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miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells

  • Authors:
    • Niannian Yang
    • Hao Cheng
    • Qiao Mo
    • Xiaobiao Zhou
    • Minqiang Xie
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Shaoyang Central Hospital, Shaoyang, Hunan 422000, P.R. China, Department of Nasopharyngeal Carcinoma, The First People's Hospital of Chenzhou, Southern Medical University, Chenzhou, Hunan 423000, P.R. China, Department of Pathology, Shaoyang Central Hospital, Shaoyang, Hunan 422000, P.R. China, Department of Otorhinolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3695-3704
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    Published online on: August 27, 2020
       https://doi.org/10.3892/mmr.2020.11468
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Abstract

Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved with tissue remodeling of nasal polyps. The present study investigated the molecular mechanisms through which miR‑155‑5p regulated EMT in chronic rhinosinusitis (CRS). Patients were divided into the following groups: CRSsNP, CRS without nasal polyposis group, CRSwNP, CRS with nasal polyposis and controls. The expression of transforming growth factor (TGF)‑β1, EMT markers, sirtuin 1 (SIRT1) and miR‑155‑5p were determined by western blotting and reverse transcription‑quantitative PCR. Cell morphology following TGF‑β1 treatment in the presence of miR‑155‑5p inhibitors or controls was observed under a microscope. Target genes and potential binding sites between miR‑155‑5p and SIRT1 were predicted by TargetScan and confirmed using dual‑luciferase reporter assay. In patients with CRS, the expression levels of E‑cadherin were downregulated and the expression levels of TGF‑β1, mesenchymal markers and miR‑155‑5p were upregulated. Additionally, these changes in expression levels were reduced or increased to a greater extent in the CRSwNP group compared with the CRSsNP group. Furthermore, TGF‑β1 expression promoted EMT in human nasal epithelial cells (HNEpCs) and upregulated miR‑155‑5p expression. These effects were reversed by miR‑155‑5p inhibitors. Additionally, SIRT1 was predicted as a target gene of miR‑155‑5p. Downregulation of miR‑155‑5p upregulated epithelial marker expression and downregulated mesenchymal marker expression by regulating SIRT1. Therefore, the downregulation of miR‑155‑5p inhibited EMT in HNEpCs by targeting SIRT1.
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View References

1 

Schleimer RP: Immunopathogenesis of chronic rhinosinusitis and nasal polyposis. Annu Rev Pathol. 12:331–357. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Lee S and Lane AP: Chronic rhinosinusitis as a multifactorial inflammatory disorder. Curr Infect Dis Rep. 13:159–168. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Savovic S, Buljcik-Cupic M, Jovancevic L, Kljajic V, Lemajic-Komazec S and Dragicevic D: Frequency and intensity of symptoms in patients with chronic rhinosinusitis. Srpski Arhiv Za Celokupno Lekarstvo. 147:132018.

4 

Hull BP and Chandra RK: Refractory chronic rhinosinusitis with nasal polyposis. Otolaryngol Clin North Am. 50:61–81. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, et al: European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl. 23:32012.PubMed/NCBI

6 

Piromchai P, Kasemsiri P, Laohasiriwong S and Thanaviratananich S: Chronic rhinosinusitis and emerging treatment options. Int J Gen Med. 6:453–464. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Koskinen A, Numminen J, Markkola A, Karjalainen J, Karstila T, Seppälä M, Julkunen A, Lemmetyinen R, Pekkanen J, Rautiainen M, et al: Diagnostic accuracy of symptoms, endoscopy, and imaging signs of chronic rhinosinusitis without nasal polyps compared to allergic rhinitis. Am J Rhinol Allergy. 32:121–131. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Li L, Feng J, Zhang D, Yong J, Wang Y, Yao J and Huang R: Differential expression of miR-4492 and IL-10 is involved in chronic rhinosinusitis with nasal polyps. Exp Ther Med. 18:3968–3976. 2019.PubMed/NCBI

9 

Konnecke M, Burmeister M, Pries R, Boscke R, Bruchhage KL, Ungefroren H, Klimek L and Wollenberg B: Epithelial-mesenchymal transition in chronic rhinosinusitis: Differences revealed between epithelial cells from nasal polyps and inferior turbinates. Arch Immunol Ther Exp (Warsz). 65:157–173. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Lu TX and Rothenberg ME: MicroRNA. J Allergy Clin Immunol. 141:1202–1207. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Qing X, Zhang Y, Peng Y, He G, Liu A and Liu H: miR-142-3p regulates inflammatory response by contributing to increased TNF-α in chronic rhinosinusitis with nasal polyposis. Ear Nose Throat J. 9:1455613198479722019.

