YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review)

  • Authors:
    • Liya Jiang
    • Juan Li
    • Chenxing Zhang
    • Yufeng Shang
    • Jun Lin
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  • Published online on: September 21, 2020     https://doi.org/10.3892/mmr.2020.11529
  • Pages: 4101-4106
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Abstract

Yes‑associated protein (YAP) acts as a transcriptional co‑activator in gene expression and cell proliferation control by binding to the transcriptional factor TEA domain (TEAD) of the Hippo signaling pathway in the nucleus, and also acts as a regulator by binding to another transcriptional co‑activator, β‑catenin of the Wnt signaling pathway. Whether YAP preferentially acts as a transcriptional co‑regulator of the activity of the Hippo signaling pathway or as a regulator in the Wnt signaling pathway depends on the cell type. Nuclear YAP upregulates the expression of β‑catenin, while cytoplasmic YAP has a negative effect on this expression. The present mini‑review focused on the important roles of YAP and further discussed the cross‑links between the Wnt and Hippo signaling pathways. The Wnt and Hippo signaling pathways are both related to the development of fibrosis or cancer. The current review discussed treatment approaches for these conditions based on the two pathways. YAP, the intersection of these two signaling pathways, has the potential to be developed as a novel treatment target, according to previous basic studies on fibroblasts and cancer cells.
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November-2020
Volume 22 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Jiang L, Li J, Zhang C, Shang Y and Lin J: YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review). Mol Med Rep 22: 4101-4106, 2020
APA
Jiang, L., Li, J., Zhang, C., Shang, Y., & Lin, J. (2020). YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review). Molecular Medicine Reports, 22, 4101-4106. https://doi.org/10.3892/mmr.2020.11529
MLA
Jiang, L., Li, J., Zhang, C., Shang, Y., Lin, J."YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review)". Molecular Medicine Reports 22.5 (2020): 4101-4106.
Chicago
Jiang, L., Li, J., Zhang, C., Shang, Y., Lin, J."YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review)". Molecular Medicine Reports 22, no. 5 (2020): 4101-4106. https://doi.org/10.3892/mmr.2020.11529