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Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis

  • Authors:
    • Kun Pang
    • Bibo Li
    • Zhiming Tang
    • Wen Yang
    • Lin Hao
    • Zhenduo Shi
    • Jianjun Zhang
    • Longjun Cai
    • Rui Li
    • Ying Liu
    • Qian Lv
    • Jicun Ding
    • Conghui Han
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Xuzhou Central Hospital, Xuzhou Clinical College Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China, Department of Urology, Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou, Jiangsu 225300, P.R. China, Department of Dermatology, Xuzhou Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China , Department of Renal Disease, Shandong First Medical University, Tai'an, Shandong 271016, P.R. China , Department of Urology, Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu 223800, P.R. China, Department of Burns and Plastic Surgery, Xuzhou Central Hospital, Xuzhou Clinical College Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Pang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3440-3452
    |
    Published online on: August 4, 2020
       https://doi.org/10.3892/mmr.2020.11407
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Abstract

Hypertrophic scars (HSs) are a type of pathological scar which are induced by surgery, burn injuries or trauma during the healing process. Due to the high recurrence rates and strong invasive properties, HSs have become a major clinical issue. Resveratrol has been identified as a potential agent to suppress scar formation; however, the underlying mechanism of action remains unclear. Therefore, the present study aimed to investigate the effect of resveratrol on HS-derived fibroblasts (HSFBs) in vitro. MTT assay was performed to evaluate cell viability following the resveratrol treatment. Western blot and RT-qPCR analysis was used to identify the expression levels and the relationship among autophagic markers, miR-4654 and resveratrol treatment. Finally, GFP-LC3 stable HSFBs cells were generated to further assess the effect of resveratrol. The results revealed that resveratrol significantly induced cell death in a dose-dependent manner and induced autophagy by downregulating the expression levels of Rheb in HSFBs. Notably, microRNA-4654 (miR-4654) was significantly decreased in the HSFBs and re-upregulated by resveratrol treatment dose-dependently. Through the bioinformatic analysis and luciferase assay, miR-4654 was identified to directly target Rheb. Transfection studies showed that miR-4654 negative correlated with Rheb expression, suggesting that the autophagic process may be altered by the miR-4654/Rheb axis under the control of resveratrol. In conclusion, the results of the present study suggested that resveratrol may promote autophagy by upregulating miR-4654, which in turn may suppress Rheb expression via directly binding to the 3'-untranslated region of Rheb. These findings provided a novel insight into the development of potential therapeutic targets for HSs.
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1 

Lee HJ and Jang YJ: Recent Understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci. 19:34402018.

2 

Zhu Z, Ding J, Shankowsky HA and Tredget EE: The molecular mechanism of hypertrophic scar. J Cell Commun Signal. 7:239–252. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Wang X, Zhang Y, Jiang BH, Zhang Q, Zhou RP, Zhang L and Wang C: Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. Exp Cell Res. 361:201–209. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C and Brown RA: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 3:349–363. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Alster T: Laser scar revision: Comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids. Dermatol Surg. 29:25–29. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Wittenberg GP, Fabian BG, Bogomilsky JL, Schultz LR, Rudner EJ, Chaffins ML, Saed GM, Burns RL and Fivenson DP: Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment. Arch Dermatol. 135:1049–1055. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A and Tredget EE: Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol. 226:1265–1273. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Armour A, Scott PG and Tredget EE: Cellular and molecular pathology of HTS: Basis for treatment. Wound Repair Regen. 15 (Suppl 1):S6–S17. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Li P, He QY and Luo CQ: Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro. J Dermatol. 41:903–911. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Li Z, Wang J and Yang X: Functions of autophagy in pathological cardiac hypertrophy. Int J Biol Sci. 11:672–678. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Wu H, Wang Y, Wang X, Li R and Yin D: MicroRNA-365 accelerates cardiac hypertrophy by inhibiting autophagy via the modulation of Skp2 expression. Biochem Biophys Res Commun. 4:304–310. 2017. View Article : Google Scholar

12 

Goutas A, Syrrou C, Papathanasiou I, Tsezou A and Trachana V: The autophagic response to oxidative stress in osteoarthritic chondrocytes is deregulated. Free Radical Biol Med. 126:122–132. 2018. View Article : Google Scholar

13 

Xu J, Camfield R and Gorski SM: The interplay between exosomes and autophagy-partners in crime. J Cell Sci. 131:jcs2152102018. View Article : Google Scholar : PubMed/NCBI

14 

Li L, Huang C, He Y, Sang Z, Liu G and Dai H: Knockdown of long non-coding RNA GAS5 increases miR-23a by targeting ATG3 involved in autophagy and cell viability. Cell Physiol Biochem. 48:1723–1734. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Sun K, Deng W, Zhang S, Cai N, Jiao S, Song J and Wei L: Paradoxical roles of autophagy in different stages of tumorigenesis: Protector for normal or cancer cells. Cell Bio Sci. 3:352013.

