Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury

Corrigendum in: /10.3892/mmr.2020.11621
  • Authors:
    • Rong‑Qiang Yang
    • Peng‑Fei Guo
    • Zhao Ma
    • Cheng Chang
    • Qing‑Nan Meng
    • Ya Gao
    • Imran Khan
    • Xiao‑Bo Wang
    • Zheng‑Jun Cui
  • View Affiliations / Copyright

    Affiliations: Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3405-3417
    |
    Published online on: August 4, 2020
       https://doi.org/10.3892/mmr.2020.11413
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The overexpression of inducible nitric oxide synthase (iNOS) induces cell apoptosis through various signal transduction pathways and aggravates lung injury. Caspase‑3 is an important protein in the apoptotic pathway and its activation can exacerbate apoptosis. Simvastatin, a hydroxymethyl glutaryl‑A reductase inhibitor, protects against smoke inhalation injury by inhibiting the synthesis and release of inflammatory factors and decreasing cell apoptosis. Following the establishment of an animal model of smoke inhalation injury, lung tissue and serum were collected at different time points and the protein and mRNA expression of iNOS and caspase‑3 in lung tissue by immunochemistry, western blot and reverse transcription‑quantitative polymerase chain reaction, the malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in lung tissue and serum were analyzed using thiobarbituric acid method and the WST‑1 method. The results were statistically analyzed. The lung tissues of the rats in the saline group and the low‑, middle‑ and high‑dose groups exhibited clear edema and hemorrhage, and had significantly higher pathological scores at the various time points compared with the rats in the control group (P<0.05). Furthermore, lung tissue and serum samples obtained from these four groups had significantly higher mRNA and protein expression levels of iNOS and caspase‑3 (P<0.05), significantly lower SOD activity and higher MDA content (P<0.05). Compared with the saline group, the low‑, middle‑ and high‑dose groups had significantly lower pathological scores (P<0.05), significantly lower mRNA and protein expression levels of iNOS, caspase‑3 and MDA content in lung tissues (P<0.05) and significantly higher SOD activity in lung tissues and serum. The middle‑ and high‑dose groups had significantly lower pathological scores (P<0.05), significantly decreased iNOS and caspase‑3 mRNA and protein expression in lung tissues, significantly higher SOD activity in lung tissues and serum and a significantly lower MDA content (P<0.05) compared with the low‑dose group. With the exception of SOD activity in lung tissues at 24 and 72 h and MDA content in serum at 48 h, no significant differences were observed between the middle‑ and high‑dose groups. The present study demonstrated that there was an association between the therapeutic effect and dosage of simvastatin within a definitive range. In rats with smoke inhalation injury, simvastatin inhibited iNOS and caspase‑3 expression in lung tissues and mitigated oxidative stress, thereby exerting a protective effect. In addition, the effect and dose were associated within a definitive range.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

Figure 14

Figure 15

View References

1 

Ballard-Croft C, Sumpter LR, Broaddus R, Alexander J, Wang D and Zwischenberger JB: Ovine smoke/burn ARDS model: A new ventilator-controlled smoke delivery system. J Surg Res. 164:3405–e162. 2010. View Article : Google Scholar

2 

De Carvalho FO, Silva ÉR, Felipe FA, Teixeira LGB, Zago LBS, Nunes PS, Shanmugam S, Serafini MR and Araújo AAS: Natural and synthetic products used for the treatment of smoke inhalation: A patent review. Expert Opin Ther Pat. 27:877–886. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Tanizaki S: Assessing inhalation injury in the emergency room. Open Access Emerg Med. 7:31–37. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Lee AS and Mellins RB: Lung injury from smoke inhalation. Paediatr Respir Rev. 7:123–128. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Matthay MA and Zemans RL: The acute respiratory distress syndrome: Pathogenesis and treatment. Annu Rev Pathol. 6:147–163. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Barsanti KC, Luo W, Isabelle LM, Pankow JF and Peyton DH: Tobacco smoke particulate matter chemistry by NMR. Magn Reson Chem. 45:167–170. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Wu ZY, Li H and Tang YJ: Effect of simvastatin on the SIRT2/NF-κB pathway in rats with acute pulmonary embolism. Pharm Biol. 56:511–518. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Cox RA, Jacob S, Oliveras G, Murakami K, Enkhbaatar P, Traber L, Schmalstieg FC, Herndon DN, Traber DL and Hawkins HK: Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury. Exp Lung Res. 35:104–118. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Liu X, Ai F, Li H, Xu Q, Mei L, Miao J, Wen Q, Zhang C, Zhang S, Zhou J, et al: Anti-inflammatory effects of shenfu injection against acute lung injury through inhibiting HMGB1-NF-κB pathway in a rat model of endotoxin shock. Evid Based Complement Alternat Med. 2019:98576832019. View Article : Google Scholar : PubMed/NCBI

