Open Access

Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice

  • Authors:
    • Zhiping Li
    • Hui Bi
    • Hongbo Jiang
    • Jingjing Song
    • Qingfan Meng
    • Yizhi Zhang
    • Xiaofang Fei
  • View Affiliations

  • Published online on: December 2, 2020     https://doi.org/10.3892/mmr.2020.11747
  • Article Number: 108
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Emodin is a naturally‑occurring medicinal herbal ingredient that possesses numerous pharmacological properties, including anti‑inflammatory and antioxidant effects. In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to β‑amyloid peptide (Aβ)‑induced apoptosis and in amyloid precursor protein (APP)/presenilin‑1 (PS1) double‑transgenic mice. U251 is a type of human astroglioma cell line (cat. no. BNCC337874; BeNa Culture Collection). In apoptotic U251 cells, 3‑h emodin pre‑treatment prior to 24‑h Aβ co‑exposure improved cell viability, suppressed lactate dehydrogenase leakage and caspase‑3, ‑8 and ‑9 activation to inhibit apoptosis. Compared with those after Aβ exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over‑accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor‑erythroid‑2‑related factor 2 (Nrf2), haemeoxygenase‑1, superoxide dismutase 1, Bcl‑2 and catalase in addition to decreasing the expression levels of Bax. In APP/PS1 mice, an 8‑week course of emodin administration improved spatial memory and learning ability and decreased anxiety. Emodin was also found to regulate key components in the Nrf2 pathway and decreased the deposition of Aβ, phosphorylated‑τ and 4‑hydroxy‑2‑nonenal in APP/PS1 mice. Taken together, the present data suggest that emodin may serve as a promising candidate for the treatment of Alzheimer's disease.
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February-2021
Volume 23 Issue 2

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Spandidos Publications style
Li Z, Bi H, Jiang H, Song J, Meng Q, Zhang Y and Fei X: Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice. Mol Med Rep 23: 108, 2021
APA
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., & Fei, X. (2021). Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice. Molecular Medicine Reports, 23, 108. https://doi.org/10.3892/mmr.2020.11747
MLA
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., Fei, X."Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice". Molecular Medicine Reports 23.2 (2021): 108.
Chicago
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., Fei, X."Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice". Molecular Medicine Reports 23, no. 2 (2021): 108. https://doi.org/10.3892/mmr.2020.11747