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Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis

  • Authors:
    • Hanhua Yang
    • Shufeng Tian
    • Lichun Xie
    • Yunbin Chen
    • Lian Ma
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Pediatrics, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3493-3503
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    Published online on: August 19, 2020
       https://doi.org/10.3892/mmr.2020.11436
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Abstract

Neonatal hypoxic‑ischemic brain damage (HIBD) is a common clinical syndrome in newborns. Hypothermia is the only approved therapy for the clinical treatment; however, the therapeutic window of hypothermia is confined to 6 h after birth and even then, >40% of the infants either die or survive with various impairments, including cerebral palsy, seizure disorder and intellectual disability following hypothermic treatment. The aim of the present study was to determine whether nasal transplantation of Cytoglobin (CYGB) genetically modified human umbilical cord‑derived mesenchymal stem cells (CYGB‑HuMSCs) exhibited protective effects in neonatal rats with HIBD compared with those treated without genetically modified CYGB. A total of 120 neonatal Sprague‑Dawley rats (postnatal day 7) were assigned to either a Sham, HIBD, HuMSCs or CYGB‑HuMSCs group (n = 30 rats/group). For HIBD modeling, rats underwent left carotid artery ligation and were exposed to 8% oxygen for 2.5 h. A total of 30 min after HI, HuMSCs (or CYGB‑HuMSCs) labeled with enhanced‑green fluorescent protein (eGFP) were intranasally administered. After modeling for 3, 14 and 29 days, five randomly selected rats were sacrificed in each group, and the expression levels of CYGB, ERK, JNK and p38 in brain tissues were determined. Nissl staining of the cortex and hippocampal Cornu Ammonis 1 area of rats in each group were compared after 3 days of modeling. TUNEL assay and immunofluorescence were performed 3 days after modeling. Long term memory in rats was assessed using a Morris‑water maze 29 days after modeling. The HIBD group demonstrated significant deficiencies compared with the Sham group based on Nissl staining, TUNEL assay and the Morris‑water maze test. HuMSC treated rats exhibited improvement on in all the tests, and CYGB‑HuMSCs treatment resulted in further improvements. PCR and western blotting results indicated that the CYGB mRNA and protein levels were increased from day 3 to day 29 after transplantation of CYGB‑HuMSCs. Furthermore, it was identified that CYGB‑HuMSC transplantation suppressed p38 signaling at all experimental time points. Immunofluorescence indicated the scattered presence of HuMSCs or CYGB‑HuMSCs in damaged brain tissue. No eGFP and glial fibrillary acidic protein or eGFP and neuron‑specific enolase double‑stained positive cells were found in the brain tissues. Therefore, CYGB‑HuMSCs may serve as a gene transporter, as well as exert a neuroprotective and antiapoptotic effect in HIBD, potentially via the p38 mitogen‑activated protein kinase signaling pathway.
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View References

1 

Novak CM, Ozen M and Burd I: Perinatal brain injury: Mechanisms, prevention, and outcomes. Clin Perinatol. 45:3493–375. 2018. View Article : Google Scholar

2 

du Plessis AJ and Volpe JJ: Perinatal brain injury in the preterm and term newborn. Curr Opin Neurol. 15:151–157. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Triulzi F, Parazzini C and Righini A: Patterns of damage in the mature neonatal brain. Pediatr Radiol. 36:608–620. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Gale C, Statnikov Y, Jawad S, Uthaya SN and Modi N; Brain Injuries expert working group, : Neonatal brain injuries in England: Population-based incidence derived from routinely recorded clinical data held in the National Neonatal Research Database. Arch Dis Child Fetal Neonatal Ed. 103:301–306. 2018. View Article : Google Scholar

5 

Bass JL, Corwin M, Gozal D, Moore C, Nishida H, Parker S, Schonwald A, Wilker RE, Stehle S and Kinane TB: The effect of chronic or intermittent hypoxia on cognition in childhood: A review of the evidence. Pediatrics. 114:805–816. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Yildiz EP, Ekici B and Tatli B: Neonatal hypoxic ischemic encephalopathy: An update on disease pathogenesis and treatment. Expert Rev Neurother. 17:449–459. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Chiang MC, Jong YJ and Lin CH: Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy. Pediatr Neonatol. 58:475–483. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Srinivasakumar P, Zempel J, Wallendorf M, Lawrence R, Inder T and Mathur A: Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: Electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 163:465–470. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ma H, Sinha B, Pandya RS, Lin N, Popp AJ, Li J, Yao J and Wang X: Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury. Curr Mol Med. 12:1282–1296. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Pesce A, Bolognesi M, Bocedi A, Ascenzi P, Dewilde S, Moens L, Hankeln T and Burmester T: Neuroglobin and cytoglobin. Fresh blood for the vertebrate globin family. EMBO Rep. 3:1146–1151. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Gell DA: Structure and function of haemoglobins. Blood Cells Mol Dis. 70:13–42. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Burmester T and Hankeln T: Function and evolution of vertebrate globins. Acta Physiol (Oxf). 211:501–514. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Trent JT III and Hargrove MS: A ubiquitously expressed human hexacoordinate hemoglobin. J Biol Chem. 277:19538–19545. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Stagner JI, Parthasarathy SN, Wyler K and Parthasarathy RN: Protection from ischemic cell death by the induction of cytoglobin. Transplant Proc. 37:3452–3453. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Hankeln T, Ebner B, Fuchs C, Gerlach F, Haberkamp M, Laufs TL, Roesner A, Schmidt M, Weich B, Wystub S, et al: Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem. 99:110–119. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Avivi A, Gerlach F, Joel A, Reuss S, Burmester T, Nevo E and Hankeln T: Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax. Proc Natl Acad Sci USA. 107:21570–21575. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Singh S, Manda SM, Sikder D, Birrer MJ, Rothermel BA, Garry DJ and Mammen PP: Calcineurin activates cytoglobin transcription in hypoxic myocytes. J Biol Chem. 284:10409–10421. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Tian SF, Yang HH, Xiao DP, Huang YJ, He GY, Ma HR, Xia F and Shi XC: Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model. J Biol Chem. 288:15988–16003. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Li Y and Chopp M: Marrow stromal cell transplantation in stroke and traumatic brain injury. Neurosci Lett. 456:120–123. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Zhao L, Johnson T and Liu D: Therapeutic angiogenesis of adipose-derived stem cells for ischemic diseases. Stem Cell Res Ther. 8:1252017. View Article : Google Scholar : PubMed/NCBI