10 

Hosogi S, Iwasaki Y, Yamada T, Komatani-Tamiya N, Hiramatsu A, Kohno Y, Ueda M, Arimoto T and Marunaka Y: Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung injury. Biomed Res. 29:257–266. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Ray PD, Huang BW and Tsuji Y: Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 24:981–990. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Liu S, Yue Y, Pan P, Zhang L, Su X, Li H, Li H, Li Y, Dai M, Li Q and Mao Z: IRF-1 intervention in the classical ROS-dependent release of NETs during LPS-induced acute lung injury in mice. Inflammation. 42:387–403. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Montaño M, Cisneros J, Ramírez-Venegas A, Pedraza-Chaverri J, Mercado D, Ramos C and Sansores RH: Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking. Inhal Toxicol. 22:868–874. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Karmali KN, Lloyd-Jones DM, Berendsen MA, Goff DC Jr, Sanghavi DM, Brown NC, Korenovska L and Huffman MD: Drugs for primary prevention of atherosclerotic cardiovascular disease: An overview of systematic reviews. JAMA Cardiol. 1:341–349. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Yan YL, Qiu B, Hu LJ, Jing XD, Liu YJ, Deng SB, Du JL and She Q: Efficacy and safety evaluation of intensive statin therapy in older patients with coronary heart disease: A systematic review and meta-analysis. Eur J Clin Pharmacol. 69:2001–2009. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Wang L, Mehta S, Gillis C, Law C and Taneja R: Modulation of neutrophil apoptosis by murine pulmonary microvascular endothelial cell inducible nitric oxide synthase. Biochem Biophys Res Commun. 401:207–212. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Aoki T, Kataoka H, Ishibashi R, Nozaki K and Hashimoto N: Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke. 39:1276–1285. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Esposito E, Rinaldi B, Mazzon E, Donniacuo M, Impellizzeri D, Paterniti I, Capuano A, Bramanti P and Cuzzocrea S: Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: Involvement of PPAR-alpha. J Neuroinflammation. 9:812012. View Article : Google Scholar : PubMed/NCBI

19 

Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS and McAuley DF: Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med. 179:1107–1114. 2009. View Article : Google Scholar : PubMed/NCBI

20 

National Research Council Committee for the Update of the Guide for the Care and Use of Laboratory Animals: The National Academies Collection: Reports funded by National Institutes of Health. Guide for the Care and Use of Laboratory Animals. National Academies Press (US) Copyright© 2011; National Academy of Sciences, Washington (DC): 2011, PubMed/NCBI

21 

Liu PY, Liu YW, Lin LJ, Chen JH and Liao JK: Evidence for statin pleiotropy in humans: Differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function and inflammation. Circulation. 119:131–138. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Zhu F, Qiu X, Wang J, Jin Y, Sun Y, Lv T and Xia Z: A rat model of smoke inhalation injury. Inhal Toxicol. 24:356–364. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Garip S and Severcan F: Determination of simvastatin-induced changes in bone composition and structure by Fourier transform infrared spectroscopy in rat animal model. J Pharm Biomed Anal. 52:580–588. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

de Carvalho FO, Felipe FA, de Melo Costa AC, Teixeira LG, Silva ÉR, Nunes PS, Shanmugam S, de Lucca Junior W, Quintans JS and de Souza Araújo AA: Inflammatory mediators and oxidative stress in animals subjected to smoke inhalation: A systematic review. Lung. 194:487–499. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Lange M, Szabo C, Traber DL, Horvath E, Hamahata A, Nakano Y, Traber LD, Cox RA, Schmalstieg FC, Herndon DN and Enkhbaatar P: Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis. Shock. 37:468–472. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Tan W, Xue-bin C, Tian Z, Xiao-wu C, Pei-pei H, Zhi-bin C and Bei-sha T: Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease. Int J Neurosci. 126:278–286. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Lee HJ, Shin JS, Lee WS, Shim HY, Park JM, Jang DS and Lee KT: Chikusetsusaponin IVa methyl ester isolated from the roots of achyranthes japonica suppresses LPS-induced iNOS, TNF-α, IL-6, and IL-1β expression by NF-κB and AP-1 inactivation. Biol Pharm Bull. 39:657–664. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Matsumoto J, Dohgu S, Takata F, Machida T, Bölükbaşi Hatip FF, Hatip-Al-Khatib I, Yamauchi A and Kataoka Y: TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res. 1692:34–44. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Sun JL, Gao Y, Cui ZJ and Guo PF: The anti-inflammatory effects of simvastatin in a rat model of smoke inhalation lung injury. Int J Clin Exp Med. 12:12740–12746. 2019.