16 

Pabon MA, Ma KC and Choi AM: Autophagy and obesity-related lung disease. Am J Respir Cell Mol Biol. 54:636–646. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Luo L and Qin ZH: Autophagy, aging, and longevity. Adv Exp Med Biol. 1206:509–525. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Lv L, Lin K, Gao W, He ZL, Gao ZM, Li ZF and Li JJ: Starvation induces autophagy of hypertrophic scar fibroblasts. Chin J Pathophysiology. 29:330–333. 2013.

19 

Xu J, Zhao J, Evan G, Xiao C, Cheng Y and Xiao J: Circulating microRNAs: Novel biomarkers for cardiovascular diseases. J Mol Med (Berl). 90:865–875. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Alevizos I and Illei GG: MicroRNAs as biomarkers in rheumatic diseases. Nat Rev Rheumatol. 6:391–398. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Wang H, Bei Y, Huang P, Zhou Q, Shi J, Sun Q, Zhong J, Li X, Kong X and Xiao J: Inhibition of miR-155 protects against LPS-induced cardiac dysfunction and apoptosis in mice. Mol Ther Nucleic Acids. 5:e3742016. View Article : Google Scholar : PubMed/NCBI

22 

Behm-Ansmant I, Rehwinkel J and Izaurralde E: MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay. Cold Spring Harb Symp Quant Biol. 71:523–530. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, et al: miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury. Theranostics. 7:664–676. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Lv J, Yang L, Guo R, Shi Y, Zhang Z and Ye J: Ox-LDL-induced MicroRNA-155 promotes autophagy in human endothelial cells via repressing the Rheb/mTOR pathway. Cell Physiol Biochem. 43:1436–1448. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Wang P, Zhang J, Zhang L, Zhu Z, Fan J, Chen L, Zhuang L, Luo J, Chen H, Liu L, et al: MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells. Gastroenterology. 145:1133–1143. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Li G, Zhou R, Zhang Q, Jiang B, Wu Q and Wang C: Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts. Exp Cell Res. 339:360–366. 2015.PubMed/NCBI

27 

Zhang Q, Guo B, Hui Q, Chang P and Tao K: miR-137 inhibits proliferation and metastasis of hypertrophic scar fibroblasts via targeting pleiotrophin. Cell Physiol Biochem. 49:985–995. 2018. View Article : Google Scholar

28 

Xu XH, Ding DF, Yong HJ, Dong CL, You N, Ye XL, Pan ML, Ma JH, You Q and Lu YB: Resveratrol transcriptionally regulates miRNA-18a-5p expression ameliorating diabetic nephropathy via increasing autophagy. Eur Rev Med Pharmacol Sci. 21:4952–4965. 2017.PubMed/NCBI

29 

Han Y, Jo H, Cho JH, Dhanasekaran DN and Song YS: Resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer. Int J Mol Sci. 20:9252019. View Article : Google Scholar

30 

Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, et al: Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab. 18:533–545. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Kou X and Chen N: Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer's disease. Nutrients. 9:9272017. View Article : Google Scholar

32 

Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, Liu CG and Yang JM: Regulation of autophagy by a Beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy. 6:816–623. 2009. View Article : Google Scholar

33 

Mehta M, Branford OA and Rolfe KJ: The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring. Burns Trauma. 4:152016. View Article : Google Scholar : PubMed/NCBI

34 

Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G and Sadoshima J: Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome. Circulation. 125:1134–1146. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Zeng G, Zhong F, Li J, Luo S and Zhang P: Resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. Biosci Biotechnol Biochem. 77:2389–2396. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Bai XZ, Liu JQ, Yang LL, Fan L, He T, Su LL, Shi JH, Tang CW, Zheng Z and Hu DH: Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. Br J Pharmacol. 173:1589–1601. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Braunwald E: The war against heart failure: The Lancet lecture. Lancet. 385:812–824. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Doherty J and Baehrecke EH: Life, death and autophagy. Nat Cell Biol. 20:1110–1117. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Levy JMM, Towers CG and Thorburn A: Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Nikoletopoulou V, Markaki M, Palikaras K and Tavernarakis N: Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 1833:3448–3459. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Mizushima N and Komatsu M: Autophagy: Renovation of cells and tissues. Cell. 147:728–741. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Shi JH, Hu DH, Zhang ZF, Bai XZ, Wang HT, Zhu XX, Su YJ and Tang CW: Reduced expression of microtubule-associated protein 1 light chain 3 in hypertrophic scars. Arch Dermatol Res. 304:209–215. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Shi J, Xiao H, Li J, Zhang J, Li Y, Zhang J, Wang X, Bai X, Tao K, Hu D and Guan H: Wild-type p53-modulated autophagy and autophagic fibroblast apoptosis inhibit hypertrophic scar formation. Lab Invest. 98:1423–1437. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Shi J, Wang H, Guan H, Shi S, Li Y, Wu X, Li N, Yang C, Bai X, Cai W, et al: IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis. 7:e21332016. View Article : Google Scholar : PubMed/NCBI