21 

Park WS, Sung SI, Ahn SY, Yoo HS, Sung DK, Im GH, Choi SJ and Chang YS: Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy. PLoS One. 10:e01208932015. View Article : Google Scholar : PubMed/NCBI

22 

Gonzales-Portillo GS, Reyes S, Aguirre D, Pabon MM and Borlongan CV: Stem cell therapy for neonatal hypoxic-ischemic encephalopathy. Front Neurol. 5:1472014. View Article : Google Scholar : PubMed/NCBI

23 

van Velthoven CT, Kavelaars A and Heijnen CJ: Mesenchymal stem cells as a treatment for neonatal ischemic brain damage. Pediatr Res. 71:474–481. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Zhang X, Zhang Q, Li W, Nie D, Chen W, Xu C, Yi X, Shi J, Tian M, Qin J, et al: Therapeutic effect of human umbilical cord mesenchymal stem cells on neonatal rat hypoxic-ischemic encephalopathy. J Neurosci Res. 92:35–45. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Zhou X, Gu J, Gu Y, He M, Bi Y, Chen J and Li T: Human umbilical cord-derived mesenchymal stem cells improve learning and memory function in hypoxic-ischemic brain-damaged rats via an IL-8-mediated secretion mechanism rather than differentiation pattern induction. Cell Physiol Biochem. 35:2383–2401. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kim YS, Hwang KA, Go RE, Kim CW and Choi KC: Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review). Oncol Rep. 33:2107–2112. 2015. View Article : Google Scholar : PubMed/NCBI

27 

High KA and Roncarolo MG: Gene therapy. N Engl J Med. 381:455–464. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Aiuti A, Slavin S, Aker M, Ficara F, Deola S, Mortellaro A, Morecki S, Andolfi G, Tabucchi A, Carlucci F, et al: Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science. 296:2410–2413. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Wang H, Qiu X, Ni P, Qiu X, Lin X, Wu W, Xie L, Lin L, Min J, Lai X, et al: Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats. Int J Mol Med. 33:263–270. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kilkenny C, Browne WJ, Cuthill IC, Emerson M and Altman DG: Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol. 8:e10004122010. View Article : Google Scholar : PubMed/NCBI

31 

Rice JE III, Vannucci RC and Brierley JB: The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol. 9:131–141. 1981. View Article : Google Scholar : PubMed/NCBI

32 

Donega V, Nijboer CH, van Tilborg G, Dijkhuizen RM, Kavelaars A and Heijnen CJ: Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury. Exp Neurol. 261:53–64. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Hoogewijs D, Vogler M, Zwenger E, Krull S and Zieseniss A: Oxygen-dependent regulation of aquaporin-3 expression. Hypoxia (Auckl). 4:91–97. 2016.PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Douglas-Escobar M and Weiss MD: Hypoxic-ischemic encephalopathy: A review for the clinician. JAMA Pediatr. 169:397–403. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Burmester T, Ebner B, Weich B and Hankeln T: Cytoglobin: A novel globin type ubiquitously expressed in vertebrate tissues. Mol Biol Evol. 19:416–421. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Ascenzi P, Gustincich S and Marino M: Mammalian nerve globins in search of functions. IUBMB life. 66:268–276. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Amdahl MB, DeMartino AW, Tejero J and Gladwin MT: Cytoglobin at the crossroads of vascular remodeling. Arterioscler Thromb Vasc Biol. 37:1803–1805. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Vinogradov SN and Moens L: Diversity of globin function: Enzymatic, transport, storage, and sensing. J Biol Chem. 283:8773–8777. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Tejero J and Gladwin MT: The globin superfamily: Functions in nitric oxide formation and decay. Biol Chem. 395:631–639. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Hodges NJ, Innocent N, Dhanda S and Graham M: Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. Mutagenesis. 23:293–298. 2008. View Article : Google Scholar : PubMed/NCBI