31 

Refaie MMM, El-Hussieny M and Zenhom NM: Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways. Environ Toxicol Pharmacol. 58:212–219. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Wang X, Luo B, Lu Y, Pang D, Zheng J, Mo J, Huang H and Feng J: The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. Cell Tissue Res. 374:137–148. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabo C, Szabo E, Virag L, Salzman A and Traber DL: Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. Am J Respir Crit Care Med. 163:745–752. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Shun-Zhen Q and Hong-Hang Z: The effects of inhaled nitric oxide on the levels of cGMP plasma and lung tissue in a canine model of smoke inhalation injury. Burns. 28:299–304. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Lange M, Hamahata A, Enkhbaatar P, Cox RA, Nakano Y, Westphal M, Traber LD, Herndon D and Traber DL: Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury. Shock. 35:626–631. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Rössig L, Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Mülsch A and Dimmeler S: Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 274:6823–6826. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Kim YM, Talanian RV and Billiar TR: Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem. 272:31138–31148. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Bai S, Hu Z, Yang Y, Yin Y, Li W, Wu L and Fang M: Anti-inflammatory and neuroprotective effects of triptolide via the NF-κB signaling pathway in a rat MCAO model. Anat Rec (Hoboken). 299:256–266. 2016.20. Enkhbaatar P, Wang J, Saunders F, Lange M, Hamahata A, Rehberg S, Parkinson JF, Traber LD, Herndon DN and Traber DL: Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma. Burns 37: 638–645, 2011. View Article : Google Scholar : PubMed/NCBI

39 

Li WC, Zou ZJ, Zhou MG, Chen L, Zhou L, Zheng YK and He ZJ: Effects of simvastatin on the expression of inducible NOS in acute lung injury in septic rats. Int J Clin Exp Pathol. 8:15106–15111. 2015.PubMed/NCBI

40 

Ahmed AM: Inhibition of inducible nitric oxide synthase (iNOS) by simvastatin attenuates cardiac hypertrophy in rats. Folia Morphol (Warsz). 76:15–27. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Kim BC, Kim YS, Lee JW, Seo JH, Ji ES, Lee H, Park YI and Kim CJ: Protective effect of coriolus versicolor cultivated in citrus extract against nitric oxide-Induced apoptosis in human neuroblastoma SK-N-MC cells. Exp Neurobiol. 20:100–109. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Lange M, Szabo C, Enkhbaatar P, Connelly R, Horvath E, Hamahata A, Cox RA, Esechie A, Nakano Y, Traber LD, et al: Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury. Am J Physiol Lung Cell Mol Physiol. 300:L167–L175. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Liu X, Jin X, Yu D and Liu G: Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice. Int Immunopharmacol. 76:1058862019. View Article : Google Scholar : PubMed/NCBI

44 

Chung HT, Pae HO, Choi BM, Billiar TR and Kim YM: Nitric oxide as a bioregulator of apoptosis. Biochem Biophys Res Commun. 282:1075–1079. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Albert M, Corsilli D, Williamson DR, Brosseau M, Bellemare P, Delisle S, Nguyen AQ and Varin F: Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World J Crit Care Med. 6:74–78. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Li JT, Wang WQ, Wang L, Liu NN, Zhao YL, Zhu XS, Liu QQ, Gao CF, Yang AG and Jia L: Subanesthetic isoflurane relieves zymosan-induced neutrophil inflammatory response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling. Oncotarget. 7:31772–31789. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Lossi L, Castagna C and Merighi A: Caspase-3 mediated cell death in the normal development of the mammalian cerebellum. Int J Mol Sci. 19:39992018. View Article : Google Scholar

48 

Li H, Wan A, Xu G and Ye D: Small changes huge impact: The role of thioredoxin 1 in the regulation of apoptosis by S-nitrosylation. Acta Biochim Biophys Sin (Shanghai). 45:153–161. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Badshah H, Ali T and Kim MO: Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway. Sci Rep. 6:244932016. View Article : Google Scholar : PubMed/NCBI