12 

Lu C, Chen B, Chen C, Li H, Wang D, Tan Y and Weng H: CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p. J Cell Mol Med. 24:1700–1712. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Zhao L, Ouyang Y, Bai Y, Gong J and Liao H: miR-155-5p inhibits the viability of vascular smooth muscle cell via targeting FOS and ZIC3 to promote aneurysm formation. Eur J Pharmacol. 853:145–152. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Thwin M, Weitzel EK, McMains KC, Athanasiadis T, Psaltis A, Field J and Wormald PJ: Validating the use of report-derived lund-macKay scores. Am J Rhinol Allergy. 23:33–35. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Lund VJ and Kennedy DW: Quantification for staging sinusitis. The staging and therapy group. Ann Otol Rhinol Laryngol Suppl. 167:17–21. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Linder A: Symptom scores as measures of the severity of rhinitis. Clin Allergy. 18:29–37. 1988. View Article : Google Scholar : PubMed/NCBI

17 

Li X, Li C, Zhu G, Yuan W and Xiao ZA: TGF-β1 induces epithelial-mesenchymal transition of chronic sinusitis with nasal polyps through MicroRNA-21. Int Arch Allergy Immunol. 179:304–319. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Liu F, Kong X, Lv L and Gao J: TGF-β1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes. Cancer Lett. 359:288–298. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Park IH, Kang JH, Shin JM and Lee HM: Trichostatin A inhibits epithelial mesenchymal transition induced by TGF-β1 in airway epithelium. PLoS One. 11:e01620582016. View Article : Google Scholar : PubMed/NCBI

21 

Chaffer CL, San Juan BP, Lim E and Weinberg RA: EMT, cell plasticity and metastasis. Cancer Metastasis Rev. 35:645–654. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Ma Z, Shen Y, Zeng Q, Liu J, Yang L, Fu R and Hu G: MiR-150-5p regulates EGR2 to promote the development of chronic rhinosinusitis via the DC-Th axis. Int Immunopharmacol. 54:188–197. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Wu ZW, Liu YF, Wang S and Li B: miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-κB pathway. Genet Mol Res. 14:18703–18712. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Canfrán-Duque A, Rotllan N, Zhang X, Fernández-Fuertes M, Ramírez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández-Hernando C and Suárez Y: Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med. 9:1244–1262. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Al-Haidari AA, Syk I and Thorlacius H: miR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting rhoA. Oncotarget. 8:14887–14896. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Li DP, Fan J, Wu YJ, Xie YF, Zha JM and Zhou XM: MiR-155 up-regulated by TGF-β promotes epithelial-mesenchymal transition, invasion and metastasis of human hepatocellular carcinoma cells in vitro. Am J Transl Res. 9:2956–2965. 2017.PubMed/NCBI

27 

Zhao H, Zhang J, Shao H, Liu J, Jin M, Chen J and Huang Y: Transforming growth factor β1/Smad4 signaling affects osteoclast differentiation via regulation of miR-155 expression. Mol Cells. 40:211–221. 2017.PubMed/NCBI

28 

Koennecke M, Benecke F, Masche A, Linke R, Bruchhage KL, Pries R, Klimek L and Wollenberg B: Increased phosphorylation of eNOS in nasal polyps of chronic rhinosinusitis patients can be diminished by 1,8-cineol. Nitric Oxide. 78:89–94. 2018. View Article : Google Scholar : PubMed/NCBI

29 

DeConde AS and Soler ZM: Chronic rhinosinusitis: Epidemiology and burden of disease. Am J Rhinol Allergy. 30:134–139. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Hupin C, Gohy S, Bouzin C, Lecocq M, Polette M and Pilette C: Features of mesenchymal transition in the airway epithelium from chronic rhinosinusitis. Allergy. 69:1540–1549. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Lee HM, Kang JH, Shin JM, Lee SA and Park IH: Chemical chaperone of endoplasmic reticulum stress inhibits epithelial-mesenchymal transition induced by TGF-β1 in airway epithelium via the c-src pathway. Mediators Inflamm. 2017:81232812017. View Article : Google Scholar : PubMed/NCBI

32 

Pu Y, Liu Y, Liao S, Miao S, Zhou L and Wan L: Azithromycin ameliorates OVA-induced airway remodeling in Balb/c mice via suppression of epithelial-to-mesenchymal transition. Int Immunopharmacol. 58:87–93. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Hirota N and Martin JG: Mechanisms of airway remodeling. Chest. 144:1026–1032. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Tian X, Tian X, Huo R, Chang Q, Zheng G, Du Y, Chen Y and Niu B: Bacillus calmette-guerin alleviates airway inflammation and remodeling by preventing TGF-β1 induced epithelial-mesenchymal transition. Hum Vaccin Immunother. 13:1758–1764. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Cruz-Solbes AS and Youker K: Epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT): Role and implications in kidney fibrosis. Results Probl Cell Differ. 60:345–372. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Title AC, Hong SJ, Pires ND, Hasenöhrl L, Godbersen S, Stokar-Regenscheit N, Bartel DP and Stoffel M: Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion. Nat Commun. 9:46712018. View Article : Google Scholar : PubMed/NCBI