42 

De Beuf A, Hou XH, D'Haese PC and Verhulst A: Epoetin delta reduces oxidative stress in primary human renal tubular cells. J Biomed Biotechnol. 2010:3957852010. View Article : Google Scholar : PubMed/NCBI

43 

Lv W, Booz GW, Fan F, Wang Y and Roman RJ: Oxidative stress and renal fibrosis: Recent insights for the development of novel therapeutic strategies. Front Physiol. 9:1052018. View Article : Google Scholar : PubMed/NCBI

44 

Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M and Sawant D: Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 110:7–15. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Hong SQ, Zhang HT, You J, Zhang MY, Cai YQ, Jiang XD and Xu RX: Comparison of transdifferentiated and untransdifferentiated human umbilical mesenchymal stem cells in rats after traumatic brain injury. Neurochem Res. 36:2391–2400. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Lin YC, Ko TL, Shih YH, Lin MY, Fu TW, Hsiao HS, Hsu JY and Fu YS: Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. Stroke. 42:2045–2053. 2011. View Article : Google Scholar : PubMed/NCBI

47 

van Velthoven CT, Kavelaars A, van Bel F and Heijnen CJ: Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage. Pediatr Res. 68:419–422. 2010.PubMed/NCBI

48 

Cunningham CJ, Redondo-Castro E and Allan SM: The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke. J Cereb Blood Flow Metab. 38:1276–1292. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Li Y, Cheng Q, Hu G, Deng T, Wang Q, Zhou J and Su X: Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke. Exp Ther Med. 15:4067–4079. 2018.PubMed/NCBI

50 

Gu Y, He M, Zhou X, Liu J, Hou N, Bin T, Zhang Y, Li T and Chen J: Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte. Sci Rep. 6:185872016. View Article : Google Scholar : PubMed/NCBI

51 

Cuadrado A and Nebreda AR: Mechanisms and functions of p38 MAPK signalling. Biochem J. 429:403–417. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Sanchez A, Tripathy D, Yin X, Desobry K, Martinez J, Riley J, Gay D, Luo J and Grammas P: p38 MAPK: A mediator of hypoxia-induced cerebrovascular inflammation. J Alzheimers Dis. 32:587–597. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Cakmak H, Seval-Celik Y, Arlier S, Guzeloglu-Kayisli O, Schatz F, Arici A and Kayisli UA: p38 Mitogen-activated protein kinase is involved in the pathogenesis of endometriosis by modulating inflammation, but not cell survival. Reprod Sci. 25:587–597. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Amir M, Somakala K and Ali S: p38 MAP kinase inhibitors as anti inflammatory agents. Mini Rev Med Chem. 13:2082–2096. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Cheung WD and Hart GW: AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J Biol Chem. 283:13009–13020. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Park EC and Rongo C: The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. Elife. 5:e120102016. View Article : Google Scholar : PubMed/NCBI

57 

Tormos AM, Taléns-Visconti R, Nebreda AR and Sastre J: p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species. Free Radic Res. 47:905–916. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Zhang H, Tao L, Jiao X, Gao E, Lopez BL, Christopher TA, Koch W and Ma XL: Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart. Free Radic Biol Med. 43:39–47. 2007. View Article : Google Scholar : PubMed/NCBI

59 

Xu ZJ, Shu S, Li ZJ, Liu YM, Zhang RY and Zhang Y: Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-β/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues. Medicine (Baltimore). 96:e58792017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Tian S, Xie L, Chen Y and Ma L: Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis . Mol Med Rep 22: 3493-3503, 2020.
APA
Yang, H., Tian, S., Xie, L., Chen, Y., & Ma, L. (2020). Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis . Molecular Medicine Reports, 22, 3493-3503. https://doi.org/10.3892/mmr.2020.11436
MLA
Yang, H., Tian, S., Xie, L., Chen, Y., Ma, L."Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis ". Molecular Medicine Reports 22.4 (2020): 3493-3503.
Chicago
Yang, H., Tian, S., Xie, L., Chen, Y., Ma, L."Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis ". Molecular Medicine Reports 22, no. 4 (2020): 3493-3503. https://doi.org/10.3892/mmr.2020.11436
Copy and paste a formatted citation
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Spandidos Publications style
Yang H, Tian S, Xie L, Chen Y and Ma L: Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis . Mol Med Rep 22: 3493-3503, 2020.
APA
Yang, H., Tian, S., Xie, L., Chen, Y., & Ma, L. (2020). Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis . Molecular Medicine Reports, 22, 3493-3503. https://doi.org/10.3892/mmr.2020.11436
MLA
Yang, H., Tian, S., Xie, L., Chen, Y., Ma, L."Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis ". Molecular Medicine Reports 22.4 (2020): 3493-3503.
Chicago
Yang, H., Tian, S., Xie, L., Chen, Y., Ma, L."Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis ". Molecular Medicine Reports 22, no. 4 (2020): 3493-3503. https://doi.org/10.3892/mmr.2020.11436
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