50 

Westphal M, Enkhbaatar P, Schmalstieg FC, Kulp GA, Traber LD, Morita N, Cox RA, Hawkins HK, Westphal-Varghese BB, Rudloff HE, et al: Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep. Crit Care Med. 36:1196–1204. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Sterner JB, Zanders TB, Morris MJ and Cancio LC: Inflammatory mediators in smoke inhalation injury. Inflamm Allergy Drug Targets. 8:63–69. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Fraunberger P, Grone E, Grone HJ and Walli AK: Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol. Shock. 32:159–163. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Wassmann S, Laufs U, Bäumer AT, Müller K, Ahlbory K, Linz W, Itter G, Rösen R, Böhm M and Nickenig G: HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension. 37:1450–1457. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Nie Z, Deng S, Zhang L, Chen S, Lu Q and Peng H: Crocin protects against dexamethasone-induced osteoblast apoptosis by inhibiting the ROS/Ca2+-mediated mitochondrial pathway. Mol Med Rep. 20:401–408. 2019.PubMed/NCBI

55 

Wang KS, Lv Y, Wang Z, Ma J, Mi C, Li X, Xu GH, Piao LX, Zheng SZ and Jin X: Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway. Oncol Rep. 37:3397–3404. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Mondal NK, Saha H, Mukherjee B, Tyagi N and Ray MR: Inflammation, oxidative stress, and higher expression levels of Nrf2 and NQO1 proteins in the airways of women chronically exposed to biomass fuel smoke. Mol Cell Biochem. 447:63–76. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Sun A, Wang W, Ye X, Wang Y, Yang X, Ye Z, Sun X and Zhang C: Protective effects of methane-rich saline on rats with lipopolysaccharide-induced acute lung injury. Oxid Med Cell Longev. 2017:74301932017. View Article : Google Scholar : PubMed/NCBI

58 

Kanugula AK, Gollavilli PN, Vasamsetti SB, Karnewar S, Gopoju R, Ummanni R and Kotamraju S: Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: Intermediacy of nitric oxide and antioxidant defence mechanisms. FEBS J. 281:3719–3738. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Ferraro SA, Yakisich JS, Gallo FT and Tasat DR: Simvastatin pretreatment prevents ambient particle-induced lung injury in mice. Inhal Toxicol. 23:889–896. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang RQ, Guo PF, Ma Z, Chang C, Meng QN, Gao Y, Khan I, Wang XB and Cui ZJ: Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621. Mol Med Rep 22: 3405-3417, 2020.
APA
Yang, R., Guo, P., Ma, Z., Chang, C., Meng, Q., Gao, Y. ... Cui, Z. (2020). Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621. Molecular Medicine Reports, 22, 3405-3417. https://doi.org/10.3892/mmr.2020.11413
MLA
Yang, R., Guo, P., Ma, Z., Chang, C., Meng, Q., Gao, Y., Khan, I., Wang, X., Cui, Z."Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621". Molecular Medicine Reports 22.4 (2020): 3405-3417.
Chicago
Yang, R., Guo, P., Ma, Z., Chang, C., Meng, Q., Gao, Y., Khan, I., Wang, X., Cui, Z."Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621". Molecular Medicine Reports 22, no. 4 (2020): 3405-3417. https://doi.org/10.3892/mmr.2020.11413
Copy and paste a formatted citation
x
Spandidos Publications style
Yang RQ, Guo PF, Ma Z, Chang C, Meng QN, Gao Y, Khan I, Wang XB and Cui ZJ: Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621. Mol Med Rep 22: 3405-3417, 2020.
APA
Yang, R., Guo, P., Ma, Z., Chang, C., Meng, Q., Gao, Y. ... Cui, Z. (2020). Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621. Molecular Medicine Reports, 22, 3405-3417. https://doi.org/10.3892/mmr.2020.11413
MLA
Yang, R., Guo, P., Ma, Z., Chang, C., Meng, Q., Gao, Y., Khan, I., Wang, X., Cui, Z."Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621". Molecular Medicine Reports 22.4 (2020): 3405-3417.
Chicago
Yang, R., Guo, P., Ma, Z., Chang, C., Meng, Q., Gao, Y., Khan, I., Wang, X., Cui, Z."Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury Corrigendum in /10.3892/mmr.2020.11621". Molecular Medicine Reports 22, no. 4 (2020): 3405-3417. https://doi.org/10.3892/mmr.2020.11413
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team