37 

Lu L, Zhu J, Zhang Y, Wang Y, Zhang S and Xia A: Febuxostat inhibits TGF-β1-induced epithelial-mesenchymal transition via downregulation of USAG-1 expression in madin-darby canine kidney cells in vitro. Mol Med Rep. 19:1694–1704. 2019.PubMed/NCBI

38 

Sisto M, Lisi S and Ribatti D: The role of the epithelial-to-mesenchymal transition (EMT) in diseases of the salivary glands. Histochem Cell Biol. 150:133–147. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Khalmuratova R, Park JW and Shin HW: Immune cell responses and mucosal barrier disruptions in chronic rhinosinusitis. Immune Netw. 17:60–67. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Chen L, Xiao L, Liu J, Shen Y, Ke X, Huang J, Hu G and Yang Y: Differential expression of the aryl hydrocarbon receptor and transforming growth factor beta 1 in chronic rhinosinusitis with nasal polyps with allergic rhinitis. ORL J Otorhinolaryngol Relat Spec. 79:295–305. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Kim SI and Choi ME: TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease. Kidney Res Clin Pract. 31:94–105. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Mahmood MQ, Reid D, Ward C, Muller HK, Knight DA, Sohal SS and Walters EH: Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis. Respirology. 22:133–140. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Ryu NH, Shin JM, Um JY, Park IH and Lee HM: Wogonin inhibits transforming growth factor β1-induced extracellular matrix production via the p38/activator protein 1 signaling pathway in nasal polyp-derived fibroblasts. Am J Rhinol Allergy. 30:128–133. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Zhao XS, Han B, Zhao JX, Tao N and Dong CY: miR-155-5p affects wilms' tumor cell proliferation and apoptosis via targeting CREB1. Eur Rev Med Pharmacol Sci. 23:1030–1037. 2019.PubMed/NCBI

45 

Wang Y, Zheng ZJ, Jia YJ, Yang YL and Xue YM: Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease. J Transl Med. 16:1462018. View Article : Google Scholar : PubMed/NCBI

46 

Zhang D, Cui Y, Li B, Luo X, Li B and Tang Y: miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-β signaling pathway. Mol Biosyst. 13:215–224. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Wang J, He W, Xu X, Guo L, Zhang Y, Han S and Shen D: The mechanism of TGF-β/miR-155/c-Ski regulates endothelial-mesenchymal transition in human coronary artery endothelial cells. Biosci Rep. 37:BSR201606032017. View Article : Google Scholar : PubMed/NCBI

48 

Lee M, Kim DW, Yoon H, So D, Khalmuratova R, Rhee CS, Park JW and Shin HW: Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition. J Allergy Clin Immunol. 137:87–98. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Huang G, Hao F and Hu X: Downregulation of microRNA-155 stimulates sevoflurane-mediated cardioprotection against myocardial ischemia/reperfusion injury by binding to SIRT1 in mice. J Cell Biochem. 120:15494–15505. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang N, Cheng H, Mo Q, Zhou X and Xie M: miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells. Mol Med Rep 22: 3695-3704, 2020.
APA
Yang, N., Cheng, H., Mo, Q., Zhou, X., & Xie, M. (2020). miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells. Molecular Medicine Reports, 22, 3695-3704. https://doi.org/10.3892/mmr.2020.11468
MLA
Yang, N., Cheng, H., Mo, Q., Zhou, X., Xie, M."miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells". Molecular Medicine Reports 22.5 (2020): 3695-3704.
Chicago
Yang, N., Cheng, H., Mo, Q., Zhou, X., Xie, M."miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells". Molecular Medicine Reports 22, no. 5 (2020): 3695-3704. https://doi.org/10.3892/mmr.2020.11468
Copy and paste a formatted citation
x
Spandidos Publications style
Yang N, Cheng H, Mo Q, Zhou X and Xie M: miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells. Mol Med Rep 22: 3695-3704, 2020.
APA
Yang, N., Cheng, H., Mo, Q., Zhou, X., & Xie, M. (2020). miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells. Molecular Medicine Reports, 22, 3695-3704. https://doi.org/10.3892/mmr.2020.11468
MLA
Yang, N., Cheng, H., Mo, Q., Zhou, X., Xie, M."miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells". Molecular Medicine Reports 22.5 (2020): 3695-3704.
Chicago
Yang, N., Cheng, H., Mo, Q., Zhou, X., Xie, M."miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells". Molecular Medicine Reports 22, no. 5 (2020): 3695-3704. https://doi.org/10.3892/mmr.2020.11468
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