Open Access

Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β

  • Authors:
    • Jian Wang
    • Yuanting Liu
    • Ying Li
    • Xuan Zheng
    • Jianhui Gan
    • Zhaoyuan Wan
    • Jun Zhang
    • Yan Liu
    • Yaqi Wang
    • Wanning Hu
    • Yufeng Li
    • Yankun Liu
  • View Affiliations

  • Published online on: November 23, 2020     https://doi.org/10.3892/mmr.2020.11723
  • Article Number: 84
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRs) carried in exosomes serve an important role in the pre‑metastatic microenvironment and in intercellular interactions. However, the function of exosomal‑miR‑10a derived from primary colorectal cancer (CRC) cells on fibroblasts in the lung metastatic microenvironment of patients with CRC remains unclear. Reverse transcription‑quantitative PCR was performed using samples from patients with CRC, and demonstrated that the expression levels of miR‑10a were significantly lower in serum and cancer tissue samples from patients with CRC compared with in serum from healthy individuals and paired non‑cancerous tissues, respectively. In addition, the expression levels of miR‑10a were inversely associated with the invasion depth of CRC. Exosomal‑miR‑10a derived from CRC cells reduced the proliferative and migratory activities of primary normal human lung fibroblasts (NHLFs), and the expression levels of IL‑6, IL‑8 and IL‑1β in NHLFs. The present study provided insight into the phenotypic alterations of NHLFs induced by exosomal‑miR‑10a derived from CRC cells, which may aid understanding of the mechanism underlying the process of CRC lung metastasis.
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January-2021
Volume 23 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang J, Liu Y, Li Y, Zheng X, Gan J, Wan Z, Zhang J, Liu Y, Wang Y, Hu W, Hu W, et al: Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β. Mol Med Rep 23: 84, 2021
APA
Wang, J., Liu, Y., Li, Y., Zheng, X., Gan, J., Wan, Z. ... Liu, Y. (2021). Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β. Molecular Medicine Reports, 23, 84. https://doi.org/10.3892/mmr.2020.11723
MLA
Wang, J., Liu, Y., Li, Y., Zheng, X., Gan, J., Wan, Z., Zhang, J., Liu, Y., Wang, Y., Hu, W., Li, Y., Liu, Y."Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β". Molecular Medicine Reports 23.1 (2021): 84.
Chicago
Wang, J., Liu, Y., Li, Y., Zheng, X., Gan, J., Wan, Z., Zhang, J., Liu, Y., Wang, Y., Hu, W., Li, Y., Liu, Y."Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β". Molecular Medicine Reports 23, no. 1 (2021): 84. https://doi.org/10.3892/mmr.2020.11723