Open Access

Exosomal non‑coding RNAs: Novel biomarkers with emerging clinical applications in gastric cancer (Review)

  • Authors:
    • Xu Lu
    • Yu Zhang
    • Guangfei Xie
    • Ye Ding
    • Hui Cong
    • Shihai Xuan
  • View Affiliations

  • Published online on: September 17, 2020     https://doi.org/10.3892/mmr.2020.11519
  • Pages: 4091-4100
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is one of the most common types of malignant tumor and it demonstrates high mortality rates. The majority of cases of GC are diagnosed at an advanced stage, which seriously endangers the health of the patient. Therefore, discovering a novel diagnostic method for GC is a current priority. Exosomes are 40 to 150‑nm‑diameter vesicles consisting of a lipid bilayer secreted by a variety of cells that exist in multiple different types of body fluids. Exosomes contain diverse types of active substances, including RNAs, proteins and lipids, and play important roles in tumor cell communication, metastasis and neovascularization, as well as tumor growth. Non‑coding RNAs (ncRNAs) do not code proteins, and instead have roles in a variety of genetic mechanisms, such as regulating the structure, expression and stability of RNAs, and modulating the translation and function of proteins. In recent years, exosomal ncRNAs have become a novel focus in research. An increasing number of studies have demonstrated that exosomal ncRNAs can be used in the prediction and treatment of GC. The present review briefly discusses the role of exosomal ncRNAs as a potential biomarker, and summarizes important regulatory genes involved in the development and progression of GC.
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November-2020
Volume 22 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Lu X, Zhang Y, Xie G, Ding Y, Cong H and Xuan S: Exosomal non‑coding RNAs: Novel biomarkers with emerging clinical applications in gastric cancer (Review). Mol Med Rep 22: 4091-4100, 2020
APA
Lu, X., Zhang, Y., Xie, G., Ding, Y., Cong, H., & Xuan, S. (2020). Exosomal non‑coding RNAs: Novel biomarkers with emerging clinical applications in gastric cancer (Review). Molecular Medicine Reports, 22, 4091-4100. https://doi.org/10.3892/mmr.2020.11519
MLA
Lu, X., Zhang, Y., Xie, G., Ding, Y., Cong, H., Xuan, S."Exosomal non‑coding RNAs: Novel biomarkers with emerging clinical applications in gastric cancer (Review)". Molecular Medicine Reports 22.5 (2020): 4091-4100.
Chicago
Lu, X., Zhang, Y., Xie, G., Ding, Y., Cong, H., Xuan, S."Exosomal non‑coding RNAs: Novel biomarkers with emerging clinical applications in gastric cancer (Review)". Molecular Medicine Reports 22, no. 5 (2020): 4091-4100. https://doi.org/10.3892/mmr.2020.11519