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CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression

  • Authors:
    • Hangwei Fu
    • Yida Zhang
    • Yin Chen
    • Junying Chen
    • Ping Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing 400042, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 46
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    Published online on: November 12, 2020
       https://doi.org/10.3892/mmr.2020.11684
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Abstract

Constitutive photomorphogenesis 9 signalosome subunit 1 (CSN1) plays an important role in the ubiquitin-proteasome pathway and regulates various cellular processes, such as the cell cycle and DNA repair. The CSN complex consists of eight subunits (CSN1 to CSN8) and regulates the tumorigenesis of a variety of tumor types. However, the exact role of CSN1 in hepatocellular carcinoma (HCC) remains unclear. The present study evaluated the expression and biological effects of CSN1 in HCC tissue samples and cell lines. CSN1 was significantly overexpressed in HCC tissue and cell lines, compared with their normal counterparts. In patients with HCC, elevated CSN1 levels correlated with tumor size, tumor metastasis and tumor stage. Loss‑of‑function assays indicated that CSN1 knockdown inhibited the proliferation and migration HCC cells. In addition, CSN1 promoted the expression of cyclin A2 in a ubiquitination‑independent manner. Lastly, xenograft experiments indicated that CSN1 promoted HCC tumor growth in vivo. The present study suggested that CSN1 inhibition could represent a potential approach for the prevention of HCC progression and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Fu H, Zhang Y, Chen Y, Chen J and Chen P: CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Mol Med Rep 23: 46, 2021.
APA
Fu, H., Zhang, Y., Chen, Y., Chen, J., & Chen, P. (2021). CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Molecular Medicine Reports, 23, 46. https://doi.org/10.3892/mmr.2020.11684
MLA
Fu, H., Zhang, Y., Chen, Y., Chen, J., Chen, P."CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression". Molecular Medicine Reports 23.1 (2021): 46.
Chicago
Fu, H., Zhang, Y., Chen, Y., Chen, J., Chen, P."CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression". Molecular Medicine Reports 23, no. 1 (2021): 46. https://doi.org/10.3892/mmr.2020.11684
Copy and paste a formatted citation
x
Spandidos Publications style
Fu H, Zhang Y, Chen Y, Chen J and Chen P: CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Mol Med Rep 23: 46, 2021.
APA
Fu, H., Zhang, Y., Chen, Y., Chen, J., & Chen, P. (2021). CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Molecular Medicine Reports, 23, 46. https://doi.org/10.3892/mmr.2020.11684
MLA
Fu, H., Zhang, Y., Chen, Y., Chen, J., Chen, P."CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression". Molecular Medicine Reports 23.1 (2021): 46.
Chicago
Fu, H., Zhang, Y., Chen, Y., Chen, J., Chen, P."CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression". Molecular Medicine Reports 23, no. 1 (2021): 46. https://doi.org/10.3892/mmr.2020.11684
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