laboratory Animals. ILAR J. 38:41–48. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Gong S, Qu X, Yang S, Zhou S, Li P and Zhang Q: RFC3 induces epithelialmesenchymal transition in lung adenocarcinoma cells through the Wnt/β-catenin pathway and possesses prognostic value in lung adenocarcinoma. Int J Mol Med. 44:2276–2288. 2019.PubMed/NCBI

32 

Sherr CJ and Roberts JM: CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG and Xiong Y: Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:2939–2952. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Stein C, Riedl S, Ruthnick D, Nötzold RR and Bauer UM: The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids Res. 40:9522–9533. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Auclair Y and Richard S: The role of arginine methylation in the DNA damage response. DNA Repair (Amst). 12:459–465. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Biggar KK and Li SS: Non-histone protein methylation as a regulator of cellular signalling and function. Nat Rev Mol Cell Biol. 16:5–17. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Malumbres M and Carnero A: Cell cycle deregulation: A common motif in cancer. Prog Cell Cycle Res. 5:5–18. 2003.PubMed/NCBI

38 

AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, et al: Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma. Proc Natl Acad Sci USA. 116:17990–18000. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Raposo AE and Piller SC: Protein arginine methylation: An emerging regulator of the cell cycle. Cell Div. 13:32018. View Article : Google Scholar : PubMed/NCBI

40 

Kleinschmidt MA, de Graaf P, van Teeffelen HA and Timmers HT: Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. PLoS One. 7:e414462012. View Article : Google Scholar : PubMed/NCBI

41 

Phalke S, Mzoughi S, Bezzi M, Jennifer N, Mok WC, Low DH, Thike AA, Kuznetsov VA, Tan PH, Voorhoeve PM and Guccione E: p53-independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res. 40:9534–9542. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, Lüscher B and Amati B: Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature. 449:933–937. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, Hsieh J and Bauer UM: PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev. 21:3369–3380. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Vermeulen M, Mann M, Bähler J, Green RD and Kouzarides T: Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature. 449:928–932. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang J, Meng Q, Shi R and Xu Y: PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18. Mol Med Rep 22: 3161-3172, 2020.
APA
Tang, J., Meng, Q., Shi, R., & Xu, Y. (2020). PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18. Molecular Medicine Reports, 22, 3161-3172. https://doi.org/10.3892/mmr.2020.11402
MLA
Tang, J., Meng, Q., Shi, R., Xu, Y."PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18". Molecular Medicine Reports 22.4 (2020): 3161-3172.
Chicago
Tang, J., Meng, Q., Shi, R., Xu, Y."PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18". Molecular Medicine Reports 22, no. 4 (2020): 3161-3172. https://doi.org/10.3892/mmr.2020.11402
Copy and paste a formatted citation
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Spandidos Publications style
Tang J, Meng Q, Shi R and Xu Y: PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18. Mol Med Rep 22: 3161-3172, 2020.
APA
Tang, J., Meng, Q., Shi, R., & Xu, Y. (2020). PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18. Molecular Medicine Reports, 22, 3161-3172. https://doi.org/10.3892/mmr.2020.11402
MLA
Tang, J., Meng, Q., Shi, R., Xu, Y."PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18". Molecular Medicine Reports 22.4 (2020): 3161-3172.
Chicago
Tang, J., Meng, Q., Shi, R., Xu, Y."PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18". Molecular Medicine Reports 22, no. 4 (2020): 3161-3172. https://doi.org/10.3892/mmr.2020.11402
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