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Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice

Corrigendum in: /10.3892/mmr.2023.12994
  • Authors:
    • Zhiping Li
    • Hui Bi
    • Hongbo Jiang
    • Jingjing Song
    • Qingfan Meng
    • Yizhi Zhang
    • Xiaofang Fei
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Anesthesiology, Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China, School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China, Department of Neurology, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin 130041, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 108
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    Published online on: December 2, 2020
       https://doi.org/10.3892/mmr.2020.11747
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Abstract

Emodin is a naturally‑occurring medicinal herbal ingredient that possesses numerous pharmacological properties, including anti‑inflammatory and antioxidant effects. In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to β‑amyloid peptide (Aβ)‑induced apoptosis and in amyloid precursor protein (APP)/presenilin‑1 (PS1) double‑transgenic mice. U251 is a type of human astroglioma cell line (cat. no. BNCC337874; BeNa Culture Collection). In apoptotic U251 cells, 3‑h emodin pre‑treatment prior to 24‑h Aβ co‑exposure improved cell viability, suppressed lactate dehydrogenase leakage and caspase‑3, ‑8 and ‑9 activation to inhibit apoptosis. Compared with those after Aβ exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over‑accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor‑erythroid‑2‑related factor 2 (Nrf2), haemeoxygenase‑1, superoxide dismutase 1, Bcl‑2 and catalase in addition to decreasing the expression levels of Bax. In APP/PS1 mice, an 8‑week course of emodin administration improved spatial memory and learning ability and decreased anxiety. Emodin was also found to regulate key components in the Nrf2 pathway and decreased the deposition of Aβ, phosphorylated‑τ and 4‑hydroxy‑2‑nonenal in APP/PS1 mice. Taken together, the present data suggest that emodin may serve as a promising candidate for the treatment of Alzheimer's disease.
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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Bi H, Jiang H, Song J, Meng Q, Zhang Y and Fei X: Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994. Mol Med Rep 23: 108, 2021.
APA
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., & Fei, X. (2021). Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994. Molecular Medicine Reports, 23, 108. https://doi.org/10.3892/mmr.2020.11747
MLA
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., Fei, X."Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994". Molecular Medicine Reports 23.2 (2021): 108.
Chicago
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., Fei, X."Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994". Molecular Medicine Reports 23, no. 2 (2021): 108. https://doi.org/10.3892/mmr.2020.11747
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Spandidos Publications style
Li Z, Bi H, Jiang H, Song J, Meng Q, Zhang Y and Fei X: Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994. Mol Med Rep 23: 108, 2021.
APA
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., & Fei, X. (2021). Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994. Molecular Medicine Reports, 23, 108. https://doi.org/10.3892/mmr.2020.11747
MLA
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., Fei, X."Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994". Molecular Medicine Reports 23.2 (2021): 108.
Chicago
Li, Z., Bi, H., Jiang, H., Song, J., Meng, Q., Zhang, Y., Fei, X."Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice Corrigendum in /10.3892/mmr.2023.12994". Molecular Medicine Reports 23, no. 2 (2021): 108. https://doi.org/10.3892/mmr.2020.11747
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