46 

De Felice B, Garbi C, Santoriello M, Santillo A and Wilson RR: Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Mol Cell Biochem. 327:191–201. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Babuta M, Furi I, Bala S, Bukong TN, Lowe P, Catalano D, Calenda C, Kodys K and Szabo G: Dysregulated autophagy and lysosome function are linked to exosome production by Micro-RNA 155 in Alcoholic liver disease. Hepatology. 70:2123–2141. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Chen LJ, Wei SY and Chiu JJ: Mechanical regulation of epigenetics in vascular biology and pathobiology. J Cell Mol Med. 17:437–448. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Donaldson CJ, Lao KH and Zeng L: The salient role of microRNAs in atherogenesis. J Mol Cell Cardiol. 122:98–113. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Wu ZY, Lu L, Liang J, Guo XR, Zhang PH and Luo SJ: Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts. Genet Mol Res. 13:2727–2738. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Li C, Bai Y, Liu H, Zuo X, Yao H, Xu Y and Cao M: Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs. Acta Biochim Biophys Sin (Shanghai). 45:692–699. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Kozlova A, Pachera E, Maurer B, Jüngel A, Distler JHW, Kania G and Distler O: Regulation of fibroblast apoptosis and proliferation by MicroRNA-125b in systemic sclerosis. Arthritis Rheumatol. 71:2068–2080. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Zhang C, Zhang Y, Zhu H, Hu J and Xie Z: MiR-34a/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro. Cell Signal. 46:145–153. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Jing Z, Han W, Sui X, Xie J and Pan H: Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers. Cancer Lett. 356:332–338. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pang K, Li B, Tang Z, Yang W, Hao L, Shi Z, Zhang J, Cai L, Li R, Liu Y, Liu Y, et al: Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis. Mol Med Rep 22: 3440-3452, 2020.
APA
Pang, K., Li, B., Tang, Z., Yang, W., Hao, L., Shi, Z. ... Han, C. (2020). Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis. Molecular Medicine Reports, 22, 3440-3452. https://doi.org/10.3892/mmr.2020.11407
MLA
Pang, K., Li, B., Tang, Z., Yang, W., Hao, L., Shi, Z., Zhang, J., Cai, L., Li, R., Liu, Y., Lv, Q., Ding, J., Han, C."Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis". Molecular Medicine Reports 22.4 (2020): 3440-3452.
Chicago
Pang, K., Li, B., Tang, Z., Yang, W., Hao, L., Shi, Z., Zhang, J., Cai, L., Li, R., Liu, Y., Lv, Q., Ding, J., Han, C."Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis". Molecular Medicine Reports 22, no. 4 (2020): 3440-3452. https://doi.org/10.3892/mmr.2020.11407
Copy and paste a formatted citation
x
Spandidos Publications style
Pang K, Li B, Tang Z, Yang W, Hao L, Shi Z, Zhang J, Cai L, Li R, Liu Y, Liu Y, et al: Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis. Mol Med Rep 22: 3440-3452, 2020.
APA
Pang, K., Li, B., Tang, Z., Yang, W., Hao, L., Shi, Z. ... Han, C. (2020). Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis. Molecular Medicine Reports, 22, 3440-3452. https://doi.org/10.3892/mmr.2020.11407
MLA
Pang, K., Li, B., Tang, Z., Yang, W., Hao, L., Shi, Z., Zhang, J., Cai, L., Li, R., Liu, Y., Lv, Q., Ding, J., Han, C."Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis". Molecular Medicine Reports 22.4 (2020): 3440-3452.
Chicago
Pang, K., Li, B., Tang, Z., Yang, W., Hao, L., Shi, Z., Zhang, J., Cai, L., Li, R., Liu, Y., Lv, Q., Ding, J., Han, C."Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis". Molecular Medicine Reports 22, no. 4 (2020): 3440-3452. https://doi.org/10.3892/mmr.2020.11407
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